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ENTRY	nt06523
Name	Epigenetic regulation by Polycomb complexes
Category	Pathway view; Cellular process
Pathway	hsa03083 Polycomb repressive complex
Display	drug-target relation   disease type

N01577    PRC2.1 = (EPOP+ELOB+ELOC),(.. − H3 → PRC2.2 − H3K27me3 = cPRC1 − H2AK119+UB     WVS EZH2*     IMMAS SUZ12*     COGIS EED*     HADDTS     CTBP1*     BRYLIB1         H3-3A*     BRYLIB2         H3-3B*     DIDDF             JARID2*     TPFS                     PCGF2*     LUSYAM                     RNF2*     MCPH11                     PHC1*   N01585                    PR-DUB ⊣ cPRC1     KURIS/TPDS1                 BAP1*     MDS/BOPS                 ASXL1*     SHAPNS                 ASXL2*     BRPS                 ASXL3*     XLID106                 OGT*     XLID3/MAHCX                 HCFC1*     GADEVS                 YY1*     MRD1                 MBD5*   N01586    PRC1.1 − (USP7+TRIM27) − H2AK119+UB → PRC2.2     MCOPS2 BCOR*     SHUVER BCORL1*     HAFOUS     USP7*   N01614    PRC1.6 − (MGA,MAX+L3MBTL2+E.. − H2AK119+UB → PRC2.2     KLEFS1 EHMT1*     PH     MAX*   N01620    CK2 ⊣ PRC1.3,PRC1.5 − H2AK119+UB     OCNDS CSNK2A1*     POBINDS CSNK2B*     MRD26     AUTS2*   N01701    PRC1.3,PRC1.5 = TEX10+EP300 − H3 → H3K27ac     RSTS2/MKHK2     EP300*

		Disease name	Disease category
WVS	H01751	Weaver syndrome	Congenital malformation
IMMAS	H02522	Imagawa-Matsumoto syndrome	Congenital malformation
COGIS	H02477	Cohen-Gibson syndrome	Congenital malformation
HADDTS	H02619	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Congenital malformation
BRYLIB1	H02617	Bryant-Li-Bhoj neurodevelopmental syndrome	Congenital malformation
BRYLIB2	H02617	Bryant-Li-Bhoj neurodevelopmental syndrome	Congenital malformation
DIDDF	H02618	Developmental delay with variable intellectual disability and dysmorphic facies	Congenital malformation
TPFS	H02611	Turnpenny-Fry syndrome	Congenital malformation
LUSYAM	H02587	Luo-Schoch-Yamamoto syndrome	Congenital malformation
MCPH11	H00269	Primary microcephaly	Congenital malformation
KURIS/TPDS1	H02623	Kury-Isidor syndrome	Congenital malformation
	H02624	Tumor predisposition syndrome	Cancer
MDS/BOPS	H01481	Myelodysplastic syndrome	Hematologic disease
	H02047	Bohring-Opitz syndrome	Congenital malformation
SHAPNS	H02803	Neurodevelopmental disorder with histone modification defect	Congenital malformation
BRPS	H02382	Bainbridge-Ropers syndrome	Congenital malformation
XLID106	H00480	X-linked intellectual developmental disorder	Mental and behavioural disorder
XLID3/MAHCX	H00480	X-linked intellectual developmental disorder	Mental and behavioural disorder
	H02222	Methylmalonic acidemia and hyperhomocysteinemia, cblX type	Inherited metabolic disorder
GADEVS	H02490	Gabriele-de Vries syndrome	Mental and behavioural disorder
MRD1	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
MCOPS2	H02170	Microphthalmia, syndromic	Congenital malformation
SHUVER	H02622	Shukla-Vernon syndrome	Congenital malformation
HAFOUS	H02528	Hao-Fountain syndrome	Congenital malformation
KLEFS1	H00907	Kleefstra syndrome	Congenital malformation
PH	H01510	Malignant paraganglioma	Cancer
OCNDS	H02460	Neurodevelopmental disorder with dysmorphic facies and skeletal anomalies	Congenital malformation
POBINDS	H02635	Poirier-Bienvenu neurodevelopmental syndrome	Congenital malformation
MRD26	H00773	Autosomal dominant intellectual developmental disorder	Mental and behavioural disorder
RSTS2/MKHK2	H00504	Rubinstein-Taybi syndrome	Congenital malformation
	H02650	Menke-Hennekam syndrome	Congenital malformation