Homo sapiens (human): 7010
Help
Entry
7010 CDS
T01001
Symbol
TEK, CD202B, GLC3E, TIE-2, TIE2, VMCM, VMCM1
Name
(RefSeq) TEK receptor tyrosine kinase
KO
K05121
endothelial-specific receptor tyrosine kinase [EC:
2.7.10.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa05323
Rheumatoid arthritis
Network
nt06526
MAPK signaling
nt06530
PI3K signaling
Element
N01592
GF-RTK-RAS-ERK signaling pathway
N01599
Regulation of GF-RTK-RAS-ERK signaling, ubiquitination of RTK by CBL
N01656
GF-RTK-PI3K signaling pathway
N01658
GF-RTK-RAS-PI3K signaling pathway
Disease
H00531
Venous malformations
H01203
Primary congenital glaucoma
H02044
Cutaneous and mucosal venous malformation
Drug target
Altiratinib:
D10862
Razuprotafib:
D11540
Rebastinib (
DG01368
):
D10334
D10399
Regorafenib (
DG00720
):
D10137
<JP/US>
D10138
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
7010 (TEK)
04015 Rap1 signaling pathway
7010 (TEK)
04066 HIF-1 signaling pathway
7010 (TEK)
04151 PI3K-Akt signaling pathway
7010 (TEK)
09160 Human Diseases
09163 Immune disease
05323 Rheumatoid arthritis
7010 (TEK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
7010 (TEK)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
hsa04090
]
7010 (TEK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
7010 (TEK)
Protein kinases [BR:
hsa01001
]
Receptor tyrosine kinases (RTK)
TIE family
7010 (TEK)
CD molecules [BR:
hsa04090
]
Proteins
7010 (TEK)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
Ig_Tie2_1
fn3
Pur_ac_phosph_N
Ig_DSCAM-DSCAML_C
EGF_2
Ig_2
hEGF
Fn3_ELFN
EGF_PEAR1L
fn3_2
APH
Haspin_kinase
DUF4702
EGF_Teneurin
Pkinase_fungal
Motif
Other DBs
NCBI-GeneID:
7010
NCBI-ProteinID:
NP_000450
OMIM:
600221
HGNC:
11724
Ensembl:
ENSG00000120156
UniProt:
Q02763
Q59HG2
Structure
PDB
PDBj
LinkDB
All DBs
Position
9:27109225..27230174
Genome browser
AA seq
1124 aa
AA seq
DB search
MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIQRMTPKIVDLPDHIE
VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
NT seq
3375 nt
NT seq
+upstream
nt +downstream
nt
atggactctttagccagcttagttctctgtggagtcagcttgctcctttctggaactgtg
gaaggtgccatggacttgatcttgatcaattccctacctcttgtatctgatgctgaaaca
tctctcacctgcattgcctctgggtggcgcccccatgagcccatcaccataggaagggac
tttgaagccttaatgaaccagcaccaggatccgctggaagttactcaagatgtgaccaga
gaatgggctaaaaaagttgtttggaagagagaaaaggctagtaagatcaatggtgcttat
ttctgtgaagggcgagttcgaggagaggcaatcaggatacgaaccatgaagatgcgtcaa
caagcttccttcctaccagctactttaactatgactgtggacaagggagataacgtgaac
atatctttcaaaaaggtattgattaaagaagaagatgcagtgatttacaaaaatggttcc
ttcatccattcagtgccccggcatgaagtacctgatattctagaagtacacctgcctcat
gctcagccccaggatgctggagtgtactcggccaggtatataggaggaaacctcttcacc
tcggccttcaccaggctgatagtccggagatgtgaagcccagaagtggggacctgaatgc
aaccatctctgtactgcttgtatgaacaatggtgtctgccatgaagatactggagaatgc
atttgccctcctgggtttatgggaaggacgtgtgagaaggcttgtgaactgcacacgttt
ggcagaacttgtaaagaaaggtgcagtggacaagagggatgcaagtcttatgtgttctgt
ctccctgacccctatgggtgttcctgtgccacaggctggaagggtctgcagtgcaatgaa
gcatgccaccctggtttttacgggccagattgtaagcttaggtgcagctgcaacaatggg
gagatgtgtgatcgcttccaaggatgtctctgctctccaggatggcaggggctccagtgt
gagagagaaggcatacagaggatgaccccaaagatagtggatttgccagatcatatagaa
gtaaacagtggtaaatttaatcccatttgcaaagcttctggctggccgctacctactaat
gaagaaatgaccctggtgaagccggatgggacagtgctccatccaaaagactttaaccat
acggatcatttctcagtagccatattcaccatccaccggatcctcccccctgactcagga
gtttgggtctgcagtgtgaacacagtggctgggatggtggaaaagcccttcaacatttct
gttaaagttcttccaaagcccctgaatgccccaaacgtgattgacactggacataacttt
gctgtcatcaacatcagctctgagccttactttggggatggaccaatcaaatccaagaag
cttctatacaaacccgttaatcactatgaggcttggcaacatattcaagtgacaaatgag
attgttacactcaactatttggaacctcggacagaatatgaactctgtgtgcaactggtc
cgtcgtggagagggtggggaagggcatcctggacctgtgagacgcttcacaacagcttct
atcggactccctcctccaagaggtctaaatctcctgcctaaaagtcagaccactctaaat
ttgacctggcaaccaatatttccaagctcggaagatgacttttatgttgaagtggagaga
aggtctgtgcaaaaaagtgatcagcagaatattaaagttccaggcaacttgacttcggtg
ctacttaacaacttacatcccagggagcagtacgtggtccgagctagagtcaacaccaag
gcccagggggaatggagtgaagatctcactgcttggacccttagtgacattcttcctcct
caaccagaaaacatcaagatttccaacattacacactcctcagctgtgatttcttggaca
atattggatggctattctatttcttctattactatccgttacaaggttcaaggcaagaat
gaagaccagcacgttgatgtgaagataaagaatgccaccatcactcagtatcagctcaag
ggcctagagcctgaaacagcataccaggtggacatttttgcagagaacaacatagggtca
agcaacccagccttttctcatgaactggtgaccctcccagaatctcaagcaccagcggac
ctcggaggggggaagatgctgcttatagccatccttggctctgctggaatgacctgcctg
actgtgctgttggcctttctgatcatattgcaattgaagagggcaaatgtgcaaaggaga
atggcccaagccttccaaaacgtgagggaagaaccagctgtgcagttcaactcagggact
ctggccctaaacaggaaggtcaaaaacaacccagatcctacaatttatccagtgcttgac
tggaatgacatcaaatttcaagatgtgattggggagggcaattttggccaagttcttaag
gcgcgcatcaagaaggatgggttacggatggatgctgccatcaaaagaatgaaagaatat
gcctccaaagatgatcacagggactttgcaggagaactggaagttctttgtaaacttgga
caccatccaaacatcatcaatctcttaggagcatgtgaacatcgaggctacttgtacctg
gccattgagtacgcgccccatggaaaccttctggacttccttcgcaagagccgtgtgctg
gagacggacccagcatttgccattgccaatagcaccgcgtccacactgtcctcccagcag
ctccttcacttcgctgccgacgtggcccggggcatggactacttgagccaaaaacagttt
atccacagggatctggctgccagaaacattttagttggtgaaaactatgtggcaaaaata
gcagattttggattgtcccgaggtcaagaggtgtatgtgaaaaagacaatgggaaggctc
ccagtgcgctggatggccatcgagtcactgaattacagtgtgtacacaaccaacagtgat
gtatggtcctatggtgtgttactatgggagattgttagcttaggaggcacaccctactgc
gggatgacttgtgcagaactctacgagaagctgccccagggctacagactggagaagccc
ctgaactgtgatgatgaggtgtatgatctaatgagacaatgctggcgggagaagccttat
gagaggccatcatttgcccagatattggtgtccttaaacagaatgttagaggagcgaaag
acctacgtgaataccacgctttatgagaagtttacttatgcaggaattgactgttctgct
gaagaagcggcctag
DBGET
integrated database retrieval system
