Homo sapiens (human): 7074 Help Entry 7074              CDS       T01001                                  Symbol TIAM1, NEDLDS, TIAM-1 Name (RefSeq) TIAM Rac1 associated GEF 1   KO K05731   T-lymphoma invasion and metastasis-inducing protein 1 Organism hsa  Homo sapiens (human) Pathway hsa04014   Ras signaling pathway hsa04015   Rap1 signaling pathway hsa04024   cAMP signaling pathway hsa04062   Chemokine signaling pathway hsa04530   Tight junction hsa04810   Regulation of actin cytoskeleton hsa05205   Proteoglycans in cancer Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     7074 (TIAM1)    04015 Rap1 signaling pathway     7074 (TIAM1)    04024 cAMP signaling pathway     7074 (TIAM1)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04530 Tight junction     7074 (TIAM1)   09142 Cell motility    04810 Regulation of actin cytoskeleton     7074 (TIAM1)  09150 Organismal Systems   09151 Immune system    04062 Chemokine signaling pathway     7074 (TIAM1)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     7074 (TIAM1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04990 Domain-containing proteins not elsewhere classified [BR:hsa04990]     7074 (TIAM1) Domain-containing proteins not elsewhere classified [BR:hsa04990]  Pleckstrin homology (PH) domain-containing proteins   Dbl-Like RhoGEF family proteins    7074 (TIAM1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RhoGEF Tiam_CC_Ex PH RBD PH_9 PDZ PDZ_2 PDZ_6 Peptidase_M50 PH_11 Motif Other DBs NCBI-GeneID:  7074 NCBI-ProteinID:  NP_003244 OMIM:  600687 HGNC:  11805 Ensembl:  ENSG00000156299 Pharos:  Q13009(Tbio) UniProt:  Q13009 A0A2X0TW27 Structure PDB LinkDB All DBs Position 21:complement(31118418..31559087) Genome browser AA seq 1591 aa AA seqDB search MGNAESQHVEHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKVIHRNSEVSTRSSS TPSIPQSLAENGLEPFSQDGTLEDFGSPIWVDRVDMGLRPVSYTDSSVTPSVDSSIVLTA ASVQSMPDTEESRLYGDDATYLAEGGRRQHSYTSNGPTFMETASFKKKRSKSADIWREDS LEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETRASPRQLSTCQRANSLGDLYAQKN SGVTANGGPGSKFAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYNTLPCRKSHCLSEG ATNPQISHSNSMQGRRAKTTQDVNAGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPT TGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSP GQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESD GRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWIT AIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDSKKKKTI LDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLAFASRPTKVAMGRLGIFSVS SFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPSINQVFGEGT EAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTV VRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLYVPQPEEDIYELLYKEIEICP KVTQSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASKKGLKAGDEILEINN RAADALNSSMLKDFLSQPSLGLLVRTYPELEEGVELLESPPHRVDGPADLGESPLAFLTS NPGHSLCSEQGSSAETAPEETEGPDLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPS PQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDE LDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFK LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLL RELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVA DLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRL SIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSP ESRKDFLKAVHSILRDKHRRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPS KSLGRRRRRLARNRFTIDSDAVSASSPEKESQQPPGGGDTDRWVEEQFDLAQYEEQDDIK ETDILSDDDEFCESVKGASVDRDLQERLQATSISQRERGRKTLDSHASRMAQLKKQAALS GINGGLESASEEVIWVRREDFAPSRKLNTEI NT seq 4776 nt NT seq  +upstreamnt  +downstreamnt atgggaaacgcagaaagtcaacatgtagagcacgagttttatggagaaaagcatgccagc ctggggcgcaagcacacttcccgctccctgcgcctctcgcacaagacgcggaggaccagg cacgcttcctcggggaaggtgatccacaggaactccgaagtgagcacccgatccagcagc acccccagcatcccccagtccctggctgaaaatggcctggagcccttctcccaagatggt accctagaagacttcgggagccccatctgggtggaccgagtggacatgggcttgagacct gtgtcttacactgactcttctgtcactcccagcgtagacagcagcatcgtcctcacagca gcctctgtgcagagcatgccagacactgaggagagcaggctttacggggatgacgctaca tatttggctgagggaggcaggaggcagcattcctatacatccaatgggcccactttcatg gagacggcgagctttaagaagaaacgctccaaatctgcagacatctggcgggaggacagc ctggaattctcactctctgatctgagccaagaacatttaacaagcaacgaagaaatcttg ggttccgccgaagagaaggactgcgaggaggctcgggggatggaaacgcgggcgagtccg cggcagctcagcacctgtcagagagccaattccttgggtgacttgtatgctcagaaaaac tctggagtgacagcaaacggggggccggggagcaaatttgcaggctactgtcggaatttg gtgtctgatattcccaatcttgcaaaccataagatgccaccagctgctgctgaagagact cctccgtacagtaattataacacacttccctgtaggaaatctcactgtctctctgaaggt gccaccaacccacaaattagccatagcaacagcatgcaaggcagaagagctaaaacaact caggatgttaatgcaggcgagggcagtgagtttgcagacagtgggattgaaggggccact accgacacggacctcctgtccaggcgatctaatgccaccaactccagctactcacccacc acaggccgggcctttgtgggcagcgacagcggcagcagctccaccggggatgcggctcgt cagggggtgtacgagaacttccggcgggagctggagatgagcaccaccaacagcgagagc ctggaggaggccggctcggcgcacagcgatgagcagagcagcggcaccctgagctctccg ggccagtcggacatcctgctgaccgccgcacagggcacggtgcgcaaggccggcgccctg gccgtcaagaacttcctggtgcacaagaagaacaagaaggtggagtcagccacccggagg aagtggaagcactactgggtgtccctgaaaggatgcacgctatttttctacgagagcgac ggcaggtctgggatagaccacaacagcatccccaaacacgccgtctgggtggagaacagc attgtgcaggcggtgcctgagcaccccaagaaggactttgtcttctgcctcagcaattcc ctgggtgatgccttcctttttcagaccactagccagacggagcttgaaaactggatcacc gccatccactctgcctgcgccactgcggtcgcgaggcaccaccacaaggaagacacgctc cgactcctgaaatcagagatcaaaaaactggaacagaagattgacatggatgaaaagatg aagaaaatgggtgaaatgcagctgtcttcagtcactgactcaaagaaaaagaaaacaata ttagatcagatctttgtctgggagcaaaatctcgagcagttccaaatggacctgtttcgt ttccgctgttatttagccagccttcagggtggggagctgccaaaccccaaaaggcttctc gcttttgcaagtcgaccaacgaaagtggccatgggccgccttggaatcttttcggtatca tcgtttcatgccctggtggcagcacgcactggtgaaactggagtgagaagacgtactcag gccatgtccagatccgcgagcaagcgaaggagcaggttttcttctctgtggggtctggat actacctccaaaaagaagcagggacggccaagcatcaatcaggtgtttggagagggaacc gaagctgtaaagaaatctttagagggaatatttgatgacattgttccagatggcaagagg gagaaagaagtggtcttacctaacgttcaccagcacaaccctgactgcgacatttgggtc cacgagtatttcactccatcctggttctgtctgcccaataatcagcctgccctgacggtc gtccggccaggcgacactgcacgggacaccctggagctgatttgcaagacacatcaactg gatcattctgctcattacctgcgcctgaaatttctaatagaaaacaaaatgcagctctat gttccacagcccgaggaagacatctatgagctgctgtacaaagaaattgaaatctgtcca aaagtcactcagagcatccacattgagaagtcagatacagctgctgatacttacgggttt tcactttcttctgtggaagaagatggtattcgaaggctgtacgtgaatagtgtgaaggaa accggtttagcttccaagaaaggcctgaaagcaggagatgagattcttgagatcaataat cgtgctgctgacgccctgaactcttctatgctcaaagatttcctctcacagccctcgctg ggcctcctggtgaggacctaccccgagctggaggaaggagtggagctgctggaaagcccg ccccaccgagtggacggccctgccgaccttggcgagagccccctcgcctttctcaccagc aacccagggcacagcctttgcagcgagcagggcagcagtgctgagaccgctccagaggag accgaggggccagacttggaatcctcagatgagactgatcacagcagcaagagtacagaa caggtggccgcattttgccgcagtttgcatgagatgaacccctctgaccagagcccatct cctcaggactccacggggcctcagctggcgaccatgagacaactctcggatgcagataag ctgcgcaaggtgatctgcgagctcctggagacggagcgcacctacgtgaaggatttaaac tgtcttatggagagatacctaaagcctcttcaaaaagaaacttttctcacccaggatgag cttgacgtgctttttggaaatttaacggaaatggtagagtttcaagtagaattccttaaa actctagaagatggagtgagactggtacctgatttggaaaagcttgagaaggttgatcaa tttaagaaagtgctgttctctctggggggatcattcctgtattatgctgaccgcttcaag ctctacagtgccttctgcgccagccacacaaaagttcccaaggtcctggtgaaagccaag acagacacggctttcaaggcattcttggatgcccagaacccgaagcagcagcactcatcc acgctggagtcgtacctcatcaagcccatccagaggatcctcaagtacccacttctgctc agggagctgttcgccctgaccgatgcggagagcgaggagcactaccacctggacgtggcc atcaagaccatgaacaaggttgccagtcacatcaatgagatgcagaaaatccatgaagag tttggggctgtgtttgaccagctgattgctgaacagactggtgagaaaaaagaggttgca gatctgagcatgggagacctgcttttgcacactaccgtgatctggctgaacccgccggcc tcgctgggcaagtggaaaaaggaaccagagttggcagcattcgtcttcaaaactgctgtg gtccttgtgtataaagatggttccaaacagaagaagaaacttgtaggatctcacaggctt tccatttatgaggactgggaccccttcagatttcgacacatgatccccacggaagcgctg caggttcgagctttggcgagtgcagatgcagaggcaaatgccgtgtgtgaaattgtccat gtaaaatccgagtctgaagggaggccggagagggtctttcacttgtgctgcagctcccca gagagccgaaaggatttcctaaaggctgtgcattcaatcctgcgtgataagcacagaaga cagctcctcaaaaccgagagccttccctcatcccagcaatatgtcccttttggaggcaaa agattgtgtgcactgaagggggccaggccggccatgagcagggcagtgtctgccccaagc aagtctcttgggaggaggaggcggcggctggctcgaaacaggtttaccattgattctgat gccgtctccgcaagcagcccggagaaagagtcccagcagccccccggtggtggggacact gaccgatgggtagaggagcagtttgatcttgctcagtatgaggagcaagatgacatcaag gagacagacatcctcagtgacgatgatgagttctgtgagtccgtgaagggtgcctcagtg gacagagacctgcaggagcggcttcaggccacctccatcagtcagcgggaaagaggccgg aaaaccctggatagtcacgcgtcccgcatggcacagctcaagaagcaagctgccctgtcg gggatcaatggaggcctggagagcgcaagcgaggaagtcatttgggttaggcgtgaagac tttgccccctccaggaaactgaacactgagatctga

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