KEGG   Homo sapiens (human): 7976
Entry
7976              CDS       T01001                                 
Symbol
FZD3, Fz-3
Name
(RefSeq) frizzled-3 isoform 1 precursor
  KO
K02329  frizzled 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04150  mTOR signaling pathway
hsa04310  Wnt signaling pathway
hsa04360  Axon guidance
hsa04390  Hippo signaling pathway
hsa04519  Cadherin signaling
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04916  Melanogenesis
hsa04934  Cushing syndrome
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05217  Basal cell carcinoma
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06181  Salmonella
nt06215  WNT signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06505  WNT signaling
nt06549  Cadherin signaling
  Element
N00056  Wnt signaling pathway, Canonical pathway
N00060  LRP6-overexpression to Wnt signaling pathway
N01427  WNT5A-ROR signaling pathway
N01440  Wnt signaling modulation, LGR/RSPO
N01441  Wnt signaling modulation, SOST/LRP4
N02010  Wnt signaling pathway, PCP pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    7976 (FZD3)
   04390 Hippo signaling pathway
    7976 (FZD3)
   04150 mTOR signaling pathway
    7976 (FZD3)
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    7976 (FZD3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    7976 (FZD3)
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    7976 (FZD3)
  09158 Development and regeneration
   04360 Axon guidance
    7976 (FZD3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    7976 (FZD3)
   05206 MicroRNAs in cancer
    7976 (FZD3)
   05205 Proteoglycans in cancer
    7976 (FZD3)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    7976 (FZD3)
   05226 Gastric cancer
    7976 (FZD3)
   05217 Basal cell carcinoma
    7976 (FZD3)
   05224 Breast cancer
    7976 (FZD3)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    7976 (FZD3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    7976 (FZD3)
   05022 Pathways of neurodegeneration - multiple diseases
    7976 (FZD3)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    7976 (FZD3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    7976 (FZD3)
G protein-coupled receptors [BR:hsa04030]
 Frizzled / Smoothened family
  7976 (FZD3)
SSDB
Motif
Pfam: Frizzled Fz
Other DBs
NCBI-GeneID: 7976
NCBI-ProteinID: NP_001399840
OMIM: 606143
HGNC: 4041
UniProt: Q9NPG1
Structure
LinkDB
Position
8:28494212..28574258
AA seq 666 aa
MAMTWIVFSLWPLTVFMGHIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAAL
AMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVP
WPEDMECSRFPDCDEPYPRLVDLNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFL
HVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIF
YAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAG
SVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGV
CFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIR
IGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILF
LMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDP
NTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSIHSKVSSYHGSLHRSRDGRYTPC
SYRGMEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHITHGTSMNRVIE
EDGTSA
NT seq 2001 nt   +upstreamnt  +downstreamnt
atggctatgacttggattgtcttctctctttggcccttgactgtgttcatggggcatata
ggtgggcacagtttgttttcttgtgaacctattaccttgaggatgtgccaagatttgcct
tataatactaccttcatgcctaatcttctgaatcattatgaccaacagacagcagctttg
gcaatggagccattccaccctatggtgaatctggattgttctcgggatttccggcctttt
ctttgtgcactctacgctcctatttgtatggaatatggacgtgtcacacttccctgtcgt
aggctgtgtcagcgggcttacagtgagtgttcgaagctcatggagatgtttggtgttcct
tggcctgaagatatggaatgcagtaggttcccagattgtgatgagccatatcctcgactt
gtggatctgaatttagctggagaaccaactgaaggagccccagtggcagtgcagagagac
tatggtttttggtgtccccgagagttaaaaattgatcctgatctgggttattcttttctg
catgtgcgtgattgttcacctccttgtccaaatatgtacttcagaagagaagaactgtca
tttgctcgctatttcataggattgatttcaatcatttgcctctcggccacattgtttact
tttttaacttttttgattgatgtcacaagattccgttatcctgaaaggcctattatattt
tatgcagtctgctacatgatggtatccttaattttcttcattggatttttgcttgaagat
cgagtagcctgcaatgcatccatccctgcacaatataaggcttccacagtgacacaagga
tctcataataaagcctgtaccatgctttttatgatactctatttttttactatggctggc
agtgtatggtgggtaattcttaccatcacatggtttttagcagctgtgccaaagtggggt
agtgaagctattgagaagaaagcattgctgtttcacgccagtgcatggggcatccccgga
actctaaccatcatccttttagcgatgaataaaattgaaggtgacaatattagtggcgtg
tgttttgttggcctctacgatgttgatgcattgagatattttgttcttgctcccctctgc
ctgtatgtggtagttggggtttctctcctcttagctggcattatatccctaaacagagtt
cgaattgagattccattagaaaaggagaaccaagataaattagtgaagtttatgatccgg
atcggtgttttcagcattctttatctcgtaccactcttggttgtaattggatgctacttt
tatgagcaagcttaccggggcatctgggaaacaacgtggatacaagaacgctgcagagaa
tatcacattccatgtccatatcaggttactcaaatgagtcgtccagacttgattctcttt
ctgatgaaatacctgatggctctcatagttggcattccctctgtattttgggttggaagc
aaaaagacatgctttgaatgggccagtttttttcatggtcgtaggaaaaaagagatagtg
aatgagagccgacaggtactccaggaacctgattttgctcagtctctcctgagggatcca
aatactcctatcataagaaagtcaaggggaacttccactcaaggaacatccacccatgct
tcttcaactcagctggctatggtggatgatcaaagaagcaaagcaggaagcatccacagc
aaagtgagcagctaccacggcagcctccacagatcacgtgatggcaggtacacgccctgc
agttacagaggaatggaggagagactacctcatggcagcatgtcacgactaacagatcac
tccaggcatagtagttctcatcggctcaatgaacagtcacgacatagcagcatcagagat
ctcagtaataatcccatgactcatatcacacatggcaccagcatgaatcgggttattgaa
gaagatggaaccagtgcttaa

KEGG   Homo sapiens (human): 8323
Entry
8323              CDS       T01001                                 
Symbol
FZD6, FZ-6, FZ6, HFZ6, NDNC1, NDNC10
Name
(RefSeq) frizzled-6 isoform a precursor
  KO
K02376  frizzled 6
Organism
hsa  Homo sapiens (human)
Pathway
hsa04150  mTOR signaling pathway
hsa04310  Wnt signaling pathway
hsa04390  Hippo signaling pathway
hsa04519  Cadherin signaling
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04916  Melanogenesis
hsa04934  Cushing syndrome
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05217  Basal cell carcinoma
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06181  Salmonella
nt06215  WNT signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06505  WNT signaling
nt06549  Cadherin signaling
  Element
N00056  Wnt signaling pathway, Canonical pathway
N00060  LRP6-overexpression to Wnt signaling pathway
N01427  WNT5A-ROR signaling pathway
N01440  Wnt signaling modulation, LGR/RSPO
N01441  Wnt signaling modulation, SOST/LRP4
N02010  Wnt signaling pathway, PCP pathway
Disease
H01307  Nonsyndromic congenital nail disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    8323 (FZD6)
   04390 Hippo signaling pathway
    8323 (FZD6)
   04150 mTOR signaling pathway
    8323 (FZD6)
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    8323 (FZD6)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    8323 (FZD6)
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    8323 (FZD6)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    8323 (FZD6)
   05205 Proteoglycans in cancer
    8323 (FZD6)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    8323 (FZD6)
   05226 Gastric cancer
    8323 (FZD6)
   05217 Basal cell carcinoma
    8323 (FZD6)
   05224 Breast cancer
    8323 (FZD6)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    8323 (FZD6)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    8323 (FZD6)
   05022 Pathways of neurodegeneration - multiple diseases
    8323 (FZD6)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    8323 (FZD6)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    8323 (FZD6)
G protein-coupled receptors [BR:hsa04030]
 Frizzled / Smoothened family
  8323 (FZD6)
SSDB
Motif
Pfam: Frizzled Fz Folate_rec Integrin_alpha
Other DBs
NCBI-GeneID: 8323
NCBI-ProteinID: NP_001158087
OMIM: 603409
HGNC: 4044
UniProt: O60353
Structure
LinkDB
Position
8:103298494..103332866
AA seq 706 aa
MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEH
FLPLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEE
LECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQ
CAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVC
YSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWW
VILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVG
LYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVF
SGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKY
LMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHK
KKHYKPSSHKLKVISKSMGTSTGATANHGTSAVAITSHDYLGQETLTEIQTSPETSMREV
KADGASTPRLREQDCGEPASPAASISRLSGEQVDGKGQAGSVSESARSEGRISPKSDITD
TGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVSGVRKEQGGGCHSDT
NT seq 2121 nt   +upstreamnt  +downstreamnt
atggaaatgtttacatttttgttgacgtgtatttttctacccctcctaagagggcacagt
ctcttcacctgtgaaccaattactgttcccagatgtatgaaaatggcctacaacatgacg
tttttccctaatctgatgggtcattatgaccagagtattgccgcggtggaaatggagcat
tttcttcctctcgcaaatctggaatgttcaccaaacattgaaactttcctctgcaaagca
tttgtaccaacctgcatagaacaaattcatgtggttccaccttgtcgtaaactttgtgag
aaagtatattctgattgcaaaaaattaattgacacttttgggatccgatggcctgaggag
cttgaatgtgacagattacaatactgtgatgagactgttcctgtaacttttgatccacac
acagaatttcttggtcctcagaagaaaacagaacaagtccaaagagacattggattttgg
tgtccaaggcatcttaagacttctgggggacaaggatataagtttctgggaattgaccag
tgtgcgcctccatgccccaacatgtattttaaaagtgatgagctagagtttgcaaaaagt
tttattggaacagtttcaatattttgtctttgtgcaactctgttcacattccttactttt
ttaattgatgttagaagattcagatacccagagagaccaattatatattactctgtctgt
tacagcattgtatctcttatgtacttcattggatttttgctaggcgatagcacagcctgc
aataaggcagatgagaagctagaacttggtgacactgttgtcctaggctctcaaaataag
gcttgcaccgttttgttcatgcttttgtattttttcacaatggctggcactgtgtggtgg
gtgattcttaccattacttggttcttagctgcaggaagaaaatggagttgtgaagccatc
gagcaaaaagcagtgtggtttcatgctgttgcatggggaacaccaggtttcctgactgtt
atgcttcttgctatgaacaaagttgaaggagacaacattagtggagtttgctttgttggc
ctttatgacctggatgcttctcgctactttgtactcttgccactgtgcctttgtgtgttt
gttgggctctctcttcttttagctggcattatttccttaaatcatgttcgacaagtcata
caacatgatggccggaaccaagaaaaactaaagaaatttatgattcgaattggagtcttc
agcggcttgtatcttgtgccattagtgacacttctcggatgttacgtctatgagcaagtg
aacaggattacctgggagataacttgggtctctgatcattgtcgtcagtaccatatccca
tgtccttatcaggcaaaagcaaaagctcgaccagaattggctttatttatgataaaatac
ctgatgacattaattgttggcatctctgctgtcttctgggttggaagcaaaaagacatgc
acagaatgggctgggttttttaaacgaaatcgcaagagagatccaatcagtgaaagtcga
agagtactacaggaatcatgtgagtttttcttaaagcacaattctaaagttaaacacaaa
aagaagcactataaaccaagttcacacaagctgaaggtcatttccaaatccatgggaacc
agcacaggagctacagcaaatcatggcacttctgcagtagcaattactagccatgattac
ctaggacaagaaactttgacagaaatccaaacctcaccagaaacatcaatgagagaggtg
aaagcggacggagctagcacccccaggttaagagaacaggactgtggtgaacctgcctcg
ccagcagcatccatctccagactctctggggaacaggtcgacgggaagggccaggcaggc
agtgtatctgaaagtgcgcggagtgaaggaaggattagtccaaagagtgatattactgac
actggcctggcacagagcaacaatttgcaggtccccagttcttcagaaccaagcagcctc
aaaggttccacatctctgcttgttcacccggtttcaggagtgagaaaagagcagggaggt
ggttgtcattcagatacttga

KEGG   Homo sapiens (human): 9620
Entry
9620              CDS       T01001                                 
Symbol
CELSR1, ADGRC1, CDHF9, FMI2, HFMI2, LMPHM9, ME2
Name
(RefSeq) cadherin EGF LAG seven-pass G-type receptor 1 isoform 2 precursor
  KO
K04600  cadherin EGF LAG seven-pass G-type receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04310  Wnt signaling pathway
hsa04519  Cadherin signaling
Network
nt06505  WNT signaling
nt06549  Cadherin signaling
  Element
N02010  Wnt signaling pathway, PCP pathway
Disease
H00535  Lymphatic malformation
H03009  Yellow nail syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    9620 (CELSR1)
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    9620 (CELSR1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    9620 (CELSR1)
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    9620 (CELSR1)
   04515 Cell adhesion molecules [BR:hsa04515]
    9620 (CELSR1)
Peptidases and inhibitors [BR:hsa01002]
 Mixed peptidases
  Family P2
   9620 (CELSR1)
G protein-coupled receptors [BR:hsa04030]
 Adhesion receptor family
  Cadherin EGF LAG (CELSR)
   9620 (CELSR1)
Cell adhesion molecules [BR:hsa04515]
 Cadherins
  Major cadherins
   9620 (CELSR1)
SSDB
Motif
Pfam: Cadherin 7tm_2 Laminin_G_2 Cadherin_CELSR2_9th GAIN GPS Cadherin_FAT4_N Laminin_G_1 Ig_CLSTN Ig_Cad99C_N EGF HRM EGF_laminin Dicty_CAR EGF_TEN Cadherin_pro Fibulin_C RET_CLD1 hEGF ConA_2nd_BAM2 EGF_Teneurin Frizzled Laminin_G_3
Other DBs
NCBI-GeneID: 9620
NCBI-ProteinID: NP_055061
OMIM: 604523
HGNC: 1850
UniProt: Q9NYQ6
Structure
LinkDB
Position
22:complement(46361174..46537620)
AA seq 3014 aa
MAPPPPPVLPVLLLLAAAAALPAMGLRAAAWEPRVPGGTRAFALRPGCTYAVGAACTPRA
PRELLDVGRDGRLAGRRRVSGAGRPLPLQVRLVARSAPTALSRRLRARTHLPGCGARARL
CGTGARLCGALCFPVPGGCAAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVR
LRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGR
GSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDS
ATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE
RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEA
AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR
VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG
RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARL
HYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAV
DHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVI
TYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVT
DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPD
SGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGS
IFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDREN
VAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAK
IRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAP
LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNY
TFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITD
DMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNV
TFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVS
VLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRS
REGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYC
EVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQ
VQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVD
DCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHNRQFVGC
MRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFG
GKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFR
LQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDY
GMDQNKADIGGMLPGLTVRSVVVGGASEDKVSVRRGFRGCMQGVRMGGTPTNVATLNMNN
ALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINCVDACHLNPCENMG
ACVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPRGWWGNPVCGPCHCAVSKGFDPDCNK
TNGQCQCKENYYKLLAQDTCLPCDCFPHGSHSRTCDMATGQCACKPGVIGRQCNRCDNPF
AEVTTLGCEVIYNGCPKAFEAGIWWPQTKFGQPAAVPCPKGSVGNAVRHCSGEKGWLPPE
LFNCTTISFVDLRAMNEKLSRNETQVDGARALQLVRALRSATQHTGTLFGNDVRTAYQLL
GHVLQHESWQQGFDLAATQDADFHEDVIHSGSALLAPATRAAWEQIQRSEGGTAQLLRRL
EGYFSNVARNVRRTYLRPFVIVTANMILAVDIFDKFNFTGARVPRFDTIHEEFPRELESS
VSFPADFFRPPEEKEGPLLRPAGRRTTPQTTRPGPGTEREAPISRRRRHPDDAGQFAVAL
VIIYRTLGQLLPERYDPDRRSLRLPHRPIINTPMVSTLVYSEGAPLPRPLERPVLVEFAL
LEVEERTKPVCVFWNHSLAVGGTGGWSARGCELLSRNRTHVACQCSHTASFAVLMDISRR
ENGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRMLRSNLHSIHKHLAVALFLSQLVFVI
GINQTENPFLCTVVAILLHYIYMSTFAWTLVESLHVYRMLTEVRNIDTGPMRFYYVVGWG
IPAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSFAGPIGAVIIINTVTSVLSAKVSCQR
KHHYYGKKGIVSLLRTAFLLLLLISATWLLGLLAVNRDALSFHYLFAIFSGLQGPFVLLF
HCVLNQEVRKHLKGVLGGRKLHLEDSATTRATLLTRSLNCNTTFGDGPDMLRTDLGESTA
SLDSIVRDEGIQKLGVSSGLVRGSHGEPDASLMPRSCKDPPGHDSDSDSELSLDEQSSSY
ASSHSSDSEDDGVGAEEKWDPARGAVHSTPKGDAVANHVPAGWPDQSLAESDSEDPSGKP
RLKVETKVSVELHREEQGSHRGEYPPDQESGGAARLASSQPPEQRKGILKNKVTYPPPLT
LTEQTLKGRLREKLADCEQSPTSSRTSSLGSGGPDCAITVKSPGREPGRDHLNGVAMNVR
TGSAQADGSDSEKP
NT seq 9045 nt   +upstreamnt  +downstreamnt
atggcgccgccgccgccgcccgtgctgcccgtgctgctgctcctggccgccgccgccgcc
ctgccggcgatggggctgcgagcggccgcctgggagccgcgcgtacccggcgggacccgc
gccttcgccctccggcccggctgtacctacgcggtgggcgccgcttgcacgccccgggcg
ccgcgggagctgctggacgtgggccgcgatgggcggctggcaggacgtcggcgcgtctcg
ggcgcggggcgcccgctgccgctgcaagtccgcttggtggcccgcagtgccccgacggcg
ctgagccgccgcctgcgggcgcgcacgcaccttcccggctgcggagcccgtgcccggctc
tgcggaaccggtgcccggctctgcggggcgctctgcttccccgtccccggcggctgcgcg
gccgcgcagcattcggcgctcgcagctccgaccaccttacccgcctgccgctgcccgccg
cgccccaggccccgctgtcccggccgtcccatctgcctgccgccgggcggctcggtccgc
ctgcgtctgctgtgcgccctgcggcgcgcggctggcgccgtccgggtgggactggcgctg
gaggccgccaccgcggggacgccctccgcgtcgccatccccatcgccgcccctgccgccg
aacttgcccgaagcccgggcggggccggcgcgacgggcccggcggggcacgagcggcaga
gggagcctgaagtttccgatgcccaactaccaggtggcgttgtttgagaacgaaccggcg
ggcaccctcatcctccagctgcacgcgcactacaccatcgagggcgaggaggagcgcgtg
agctattacatggaggggctgttcgacgagcgctcccggggctacttccgaatcgactct
gccacgggcgccgtgagcacggacagcgtactggaccgcgagaccaaggagacgcacgtc
ctcagggtgaaagccgtggactacagtacgccgccgcgctcggccaccacctacatcact
gtcttggtcaaagacaccaacgaccacagcccggtcttcgagcagtcggagtaccgcgag
cgcgtgcgggagaacctggaggtgggctacgaggtgctgaccatccgcgccagcgaccgc
gactcgcccatcaacgccaacttgcgttaccgcgtgttggggggcgcgtgggacgtcttc
cagctcaacgagagctctggcgtggtgagcacacgggcggtgctggaccgggaggaggcg
gccgagtaccagctcctggtggaggccaacgaccaggggcgcaatccgggcccgctcagt
gccacggccaccgtgtacatcgaggtggaggacgagaacgacaactacccccagttcagc
gagcagaactacgtggtccaggtgcccgaggacgtggggctcaacacggctgtgctgcga
gtgcaggccacggaccgggaccagggccagaacgcggccattcactacagcatcctcagc
gggaacgtggccggccagttctacctgcactcgctgagcgggatcctggatgtgatcaac
cccttggatttcgaggatgtccagaaatactcgctgagcattaaggcccaggatgggggc
cggcccccgctcatcaattcttcaggggtggtgtctgtgcaggtgctggatgtcaacgac
aacgagcctatctttgtgagcagccccttccaggccacggtgctggagaatgtgcccctg
ggctaccccgtggtgcacattcaggcggtggacgcggactctggagagaacgcccggctg
cactatcgcctggtggacacggcctccacctttctggggggcggcagcgctgggcctaag
aatcctgcccccacccctgacttccccttccagatccacaacagctccggttggatcaca
gtgtgtgccgagctggaccgcgaggaggtggagcactacagcttcggggtggaggcggtg
gaccacggctcgccccccatgagctcctccaccagcgtgtccatcacggtgctggacgtg
aatgacaacgacccggtgttcacgcagcccacctacgagcttcgtctgaatgaggatgcg
gccgtggggagcagcgtgctgaccctgcaggcccgcgaccgtgacgccaacagtgtgatt
acctaccagctcacaggcggcaacacccggaaccgctttgcactcagcagccagagaggg
ggcggcctcatcaccctggcgctacctctggactacaagcaggagcagcagtacgtgctg
gcggtgacagcatccgacggcacacggtcgcacactgcgcatgtcctaatcaacgtcact
gatgccaacacccacaggcctgtctttcagagctcccattacacagtgagtgtcagtgag
gacaggcctgtgggcacctccattgctaccctcagtgccaacgatgaggacacaggagag
aatgcccgcatcacctacgtgattcaggaccccgtgccgcagttccgcattgaccccgac
agtggcaccatgtacaccatgatggagctggactatgagaaccaggtcgcctacacgctg
accatcatggcccaggacaacggcatcccgcagaaatcagacaccaccaccctagagatc
ctcatcctcgatgccaatgacaatgcaccccagttcctgtgggatttctaccagggttcc
atctttgaggatgctccaccctcgaccagcatcctccaggtctctgccacggaccgggac
tcaggtcccaatgggcgtctgctgtacaccttccagggtggggacgacggcgatggggac
ttctacatcgagcccacgtccggtgtgattcgcacccagcgccggctggaccgggagaat
gtggccgtgtacaacctttgggctctggctgtggatcggggcagtcccactccccttagc
gcctcggtagaaatccaggtgaccatcttggacattaatgacaatgcccccatgtttgag
aaggacgaactggagctgtttgttgaggagaacaacccagtggggtcggtggtggcaaag
attcgtgctaacgaccctgatgaaggccctaatgcccagatcatgtatcagattgtggaa
ggggacatgcggcatttcttccagctggacctgctcaacggggacctgcgtgccatggtg
gagctggactttgaggtccggcgggagtatgtgctggtggtgcaggccacgtcggctccg
ctggtgagccgagccacggtgcacatccttctcgtggaccagaatgacaacccgcctgtg
ctgcccgacttccagatcctcttcaacaactatgtcaccaacaagtccaacagtttcccc
accggcgtgatcggctgcatcccggcccatgaccccgacgtgtcagacagcctcaactac
accttcgtgcagggcaacgagctgcgcctgttgctgctggaccccgccacgggcgaactg
cagctcagccgcgacctggacaacaaccggccgctggaggcgctcatggaggtgtctgtg
tctgatggcatccacagcgtcacggccttctgcaccctgcgtgtcaccatcatcacggac
gacatgctgaccaacagcatcactgtccgcctggagaacatgtcccaggagaagttcctg
tccccgctgctggccctcttcgtggagggggtggccgccgtgctgtccaccaccaaggac
gacgtcttcgtcttcaacgtccagaacgacaccgacgtcagctccaacatcctgaacgtg
accttctcggcgctgctgcctggcggcgtccgcggccagttcttcccgtcggaggacctg
caggagcagatctacctgaatcggacgctgctgaccaccatctccacgcagcgcgtgctg
cccttcgacgacaacatctgcctgcgcgagccctgcgagaactacatgaagtgcgtgtcc
gttctgcgattcgacagctccgcgcccttcctcagctccaccaccgtgctcttccggccc
atccaccccatcaacggcctgcgctgccgctgcccgcccggcttcaccggcgactactgc
gagacggagatcgacctctgctactccgacccgtgcggcgccaacggccgctgccgcagc
cgcgagggcggctacacctgcgagtgcttcgaggacttcactggagagcactgtgaggtg
gatgcccgctcaggccgctgtgccaacggggtgtgcaagaacgggggcacctgcgtgaac
ctgctcatcggcggcttccactgcgtgtgtcctcctggcgagtatgagaggccctactgt
gaggtgaccaccaggagcttcccgccccagtccttcgtcaccttccggggcctgagacag
cgcttccacttcaccatctccctcacgtttgccactcaggaaaggaacggcttgcttctc
tacaacggccgcttcaatgagaagcacgacttcatcgccctggagatcgtggacgagcag
gtgcagctcaccttctctgcaggcgagacaacaacgaccgtggcaccgaaggttcccagt
ggtgtgagtgacgggcggtggcactctgtgcaggtgcagtactacaacaagcccaatatt
ggccacctgggcctgccccatgggccgtccggggaaaagatggccgtggtgacagtggat
gattgtgacacaaccatggctgtgcgctttggaaaggacatcgggaactacagctgcgct
gcccagggcactcagaccggctccaagaagtccctggatctgaccggccctctactcctg
gggggtgtccccaacctgccagaagacttcccagtgcacaaccggcagttcgtgggctgc
atgcggaacctgtcagtcgacggcaaaaatgtggacatggccggattcatcgccaacaat
ggcacccgggaaggctgcgctgctcggaggaacttctgcgatgggaggcggtgtcagaat
ggaggcacctgtgtcaacaggtggaatatgtatctgtgtgagtgtccactccgattcggc
gggaagaactgtgagcaagccatgcctcacccccagctcttcagcggtgagagcgtcgtg
tcctggagtgacctgaacatcatcatctctgtgccctggtacctggggctcatgttccgg
acccggaaggaggacagcgttctgatggaggccaccagtggtgggcccaccagctttcgc
ctccagatcctgaacaactacctccagtttgaggtgtcccacggcccctccgatgtggag
tccgtgatgctgtccgggttgcgggtgaccgacggggagtggcaccacctgctgatcgag
ctgaagaatgttaaggaggacagtgagatgaagcacctggtcaccatgaccttggactat
gggatggaccagaacaaggcagatatcgggggcatgcttcccgggctgacggtaaggagc
gtggtggtcggaggcgcctctgaagacaaggtctccgtgcgccgtggattccgaggctgc
atgcagggagtgaggatgggggggacgcccaccaacgtcgccaccctgaacatgaacaac
gcactcaaggtcagggtgaaggacggctgtgatgtggacgacccctgtacctcgagcccc
tgtccccccaatagccgctgccacgacgcctgggaggactacagctgcgtctgtgacaaa
gggtaccttggaataaactgtgtggatgcctgtcacctgaacccctgcgagaacatgggg
gcctgcgtgcgctcccccggctccccgcagggctacgtgtgcgagtgtgggcccagtcac
tacgggccgtactgtgagaacaaactcgaccttccgtgccccagaggctggtgggggaac
cccgtctgtggaccctgccactgtgccgtcagcaaaggctttgatcccgactgtaataag
accaacggccagtgccaatgcaaggagaattactacaagctcctagcccaggacacctgt
ctgccctgcgactgcttcccccatggctcccacagccgcacttgcgacatggccaccggg
cagtgtgcctgcaagcccggcgtcatcggccgccagtgcaaccgctgcgacaacccgttt
gccgaggtcaccacgctcggctgtgaagtgatctacaatggctgtcccaaagcatttgag
gccggcatctggtggccacagaccaagttcgggcagccggctgcggtgccatgccctaag
ggatccgttggaaatgcggtccgacactgcagcggggagaagggctggctgcccccagag
ctctttaactgtaccaccatctccttcgtggacctcagggccatgaatgagaagctgagc
cgcaatgagacgcaggtggacggcgccagggccctgcagctggtgagggcgctgcgcagt
gctacacagcacacgggcacgctctttggcaatgacgtgcgcacggcctaccagctgctg
ggccacgtccttcagcacgagagctggcagcagggcttcgacctggcagccacgcaggac
gccgactttcacgaggacgtcatccactcgggcagcgccctcctggccccagccaccagg
gcggcgtgggagcagatccagcggagcgagggcggcacggcacagctgctccggcgcctc
gagggctacttcagcaacgtggcacgcaacgtgcggcggacgtacctgcggcccttcgtc
atcgtcaccgccaacatgattcttgctgtcgacatctttgacaagttcaactttacggga
gccagggtcccgcgattcgacaccatccatgaagagttccccagggagctggagtcctcc
gtctccttcccagccgacttcttcagaccacctgaagaaaaagaaggccccctgctgagg
ccggctggccggaggaccaccccgcagaccacgcgcccggggcctggcaccgagagggag
gccccgatcagcaggcggaggcgacaccctgatgacgctggccagttcgccgtcgctctg
gtcatcatttaccgcaccctggggcagctcctgcccgagcgctacgaccccgaccgtcgc
agcctccggttgcctcaccggcccatcattaataccccgatggtgagcacgctggtgtac
agcgagggggctccgctcccgagacccctggagaggcccgtcctggtggagttcgccctg
ctggaggtggaggagcgaaccaagcctgtctgcgtgttctggaaccactccctggccgtt
ggtgggacgggagggtggtctgcccggggctgcgagctcctgtccaggaaccggacacat
gtcgcctgccagtgcagccacacagccagctttgcggtgctcatggatatctccaggcgt
gagaacggggaggtcctgcctctgaagattgtcacctatgccgctgtgtccttgtcactg
gcagccctgctggtggccttcgtcctcctgagcctggtccgcatgctgcgctccaacctg
cacagcattcacaagcacctcgccgtggcgctcttcctctctcagctggtgttcgtgatt
gggatcaaccagacggaaaacccgtttctgtgcacagtggttgccatcctcctccactac
atctacatgagcacctttgcctggaccctcgtggagagcctgcatgtctaccgcatgctg
accgaggtgcgcaacatcgacacggggcccatgcggttctactacgtcgtgggctggggc
atcccggccattgtcacaggactggcggtcggcctggacccccagggctacgggaacccc
gacttctgctggctgtcgcttcaagacaccctgatttggagctttgcggggcccatcgga
gctgttataatcatcaacacagtcacttctgtcctatctgcaaaggtttcctgccaaaga
aagcaccattattatgggaaaaaagggatcgtctccctgctgaggaccgcattcctcctg
ctgctgctcatcagcgccacctggctgctggggctgctggctgtgaaccgcgatgcactg
agctttcactacctcttcgccatcttcagcggcttacagggccccttcgtcctccttttc
cactgcgtgctcaaccaggaggtccggaagcacctgaagggcgtgctcggcgggaggaag
ctgcacctggaggactccgccaccaccagggccaccctgctgacgcgctccctcaactgc
aacaccaccttcggtgacgggcctgacatgctgcgcacagacttgggcgagtccaccgcc
tcgctggacagcatcgtcagggatgaagggatccagaagctcggcgtgtcctctgggctg
gtgaggggcagccacggagagccagacgcgtccctcatgcccaggagctgcaaggatccc
cctggccacgattccgactcagatagcgagctgtccctggatgagcagagcagctcttac
gcctcctcacactcgtcagacagcgaggacgatggggtgggagctgaggaaaaatgggac
ccggccaggggcgccgtccacagcacccccaaaggggacgctgtggccaaccacgttccg
gccggctggcccgaccagagcctggctgagagtgacagtgaggaccccagcggcaagccc
cgcctgaaggtggagaccaaggtcagcgtggagctgcaccgcgaggagcagggcagtcac
cgtggagagtaccccccggaccaggagagcgggggcgcagccaggcttgctagcagccag
cccccagagcagaggaaaggcatcttgaaaaataaagtcacctacccgccgccgctgacg
ctgacggagcagacgctgaagggccggctccgggagaagctggccgactgtgagcagagc
cccacatcctcgcgcacgtcttccctgggctctggcggccccgactgcgccatcacagtc
aagagccctgggagggagccggggcgtgaccacctcaacggggtggccatgaatgtgcgc
actgggagcgcccaggccgatggctccgactctgagaaaccgtga

KEGG   Homo sapiens (human): 1952
Entry
1952              CDS       T01001                                 
Symbol
CELSR2, ADGRC2, CDHF10, EGFL2, Flamingo1, MEGF3
Name
(RefSeq) cadherin EGF LAG seven-pass G-type receptor 2 precursor
  KO
K04601  cadherin EGF LAG seven-pass G-type receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04310  Wnt signaling pathway
hsa04519  Cadherin signaling
Network
nt06505  WNT signaling
nt06549  Cadherin signaling
  Element
N02010  Wnt signaling pathway, PCP pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    1952 (CELSR2)
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    1952 (CELSR2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1952 (CELSR2)
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1952 (CELSR2)
   04515 Cell adhesion molecules [BR:hsa04515]
    1952 (CELSR2)
Peptidases and inhibitors [BR:hsa01002]
 Mixed peptidases
  Family P2
   1952 (CELSR2)
G protein-coupled receptors [BR:hsa04030]
 Adhesion receptor family
  Cadherin EGF LAG (CELSR)
   1952 (CELSR2)
Cell adhesion molecules [BR:hsa04515]
 Cadherins
  Major cadherins
   1952 (CELSR2)
SSDB
Motif
Pfam: Cadherin 7tm_2 Cadherin_CELSR2_9th Laminin_G_2 Cadherin_FAT4_N GPS GAIN Ig_CLSTN Laminin_G_1 EGF EGF_TEN EGF_laminin RET_CLD1 Cadherin_pro Fibulin_C ConA_2nd_BAM2 EGF_Teneurin hEGF Dicty_CAR
Other DBs
NCBI-GeneID: 1952
NCBI-ProteinID: NP_001399
OMIM: 604265
HGNC: 3231
Ensembl: ENSP00000271332.3
UniProt: Q9HCU4
LinkDB
Position
1:109249539..109275751
AA seq 2923 aa
MRSPATGVPLPTPPPPLLLLLLLLLPPPLLGDQVGPCRSLGSRGRGSSGACAPMGWLCPS
SASNLWLYTSRCRDAGTELTGHLVPHHDGLRVWCPESEAHIPLPPAPEGCPWSCRLLGIG
GHLSPQGKLTLPEEHPCLKAPRLRCQSCKLAQAPGLRAGERSPEESLGGRRKRNVNTAPQ
FQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGA
VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRE
NLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEV
ESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLR
VTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGG
RPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARL
EYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTV
LDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITS
QSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVN
VNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS
YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT
DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPP
ARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQI
VEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNP
PVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTG
ELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPER
FLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFL
PSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSS
VLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTG
EHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSFPAHSFITF
RGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVS
PFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLG
NYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMAD
FIANNGTVPGCPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFL
GSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGT
GLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLS
NITVGGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSN
PCPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPN
YLGPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPT
CLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCDNPFAEVTTNGCEVNYDSCPRAI
EAGIWWPRTRFGLPAAAPCPKGSFGTAVRHCDEHRGWLPPNLFNCTSITFSELKGFAERL
QRNESGLDSGRSQQLALLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQ
DVHFTENLLRVGSALLDTANKRHWELIQQTEGGTAWLLQHYEAYASALAQNMRHTYLSPF
TIVTPNIVISVVRLDKGNFAGAKLPRYEALRGEQPPDLETTVILPESVFRETPPVVRPAG
PGEAQEPEELARRQRRHPELSQGEAVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPIINT
PVVSISVHDDEELLPRALDKPVTVQFRLLETEERTKPICVFWNHSILVSGTGGWSARGCE
VVFRNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTLTYVALGVTLAALLLTFFFLTL
LRILRSNQHGIRRNLTAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLE
ALHLYRALTEVRDVNTGPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLI
WSFAGPVAFAVSMSVFLYILAARASCAAQRQGFEKKGPVSGLQPSFAVLLLLSATWLLAL
LSVNSDTLLFHYLFATCNCIQGPFIFLSYVVLSKEVRKALKLACSRKPSPDPALTTKSTL
TSSYNCPSPYADGRLYQPYGDSAGSLHSTSRSGKSQPSYIPFLLREESALNPGQGPPGLG
DPGSLFLEGQDQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEEEAAFPGEQG
WDSLLGPGAERLPLHSTPKDGGPGPGKAPWPGDFGTTAKESSGNGAPEERLRENGDALSR
EGSLGPLPGSSAQPHKGILKKKCLPTISEKSSLLRLPLEQCTGSSRGSSASEGSRGGPPP
RPPPRQSLQEQLNGVMPIAMSIKAGTVDEDSSGSEFLFFNFLH
NT seq 8772 nt   +upstreamnt  +downstreamnt
atgcggagcccggccaccggcgtccccctcccaacgccgccgccgccgctgctgctgctg
ttgctgctgctgctgccgccgccactattgggagaccaagtggggccctgtcgttccttg
gggtccaggggacgaggctcttcgggggcctgcgcccccatgggctggctctgtccatcc
tcagcgtcgaacctctggctctacaccagccgctgcagggatgcgggcactgagctgact
ggccacctggtaccccaccacgatggcctgagggtttggtgtccagaatccgaggcccat
attcccctaccaccagctcctgaaggctgcccctggagctgtcgcctcctgggcattgga
ggccacctttccccacagggcaagctcacactgcccgaggagcacccgtgcttaaaggct
ccacggctcagatgccagtcctgcaagctggcacaggcccccgggctcagggcaggggaa
aggtcaccagaagagtccctgggtgggcgtcggaaaaggaatgtaaatacagccccccag
ttccagccccccagctaccaggccacagtgccggagaaccagccagcaggcacccctgtt
gcatccctgagggccatcgacccggacgagggtgaggcaggtcgactggagtacaccatg
gatgccctctttgatagccgctccaaccagttcttctccctggacccagtcactggtgca
gtaaccacagccgaggagctggatcgtgagaccaagagcacccacgtcttcagggtcacg
gcgcaggaccacggcatgccccgacgaagtgccctggctacactcaccatcttggttact
gacaccaatgaccatgaccctgtgttcgagcagcaggagtacaaggagagcctcagggag
aacctggaggttggctatgaggtgctcactgtcagggccacggatggtgatgcccctccc
aatgccaatattctgtaccgcctgctggaggggtctgggggcagcccctctgaagtcttt
gagatcgaccctcgctctggggtgatccgaacccgtggccctgtggatcgggaagaggtg
gaatcctaccagctgacggtagaggcaagtgaccagggtcgggacccgggtcctcggagt
accacagccgctgttttcctttctgtggaggatgacaatgataatgccccccagtttagt
gagaagcgctatgtggtccaggtgagggaggatgtgactccaggggccccagtactccga
gtcacagcctcggatcgagacaaggggagcaatgccgtggtgcactatagcatcatgagt
ggcaatgctcggggacagttttatctggatgcccagactggagctctggatgtggtgagc
cctcttgactatgagacgaccaaggagtacaccctacgggtgcgagcacaggatggtggc
cgtcccccactctctaatgtctctggcttggtgacagtacaggtcctggatatcaacgac
aatgcccccatcttcgtcagcacccctttccaggctactgtcctggagagtgtcccctta
ggctacctggttctccatgtccaggctatcgacgctgatgctggtgacaatgcccgcctg
gaataccgccttgctggggtgggacatgacttccccttcaccatcaacaatggcacaggc
tggatctctgtggctgctgaactggaccgggaggaagttgatttctacagctttggggta
gaagctcgagaccatggcactccagcactcactgcctcggccagtgtcagcgtgactgtc
ctggatgtcaacgacaacaatccaacctttacccaaccagagtacacagtgcggctcaat
gaggatgcagctgtgggcaccagcgtggtgacggtgtcagctgtggaccgtgatgctcat
agtgtcatcacctaccagatcaccagtggcaatactcgaaaccgcttctccatcaccagc
caaagtggtggtgggctggtatcccttgccctgccactggactacaaacttgagcggcag
tatgtgttggctgttaccgcctccgatggcactcggcaggacacggcacagattgtggtg
aatgtcaccgacgccaacacccatcgtcctgtctttcagagctcccactatacagtgaat
gttaatgaggaccggccggcaggcaccacggtggtgctgatcagcgccacggatgaggac
acaggtgagaatgcccgcatcacctacttcatggaggacagcatcccccagttccgcatc
gatgcagacacgggggctgtcaccacccaggctgagctggactatgaagaccaagtgtct
tacaccctggccattactgctcgggacaatggcattccccagaagtccgacaccacctac
ctggagatcctggtgaacgacgtgaatgacaatgcccctcagttcctgcgagactcctac
cagggcagtgtctatgaggatgtgccacccttcactagcgtcctgcagatctcagccact
gatcgtgattctggacttaatggcagggtcttctacaccttccaaggaggcgacgatgga
gacggtgactttattgttgagtccacgtcaggcatcgtgcgaacgctacggaggctggat
cgagagaacgtggcccagtatgtcttgcgggcatatgcagtggacaaggggatgccccca
gcccgcacacctatggaagtgacagtcactgtgttggatgtgaatgacaatccccctgtc
tttgagcaggatgagtttgatgtgtttgtggaagagaacagccccattgggctagccgtg
gcccgggtcacagccactgaccccgatgaaggcaccaatgcccagattatgtaccagatt
gtggagggcaacatccctgaggtctttcagctggacatcttctccggggagctgacagcc
ctggtagacttagactacgaggaccggcctgagtacgtcctggtcatccaggccacgtca
gctcctctggtgagccgggctacagtccacgtccgcctccttgaccgcaatgacaaccca
ccagtgctgggcaactttgagatccttttcaacaactatgtcaccaatcgctcaagcagc
ttccctgggggtgccattggccgagtacctgcccatgaccctgatatctcagatagtctg
acttacagctttgagcggggaaatgaactcagcctggtcctgctcaatgcctccacgggt
gagctgaagctaagccgcgcactggacaacaaccggcctctggaggccatcatgagcgtg
ctggtgtcagacggcgtacacagcgtgaccgcccagtgcgcgctgcgtgtgaccatcatc
accgatgagatgctcacccacagcatcacgctgcgcctggaggacatgtcacccgagcgc
ttcctgtcaccactgctaggcctcttcatccaggcggtggccgccacgctggccacgcca
ccggaccacgtggtggtcttcaacgtacagcgggacaccgacgcccccgggggccacatc
ctcaacgtgagcctgtcggtgggccagccgccagggcccgggggcgggccgcccttcctg
ccctctgaggacctgcaggagcgcctatacctcaaccgcagcctgctgacggccatctcg
gcacagcgcgtgctgcccttcgacgacaacatctgcctgcgggagccctgcgagaactac
atgcgctgcgtgtcggtgctgcgcttcgactcctccgcgcccttcatcgcctcctcctcc
gtgctcttccggcccatccaccccgtcggagggctgcgctgccgctgcccgcccggcttc
acgggtgactactgcgagaccgaggtggacctctgctactcgcggccctgtggcccccac
gggcgctgccgcagccgcgagggcggctacacctgcctctgtcgtgatggctacacgggt
gagcactgtgaggtgagtgctcgctcaggccgttgcaccccgggtgtctgcaagaatggg
ggcacctgtgtcaacctgctggtgggcggtttcaagtgcgattgcccatctggagacttc
gagaagccctactgccaggtgaccacgcgcagcttccccgcccactccttcatcaccttt
cgcggcctgcgccagcgtttccacttcaccctggccctctcgtttgccacaaaggagcgc
gacgggttgctgttgtacaatgggcgtttcaatgagaagcatgactttgtggccctcgag
gtgatccaggagcaggtccagctcaccttctctgcaggggagtcaaccaccacggtgtcc
ccattcgtgcccggaggagtcagtgatggccagtggcatacggtgcagctgaaatactac
aataagccactgttgggtcagacagggctcccacagggcccatcagagcagaaggtggct
gtggtgaccgtggatggctgtgacacaggagtggccttgcgcttcggatctgtcctgggc
aactactcctgtgctgcccagggcacccagggtggcagcaagaagtctctggatctgacg
gggcccctgctactaggcggggtgcctgacctgcccgagagcttcccagtccgaatgcgg
cagttcgtgggctgcatgcggaacctgcaggtggacagccggcacatagacatggctgac
ttcattgccaacaatggcaccgtgcctggctgccctgccaagaagaacgtgtgtgacagc
aacacttgccacaatgggggcacttgcgtgaaccagtgggacgcgttcagctgcgagtgc
cccctgggctttgggggcaagagctgcgcccaggaaatggccaatccacagcacttcctg
ggcagcagcctggtggcctggcatggcctctcgctgcccatctcccaaccctggtacctc
agcctcatgttccgcacgcgccaggccgacggtgtcctgctgcaggccatcaccaggggg
cgcagcaccatcaccctacagctacgagagggccacgtgatgctgagcgtggagggcaca
gggcttcaggcctcctctctccgtctggagccaggccgggccaatgacggtgactggcac
catgcacagctggcactgggagccagcggggggcccggccatgccattctgtccttcgat
tatgggcagcagagagcagagggcaacctgggcccccggctgcatggtctgcacctgagc
aacataacagtgggcggaatacctgggccagccggcggtgtggcccgtggctttcggggc
tgtttgcagggtgtgcgggtgagcgatacgccggagggggttaacagcctggatcccagc
catggggagagcatcaacgtggagcaaggctgtagcctgcctgacccttgtgactcaaac
ccgtgtcctgctaacagctattgcagcaacgactgggacagctattcctgcagctgtgat
ccaggttactatggtgacaactgtactaatgtgtgtgacctgaacccgtgtgagcaccag
tctgtgtgtacccgcaagcccagtgccccccatggctatacctgcgagtgtcccccaaat
taccttgggccatactgtgagaccaggattgaccagccttgtccccgtggctggtgggga
catcccacatgtggcccatgcaactgtgatgtcagcaaaggctttgacccagactgcaac
aagacaagcggcgagtgccactgcaaggagaaccactaccggcccccaggcagccccacc
tgcctcttgtgtgactgctaccccacaggctccttgtccagagtctgtgaccctgaggat
ggccagtgtccatgcaagccaggtgtcatcgggcgtcagtgtgaccgctgtgacaaccct
tttgctgaggtcaccaccaatggctgtgaagtgaattatgacagctgcccacgagcgatt
gaggctgggatctggtggccccgtacccgcttcgggctgcctgctgctgctccctgtccc
aaaggctcctttgggactgctgtgcgccactgtgatgagcacagggggtggctcccccca
aacctcttcaactgcacgtccatcaccttctcagaactgaagggcttcgctgagcggcta
cagcggaatgagtcaggcctagactcagggcgctcccagcagctagccctgctcctgcgc
aacgccacgcagcacacagctggctacttcggcagcgacgtcaaggtggcctaccagctg
gccacgcggctgctggcccacgagagcacccagcggggctttgggctgtctgccacacag
gacgtgcacttcactgagaatctgctgcgggtgggcagcgccctcctggacacagccaac
aagcggcactgggagctgatccagcagacagagggtggcaccgcctggctgctccagcac
tatgaggcctacgccagtgccctggcccagaacatgcggcacacctacctaagccccttc
accatcgtcacgcccaacattgtcatctccgtagtgcgcttggacaaagggaactttgct
ggggccaagctgccccgctacgaggccctgcgtggggagcagcccccggaccttgagaca
acagtcattctgcctgagtctgtcttcagagagacgccccccgtggtcaggcccgcaggc
cccggagaggcccaggagccagaggagctggcacggcgacagcgacggcacccggagctg
agccagggtgaggctgtggccagcgtcatcatctaccgcaccctggccgggctactgcct
cataactatgaccctgacaagcgcagcttgagagtccccaaacgcccgatcatcaacaca
cccgtggtgagcatcagcgtccatgatgatgaggagcttctgccccgggccctggacaaa
cccgtcacggtgcagttccgcctgctggagacagaggagcggaccaagcccatctgtgtc
ttctggaaccattcaatcctggtcagtggcacaggtggctggtcggccagaggctgtgaa
gtcgtcttccgcaatgagagccacgtcagctgccagtgcaaccacatgacgagcttcgct
gtgctcatggacgtttctcggcgggagaatggggagatcctgccactgaagacactgaca
tacgtggctctaggtgtcaccttggctgcccttctgctcaccttcttcttcctcactctc
ttgcgtatcctgcgctccaaccaacacggcatccgacgtaacctgacagctgccctgggc
ctggctcagctggtcttcctcctgggaatcaaccaggctgacctcccttttgcctgcaca
gtcattgccatcctgctgcacttcctgtacctctgcaccttttcctgggctctgctggag
gccttgcacctgtaccgggcactcactgaggtgcgcgatgtcaacaccggccccatgcgc
ttctactacatgctgggctggggcgtgcctgccttcatcacagggctagccgtgggcctg
gaccccgagggctacgggaaccctgacttctgctggctctccatctatgacacgctcatc
tggagttttgctggcccggtggcctttgccgtctcgatgagtgtcttcctgtacatcctg
gcggcccgggcctcctgtgctgcccagcggcagggctttgagaagaaaggtcctgtctcg
ggcctgcagccctccttcgccgtcctcctgctgctgagcgccacgtggctgctggcactg
ctctctgtcaacagcgacaccctcctcttccactacctctttgctacctgcaattgcatc
cagggccccttcatcttcctctcctatgtggtgcttagcaaggaggtccggaaagcactc
aagcttgcctgcagccgcaagcccagccctgaccctgctctgaccaccaagtccaccctg
acctcgtcctacaactgccccagcccctacgcagatgggcggctgtaccagccctacgga
gactcggccggctctctgcacagcaccagtcgctcgggcaagagtcagcccagctacatc
cccttcttgctgagggaggagtccgcactgaaccctggccaagggccccctggcctgggg
gatccaggcagcctgttcctggaaggtcaagaccagcagcatgatcctgacacggactcc
gacagtgacctgtccttagaagacgaccagagtggctcctatgcctctacccactcatca
gacagtgaggaggaagaagaggaggaggaagaggaggccgccttccctggagagcagggc
tgggatagcctgctggggcctggagcagagagactgcccctgcacagtactcccaaggat
gggggcccagggcctggcaaggccccctggccaggagactttgggaccacagcaaaagag
agtagtggcaacggggcccctgaggagcggctgcgggagaatggagatgccctgtctcga
gaggggtccctaggcccccttccaggctcttctgcccagcctcacaaaggcatccttaag
aagaagtgtctgcccaccatcagcgagaagagcagcctcctgcggctccccctggagcaa
tgcacagggtcttcccggggctcctccgctagtgagggcagccggggaggcccccctccc
cgcccaccgccccggcagagcctccaggagcagctgaacggggtcatgcccatcgccatg
agcatcaaggcaggcacggtggatgaggactcgtcaggctccgaatttctcttctttaac
ttcctgcattaa

KEGG   Homo sapiens (human): 1951
Entry
1951              CDS       T01001                                 
Symbol
CELSR3, ADGRC3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1
Name
(RefSeq) cadherin EGF LAG seven-pass G-type receptor 3 precursor
  KO
K04602  cadherin EGF LAG seven-pass G-type receptor 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04310  Wnt signaling pathway
hsa04519  Cadherin signaling
Network
nt06505  WNT signaling
nt06549  Cadherin signaling
  Element
N02010  Wnt signaling pathway, PCP pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    1951 (CELSR3)
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    1951 (CELSR3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1951 (CELSR3)
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1951 (CELSR3)
   04515 Cell adhesion molecules [BR:hsa04515]
    1951 (CELSR3)
Peptidases and inhibitors [BR:hsa01002]
 Mixed peptidases
  Family P2
   1951 (CELSR3)
G protein-coupled receptors [BR:hsa04030]
 Adhesion receptor family
  Cadherin EGF LAG (CELSR)
   1951 (CELSR3)
Cell adhesion molecules [BR:hsa04515]
 Cadherins
  Major cadherins
   1951 (CELSR3)
SSDB
Motif
Pfam: Cadherin 7tm_2 Laminin_G_2 Cadherin_CELSR2_9th Laminin_G_1 Cadherin_FAT4_N GAIN Ig_CLSTN GPS EGF HRM Ig_Cad99C_N EGF_TEN Fibulin_C EGF_laminin RET_CLD1 EGF_3 hEGF Frizzled Dicty_CAR
Other DBs
NCBI-GeneID: 1951
NCBI-ProteinID: NP_001398
OMIM: 604264
HGNC: 3230
Ensembl: ENSP00000164024.4
UniProt: Q9NYQ7
LinkDB
Position
3:complement(48636463..48662886)
AA seq 3312 aa
MMARRPPWRGLGGRSTPILLLLLLSLFPLSQEELGGGGHQGWDPGLAATTGPRAHIGGGA
LALCPESSGVREDGGPGLGVREPIFVGLRGRRQSARNSRGPPEQPNEELGIEHGVQPLGS
RERETGQGPGSVLYWRPEVSSCGRTGPLQRGSLSPGALSSGVPGSGNSSPLPSDFLIRHH
GPKPVSSQRNAGTGSRKRVGTARCCGELWATGSKGQGERATTSGAERTAPRRNCLPGASG
SGPELDSAPRTARTAPASGSAPRESRTAPEPAPKRMRSRGLFRCRFLPQRPGPRPPGLPA
RPEARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRL
VYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVA
VTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARA
AAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDEND
NAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTG
EIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSV
LENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVE
HYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTA
VDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHD
HCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN
LPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQ
FVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVR
TVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENS
IVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVI
VVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDP
DVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCV
LRVVIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDTD
VGGTVLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFDDNVCL
REPCENYMKCVSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGDFCETELDLCY
SNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNGGFRC
QCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNE
KHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQ
GPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLP
ENFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSER
WGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQG
VLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPG
GRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQLHVGGLPPGSAEEAPQGLVGCIQGVW
LGSTPSGSPALLPPSHRVNAEPGCVVTNACASGPCPPHADCRDLWQTFSCTCQPGYYGPG
CVDACLLNPCQNQGSCRHLPGAPHGYTCDCVGGYFGHHCEHRMDQQCPRGWWGSPTCGPC
NCDVHKGFDPNCNKTNGQCHCKEFHYRPRGSDSCLPCDCYPVGSTSRSCAPHSGQCPCRP
GALGRQCNSCDSPFAEVTASGCRVLYDACPKSLRSGVWWPQTKFGVLATVPCPRGALGAA
VRLCDEAQGWLEPDLFNCTSPAFRELSLLLDGLELNKTALDTMEAKKLAQRLREVTGHTD
HYFSQDVRVTARLLAHLLAFESHQQGFGLTATQDAHFNENLLWAGSALLAPETGDLWAAL
GQRAPGGSPGSAGLVRHLEEYAATLARNMELTYLNPMGLVTPNIMLSIDRMEHPSSPRGA
RRYPRYHSNLFRGQDAWDPHTHVLLPSQSPRPSPSEVLPTSSSIENSTTSSVVPPPAPPE
PEPGISIIILLVYRTLGGLLPAQFQAERRGARLPQNPVMNSPVVSVAVFHGRNFLRGILE
SPISLEFRLLQTANRSKAICVQWDPPGLAEQHGVWTARDCELVHRNGSHARCRCSRTGTF
GVLMDASPRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSLKSNVRGIHANVAA
ALGVAELLFLLGIHRTHNQLVCTAVAILLHYFFLSTFAWLFVQGLHLYRMQVEPRNVDRG
AMRFYHALGWGVPAVLLGLAVGLDPEGYGNPDFCWISVHEPLIWSFAGPVVLVIVMNGTM
FLLAARTSCSTGQREAKKTSALTLRSSFLLLLLVSASWLFGLLAVNHSILAFHYLHAGLC
GLQGLAVLLLFCVLNADARAAWMPACLGRKAAPEEARPAPGLGPGAYNNTALFEESGLIR
ITLGASTVSSVSSARSGRTQDQDSQRGRSYLRDNVLVRHGSAADHTDHSLQAHAGPTDLD
VAMFHRDAGADSDSDSDLSLEEERSLSIPSSESEDNGRTRGRFQRPLCRAAQSERLLTHP
KDVDGNDLLSYWPALGECEAAPCALQTWGSERRLGLDTSKDAANNNQPDPALTSGDETSL
GRAQRQRKGILKNRLQYPLVPQTRGAPELSWCRAATLGHRAVPAASYGRIYAGGGTGSLS
QPASRYSSREQLDLLLRRQLSRERLEEAPAPVLRPLSRPGSQECMDAAPGRLEPKDRGST
LPRRQPPRDYPGAMAGRFGSRDALDLGAPREWLSTLPPPRRTRDLDPQPPPLPLSPQRQL
SRDPLLPSRPLDSLSRSSNSREQLDQVPSRHPSREALGPLPQLLRAREDSVSGPSHGPST
EQLDILSSILASFNSSALSSVQSSSTPLGPHTTATPSATASVLGPSTPRSATSHSISELS
PDSEVPRSEGHS
NT seq 9939 nt   +upstreamnt  +downstreamnt
atgatggcgaggcggccgccgtggcggggcctcgggggacggtcgacccccatactcctg
ctccttctcctctctttgttccccctcagccaggaggagctggggggcggtgggcaccag
ggctgggacccaggcttagctgccactacggggccaagggcgcatatcggtggcggagcc
ttagctctttgtccggagtcttccggggtccgggaggatggggggcctggcctgggggtc
agggagcctatcttcgtggggctccgagggagaaggcaaagcgcccggaatagtcgaggg
ccccctgagcagccgaatgaggagctggggattgaacacggcgtccagccattgggcagc
cgcgaacgagagacaggacagggaccagggtctgtgttatactggcgcccagaggtctcc
tcttgcgggcggacaggacctttgcaaagaggtagtctgtcaccaggggctctgtcctca
ggggtcccgggctcggggaacagctcgcccctcccttcagactttttgattcggcaccac
ggtcccaagccggtgtcctcccagcggaacgctgggacaggctcccgcaaaagagtgggc
accgcgcgctgctgtggggaattatgggcaacagggagcaagggtcagggcgagagagcc
acgacatccggagcagaaaggacagccccccggcggaactgtcttccaggggcctcggga
tctggccccgagctggattcagcaccacgcacggcgaggacagctcctgcatcaggttca
gcaccccgcgagtctcggacagctcccgagccggcgcccaagcgcatgcgctcccggggt
ctcttccgctgccgcttcctcccgcagcgccccgggccgcgtcccccgggactcccggcc
cgtcctgaagccaggaaagtaacctcggcgaaccgggcacgctttcgtcgcgccgcaaac
cgccacccgcagtttccgcagtacaactaccagacgctggtgccggagaatgaggcagca
ggcaccgcggtgctacgcgtggttgctcaggacccggacgccggcgaggccgggcgccta
gtctactcgctggcggcactcatgaacagccgctcgctggagctgttcagcatcgacccg
cagagcggccttatccgtacggcggcagctctggaccgcgagagcatggagcgtcactac
ctgcgtgtgaccgcgcaggaccacgggtcgccgcgcctctcggccaccacgatggtggcc
gtgacagtagccgaccgcaacgaccactcgccggtttttgagcaagcgcagtaccgggag
acccttcgcgagaatgtggaggagggctaccctatcctgcagctgcgtgccactgacggc
gacgcgccccccaacgccaacctgcgctaccgcttcgtggggccgccagctgcgcgcgct
gcagctgccgccgccttcgagattgatccacgctccggcctcatcagcaccagcggccga
gtggaccgcgagcacatggaaagctatgagctggtggtggaagccagcgaccagggccag
gaacccgggccgcgctcggccactgtgcgcgtacacataactgtgctagacgagaacgac
aatgctcctcagttcagcgagaagcgctacgtggcgcaggtgcgcgaggatgtgcgcccc
cacacagtcgtgctgcgcgtcacggccactgaccgggacaaggacgccaacggattggtg
cactacaacatcatcagtggcaatagccgtggacactttgccatcgacagcctcactggc
gagatccaggtggtggcacctctggacttcgaggcagagagagagtatgccttgcgcatc
agggcgcaggatgctggccggccaccgctgtccaacaacacgggcctggccagcatccag
gtggtggacatcaatgaccacattcctatttttgtcagcacgcccttccaagtttctgtc
ttggaaaatgctcccttgggtcactcagtcatccacattcaggcagtcgatgcagaccat
ggggagaatgccagattggagtactccctaactggtgtggcacctgatactccttttgtg
ataaacagcgccactggctgggtctctgtgagtggtcccctggaccgtgagtctgtggag
cattacttctttggtgtggaggctcgagaccatggctcacccccactctctgcctcagcc
agtgtcaccgtgactgtgctggacgttaatgacaatcggcctgagttcacaatgaaggag
taccacctacgactgaatgaggatgcagctgtgggcaccagtgtggtcagcgtgaccgca
gtagaccgtgatgccaacagtgccatcagctaccagatcacaggcggcaacacccggaat
cgctttgccatcagcacccaggggggtgtgggtctggtgactctggctctgccactggac
tacaagcaggaacgctacttcaagctggtactaactgcatctgaccgtgcccttcatgat
cactgctatgtgcacatcaacatcacagatgccaacactcatcggccggtctttcaaagt
gcccactactcagtgagtgtgaatgaagatcggccaatgggtagcaccatagtggtcatc
agtgcctctgatgatgacgtgggtgagaatgctcgtatcacctatctcctggaggacaac
ctgccccagttccgcattgatgcagactcaggagccattacattacaggccccattagac
tatgaggaccaggtgacctacaccctggctatcacagctcgggacaatggcatcccacag
aaggcagacactacttatgtggaggtgatggtcaatgacgtgaatgacaatgctccacaa
tttgtggcctcccactatacagggctggtctctgaggatgccccacctttcaccagtgtc
ctgcagatctcagccactgaccgggatgctcatgccaatggccgggtccagtacactttc
cagaatggtgaagatggggatggagattttaccattgagcccacctctggaattgtccgt
acagtaaggcggctagaccgggaggcagtatcagtgtatgagttgactgcctacgcagtg
gacagaggtgtgcccccactccggactccagtcagtatccaggtgatggtgcaggatgtg
aacgacaatgcacctgtcttcccagctgaggagtttgaggtgcgggtgaaagagaatagc
attgtgggctcagtggtggcccagatcactgcagtggaccctgacgaaggccccaatgcc
catataatgtaccagatcgtggaggggaacatccctgagctgttccaaatggacatcttc
tctggagaactgacggcactcattgacctagactatgaggctcgccaagaatatgtgatt
gtggtgcaggccacatctgctcctttggtcagccgggccactgtgcacgtccgcctggtt
gaccagaatgacaacagccctgtgctcaacaacttccagatcctcttcaacaactatgta
tccaaccgttcagacaccttcccgtcgggcattattgggcgcatcccagcttatgacccc
gatgtctccgaccacctcttctactcctttgagcgtggcaatgagctgcagctgctggta
gtcaaccagaccagtggggagctgcgactcagccgaaagctagacaataaccgcccactg
gtggcctccatgttggtgactgtcacagatggcctgcacagcgtgacggcgcagtgtgtg
ctgcgcgtggtcatcatcacggaggagttgctggccaacagcctgaccgtgcgccttgag
aacatgtggcaggagcgcttcctgtcaccgctgctgggccgcttcctcgagggcgtggct
gcggtgctcgctacgcccgctgaggacgtcttcatcttcaacatccagaacgacacagac
gtagggggcaccgtgctcaatgtgagtttctcggcgctagctccacgtggggccggggcg
ggcgctgcagggccctggttcagctccgaggagctgcaggagcagttgtacgtgcgccgg
gcggcgctggcggctcgctccctgctcgacgtactgcccttcgacgacaacgtgtgcctg
cgagagccctgtgagaactacatgaaatgcgtgtccgtgctccgctttgactcgtccgcg
cccttcctggcctcggcctccacgctgttccgacccatccagcccatcgctggcctgcgc
tgccgctgcccgcccggattcacgggagacttttgcgagaccgagctcgacctctgctac
tccaacccatgtcgcaacggcggagcctgcgcgcggcgcgagggaggctacacgtgcgtc
tgccgcccgcgcttcaccggagaggactgcgagctggacaccgaggccggccgctgcgtg
ccgggcgtctgccgcaacgggggcacctgcaccgacgcgcccaacggcggctttcgctgc
cagtgcccggcaggcggcgccttcgagggcccgcgctgcgaggtggctgcgcgctccttc
ccgcccagttcgttcgtcatgtttcgcggcctgcggcagcgattccaccttacgctgtcc
ctctcgttcgcgacagtgcagcagagcgggctgctcttctacaacgggcgcctgaacgag
aagcacgacttcctggccctggaactcgtggctggccaagtgcggctcacatattccacg
ggtgaatccaacaccgtggtcagccccacagttccagggggcttgagtgacgggcaatgg
catacagtgcatctgagatactacaacaagccccggacagatgccctagggggtgcacag
ggcccctccaaggacaaggtggctgtgctaagcgtggatgattgtgatgtggccgtggct
ctgcagtttggtgctgagattggcaactactcatgcgcggctgctggtgtgcaaacaagc
tccaagaagtccctggacctgacgggccctcttcttctgggaggtgtccccaacctcccc
gagaacttccccgtatcccataaggacttcatcggctgtatgcgggacctgcacattgat
ggccgccgagtggacatggcggcttttgtcgcaaataatggcaccatggcaggctgccaa
gccaagctacacttttgtgactcaggcccctgcaagaacagtggcttctgctcggagcgc
tggggcagcttcagctgcgactgccctgtgggcttcggcggcaaagactgtcagcttact
atggcccatccccaccatttccgtggcaacggcacactgagctggaactttggaagtgac
atggctgtgtctgtgccatggtacctggggctggcatttcggacacgggcaacgcagggg
gtcctgatgcaagtgcaggctgggccacacagcacgctcctttgccagctagatcggggg
ttactgtctgtgacagtgaccaggggctcgggccgtgcttcccatctccttctggaccag
gtgactgtcagtgatggccggtggcacgatctgcggctggagttgcaggaggaaccaggt
ggccggcggggccaccatgtccttatggtctcactggactttagcctcttccaggacacc
atggcggtggggagtgagctgcagggcctgaaggtaaagcagctccacgtgggaggcctg
ccccccggcagtgcagaggaggctcctcagggtctggttggctgcatccagggggtgtgg
ctcggctccacaccctctggctccccggccctgctaccccccagccaccgagtgaatgcg
gagcctggctgtgttgtgaccaacgcctgtgcctctgggccctgcccacctcacgcagac
tgccgggacctctggcagaccttttcttgcacctgccagccaggttactacggcccaggc
tgtgtggatgcctgcctcctgaacccctgtcagaaccagggatcatgccggcacctgcca
ggagccccccatggctatacctgtgactgtgtgggtggctatttcgggcaccactgtgag
cacaggatggaccagcagtgcccacggggctggtgggggagcccaacctgtggcccctgc
aactgtgatgttcacaaaggttttgatcccaactgcaacaagacaaatgggcagtgtcac
tgcaaggagttccactaccgaccgcggggcagtgactcttgcctcccatgtgactgctac
cctgtgggctccacctcgcgctcatgtgcaccccacagcgggcagtgcccctgtcgccca
ggagcccttggccgccagtgcaacagctgtgacagtcccttcgcagaggtgacagccagc
ggctgccgggtgctctatgatgcctgccctaagtccctgagatctggtgtgtggtggccc
cagacaaagtttggcgtcctggccacagtgccctgtccccggggggccctgggtgctgct
gtgcggctgtgtgatgaggcccagggttggctggagcccgacctcttcaactgtacctcc
cctgcctttcgagagctcagtctgctgctggatggcctagagctgaacaagacggcactg
gataccatggaggccaagaagctggctcagcggctacgggaggtgactggccacactgac
cactattttagccaagatgttcgagtcactgcccgcctgctggcccacctgctggccttc
gagagccatcagcagggcttcgggctgacagccacacaggatgcccacttcaatgagaat
ctgctgtgggccggctctgcactgcttgccccagagacaggggacttgtgggcggcgctg
gggcagcgggcccctgggggctccccaggcagcgcgggactggtgaggcacctggaggag
tatgcagccacactcgcaaggaatatggaactcacatacctgaatcccatggggctggtg
acgcctaatatcatgctcagcattgaccgcatggagcaccccagttctccccggggggcc
cgtcgctaccctcgctaccatagcaacctctttcgaggccaggatgcctgggatcctcac
acccatgtgctgctgccttcccagtccccacggccatccccatctgaagttctgcccaca
agcagcagcatagaaaactccaccacctcaagtgtggtccccccaccagccccgccagag
ccagagcctgggatctccattatcattctcctcgtttaccgcaccttagggggactgctc
cctgcccagttccaggcagaacgccgaggtgccaggcttcctcagaaccccgtcatgaac
tccccggtggtcagcgtggctgtgttccacggacgcaacttcctaaggggaatcctggag
tcccccatcagcctagagtttcgcctgctacagacagcgaatcggagcaaggcgatctgt
gtgcagtgggacccacctggcctggcggagcagcatggtgtgtggacagcacgggactgc
gagctggtgcacaggaatgggtcccacgcacggtgtcgctgcagccggacagggaccttt
ggggtcctcatggatgcctctccccgtgagaggctggagggcgacctggagctgctggct
gtgttcacccacgtggtcgtggctgtgtctgtggctgcgctggtgctgactgcagccatc
ctgctgagcctgcgcagcctcaagtccaatgtgcgtgggatccatgccaatgtggcagcc
gccctgggggtggcagagctcctcttcctgctggggattcacaggacccacaatcagctg
gtgtgcactgcagtcgccatcctcctgcactacttcttcctcagcaccttcgcgtggctc
ttcgtgcaggggctgcacctctaccgcatgcaggttgagccacgcaacgtggaccgcggc
gccatgcgcttctaccatgccctgggctggggcgtccctgctgtgctgctgggccttgct
gtgggcctggaccctgagggctatgggaaccctgacttctgctggatctcagtccacgag
cccctcatctggagctttgctggccctgttgtcctggtcatagtgatgaacgggaccatg
tttctcctcgctgcccgcacatcctgctccacagggcagagggaggccaagaagacctct
gcactgacccttcgcagctccttcctgctgcttctgctggtcagtgcctcctggctcttt
gggctcctggcagtcaaccacagcatcctagccttccactacctccatgctggactctgc
ggcctccagggcctggcggtgctgctgctcttctgtgtcctaaatgcagatgctcgggct
gcctggatgccagcctgtctgggcaggaaggcagcgcctgaggaggcaaggccagcacct
gggctgggacctggggcctacaacaacacggctctctttgaggagagtggcctcatccgc
atcactctgggcgcctccaccgtctcctctgtgagcagtgcccgctccggccggacccag
gaccaggacagccagcggggccgcagctacctcagggacaatgtcctggttcgacatggc
tcagccgctgaccacactgaccacagcctccaggctcatgctggccccactgacctggac
gtggccatgttccatcgagatgctggcgcagactccgactctgacagtgacctgtccttg
gaggaggagaggagtctctccattccatcttcagaaagcgaggacaatggccggacgcgg
gggcgcttccaacggccactctgccgagcagcccagagtgagaggctcctcacccacccc
aaagatgtggatggcaatgacctcctgtcctactggccagccctgggggagtgcgaggca
gccccctgtgctctgcagacttggggctctgaaaggcgcctggggctggacaccagcaag
gatgcagctaacaacaaccagccagacccggccctgaccagtggggatgagacttctctg
ggccgggcccagcgccagaggaaaggcatcctgaagaaccggttgcaatacccactggtg
ccacagacccgaggtgcccctgagctgtcctggtgccgtgcagccaccttgggccaccgt
gctgtgccagctgcctcttacggtcgcatctatgctggcgggggcacgggcagcctttca
cagccagccagccgctactcttctagagaacagctggacctgctcctccggcggcaactg
agccgtgagcgactagaggaagcccctgcccctgttctacgtcccctgagccggccaggg
tcccaggaatgcatggatgctgcaccaggccgactggagcccaaagatcggggcagcacc
ctgccacggaggcagccacctcgggactaccctggcgccatggctggccgcttcgggtca
cgggatgcgctcgacttaggggcacctcgagagtggttgagcacgctgcctccgccccgc
cgcacccgggaccttgacccacagcccccacctctgcccctgtctccccagcggcaactc
tcaagggaccccctcttgccatcccggccgctggactctctgtctaggagctcgaactct
cgggagcagctggaccaggtgcctagccggcacccctcacgagaagcccttgggccactc
ccgcagctgctcagagctagggaggactcggtcagtggccccagccatggcccctccaca
gaacagttggacattctttcctccatccttgcctctttcaactcctcggccctctcctct
gtgcaatcttcaagcacacccttgggccctcacaccactgccacaccttctgccacagcc
tctgtgcttgggccctccacgccacgttctgccacgtctcacagcatctcggagctgtcg
ccagactcagaagttcccagaagtgagggtcactcctga

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