KEGG   Homo sapiens (human): 80198
Entry
80198             CDS       T01001                                 
Symbol
MUS81, SLX3
Name
(RefSeq) MUS81 structure-specific endonuclease subunit
  KO
K08991  crossover junction endonuclease MUS81 [EC:3.1.22.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03440  Homologous recombination
hsa03460  Fanconi anemia pathway
Network
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
  Element
N01448  Double Holliday junction resolution
N01465  Lesion bypass by TLS and DSB formation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    80198 (MUS81)
   03460 Fanconi anemia pathway
    80198 (MUS81)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    80198 (MUS81)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Other HR factors
     80198 (MUS81)
SSDB
Motif
Pfam: MUS81-like_WH ERCC4 EME1-MUS81_C HHH_8 MutL
Other DBs
NCBI-GeneID: 80198
NCBI-ProteinID: NP_079404
OMIM: 606591
HGNC: 29814
Ensembl: ENSG00000172732
UniProt: Q96NY9 Q53ES5
Structure
LinkDB
Position
11:65859674..65867653
AA seq 551 aa
MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSG
KEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPA
QPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSAR
PWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETA
VPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTV
RKLHVGDFVWVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCG
LERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQ
RLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLM
QVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTL
SQLYCSYGPLT
NT seq 1656 nt   +upstreamnt  +downstreamnt
atggcggccccggtccgcctgggccggaagcgcccgctgcctgcctgtcccaacccgctc
ttcgttcgctggctgaccgagtggcgggacgaggcgacccgcagcaggcgccgcacgcgc
ttcgtatttcagaaggcgctgcgttccctccgacggtacccactgccgctgcgcagcggg
aaggaagctaagatcctacagcacttcggagacgggctctgccggatgctggacgagcgg
ctgcagcggcaccgaacatcgggcggtgaccatgccccggactcaccatctggagagaac
agtccagccccgcaggggcgacttgcggaagtccaggactcttccatgccagttcctgcc
cagcccaaagcgggaggctctggcagctactggccagctcggcactcaggagcccgagtg
atactgctggtgctctaccgggagcacctgaatcctaatggtcaccacttcttaaccaag
gaggagctgctgcagaggtgtgctcagaagtcccccagggtagcccctgggagtgctcga
ccctggccagccctccgctccctccttcacaggaacctggtcctcaggacacaccagcca
gccaggtactcattgaccccagagggcctggagctggcccagaagttggccgagtcagaa
ggcctgagcttgctgaatgtgggcatcgggcccaaggagccccctggggaggagacagca
gtgccaggagcagcttcagcagagcttgccagtgaagcaggggtccagcagcagccactg
gagctgaggcctggagagtacagggtgctgttgtgtgtggacattggcgagacccggggg
ggcgggcacaggccggagctgctccgagagctacagcggctgcacgtgacccacacggtg
cgcaagctgcacgttggagattttgtgtgggtggcccaggagaccaatcctagagaccca
gcaaaccctggggagttggtactggatcacattgtggagcgcaagcgactggatgacctt
tgcagcagcatcatcgacggccgcttccgggagcagaagttccggctgaagcgctgtggt
ctggagcgccgggtatacctggtggaagagcatggttccgtccacaacctcagccttcct
gagagcacactgctgcaggctgtcaccaacactcaggtcattgatggcttttttgtgaag
cgcacagcagacattaaggagtcagccgcctacctggccctcttgacgcggggcctgcag
agactctaccagggccacaccctacgcagccgcccctggggaacccctgggaaccctgaa
tcaggggccatgacctctccaaaccctctctgctcactcctcaccttcagtgacttcaac
gcaggagccatcaagaataaggcccagtcggtgcgagaagtgtttgcccggcagctgatg
caggtgcgcggagtgagtggggagaaggcagcagccctggtggatcgatacagcacccct
gccagcctcctggccgcctatgatgcctgtgccacccccaaggaacaagagacactgctg
agcaccattaagtgtgggcgtctacagaggaatctggggcctgctctgagcaggacctta
tcccagctctactgcagctacggccccttgacctga

KEGG   Homo sapiens (human): 146956
Entry
146956            CDS       T01001                                 
Symbol
EME1, MMS4L, SLX2A
Name
(RefSeq) essential meiotic structure-specific endonuclease 1
  KO
K10882  crossover junction endonuclease EME1 [EC:3.1.22.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03440  Homologous recombination
hsa03460  Fanconi anemia pathway
Network
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
  Element
N01448  Double Holliday junction resolution
N01465  Lesion bypass by TLS and DSB formation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    146956 (EME1)
   03460 Fanconi anemia pathway
    146956 (EME1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    146956 (EME1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Other HR factors
     146956 (EME1)
SSDB
Motif
Pfam: EME1-MUS81_C ERCC4
Other DBs
NCBI-GeneID: 146956
NCBI-ProteinID: NP_689676
OMIM: 610885
HGNC: 24965
Ensembl: ENSG00000154920
UniProt: Q96AY2
Structure
LinkDB
Position
17:50373229..50381483
AA seq 570 aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAP
ELFSPPVPEIAETVTQTQPVRLLSSESEDEEEFIPLAQRLTCKFLTHKQLSPEDSSSPVK
SVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRM
KAQRPEECLKHIIVVLDPVLLQMEGGGQLLGALQTMECRCVIEAQAVPCSVTWRRRAGPS
EDREDWVEEPTVLVLLRAEAFVSMIDNGKQGSLDSTMKGKETLQGFVTDITAKTAGKALS
LVIVDQEKCFSAQNPPRRGKQGANKQTKKQQQRQPEASIGSMVSRVDAEEALVDLQLHTE
AQAQIVQSWKELADFTCAFTKAVAEAPFKKLRDETTFSFCLESDWAGGVKVDLAGRGLAL
VWRRQIQQLNRVSLEMASAVVNAYPSPQLLVQAYQQCFSDKERQNLLADIQVRRGEGVTS
TSRRIGPELSRRIYLQMTTLQPHLSLDSAD
NT seq 1713 nt   +upstreamnt  +downstreamnt
atggctctaaagaagtcatcaccctcactggattctggtgatagtgactctgaggagttg
ccaacatttgcctttctgaagaaggaaccatcttcaacaaagaggagacagcctgaaagg
gaagagaagattgtagtggttgacatctcagattgtgaagcctcctgtcctccagcacca
gagttattttcaccacctgtcccagaaatagctgaaactgtcacacaaacacagccagtc
aggttgctaagcagtgaaagtgaagatgaagaagaatttattcctctggctcaaaggctt
acatgtaagtttctgacccacaagcaactgagccctgaggactctagctccccagttaaa
agtgttttggatcatcaaaataatgaaggtgcatcatgtgactggaaaaagccctttcca
aagatccctgaagttcccctccatgataccccagagaggagtgcagcagataacaaggac
ctgatcttagatccatgctgtcagcttccagcctacctgtctacctgccctggccagagc
agcagcttggcagtaaccaaaacaaattctgacatccttccaccccagaagaaaaccaag
ccgagtcagaaggtccagggaagaggctcacacggatgccggcagcagagacaagcaagg
cagaaggaaagcaccctgagaagacaggaaagaaagaatgcagcactggttaccaggatg
aaagcccagaggccagaggaatgcttaaaacacatcattgtagtgctggatccagtgctc
ttacagatggaaggtgggggccagctcctaggagcactgcagaccatggagtgccgctgt
gtgattgaggcgcaggctgtgccttgcagtgtcacttggaggagaagggctgggccgtct
gaggacagagaggactgggtggaggagccaacagtactggtgttgctccgggcagaggca
tttgtgtccatgatcgacaatggaaagcagggaagcctggacagcactatgaaagggaag
gaaacgcttcagggctttgtaactgacatcacagcaaagacagcagggaaagctctgtca
ctggtgattgtggatcaggagaaatgcttcagtgctcagaatcctccaagaagagggaaa
cagggagcaaataaacagaccaagaagcagcagcagagacaaccagaggccagcataggg
tccatggtatccagggtagacgctgaagaggcattggtggatctgcagctacacacagaa
gcccaggctcaaattgtgcagagctggaaagagctggccgacttcacatgcgcattcaca
aaggctgtggctgaggcgcccttcaagaagctccgagatgaaactaccttctccttctgt
ctggagagtgactgggctggaggggtgaaggtggaccttgctggcaggggactcgcacta
gtctggaggagacagattcagcagctgaaccgagtcagcctggaaatggccagtgcagtt
gtgaatgcctatccctccccacagctcctggtacaggcttatcagcagtgtttttcggat
aaagaacgccagaatttgctcgcagacatacaggtgcgccgtggggaaggtgtgacatcc
acttctcgccgcattggaccagaactatccaggcgtatctaccttcagatgaccacttta
cagccacatctctctttagatagtgctgactga

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