Homo sapiens (human): 823
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Entry
823 CDS
T01001
Symbol
CAPN1, CANP, CANP1, CANPL1, SPG76, muCANP, muCL
Name
(RefSeq) calpain 1
KO
K01367
calpain-1 [EC:
3.4.22.52
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04141
Protein processing in endoplasmic reticulum
hsa04210
Apoptosis
hsa04217
Necroptosis
hsa04218
Cellular senescence
hsa04382
Cornified envelope formation
hsa05010
Alzheimer disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05131
Shigellosis
Network
nt06460
Alzheimer disease
nt06466
Pathways of neurodegeneration
nt06539
Cytoskeleton in muscle cells
nt06545
Cornified envelope formation
Element
N00997
Mutation-caused aberrant Abeta to electron transfer in Complex I
N01018
Mutation-caused aberrant Abeta to anterograde axonal transport
N01821
Sarcomere, M-band
N01931
Processing of filaggrin to amino acids
Disease
H00266
Hereditary spastic paraplegia
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
823 (CAPN1)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
823 (CAPN1)
04217 Necroptosis
823 (CAPN1)
04218 Cellular senescence
823 (CAPN1)
09150 Organismal Systems
09158 Development and regeneration
04382 Cornified envelope formation
823 (CAPN1)
09160 Human Diseases
09171 Infectious disease: bacterial
05131 Shigellosis
823 (CAPN1)
09164 Neurodegenerative disease
05010 Alzheimer disease
823 (CAPN1)
05022 Pathways of neurodegeneration - multiple diseases
823 (CAPN1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
823 (CAPN1)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.22 Cysteine endopeptidases
3.4.22.52 calpain-1
823 (CAPN1)
Peptidases and inhibitors [BR:
hsa01002
]
Cysteine peptidases
Family C2: calpain family
823 (CAPN1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Peptidase_C2
Calpain_III
EF-hand_6
EF-hand_1
EF-hand_8
EF-hand_7
CAPN13-like_C_EFh
Motif
Other DBs
NCBI-GeneID:
823
NCBI-ProteinID:
NP_001185797
OMIM:
114220
HGNC:
1476
Ensembl:
ENSG00000014216
UniProt:
P07384
B2RDI5
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:65181373..65212006
Genome browser
AA seq
714 aa
AA seq
DB search
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
NT seq
2145 nt
NT seq
+upstream
nt +downstream
nt
atgtcggaggagatcatcacgccggtgtactgcactggggtgtcagcccaagtgcagaag
cagcgggccagggagctgggcctgggccgccatgagaatgccatcaagtacctgggccag
gattatgagcagctgcgggtgcgatgcctgcagagtgggaccctcttccgtgatgaggcc
ttccccccggtaccccagagcctgggttacaaggacctgggtcccaattcctccaagacc
tatggcatcaagtggaagcgtcccacggaactgctgtcaaacccccagttcattgtggat
ggagctacccgcacagacatctgccagggagcactgggggactgctggctcttggcggcc
atcgcctccctcactctcaacgacaccctcctgcaccgagtggttccgcacggccagagc
ttccagaatggctatgccggcatcttccatttccagctgtggcaatttggggagtgggtg
gacgtggtcgtggatgacctgctgcccatcaaggacgggaagctagtgttcgtgcactct
gccgaaggcaacgagttctggagcgccctgcttgagaaggcctatgccaaggtaaatggc
agctacgaggccctgtcagggggcagcacctcagagggctttgaggacttcacaggcggg
gttaccgagtggtacgagttgcgcaaggctcccagtgacctctaccagatcatcctcaag
gcgctggagcggggctccctgctgggctgctccatagacatctccagcgttctagacatg
gaggccatcactttcaagaagttggtgaagggccatgcctactctgtgaccggggccaag
caggtgaactaccgaggccaggtggtgagcctgatccggatgcggaacccctggggcgag
gtggagtggacgggagcctggagcgacagctcctcagagtggaacaacgtggacccatat
gaacgggaccagctccgggtcaagatggaggacggggagttctggatgtcattccgagac
ttcatgcgggagttcacccgcctggagatctgcaacctcacacccgacgccctcaagagc
cggaccatccgcaaatggaacaccacactctacgaaggcacctggcggcgggggagcacc
gcggggggctgccgaaactacccagccaccttctgggtgaaccctcagttcaagatccgg
ctggatgagacggatgacccggacgactacggggaccgcgagtcaggctgcagcttcgtg
ctcgcccttatgcagaagcaccgtcgccgcgagcgccgcttcggccgcgacatggagact
attggcttcgcggtctacgaggtccctccggagctggtgggccagccggccgtacacttg
aagcgtgacttcttcctggccaatgcgtctcgggcgcgctcagagcagttcatcaacctg
cgagaggtcagcacccgcttccgcctgccacccggggagtatgtggtggtgccctccacc
ttcgagcccaacaaggagggcgacttcgtgctgcgcttcttctcagagaagagtgctggg
actgtggagctggatgaccagatccaggccaatctccccgatgagcaagtgctctcagaa
gaggagattgacgagaacttcaaggccctcttcaggcagctggcaggggaggacatggag
atcagcgtgaaggagttgcggacaatcctcaataggatcatcagcaaacacaaagacctg
cggaccaagggcttcagcctagagtcgtgccgcagcatggtgaacctcatggatcgtgat
ggcaatgggaagctgggcctggtggagttcaacatcctgtggaaccgcatccggaattac
ctgtccatcttccggaagtttgacctggacaagtcgggcagcatgagtgcctacgagatg
cggatggccattgagtcggcaggcttcaagctcaacaagaagctgtacgagctcatcatc
acccgctactcggagcccgacctggcggtcgactttgacaatttcgtttgctgcctggtg
cggctagagaccatgttccgatttttcaaaactctggacacagatctggatggagttgtg
acctttgacttgtttaagtggttgcagctgaccatgtttgcatga
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