Entry Name Mutation-caused aberrant Abeta to anterograde axonal transport
Definition APP* -> Abeta -> CHRNA7 -> Ca2+ -> CAPN -> CDK5R1 == CDK5 -> MAPT -| (TUBA+TUBB)
Expanded 351v1 -> (C16515,C16514) -> 1139 -> C00076 -> (823,824) -> 8851 == 1020 -> 4137 -| ((7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688))
Class Type Variant
Pathway Disease Gene 351 APP; amyloid beta precursor protein
1139 CHRNA7; cholinergic receptor nicotinic alpha 7 subunit
8851 CDK5R1; cyclin dependent kinase 5 regulatory subunit 1
1020 CDK5; cyclin dependent kinase 5
4137 MAPT; microtubule associated protein tau
7846 TUBA1A; tubulin alpha 1a
10376 TUBA1B; tubulin alpha 1b
84790 TUBA1C; tubulin alpha 1c
7278 TUBA3C; tubulin alpha 3c
113457 TUBA3D; tubulin alpha 3d
112714 TUBA3E; tubulin alpha 3e
7277 TUBA4A; tubulin alpha 4a
51807 TUBA8; tubulin alpha 8
203068 TUBB; tubulin beta class I
81027 TUBB1; tubulin beta 1 class VI
7280 TUBB2A; tubulin beta 2A class IIa
347733 TUBB2B; tubulin beta 2B class IIb
10381 TUBB3; tubulin beta 3 class III
10382 TUBB4A; tubulin beta 4A class IVa
10383 TUBB4B; tubulin beta 4B class IVb
84617 TUBB6; tubulin beta 6 class V
347688 TUBB8; tubulin beta 8 class VIII
Variant 351v1 (APP*) APP mutation
Metabolite C16515 Beta-amyloid protein 42
C16514 Beta-amyloid protein 40
Reference Authors Wasser CR, Herz J
Title Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
Journal Reference Authors Vargas LM, Cerpa W, Munoz FJ, Zanlungo S, Alvarez AR
Title Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
Journal Reference Authors Wang ZX, Tan L, Yu JT
Title Axonal transport defects in Alzheimer's disease.
Journal Reference Authors Zempel H, Thies E, Mandelkow E, Mandelkow EM
Title Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines.
Journal LinkDB All DBs
