Homo sapiens (human): 824
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Entry
824 CDS
T01001
Symbol
CAPN2, CANP2, CANPL2, CANPml, mCANP
Name
(RefSeq) calpain 2
KO
K03853
calpain-2 [EC:
3.4.22.53
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04141
Protein processing in endoplasmic reticulum
hsa04210
Apoptosis
hsa04217
Necroptosis
hsa04218
Cellular senescence
hsa04510
Focal adhesion
hsa05010
Alzheimer disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05131
Shigellosis
Network
nt06460
Alzheimer disease
nt06466
Pathways of neurodegeneration
Element
N00997
Mutation-caused aberrant Abeta to electron transfer in Complex I
N01018
Mutation-caused aberrant Abeta to anterograde axonal transport
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
824 (CAPN2)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
824 (CAPN2)
04217 Necroptosis
824 (CAPN2)
04218 Cellular senescence
824 (CAPN2)
09144 Cellular community - eukaryotes
04510 Focal adhesion
824 (CAPN2)
09160 Human Diseases
09171 Infectious disease: bacterial
05131 Shigellosis
824 (CAPN2)
09164 Neurodegenerative disease
05010 Alzheimer disease
824 (CAPN2)
05022 Pathways of neurodegeneration - multiple diseases
824 (CAPN2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
824 (CAPN2)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.22 Cysteine endopeptidases
3.4.22.53 calpain-2
824 (CAPN2)
Peptidases and inhibitors [BR:
hsa01002
]
Cysteine peptidases
Family C2: calpain family
824 (CAPN2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Peptidase_C2
Calpain_III
EF-hand_6
EF-hand_1
EF-hand_8
EF-hand_7
Motif
Other DBs
NCBI-GeneID:
824
NCBI-ProteinID:
NP_001739
OMIM:
114230
HGNC:
1479
Ensembl:
ENSG00000162909
UniProt:
P17655
Q59EF6
Structure
PDB
LinkDB
All DBs
Position
1:223701597..223776018
Genome browser
AA seq
700 aa
AA seq
DB search
MAGIAAKLAKDREAAEGLGSHDRAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGF
KELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEI
LARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL
LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGC
SIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDN
CPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTK
MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQR
KMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPG
EYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQ
LAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYIL
WTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFD
NFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL
NT seq
2103 nt
NT seq
+upstream
nt +downstream
nt
atggcgggcatcgcggccaagctggcgaaggaccgggaggcggccgaggggctgggctcc
cacgacagggccatcaagtacctcaaccaggactacgaggcgctgcggaacgagtgcctg
gaggccgggacgctcttccaggacccgtccttcccggccatcccctcggccctgggcttc
aaggagttggggccctactccagcaaaacccggggcatcgagtggaagcgccccacggag
atctgcgctgacccccagtttatcattggaggagccacccgcacagacatctgccaagga
gccctgggtgactgctggctgctggcagccattgcctccctcaccttgaatgaagaaatc
ctggctcgagtcgtccccctaaaccagagcttccaggaaaactatgcagggatctttcac
ttccagttctggcaatacggcgagtgggtggaggtggtggtggatgacaggctgcccacc
aaggacggggagctgctctttgtgcattcagccgaagggagcgagttctggagcgccctg
ctggagaaggcatacgccaagatcaacggatgctatgaagcgctatcagggggtgccacc
actgagggcttcgaagacttcaccggaggcattgctgagtggtatgagttgaagaagccc
cctcccaacctgttcaagatcatccagaaagctctgcaaaaaggctctctccttggctgc
tccatcgacatcaccagcgccgcggactcggaggccatcacgtttcagaagctggtgaag
gggcacgcgtactcggtcaccggagccgaggaggttgaaagtaacggaagcctacagaaa
ctgatccgcatccgaaatccctggggagaagtggagtggacagggcggtggaatgacaac
tgcccaagctggaacactatagacccagaggagagggaaaggctgaccagacggcatgaa
gatggagaattctggatgtctttcagtgacttcctgaggcactattcccgcctggagatc
tgtaacctgaccccagacactctcaccagcgatacctacaagaagtggaaactcaccaaa
atggatgggaactggaggcggggctccaccgcgggaggttgcaggaactacccgaacaca
ttctggatgaaccctcagtacctgatcaagctggaggaggaggatgaggacgaggaggat
ggggagagcggctgcaccttcctggtggggctcattcagaagcaccgacggcggcagagg
aagatgggcgaggacatgcacaccatcggctttggcatctatgaggttccagaggagtta
agtgggcagaccaacatccacctcagcaaaaacttcttcctgacgaatcgcgccagggag
cgctcagacaccttcatcaacctccgggaggtgctcaaccgcttcaagctgccgccagga
gagtacattctcgtgccttccaccttcgaacccaacaaggatggggatttctgcatccgg
gtcttttctgaaaagaaagctgactaccaagctgtcgatgatgaaatcgaggccaatctt
gaagagttcgacatcagcgaggatgacattgatgatggattcaggagactgtttgcccag
ttggcaggagaggatgcggagatctctgcctttgagctgcagaccatcctgagaagggtt
ctagcaaagcgccaagatatcaagtcagatggcttcagcatcgagacatgcaaaattatg
gttgacatgctagattcggacgggagtggcaagctggggctgaaggagttctacattctc
tggacgaagattcaaaaataccaaaaaatttaccgagaaatcgacgttgacaggtctggt
accatgaattcctatgaaatgcggaaggcattagaagaagcaggtttcaagatgccctgt
caactccaccaagtcatcgttgctcggtttgcagatgaccagctcatcatcgattttgat
aattttgttcggtgtttggttcggctggaaacgctattcaagatatttaagcagctggat
cccgagaatactggaacaatagagctcgaccttatctcttggctctgtttctcagtactt
tga
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