KEGG T01001: 8379

Homo sapiens (human): 8379

Entry

8379              CDS       T01001

Symbol

MAD1L1, MAD1, MVA7, PIG9, TP53I9, TXBP181

Name

(RefSeq) mitotic arrest deficient 1 like 1

K06679

mitotic spindle assembly checkpoint protein MAD1

Organism

hsa Homo sapiens (human)

Pathway

hsa04110

Cell cycle

hsa04114

Oocyte meiosis

hsa04914

Progesterone-mediated oocyte maturation

hsa05166

Human T-cell leukemia virus 1 infection

hsa05203

Viral carcinogenesis

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06230  Cell cycle (cancer)
nt06515  Regulation of kinetochore-microtubule interactions

Element

N00222

HTLV-1 Tax to spindle assembly checkpoint signaling

N00493

Spindle assembly checkpoint signaling

N01529

Recruitment and formation of the MCC

N01532

Kinetochore targeting of MAD1-MAD2

Disease

H00024

Prostate cancer

H01288

Mosaic variegated aneuploidy syndrome

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    8379 (MAD1L1)
   04114 Oocyte meiosis
    8379 (MAD1L1)
09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    8379 (MAD1L1)
09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    8379 (MAD1L1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    8379 (MAD1L1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    8379 (MAD1L1)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Core SAC proteins
     8379 (MAD1L1)

SSDB

Motif

Pfam:

MAD TSC22 Anti-RecBCD_p2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

7:complement(1815795..2232945)

AA seq 718 aa
MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS
KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA
EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV
KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA
IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL
VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR
GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS
ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML
KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT
KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE
VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG
DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA

NT seq 2157 nt +upstreamnt +downstreamnt
atggaagacctgggggaaaacaccatggttttatccaccctgagatctttgaacaacttc
atctctcagcgtgtggagggaggctctggactggatatttctacctcggccccaggttct
ctgcagatgcagtaccagcagagcatgcagctggaggaaagagcagagcagatccgttcg
aagtcccacctcatccaggtggagcgggagaaaatgcagatggagctgagtcacaagagg
gctcgagtggagctggagagagcagccagcaccagtgccaggaactacgagcgtgaggtc
gaccgcaaccaggagctcctgacgcgcatccggcagcttcaggagcgggaggccggggcg
gaggagaagatgcaggagcagctggagcgcaacaggcagtgtcagcagaacttggatgct
gccagcaagaggctgcgtgagaaagaggacagtctggcccaggctggcgagaccatcaac
gcactgaaggggaggatctcggaactgcagtggagcgtgatggaccaggagatgcgggtg
aagcgcctggagtcggagaagcaggagctgcaggagcagctggacctgcaacacaaaaaa
tgccaggaagccaatcagaaaatccaggaactccaggccagccaagaagcaagagcagac
cacgagcagcagattaaggatctggagcagaagctgtccctgcaagagcaggatgcagcg
attgtgaagaacatgaagtctgagctggtacggctccctaggctggaacgggagctgaag
cagctgcgggaggagagcgcgcacctgcgggagatgagagagaccaacgggctgctccag
gaagagctggaagggctgcagaggaagctggggcgccaggagaagatgcaggagacgctg
gttggcttggagctggagaacgagaggctgctggccaagctgcaaagctgggagagactg
gaccagaccatgggcctgagcatcaggactccagaagacctttccagattcgtggttgag
ctgcagcagagggagcttgccttgaaggacaagaacagcgccgtcaccagcagcgcccgg
gggctggagaaggccaggcagcagctgcaggaggagctccggcaggtcagcggccagctg
ttggaggagaggaagaagcgcgagacccacgaggcgctggcccggaggctccagaaacgg
gtcctgctgctcaccaaggagcgggacggtatgcgggccatcctggggtcctacgacagc
gagctgaccccggccgagtactcaccccagctgacgcggcgcatgcgggaggctgaggat
atggtgcagaaggtgcacagccacagcgccgagatggaggctcagctgtcgcaggccctg
gaggagctgggaggccagaaacaaagagcagacatgctggagatggagctgaagatgctg
aagtctcagtccagctctgccgaacagagcttcctgttctccagggaggaggcggacacg
ctcaggttgaaggtcgaggagctggaaggcgagcggagtcggctggaggaggaaaagagg
atgctggaggcacagctggagcggcgagctctgcagggtgactatgaccagagcaggacc
aaagtgctgcacatgagcctgaaccccaccagtgtggccaggcagcgcctgcgcgaggac
cacagccagctgcaggcggagtgcgagcgactgcgcgggctcctgcgcgccatggagaga
ggaggcaccgtcccagccgaccttgaggctgccgccgcgagtctgccatcgtccaaggag
gtggcagagctgaagaagcaggtggagagtgccgagctgaagaaccagcggctcaaggag
gttttccagaccaagatccaggagttccgcaaggcctgctacacgctcaccggctaccag
atcgacatcaccacggagaaccagtaccggctgacctcgctgtacgccgagcacccaggc
gactgcctcatcttcaaggccaccagcccctcgggttccaagatgcagctactggagaca
gagttctcacacaccgtgggcgagctcatcgaggtgcacctgcggcgccaggacagcatc
cctgccttcctcagctcgctcaccctcgagctcttcagccgccagaccgtggcgtag

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