KEGG   NETWORK: N00493
Entry
N00493                      Network                                
Name
Spindle assembly checkpoint signaling
Definition
MAD1L1 -> (MAD2L1/2+BUB1B+BUB3) -| (ANAPC+CDC20) -| PTTG -| ESPL1
  Expanded
8379 -> ((4085,10459)+701+9184) -| ((64682,29882,996,29945,51433,8881,51434,10393,51529,246184,25847,8697)+991) -| (9232,10744) -| 9700
Class
nt06230 Cell cycle (cancer)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Reference
Pathway
hsa04110  Cell cycle
Gene
8379  MAD1L1; mitotic arrest deficient 1 like 1
4085  MAD2L1; mitotic arrest deficient 2 like 1
10459  MAD2L2; mitotic arrest deficient 2 like 2
701  BUB1B; BUB1 mitotic checkpoint serine/threonine kinase B
9184  BUB3; BUB3, mitotic checkpoint protein
64682  ANAPC1; anaphase promoting complex subunit 1
29882  ANAPC2; anaphase promoting complex subunit 2
996  CDC27; cell division cycle 27
29945  ANAPC4; anaphase promoting complex subunit 4
51433  ANAPC5; anaphase promoting complex subunit 5
8881  CDC16; cell division cycle 16
51434  ANAPC7; anaphase promoting complex subunit 7
10393  ANAPC10; anaphase promoting complex subunit 10
51529  ANAPC11; anaphase promoting complex subunit 11
246184  CDC26; cell division cycle 26
25847  ANAPC13; anaphase promoting complex subunit 13
8697  CDC23; cell division cycle 23
991  CDC20; cell division cycle 20
9232  PTTG1; pituitary tumor-transforming 1
10744  PTTG2; pituitary tumor-transforming 2
9700  ESPL1; extra spindle pole bodies like 1, separase
Reference
PMID:25977749
  Authors
Ibrahim B
  Title
Spindle assembly checkpoint is sufficient for complete Cdc20 sequestering in mitotic control.
  Journal
Comput Struct Biotechnol J 13:320-8 (2015)
DOI:10.1016/j.csbj.2015.03.006
Reference
PMID:12186941
  Authors
Zhou J, Yao J, Joshi HC
  Title
Attachment and tension in the spindle assembly checkpoint.
  Journal
J Cell Sci 115:3547-55 (2002)
DOI:10.1242/jcs.00029
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