KEGG   Homo sapiens (human): 84464
Entry
84464             CDS       T01001                                 
Symbol
SLX4, BTBD12, FANCP, MUS312
Name
(RefSeq) SLX4 structure-specific endonuclease subunit
  KO
K10484  structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Organism
hsa  Homo sapiens (human)
Pathway
hsa03460  Fanconi anemia pathway
Network
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
  Element
N01448  Double Holliday junction resolution
N01465  Lesion bypass by TLS and DSB formation
Disease
H00238  Fanconi anemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03460 Fanconi anemia pathway
    84464 (SLX4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    84464 (SLX4)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    84464 (SLX4)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit type E3
   Cul3 complex
    Adoptor and target recognizing subunit (BTB)
     84464 (SLX4)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Other HR factors
     84464 (SLX4)
SSDB
Motif
Pfam: Slx4 BTB
Other DBs
NCBI-GeneID: 84464
NCBI-ProteinID: NP_115820
OMIM: 613278
HGNC: 23845
Ensembl: ENSG00000188827
UniProt: Q8IY92
Structure
LinkDB
Position
16:complement(3581181..3611606)
AA seq 1834 aa
MKLSVNEAQLGFYLGSLSHLSACPGIDPRSSEDQPESLKTGQMMDESDEDFKELCASFFQ
RVKKHGIKEVSGERKTQKAASNGTQIRSKLKRTKQTATKTKTLQGPAEKKPPSGSQAPRT
KKQRVTKWQASEPAHSVNGEGGVLASAPDPPVLRETAQNTQTGNQQEPSPNLSREKTREN
VPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAAREEN
VPKDPQEEMMAGNVYGLGPPAPESDAAVALTLQQEFARVGASAHDDSLEEKGLFFCQICQ
KNLSAMNVTRREQHVNRCLDEAEKTLRPSVPQIPECPICGKPFLTLKSRTSHLKQCAVKM
EVGPQLLLQAVRLQTAQPEGSSSPPMFSFSDHSRGLKRRGPTSKKEPRKRRKVDEAPSED
LLVAMALSRSEMEPGAAVPALRLESAFSERIRPEAENKSRKKKPPVSPPLLLVQDSETTG
RQIEDRVALLLSEEVELSSTPPLPASRILKEGWERAGQCPPPPERKQSFLWEGSALTGAW
AMEDFYTARLVPPLVPQRPAQGLMQEPVPPLVPPEHSELSERRSPALHGTPTAGCGSRGP
SPSASQREHQALQDLVDLAREGLSASPWPGSGGLAGSEGTAGLDVVPGGLPLTGFVVPSQ
DKHPDRGGRTLLSLGLLVADFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQY
VNNEGFSAVEDGVLTQRVLLGDVSTEAARTFLHYLYTADTGLPPGLSSELSSLAHRFGVS
ELVHLCEQVPIATDSEGKPWEEKEAENCESRAENFQELLRSMWADEEEEAETLLKSKDHE
EDQENVNEAEMEEIYEFAATQRKLLQEERAAGAGEDADWLEGGSPVSGQLLAGVQVQKQW
DKVEEMEPLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSSCSS
PSRDCQAERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQITSEPEEQSGAVRERGLEVSH
RLAPWQASPPHPCRFLLGPPQGGSPRGSHHTSGSSLSTPRSRGGTSQVGSPTLLSPAVPS
KQKRDRSILTLSKEPGHQKGKERRSVLECRNKGVLMFPEKSPSIDLTQSNPDHSSSRSQK
SSSKLNEEDEVILLLDSDEELELEQTKMKSISSDPLEEKKALEISPRSCELFSIIDVDAD
QEPSQSPPRSEAVLQQEDEGALPENRGSLGRRGAPWLFCDRESSPSEASTTDTSWLVPAT
PLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNREGNEVAQKFSVIRPQTPPPQT
PSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPISGDRAHFSRRFLKHSPPG
PSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPIDH
WNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGN
SRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPI
TPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDSEDESQSSQPL
LQAPHCQTLASQTYKPSRAGVHAQQEATTGPGAHRPKGPAKTKGPRHQRKHHESITPPSR
SPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFESAGEEEGEGEV
SASQAAVQAADTDEALRCYIRSKPALYQKVLLYQPFELRELQAELRQNGLRVSSRRLLDF
LDTHCITFTTAATRREKLQGRRRQPRGKKKVERN
NT seq 5505 nt   +upstreamnt  +downstreamnt
atgaaactgagtgtgaatgaggctcagctaggcttctacttgggttcactttctcatctg
tctgcctgtcctgggattgaccctcgctcctctgaagaccagcctgaaagccttaaaact
ggtcagatgatggatgagtctgatgaggactttaaagaactctgcgctagctttttccaa
agggtgaaaaaacatggaatcaaggaagtgtcaggagaaaggaagacacaaaaggctgcc
tcaaacggcactcagataagaagcaaattgaaaaggaccaaacaaactgctaccaagacc
aaaacccttcaaggccctgcagagaagaaacctccgtctggcagccaggcccctaggact
aaaaagcaaagggtaaccaaatggcaagcaagtgaaccggcccactctgtgaatggggag
gggggtgtgcttgcctctgctccagatccacctgtgctccgggaaacagcacaaaacacc
cagacgggtaaccagcaagaaccatcgccaaacctttccagagagaaaaccagagagaat
gtgcccaacagcgactcccagcctcctccttcctgtttgacaacagcagtgccaagtccc
tccaaaccccgcacagcacaattggtcctacagcgaatgcagcagttcaagagagcagac
cccgagcgtttgagacacgcttcagaagagtgctccctcgaggctgcgcgggaagaaaat
gtcccaaaggatcctcaagaggagatgatggcggggaatgtgtatgggcttgggccccct
gccccagagagcgacgctgcggtggccttgaccctgcagcaggagtttgcacgggtagga
gcatcggcacatgatgatagcctggaggaaaagggtttgttcttctgccagatttgtcaa
aagaacctctcagccatgaacgtgacccgaagggaacagcatgtgaacaggtgcttggat
gaagctgaaaagacactaagaccttctgtgcctcagatccctgagtgcccgatttgtggg
aaaccgtttcttaccttaaagagcagaaccagtcacttgaagcagtgtgctgtgaagatg
gaggttggcccccagctcctgcttcaggctgtgcggctgcagacagcacagcctgagggt
agcagcagcccacccatgttcagcttcagtgatcacagtagaggtctgaaacggagagga
cccaccagcaagaaggagccacggaagaggcggaaggtggacgaggcaccgtccgaggac
ctgctggtggccatggctctgtcccggtcggagatggagccgggtgcggctgtaccagcg
ctcaggctggaaagtgccttttctgagaggataagaccagaagcagagaataaaagtcgc
aagaagaaacccccggtatcccccccattgttgttagtccaggactctgaaaccacaggc
cgacagatagaggaccgtgtggccctgctcctctctgaggaagtggaattgtctagcacg
ccaccacttcctgccagcaggattttaaaggaagggtgggaaagagcgggccagtgtcct
cctccacctgaacgcaagcagagctttctgtgggagggcagcgcactgactggggcctgg
gccatggaggacttctacacggccaggctggtccctcctctcgtgccccagcggcctgcc
cagggccttatgcaggagcccgtgccgcctctggtgccacctgagcactcagagctgagc
gagcgaaggtcacccgctctccacggcacccccactgcaggctgtggctccaggggcccg
tcgccttcggccagccagagggagcaccaggccctgcaggacctcgtggacctggcgagg
gagggactgagcgccagcccgtggcccggcagtgggggcctggctggctcggaagggact
gcagggttggacgtggtgcccggcggccttcctctgactgggtttgtggtgccatcgcag
gacaagcacccggacaggggcggccgcaccttgctctccctcgggctgctggttgctgac
tttggcgccatggtcaataacccacacctgagtgatgtccagtttcagacggacagcggg
gaggtgctttacgcccacaagttcgtgctttatgcccgatgcccgctcctcatccagtat
gtgaacaatgaaggcttctccgctgtagaggacggggttctgacccagcgtgtcctgctg
ggtgacgtgagcaccgaggccgcccgcacgttcctgcactatctctacactgcggacact
ggccttcctcctggccttagctctgagctgagctccctggcccacaggtttggcgtgagt
gagctcgttcacctgtgcgaacaggtgcctattgccactgactcagagggcaaaccatgg
gaggagaaggaagcagagaattgcgaaagcagggccgagaatttccaggaactcttgagg
tcaatgtgggcagatgaagaggaggaagcggagactttgttgaaatccaaggaccacgaa
gaagatcaagaaaacgtgaatgaagcagaaatggaagaaatttatgaatttgcagctact
cagcgaaagcttctccaggaagaaagggcagcgggtgccggcgaggacgctgactggctg
gagggtggcagtccggtttctgggcaactcctagcaggtgtccaggtgcagaaacagtgg
gacaaggtggaggagatggagccgttggagccaggaagagatgaggccgccaccacctgg
gagaagatgggacagtgcgctctcccgccaccccagggccagcactcaggggcacgggga
gcagaggcccctgagcaggaggcgccagaggaggcgcttggccattccagctgctccagc
ccttccagggactgccaggcagagagaaaagaaggctctcttccgcactcagatgatgcc
ggggattacgaacagctcttctcatcaactcagggagagatctcagagccgtcccaaata
acaagtgagcccgaggaacaaagtggcgctgtcagggaaagggggctggaggtttctcat
cgcctggctccctggcaggcatctccaccgcacccgtgccgcttcctattggggcctccc
cagggcgggagtccccgcgggtctcatcacacaagtgggtcgtccctgtcaacaccccgg
tcccgtggcggaacttcccaggtgggctccccaaccttgctgtctccagctgtgccatca
aagcagaaaagggacaggagcatcctcacgctgtctaaagagccagggcaccagaaaggc
aaagagcgtcggtccgtgctggagtgcagaaataagggggtcctgatgttcccagaaaaa
tctccgtctattgacctaacccagtcaaatcctgaccattcgagctccagatctcagaaa
tcttcatccaaactgaacgaagaagatgaggtcatcctcttactggactcggatgaggag
ctggagctagaacaaaccaaaatgaagtccatttctagtgatcctctggaagaaaagaaa
gctctagaaattagccctaggtcctgtgagctgttttccatcattgatgttgatgcagat
caggaaccttcccagagcccaccaagaagcgaagctgtgctgcagcaggaggatgagggg
gcgctgccggagaatcggggctctttgggcaggagaggggctccctggctgttctgtgac
cgtgagagcagccccagcgaggccagcaccacagacacctcgtggctggtgcccgccacc
ccgctggccagcagaagccgtgactgttcttcccagacccaaatcagcagcctcaggagc
gggctggccgtgcaggcggtgactcagcacacgcccagggcctcagtaggaaacagggaa
gggaacgaagtcgcacagaagttttctgtcatcaggccccagacaccaccgccccagaca
ccgtcctcatgcctcactcccgtctctccaggaacttctgacggcagaaggcaaggccac
agaagcccttcccgtccccaccccgggggccacccgcactcctctccgctggctccacat
cccatctcaggggaccgcgcccacttcagcaggcggttcctgaaacactcgccgcctggg
ccaagcttcctgaaccagaccccagcgggtgaagtggtggaagtcggagacagtgacgat
gagcaggaggtggcctcccatcaggccaacagaagccccccactggacagtgacccccca
attccaattgacgactgctgctggcacatggagcccctctcgccaattcccattgaccac
tggaacctggagcggaccggccccctgagcaccagcagccccagccgcaggatgaacgag
gccgccgacagccgtgactgtcgctccccgggactcctggacaccacccccatccgagga
agctgcactacccagaggaaattgcaagagaagtcctcgggcgcgggctccctggggaat
agcaggccgagctttctgaattcggctctgtgggacgtttgggacggggaagagcagagg
cctccagagacccctcctccggcccagatgccaagcgctggtggagctcagaagcccgaa
gggttagagacacccaaaggtgctaatcggaagaagaacttgccccccaaagtgcccata
acgccgatgccacagtattccattatggagacgccggtgctgaagaaggaactggatagg
tttggagtccgccctctgcctaaacgccagatggttctgaagctgaaggagatattccag
tacactcaccagaccctggactcagactccgaggacgagagccagtcctcacagccgctg
ttgcaggcgcctcactgccagaccctcgcctcccagacctacaagccttcaagggcaggg
gtccatgcccagcaggaggccaccacaggacctggggcccataggcccaagggacctgct
aagaccaagggcccccgacatcaaaggaagcatcatgaaagcatcacacccccaagcagg
tcgcccaccaaggaggcacctccaggcctcaatgatgacgcccagatcccagcctctcaa
gaatccgtggccacctctgtggatggcagtgacagctccttgagctcacagagttcttcc
tcctgtgagtttggagcggcatttgagtctgcaggtgaagaggagggcgagggggaggtc
agtgcctcgcaggcagccgtgcaggcggcggacacagacgaggcgctgaggtgctacatc
cgctccaagccggccctgtaccagaaggtgctgctgtaccagccctttgagctgcgggag
ctgcaggcagagctgaggcagaacggcctccgtgtgtcctcgcgcaggctgttggacttc
ctggacacccactgtatcaccttcaccactgccgccacccgcagggagaagctccagggc
aggaggcggcagcctcggggcaagaagaaggtggagcggaactga

KEGG   Homo sapiens (human): 548593
Entry
548593            CDS       T01001                                 
Symbol
SLX1A, GIYD1
Name
(RefSeq) structure-specific endonuclease subunit SLX1A
  KO
K15078  structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03460  Fanconi anemia pathway
Network
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
  Element
N01448  Double Holliday junction resolution
N01465  Lesion bypass by TLS and DSB formation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03460 Fanconi anemia pathway
    548593 (SLX1A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    548593 (SLX1A)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Other HR factors
     548593 (SLX1A)
SSDB
Motif
Pfam: SLX1_C GIY-YIG
Other DBs
NCBI-GeneID: 548593
NCBI-ProteinID: NP_001014999
OMIM: 615822
HGNC: 20922
Ensembl: ENSG00000132207
UniProt: Q9BQ83
LinkDB
Position
16:30193843..30197566
AA seq 275 aa
MGPAGVAARPGRFFGVYLLYCLNPRYRGRVYVGFTVNTARRVQQHNGGRKKGGAWRTSGR
GPWEMVLVVHGFPSSVAALRFEWAWQHPHASRRLAHVGPRLRGETAFAFHLRVLAHMLRA
PPWARLPLTLRWVRPDLRQDLCLPPPPHVPLAFGPPPPQAPAPRRRAGPFDDAEPEPDQG
DPGACCSLCAQTIQDEEGPLCCPHPGCLLRAHVICLAEEFLQEEPGQLLPLEGQCPCCEK
SLLWGDLIWLCQMDTEKEVEDSELEEAHWTDLLET
NT seq 828 nt   +upstreamnt  +downstreamnt
atgggtcccgcgggggtcgcggcgaggccagggcgctttttcggcgtctacctgctctac
tgcctgaacccccggtaccggggccgcgtctacgtggggttcactgtcaacactgctcgt
cgggtccagcagcacaatgggggccgcaaaaaaggcggggcctggcggaccagcgggcga
gggccctgggagatggtgctcgtcgtgcacggcttcccgtcctccgtggccgcccttcgg
tttgagtgggcttggcagcacccgcacgcctcgcgccgcctggcgcacgtggggcctcgc
ctgcgaggagagacagccttcgctttccacctgcgcgtgctggcgcacatgctgcgcgca
ccgccctgggctcgcctcccgctcacgctgcgctgggtgcgcccagacctccgccaggac
ctctgcctcccgccgccgccgcacgtgcctctggccttcgggcctccaccgccccaggcc
ccggccccaaggcgccgcgcaggtccctttgatgacgcggagcctgagccagaccagggg
gatccaggggcctgctgctccctgtgcgcccagaccatccaggatgaagaggggcccttg
tgttgcccccaccctggctgcctgctaagggcccatgtgatctgcctggcagaggagttt
cttcaggaagaaccagggcagcttctgcccctagagggccaatgcccttgctgtgagaag
tcactgctttggggagacctgatctggctgtgccagatggacactgagaaagaagtagaa
gactcagaattagaagaggcacactggacagacctgctggagacctga

KEGG   Homo sapiens (human): 79008
Entry
79008             CDS       T01001                                 
Symbol
SLX1B, GIYD2
Name
(RefSeq) structure-specific endonuclease subunit SLX1B
  KO
K15078  structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03460  Fanconi anemia pathway
Network
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
  Element
N01448  Double Holliday junction resolution
N01465  Lesion bypass by TLS and DSB formation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03460 Fanconi anemia pathway
    79008 (SLX1B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    79008 (SLX1B)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Other HR factors
     79008 (SLX1B)
SSDB
Motif
Pfam: SLX1_C GIY-YIG
Other DBs
NCBI-GeneID: 79008
NCBI-ProteinID: NP_076949
OMIM: 615823
HGNC: 28748
Ensembl: ENSG00000181625
UniProt: Q9BQ83
LinkDB
Position
16:29454533..29458220
AA seq 275 aa
MGPAGVAARPGRFFGVYLLYCLNPRYRGRVYVGFTVNTARRVQQHNGGRKKGGAWRTSGR
GPWEMVLVVHGFPSSVAALRFEWAWQHPHASRRLAHVGPRLRGETAFAFHLRVLAHMLRA
PPWARLPLTLRWVRPDLRQDLCLPPPPHVPLAFGPPPPQAPAPRRRAGPFDDAEPEPDQG
DPGACCSLCAQTIQDEEGPLCCPHPGCLLRAHVICLAEEFLQEEPGQLLPLEGQCPCCEK
SLLWGDLIWLCQMDTEKEVEDSELEEAHWTDLLET
NT seq 828 nt   +upstreamnt  +downstreamnt
atgggtcccgcgggggtcgcggcgaggccagggcgctttttcggcgtctacctgctctac
tgcctgaacccccggtaccggggccgcgtctacgtggggttcactgtcaacactgctcgt
cgggtccagcagcacaatgggggccgcaaaaaaggcggggcctggcggaccagcgggcga
gggccctgggagatggtgctcgtcgtgcacggcttcccgtcctccgtggccgcccttcgg
tttgagtgggcttggcagcacccgcacgcctcgcgccgcctggcgcacgtggggcctcgc
ctgcgaggagagacagccttcgctttccacctgcgcgtgctggcgcacatgctgcgcgca
ccgccctgggctcgcctcccgctcacgctgcgctgggtgcgcccagacctccgccaggac
ctctgcctcccgccgccgccgcacgtgcctctggccttcgggcctccaccgccccaggcc
ccggccccaaggcgccgcgcaggtccctttgatgacgcggagcctgagccagaccagggg
gatccaggggcctgctgctccctgtgcgcccagaccatccaggatgaagaggggcccttg
tgttgcccccaccctggctgcctgctaagggcccatgtgatctgcctggcagaggagttt
cttcaggaagaaccagggcagcttctgcccctagagggccaatgcccttgctgtgagaag
tcactgctttggggagacctgatctggctgtgccagatggacactgagaaagaagtagaa
gactcagaattagaagaggcacactggacagacctgctggagacctga

KEGG   Homo sapiens (human): 80198
Entry
80198             CDS       T01001                                 
Symbol
MUS81, SLX3
Name
(RefSeq) MUS81 structure-specific endonuclease subunit
  KO
K08991  crossover junction endonuclease MUS81 [EC:3.1.22.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03440  Homologous recombination
hsa03460  Fanconi anemia pathway
Network
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
  Element
N01448  Double Holliday junction resolution
N01465  Lesion bypass by TLS and DSB formation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    80198 (MUS81)
   03460 Fanconi anemia pathway
    80198 (MUS81)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    80198 (MUS81)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Other HR factors
     80198 (MUS81)
SSDB
Motif
Pfam: MUS81-like_WH ERCC4 EME1-MUS81_C HHH_8 MutL
Other DBs
NCBI-GeneID: 80198
NCBI-ProteinID: NP_079404
OMIM: 606591
HGNC: 29814
Ensembl: ENSG00000172732
UniProt: Q96NY9 Q53ES5
Structure
LinkDB
Position
11:65859674..65867653
AA seq 551 aa
MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSG
KEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPA
QPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSAR
PWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETA
VPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTV
RKLHVGDFVWVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCG
LERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQ
RLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLM
QVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTL
SQLYCSYGPLT
NT seq 1656 nt   +upstreamnt  +downstreamnt
atggcggccccggtccgcctgggccggaagcgcccgctgcctgcctgtcccaacccgctc
ttcgttcgctggctgaccgagtggcgggacgaggcgacccgcagcaggcgccgcacgcgc
ttcgtatttcagaaggcgctgcgttccctccgacggtacccactgccgctgcgcagcggg
aaggaagctaagatcctacagcacttcggagacgggctctgccggatgctggacgagcgg
ctgcagcggcaccgaacatcgggcggtgaccatgccccggactcaccatctggagagaac
agtccagccccgcaggggcgacttgcggaagtccaggactcttccatgccagttcctgcc
cagcccaaagcgggaggctctggcagctactggccagctcggcactcaggagcccgagtg
atactgctggtgctctaccgggagcacctgaatcctaatggtcaccacttcttaaccaag
gaggagctgctgcagaggtgtgctcagaagtcccccagggtagcccctgggagtgctcga
ccctggccagccctccgctccctccttcacaggaacctggtcctcaggacacaccagcca
gccaggtactcattgaccccagagggcctggagctggcccagaagttggccgagtcagaa
ggcctgagcttgctgaatgtgggcatcgggcccaaggagccccctggggaggagacagca
gtgccaggagcagcttcagcagagcttgccagtgaagcaggggtccagcagcagccactg
gagctgaggcctggagagtacagggtgctgttgtgtgtggacattggcgagacccggggg
ggcgggcacaggccggagctgctccgagagctacagcggctgcacgtgacccacacggtg
cgcaagctgcacgttggagattttgtgtgggtggcccaggagaccaatcctagagaccca
gcaaaccctggggagttggtactggatcacattgtggagcgcaagcgactggatgacctt
tgcagcagcatcatcgacggccgcttccgggagcagaagttccggctgaagcgctgtggt
ctggagcgccgggtatacctggtggaagagcatggttccgtccacaacctcagccttcct
gagagcacactgctgcaggctgtcaccaacactcaggtcattgatggcttttttgtgaag
cgcacagcagacattaaggagtcagccgcctacctggccctcttgacgcggggcctgcag
agactctaccagggccacaccctacgcagccgcccctggggaacccctgggaaccctgaa
tcaggggccatgacctctccaaaccctctctgctcactcctcaccttcagtgacttcaac
gcaggagccatcaagaataaggcccagtcggtgcgagaagtgtttgcccggcagctgatg
caggtgcgcggagtgagtggggagaaggcagcagccctggtggatcgatacagcacccct
gccagcctcctggccgcctatgatgcctgtgccacccccaaggaacaagagacactgctg
agcaccattaagtgtgggcgtctacagaggaatctggggcctgctctgagcaggacctta
tcccagctctactgcagctacggccccttgacctga

KEGG   Homo sapiens (human): 146956
Entry
146956            CDS       T01001                                 
Symbol
EME1, MMS4L, SLX2A
Name
(RefSeq) essential meiotic structure-specific endonuclease 1
  KO
K10882  crossover junction endonuclease EME1 [EC:3.1.22.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03440  Homologous recombination
hsa03460  Fanconi anemia pathway
Network
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
  Element
N01448  Double Holliday junction resolution
N01465  Lesion bypass by TLS and DSB formation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    146956 (EME1)
   03460 Fanconi anemia pathway
    146956 (EME1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    146956 (EME1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Other HR factors
     146956 (EME1)
SSDB
Motif
Pfam: EME1-MUS81_C ERCC4
Other DBs
NCBI-GeneID: 146956
NCBI-ProteinID: NP_689676
OMIM: 610885
HGNC: 24965
Ensembl: ENSG00000154920
UniProt: Q96AY2
Structure
LinkDB
Position
17:50373229..50381483
AA seq 570 aa
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAP
ELFSPPVPEIAETVTQTQPVRLLSSESEDEEEFIPLAQRLTCKFLTHKQLSPEDSSSPVK
SVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRM
KAQRPEECLKHIIVVLDPVLLQMEGGGQLLGALQTMECRCVIEAQAVPCSVTWRRRAGPS
EDREDWVEEPTVLVLLRAEAFVSMIDNGKQGSLDSTMKGKETLQGFVTDITAKTAGKALS
LVIVDQEKCFSAQNPPRRGKQGANKQTKKQQQRQPEASIGSMVSRVDAEEALVDLQLHTE
AQAQIVQSWKELADFTCAFTKAVAEAPFKKLRDETTFSFCLESDWAGGVKVDLAGRGLAL
VWRRQIQQLNRVSLEMASAVVNAYPSPQLLVQAYQQCFSDKERQNLLADIQVRRGEGVTS
TSRRIGPELSRRIYLQMTTLQPHLSLDSAD
NT seq 1713 nt   +upstreamnt  +downstreamnt
atggctctaaagaagtcatcaccctcactggattctggtgatagtgactctgaggagttg
ccaacatttgcctttctgaagaaggaaccatcttcaacaaagaggagacagcctgaaagg
gaagagaagattgtagtggttgacatctcagattgtgaagcctcctgtcctccagcacca
gagttattttcaccacctgtcccagaaatagctgaaactgtcacacaaacacagccagtc
aggttgctaagcagtgaaagtgaagatgaagaagaatttattcctctggctcaaaggctt
acatgtaagtttctgacccacaagcaactgagccctgaggactctagctccccagttaaa
agtgttttggatcatcaaaataatgaaggtgcatcatgtgactggaaaaagccctttcca
aagatccctgaagttcccctccatgataccccagagaggagtgcagcagataacaaggac
ctgatcttagatccatgctgtcagcttccagcctacctgtctacctgccctggccagagc
agcagcttggcagtaaccaaaacaaattctgacatccttccaccccagaagaaaaccaag
ccgagtcagaaggtccagggaagaggctcacacggatgccggcagcagagacaagcaagg
cagaaggaaagcaccctgagaagacaggaaagaaagaatgcagcactggttaccaggatg
aaagcccagaggccagaggaatgcttaaaacacatcattgtagtgctggatccagtgctc
ttacagatggaaggtgggggccagctcctaggagcactgcagaccatggagtgccgctgt
gtgattgaggcgcaggctgtgccttgcagtgtcacttggaggagaagggctgggccgtct
gaggacagagaggactgggtggaggagccaacagtactggtgttgctccgggcagaggca
tttgtgtccatgatcgacaatggaaagcagggaagcctggacagcactatgaaagggaag
gaaacgcttcagggctttgtaactgacatcacagcaaagacagcagggaaagctctgtca
ctggtgattgtggatcaggagaaatgcttcagtgctcagaatcctccaagaagagggaaa
cagggagcaaataaacagaccaagaagcagcagcagagacaaccagaggccagcataggg
tccatggtatccagggtagacgctgaagaggcattggtggatctgcagctacacacagaa
gcccaggctcaaattgtgcagagctggaaagagctggccgacttcacatgcgcattcaca
aaggctgtggctgaggcgcccttcaagaagctccgagatgaaactaccttctccttctgt
ctggagagtgactgggctggaggggtgaaggtggaccttgctggcaggggactcgcacta
gtctggaggagacagattcagcagctgaaccgagtcagcctggaaatggccagtgcagtt
gtgaatgcctatccctccccacagctcctggtacaggcttatcagcagtgtttttcggat
aaagaacgccagaatttgctcgcagacatacaggtgcgccgtggggaaggtgtgacatcc
acttctcgccgcattggaccagaactatccaggcgtatctaccttcagatgaccacttta
cagccacatctctctttagatagtgctgactga

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