Homo sapiens (human): 9700
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Entry
9700 CDS
T01001
Symbol
ESPL1, ESP1, SEPA
Name
(RefSeq) separin
KO
K02365
separase [EC:
3.4.22.49
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04110
Cell cycle
hsa04114
Oocyte meiosis
hsa05166
Human T-cell leukemia virus 1 infection
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06230
Cell cycle (cancer)
nt06512
Chromosome cohesion and segregation
Element
N00221
HTLV-1 Tax to spindle assembly checkpoint signaling
N00493
Spindle assembly checkpoint signaling
N01486
Cohesin dissociation in anaphase
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09143 Cell growth and death
04110 Cell cycle
9700 (ESPL1)
04114 Oocyte meiosis
9700 (ESPL1)
09160 Human Diseases
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
9700 (ESPL1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
9700 (ESPL1)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
9700 (ESPL1)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.22 Cysteine endopeptidases
3.4.22.49 separase
9700 (ESPL1)
Peptidases and inhibitors [BR:
hsa01002
]
Cysteine peptidases
Family C50: separase family
9700 (ESPL1)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Sister chromatid separation proteins
Separase
9700 (ESPL1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Separin_C
Motif
Other DBs
NCBI-GeneID:
9700
NCBI-ProteinID:
NP_036423
OMIM:
604143
HGNC:
16856
Ensembl:
ENSP00000257934.4
UniProt:
Q14674
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:53268299..53293638
Genome browser
AA seq
2120 aa
AA seq
DB search
MRSFKRVNFGTLLSSQKEAEELLPALKEFLSNPPAGFPSSRSDAERRQACDAILRACNQQ
LTAKLACPRHLGSLLELAELACDGYLVSTPQRPPLYLERILFVLLRNAAAQGSPEATLRL
AQPLHACLVQCSREAAPQDYEAVARGSFSLLWKGAEALLERRAAFAARLKALSFLVLLED
ESTPCEVPHFASPTACRAVAAHQLFDASGHGLNEADADFLDDLLSRHVIRALVGERGSSS
GLLSPQRALCLLELTLEHCRRFCWSRHHDKAISAVEKAHSYLRNTNLAPSLQLCQLGVKL
LQVGEEGPQAVAKLLIKASAVLSKSMEAPSPPLRALYESCQFFLSGLERGTKRRYRLDAI
LSLFAFLGGYCSLLQQLRDDGVYGGSSKQQQSFLQMYFQGLHLYTVVVYDFAQGCQIVDL
ADLTQLVDSCKSTVVWMLEALEGLSGQELTDHMGMTASYTSNLAYSFYSHKLYAEACAIS
EPLCQHLGLVKPGTYPEVPPEKLHRCFRLQVESLKKLGKQAQGCKMVILWLAALQPCSPE
HMAEPVTFWVRVKMDAARAGDKELQLKTLRDSLSGWDPETLALLLREELQAYKAVRADTG
QERFNIICDLLELSPEETPAGAWARATHLVELAQVLCYHDFTQQTNCSALDAIREALQLL
DSVRPEAQARDQLLDDKAQALLWLYICTLEAKMQEGIERDRRAQAPGNLEEFEVNDLNYE
DKLQEDRFLYSNIAFNLAADAAQSKCLDQALALWKELLTKGQAPAVRCLQQTAASLQILA
ALYQLVAKPMQALEVLLLLRIVSERLKDHSKAAGSSCHITQLLLTLGCPSYAQLHLEEAA
SSLKHLDQTTDTYLLLSLTCDLLRSQLYWTHQKVTKGVSLLLSVLRDPALQKSSKAWYLL
RVQVLQLVAAYLSLPSNNLSHSLWEQLCAQGWQTPEIALIDSHKLLRSIILLLMGSDILS
TQKAAVETSFLDYGENLVQKWQVLSEVLSCSEKLVCHLGRLGSVSEAKAFCLEALKLTTK
LQIPRQCALFLVLKGELELARNDIDLCQSDLQQVLFLLESCTEFGGVTQHLDSVKKVHLQ
KGKQQAQVPCPPQLPEEELFLRGPALELVATVAKEPGPIAPSTNSSPVLKTKPQPIPNFL
SHSPTCDCSLCASPVLTAVCLRWVLVTAGVRLAMGHQAQGLDLLQVVLKGCPEAAERLTQ
ALQASLNHKTPPSLVPSLLDEILAQAYTLLALEGLNQPSNESLQKVLQSGLKFVAARIPH
LEPWRASLLLIWALTKLGGLSCCTTQLFASSWGWQPPLIKSVPGSEPSKTQGQKRSGRGR
QKLASAPLRLNNTSQKGLEGRGLPCTPKPPDRIRQAGPHVPFTVFEEVCPTESKPEVPQA
PRVQQRVQTRLKVNFSDDSDLEDPVSAEAWLAEEPKRRGTASRGRGRARKGLSLKTDAVV
APGSAPGNPGLNGRSRRAKKVASRHCEERRPQRASDQARPGPEIMRTIPEEELTDNWRKM
SFEILRGSDGEDSASGGKTPAPGPEAASGEWELLRLDSSKKKLPSPCPDKESDKDLGPRL
RLPSAPVATGLSTLDSICDSLSVAFRGISHCPPSGLYAHLCRFLALCLGHRDPYATAFLV
TESVSITCRHQLLTHLHRQLSKAQKHRGSLEIADQLQGLSLQEMPGDVPLARIQRLFSFR
ALESGHFPQPEKESFQERLALIPSGVTVCVLALATLQPGTVGNTLLLTRLEKDSPPVSVQ
IPTGQNKLHLRSVLNEFDAIQKAQKENSSCTDKREWWTGRLALDHRMEVLIASLEKSVLG
CWKGLLLPSSEEPGPAQEASRLQELLQDCGWKYPDRTLLKIMLSGAGALTPQDIQALAYG
LCPTQPERAQELLNEAVGRLQGLTVPSNSHLVLVLDKDLQKLPWESMPSLQALPVTRLPS
FRFLLSYSIIKEYGASPVLSQGVDPRSTFYVLNPHNNLSSTEEQFRANFSSEAGWRGVVG
EVPRPEQVQEALTKHDLYIYAGHGAGARFLDGQAVLRLSCRAVALLFGCSSAALAVRGNL
EGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLGAGPGAPLLYYVNQARQAP
RLKYLIGAAPIAYGLPVSLR
NT seq
6363 nt
NT seq
+upstream
nt +downstream
nt
atgaggagcttcaaaagagtcaactttgggactctgctaagcagccagaaggaggctgaa
gagttgctgcccgccttgaaggagttcctgtccaaccctccagctggttttcccagcagc
cgatctgatgctgagaggagacaagcttgtgatgccatcctgagggcttgcaaccagcag
ctgactgctaagctagcttgccctaggcatctggggagcctgctggagctggcagagctg
gcctgtgatggctacttagtgtctaccccacagcgtcctcccctctacctggaacgaatt
ctctttgtcttactgcggaatgctgctgcacaaggaagcccagaggccacactccgcctt
gctcagcccctccatgcctgcttggtgcagtgctctcgcgaggctgctccccaggactat
gaggccgtggctcggggcagcttttctctgctttggaagggggcagaagccctgttggaa
cggcgagctgcatttgcagctcggctgaaggccttgagcttcctagtactcttggaggat
gaaagtaccccttgtgaggttcctcactttgcttctccaacagcctgtcgagcggtagct
gcccatcagctatttgatgccagtggccatggtctaaatgaagcagatgctgatttccta
gatgacctgctctccaggcacgtgatcagagccttggtgggtgagagagggagctcttct
gggcttctttctccccagagggccctctgcctcttggagctcaccttggaacactgccgt
cgcttttgctggagccgccaccatgacaaagccatcagcgcagtggagaaggctcacagt
tacctaaggaacaccaatctagcccctagccttcagctatgtcagctgggggttaagctg
ctgcaggttggggaggaaggacctcaggcagtggccaagcttctgatcaaggcatcagct
gtcctgagcaagagtatggaggcaccatcacccccacttcgggcattgtatgagagctgc
cagttcttcctttcaggcctggaacgaggcaccaagaggcgctatagacttgatgccatt
ctgagcctctttgcttttcttggagggtactgctctcttctgcagcagctgcgggatgat
ggtgtgtatgggggctcctccaagcaacagcagtcttttcttcagatgtactttcaggga
cttcacctctacactgtggtggtttatgactttgcccaaggctgtcagatagttgatttg
gctgacctgacccaactagtggacagttgtaaatctaccgttgtctggatgctggaggcc
ttagagggcctgtcgggccaagagctgacggaccacatggggatgaccgcttcttacacc
agtaatttggcctacagcttctatagtcacaagctctatgccgaggcctgtgccatctct
gagccgctctgtcagcacctgggtttggtgaagccaggcacttatcccgaggtgcctcct
gagaagttgcacaggtgcttccggctacaagtagagagtttgaagaaactgggtaaacag
gcccagggctgcaagatggtgattttgtggctggcagccctgcaaccctgtagccctgaa
cacatggctgagccagtcactttctgggttcgggtcaagatggatgcggccagggctgga
gacaaggagctacagctaaagactctgcgagacagcctcagtggctgggacccggagacc
ctggccctcctgctgagggaggagctgcaggcctacaaggcggtgcgggccgacactgga
caggaacgcttcaacatcatctgtgacctcctggagctgagccccgaggagacaccagcc
ggggcctgggcacgagccacccacctggtagaactggctcaggtgctctgctaccacgac
tttacgcagcagaccaactgctctgctctggatgctatccgggaagccctgcagcttctg
gactctgtgaggcctgaggcccaggccagagatcagcttctggacgataaagcacaggcc
ttgctgtggctttacatctgtactctggaagccaaaatgcaggaaggtatcgagcgggat
cggagagcccaggcccctggtaacttggaggaatttgaagtcaatgacctgaactatgaa
gataaactccaggaagatcgtttcctatacagtaacattgccttcaacctggctgcagat
gctgctcagtccaaatgcctggaccaagccctggccctgtggaaggagctgcttacaaag
gggcaggccccagctgtacggtgtctccagcagacagcagcctcactgcagatcctagca
gccctctaccagctggtggcaaagcccatgcaggctctggaggtcctcctgctgctacgg
attgtctctgagagactgaaggaccactcgaaggcagctggctcctcctgccacatcacc
cagctcctcctgaccctcggctgtcccagctatgcccagttacacctggaagaggcagca
tcgagcctgaagcatctcgatcagactactgacacatacctgctcctttccctgacctgt
gatctgcttcgaagtcaactctactggactcaccagaaggtgaccaagggtgtctctctg
ctgctgtctgtgcttcgggatcctgccctccagaagtcctccaaggcttggtacttgctg
cgtgtccaggtcctgcagctggtggcagcttaccttagcctcccgtcaaacaacctctca
cactccctgtgggagcagctctgtgcccaaggctggcagacacctgagatagctctcata
gactcccataagctcctccgaagcatcatcctcctgctgatgggcagtgacattctctca
actcagaaagcagctgtggagacatcgtttttggactatggtgaaaatctggtacaaaaa
tggcaggttctttcagaggtgctgagctgctcagagaagctggtctgccacctgggccgc
ctgggtagtgtgagtgaagccaaggccttttgcttggaggccctaaaacttacaacaaag
ctgcagataccacgccagtgtgccctgttcctggtgctgaagggcgagctggagctggcc
cgcaatgacattgatctctgtcagtcggacctgcagcaggttctgttcttgcttgagtct
tgcacagagtttggtggggtgactcagcacctggactctgtgaagaaggtccacctgcag
aaggggaagcagcaggcccaggtcccctgtcctccacagctcccagaggaggagctcttc
ctaagaggccctgctctagagctggtggccactgtggccaaggagcctggccccatagca
ccttctacaaactcctccccagtcttgaaaaccaagccccagcccatacccaacttcctg
tcccattcacccacctgtgactgctcgctctgcgccagccctgtcctcacagcagtctgt
ctgcgctgggtattggtcacggcaggggtgaggctggccatgggccaccaagcccagggt
ctggatctgctgcaggtcgtgctgaagggctgtcctgaagccgctgagcgcctcacccaa
gctctccaagcttccctgaatcataaaacacccccctccttggttccaagcctcttggat
gagatcttggctcaagcatacacactgttggcactggagggcctgaaccagccatcaaac
gagagcctgcagaaggttctacagtcagggctgaagtttgtagcagcacggataccccac
ctagagccctggcgagccagcctgctcttgatttgggccctcacaaaactaggtggcctc
agctgctgtactacccaactttttgcaagctcctggggctggcagccaccattaataaaa
agtgtccctggctcagagccctctaagactcagggccaaaaacgttctggacgagggcgc
caaaagttagcctctgctcccctgcgcctcaataatacctctcagaaaggtctggaaggt
agaggactgccctgcacacctaaacccccagaccggatcaggcaagctggccctcatgtc
cccttcacggtgtttgaggaagtctgccctacagagagcaagcctgaagtaccccaggcc
cccagggtacaacagagagtccagacgcgcctcaaggtgaacttcagtgatgacagtgac
ttggaagaccctgtctcagctgaggcctggctggcagaggagcctaagagacggggcact
gcttcccggggccgggggcgagcaaggaagggcctgagcctaaagacggatgccgtggtt
gccccaggtagtgcccctgggaaccctggcctgaatggcaggagccggagggccaagaag
gtggcatcaagacattgtgaggagcggcgtccccagagggccagtgaccaggccaggcct
ggccctgagatcatgaggaccatccctgaggaagaactgactgacaactggagaaaaatg
agctttgagatcctcaggggctctgacggggaagactcagcctcaggtgggaagactcca
gctccgggccctgaggcagcttctggagaatgggagctgctgaggctggattccagcaag
aagaagctgcccagcccatgcccagacaaggagagtgacaaggaccttggtcctcggctc
cggctcccctcagcccccgtagccactggtctttctaccctggactccatctgtgactcc
ctgagtgttgctttccggggcattagtcactgtcctcctagtgggctctatgcccacctc
tgccgcttcctggccttgtgcctgggccaccgggatccttatgccactgctttccttgtc
accgagtctgtctccatcacctgtcgccaccagctgctcacccacctccacagacagctc
agcaaggcccagaagcaccgaggatcacttgaaatagcagaccagctgcaggggctgagc
cttcaggagatgcctggagatgtccccctggcccgcatccagcgcctcttttccttcagg
gctttggaatctggccacttcccccagcctgaaaaggagagtttccaggagcgcctggct
ctgatccccagtggggtgactgtgtgtgtgttggccctggccaccctccagcccggaacc
gtgggcaacaccctcctgctgacccggctggaaaaggacagtcccccagtcagtgtgcag
attcccactggccagaacaagcttcatctgcgttcagtcctgaatgagtttgatgccatc
cagaaggcacagaaagagaacagcagctgtactgacaagcgagaatggtggacagggcgg
ctggcactggaccacaggatggaggttctcatcgcttccctagagaagtctgtgctgggc
tgctggaaggggctgctgctgccgtccagtgaggagcccggccctgcccaggaggcctcc
cgcctacaggagctgctacaggactgtggctggaaatatcctgaccgcactctgctgaaa
atcatgctcagtggtgccggtgccctcacccctcaggacattcaggccctggcctacggg
ctgtgcccaacccagccagagcgagcccaggagctcctgaatgaggcagtaggacgtcta
cagggcctgacagtaccaagcaatagccaccttgtcttggtcctagacaaggacttgcag
aagctgccgtgggaaagcatgcccagcctccaagcactgcctgtcacccggctgccctcc
ttccgcttcctactcagctactccatcatcaaagagtatggggcctcgccagtgctgagt
caaggggtggatccacgaagtaccttctatgtcctgaaccctcacaataacctgtcaagc
acagaggagcaatttcgagccaatttcagcagtgaagctggctggagaggagtggttggg
gaggtgccaagacctgaacaggtgcaggaagccctgacaaagcatgatttgtatatctat
gcagggcatggggctggtgcccgcttccttgatgggcaggctgtcctgcggctgagctgt
cgggcagtggccctgctgtttggctgtagcagtgcggccctggctgtgcgtggaaacctg
gagggggctggcatcgtgctcaagtacatcatggctggttgccccttgtttctgggtaat
ctctgggatgtgactgaccgcgacattgaccgctacacggaagctctgctgcaaggctgg
cttggagcaggcccaggggccccccttctctactatgtaaaccaggcccgccaagctccc
cgactcaagtatcttattggggctgcacctatagcctatggcttgcctgtctctctgcgg
taa
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