Homo sapiens (human): 388698 Help Entry 388698            CDS       T01001                                  Symbol FLG2, IFPS, PSS6 Name (RefSeq) filaggrin-2   KO K10384   filaggrin Organism hsa  Homo sapiens (human) Pathway hsa04382   Cornified envelope formation Network nt06545  Cornified envelope formation   Element N01930   Processing of profilaggrin to filaggrin and binding to keratin filaments N01931   Processing of filaggrin to amino acids Disease H00737   Peeling skin syndrome Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09158 Development and regeneration    04382 Cornified envelope formation     388698 (FLG2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hsa04812]     388698 (FLG2) Cytoskeleton proteins [BR:hsa04812]  Eukaryotic cytoskeleton proteins   Intermediate filaments    Intermediate filament-binding proteins     388698 (FLG2) SSDB OrthologParalogGFIT Motif Pfam:  S_100 EF-hand_7 EF-hand_1 EF-hand_FSTL1 Motif Other DBs NCBI-GeneID:  388698 NCBI-ProteinID:  NP_001014364 OMIM:  616284 HGNC:  33276 Ensembl:  ENSP00000373370.4 UniProt:  Q5D862 LinkDB All DBs Position 1:complement(152348735..152360006) Genome browser AA seq 2391 aa AA seqDB search MTDLLRSVVTVIDVFYKYTKQDGECGTLSKGELKELLEKELHPVLKNPDDPDTVDVIMHM LDRDHDRRLDFTEFLLMIFKLTMACNKVLSKEYCKASGSKKHRRGHRHQEEESETEEDEE DTPGHKSGYRHSSWSEGEEHGYSSGHSRGTVKCRHGSNSRRLGRQGNLSSSGNQEGSQKR YHRSSCGHSWSGGKDRHGSSSVELRERINKSHISPSRESGEEYESGSGSNSWERKGHGGL SCGLETSGHESNSTQSRIREQKLGSSCSGSGDSGRRSHACGYSNSSGCGRPQNASSSCQS HRFGGQGNQFSYIQSGCQSGIKGGQGHGCVSGGQPSGCGQPESNPCSQSYSQRGYGAREN GQPQNCGGQWRTGSSQSSCCGQYGSGGSQSCSNGQHEYGSCGRFSNSSSSNEFSKCDQYG SGSSQSTSFEQHGTGLSQSSGFEQHVCGSGQTCGQHESTSSQSLGYDQHGSSSGKTSGFG QHGSGSGQSSGFGQCGSGSGQSSGFGQHGSVSGQSSGFGQHGSVSGQSSGFGQHESRSRQ SSYGQHGSGSSQSSGYGQYGSRETSGFGQHGLGSGQSTGFGQYGSGSGQSSGFGQHGSGS GQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGS GSGQSSGFGQHVSGSGQSSGFGQHESRSGHSSYGQHGFGSSQSSGYGQHGSSSGQTSGFG QHELSSGQSSSFGQHGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQS SGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSAGFGQHGSGSGQSSGFGQHESRS HQSSYGQHGSGSSQSSGYGQHGSSSGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFGQH GTGSGQYSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQSSG FGQHGSGSGQSSGFGQHESGSGKSSGFGQHESRSSQSNYGQHGSGSSQSSGYGQHGSSSG QTTGFGQHRSSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQSSGFGQYESRSRQSSYGQHG SGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGSGSGQSSGFGQHGSGTGKSSG FAQHEYRSGQSSYGQHGTGSSQSSGCGQHESGSGPTTSFGQHVSGSDNFSSSGQHISDSG QSTGFGQYGSGSGQSTGLGQGESQQVESGSTVHGRQETTHGQTINTTRHSQSGQGQSTQT GSRVTRRRRSSQSENSDSEVHSKVSHRHSEHIHTQAGSHYPKSGSTVRRRQGTTHGQRGD TTRHGHSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHRPHSQEQTHSQAGSQHGES ESTVHERHETTYGQTGEATGHGHSGHGQSTQRGSRTTGRRGSGHSESSDSEVHSGGSHRP QSQEQTHGQAGSQHGESGSTVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSG HSESSDSEVHSGGSHTHSGHTHGQSGSQHGESESIIHDRHRITHGQTGDTTRHSYSGHEQ TTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPEFTVHERHGTT HGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSEVHSGVSHTHTGHTHGQAGSQ HGQSESIVPERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSGHSEYSDSEGYSGV SHTHSGHTHGQARSQHGESESIVHERHGTIHGQTGDTTRHAHSGHGQSTQTGSRTTGRRS SGHSEYSDSEGHSGFSQRPHSRGHTHGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQS GHGQSTQSGSSTTGRRRSGHSESSDSEVHSGGSHTHSGHTHSQARSQHGESESTVHKRHQ TTHGQTGDTTEHGHPSHGQTIQTGSRTTGRRGSGHSEYSDSEGPSGVSHTHSGHTHGQAG SHYPESGSSVHERHGTTHGQTADTTRHGHSGHGQSTQRGSRTTGRRASGHSEYSDSEGHS GVSHTHSGHAHGQAGSQHGESGSSVHERHGTTHGQTGDTTRHAHSGHGQSTQRGSRTAGR RGSGHSESSDSEVHSGVSHTHSGHTYGQARSQHGESGSAIHGRQGTIHGQTGDTTRHGQS GHGQSTQTGSRTTGRQRSSHSESSDSEVHSEASPTHSGHTHSQAGSRHGQSGSSGHGRQG TTHGQTGDTTRHAHYGYGQSTQRGSRTTGRRGSGHSESSDSEVHSWGSHTHSGHIQGQAG SQQRQPGSTVHGRLETTHGQTGDTTRHGHSGYGQSTQTGSRSSRASHFQSHSSERQRHGS SQVWKHGSYGPAEYDYGHTGYGPSGGSRKSISNSHLSWSTDSTANKQLSRH NT seq 7176 nt NT seq  +upstreamnt  +downstreamnt atgaccgacctcttgagaagtgttgtcaccgtaattgatgttttctacaaatacaccaag caagatggggagtgtggcacactgagcaagggtgaactaaaggaacttctggagaaagag cttcatccagttctgaagaacccagatgatccagacacagtggatgtcatcatgcatatg ctggatcgagatcatgacagaagattggactttactgagtttcttttgatgatattcaag ctgactatggcctgcaacaaggtcctcagcaaagaatactgcaaagcttcagggtcaaag aagcataggcgtggtcaccgacaccaagaagaagaaagtgaaacagaagaggatgaagag gatacaccaggacataaatcaggttacagacattcaagttggagtgagggagaggagcat ggatatagttctgggcactcaaggggaactgtgaaatgtagacatgggtccaactccagg aggctaggaagacaaggtaatttatccagctctgggaaccaagagggatctcagaaaaga taccacaggtccagctgtggtcattcatggagtggtggcaaagacagacatggttccagc tctgtagaactgagagaaagaataaacaagtcacacattagcccttctagggaatctggg gaggagtatgaatctggatctggatcaaacagttgggaaaggaaaggtcatggtggtctg tcatgtggattggagactagtgggcatgaatcaaactctactcagtcaagaattagagaa caaaagcttgggtctagctgttcaggttcaggagacagtgggaggcgaagtcatgcatgt ggttatagcaattcaagtgggtgtggaaggccacaaaatgcttcaagttcttgtcagtca catagatttggagggcaaggaaatcaatttagctatattcagtcaggctgtcagtcagga attaagggaggacaaggccatggctgtgtctcaggaggtcagccctctggatgtggtcaa cctgagtctaacccctgtagtcagtcctatagtcagagaggatatggagctagagaaaat ggtcaaccacagaactgtggaggacaatggagaacaggctcaagtcagtcctcttgctgt ggacaatatgggtctggaggtagccagtcttgtagtaatggtcaacatgaatatggttcc tgtggccgcttttcaaactcttctagttcaaatgaattttccaaatgtgatcaatatggg tctggttcaagtcagtctactagctttgaacaacatggaacaggcttgagtcagtcctct gggttcgaacaacatgtatgtggctcaggtcaaacttgtggccagcatgagtctacatca agtcaatccttgggctatgaccagcatgggtctagctcaggtaagacatctggctttgga caacatgggtctggctcaggtcagtcctctggctttggacaatgtgggtcaggctcaggt cagtcctctggctttggacagcatgggtctgtctcaggacaatcctctggttttggacag catgggtctgtctcaggacaatcctctggttttggacaacatgagtctagatcacgtcag tctagctatggccaacatggttctggctcaagtcaatcatctggctatggccaatatggg tctagagagacatctggctttggacaacatgggttgggctcaggtcaatccactggcttt ggccaatatggatcgggctcaggtcagtcctctggctttggacaacatgggtctggctca ggacaatcctctggctttggacaacatgagtctagatcaggtcagtctagttatggccaa cacagttctggctcaagtcagtcatctggctatggccaacatgggtctagacagacatct ggctttggacaacatgggtcaggctcaagtcaatccactggctttggccaatatggatca ggctcaggtcagtcctctggctttggacaacatgtttctggctcaggacaatcctctggt tttggacaacatgagtctagatcaggtcattctagctatggccaacatggttttggctca agtcaatcatctggctatggtcaacatgggtcaagttcaggacagacatctggatttgga caacacgagttaagctcaggtcagtcttccagctttggccaacatggatcaggctcaggt cagtcctctggctttggacaacatgggtctggctcaggacaatcctctggctttggacaa catgagtctagatcaggtcagtctagctatggccaacacagttctggctcaagtcagtca tctggctatggccaacatgggtctagacagacatctggctttggacaacatgggtcaggc tcaagtcaatccactggctttggccaatatggatcaggctcaggtcagtccgctggcttt ggacaacatgggtctggctcaggacaatcctctggctttggacagcatgagtctagatca catcagtccagctatggccaacatggttctggctcaagtcaatcatctggctatggtcaa catgggtcaagttcgggacagacatctggctttggacaacacaggtcaagctcaggtcaa tactctggctttggacaacatggatcaggctcaggtcagtccagtggctttggacaacat gggactggctcaggacaatactctggttttggacaacatgagtctagatcacatcagtct agctatggccaacatggttctggctcaagtcagtcatctggctatggtcaacatgggtca agttcaggacagacttttggatttggacaacacaggtcaggctcaggtcaatcctctggc tttggccaacatggatcaggctcaggtcagtcctctggctttggacaacatgagtcaggc tcaggaaaatcctctggctttggacagcatgagtctagatcaagtcagtctaattatggc caacatggttctggctcaagtcagtcatctggctatggtcaacatgggtctagttcagga cagacaactggctttggacaacacaggtcaagctcaggccaatactcaggctttggacaa catggatcaggctcagatcagtcctctggctttggacaacatgggactggttcaggacaa tcctctggttttggacaatatgagtctagatcacgtcagtctagctatggccaacatggt tctggctcaagtcaatcatctggctatggtcaacatgggtcaaattcaggacagacatct ggatttggacaacacaggccaggctcaggtcagtcctctggctttggccaatatggatcg ggctcaggtcagtcttctggctttggacaacatgggtcaggcacaggtaaatcctctggc tttgcacagcatgagtacagatcaggtcagtctagctatggccaacatggtactggctcc agtcaatcatctggctgtggccaacatgagtctggctcaggtccaaccacaagttttgga cagcatgtgtctggctcagacaatttctctagttctggacaacatatatctgactcaggt cagtccactggatttggccaatatggttcaggctcaggtcaatcaactggcttgggccag ggtgaatctcaacaagtagagtcaggatccacagttcatgggagacaggaaactactcat ggtcagacaataaataccactagacatagccagtctggtcaaggacaatccacacagaca gggtccagggtaactagaagacgaagatctagccaaagtgagaacagtgacagtgaagtg cactcaaaggtctcacacagacattcagaacacattcacacacaagctggatctcactac ccaaagtcaggatccacagttcgcagaagacaaggaactactcatggacagagaggagat accactagacatggccattctggtcatggacagtctacacagacaggttccagaacatct ggaagacagagatttagccacagtgatgccactgacagtgaagtgcactcaggggtctca catagaccacactcacaagaacaaactcacagccaagctggatctcaacatggagagtca gaatccacagttcatgagagacatgaaactacttatggacagacaggagaggccactgga catggccactctggtcatggacagtccacacagagagggtccaggacaactggaagaagg ggatctggccatagtgagtccagtgacagtgaagtgcactcagggggctcacacagacca caatcacaagaacaaactcatggccaagccggatctcaacatggagagtcaggatccaca gttcatgggagacacggaactactcatggacagacaggagataccactagacatgcccac tatcatcatggaaaatccacacagagagggtccagtacaactggaagaaggggatctggc cacagtgagtccagtgacagtgaagtgcactcagggggctcgcacacacattcaggacac actcacggccaaagtggatctcaacatggagagtcagaatccataattcatgacagacac agaattactcatggacagacaggagataccactagacattcctactctggtcatgaacaa accacacagacagggtccaggacaactggaagacagagaactagccacagtgagtccact gacagtgaagtgcactcagggggctcacacagaccacactcacgagaacacacttacggc caagccggatctcaacatgaagagccagaattcacagttcatgagagacacggaactact catggacagataggagataccactggacattcccactctggtcatggacagtccacacag agagggtccaggacaactggaagacagagatctagccacagtgagtccagtgacagtgaa gtgcactcaggggtctcacacacacatacaggacacactcatggtcaagctggatctcaa catggacagtcagaatccatagttcctgagagacatggaactactcatggacagacagga gataccactagacatgcccactatcatcatggattaaccacacagacagggtccaggact actggaagaaggggatctggccacagtgagtacagtgacagtgaagggtactcaggagtc tcacatacacattcaggacacactcatggccaagccagatctcaacatggagagtcagaa tccatagttcatgagagacatggaactatacatggacagacaggcgataccaccagacat gcccactctggtcatggacagtccacacagacagggtccaggaccactggaagaaggtca tctggccacagtgagtacagtgacagtgaagggcactcagggttctcacaaagaccacac tcacgaggacacactcacggccaggctggatctcaacatggagagtcagaatccatagtt gacgagagacatggaactactcatggacagacaggagataccagtggacattctcaatct ggtcatggacagtccacacagtcaggatccagtacaactggaagaaggagatctggccac agtgagtccagtgacagtgaagtgcactcagggggctcacatacacattcaggacacaca cacagccaagccaggtctcaacatggagagtcagaatccacagttcacaagagacaccaa actactcatggacagacaggagataccactgaacatggccaccctagtcatggacaaacc atacagacagggtccaggacaactggaagaaggggatctggccacagtgagtacagtgac agtgaagggccctcaggggtctcacacacacattcaggacacactcacggtcaagctgga tctcactatccagagtcaggatcctcagttcatgagagacacggaactactcatggacaa acagcagataccactagacatggccactctggtcatggacagtccacacagagagggtcc aggacaactggaagaagggcatctggccacagtgagtacagtgacagtgaagggcactca ggggtctcacacacacattcaggacacgctcatggccaagccggatctcaacatggagag tcaggatcctcagttcatgagagacacggaactactcatggacagacaggagataccact agacatgctcactctggtcatggacagtccacacagagagggtcaaggacagctggaaga aggggatctggccacagtgagtccagtgacagtgaagtgcactcaggggtctcacacaca cattcaggacacacttatggccaagccagatctcaacatggagagtcaggatctgccatt cacgggagacagggaactatacatggacagacaggagataccactagacatggccagtct ggtcatggacagtccacacagacaggttccaggacaactggaagacaaagatctagtcac agtgagtccagtgatagtgaagtgcactcagaggcctcacccacacattcaggacacact cacagccaagccggatctcgacatggacagtcaggatcctcaggtcatgggagacaggga actactcatggacagacaggagataccactagacatgcccactatggttatggacaatcc acacagagagggtccaggacaactggaagaaggggatctggccacagtgagtccagtgac agtgaagtgcactcatggggctcacacacacattcaggacacattcagggccaagctgga tctcaacaaagacagccaggatccacagttcatgggagactggaaactactcatggacag acaggagataccactagacatggccattctggttatggacaatccacacagacaggttcc agatctagtagagcaagtcattttcagtcacatagtagtgaaaggcaaaggcatggatca agtcaggtttggaaacatggcagctatggacctgcagaatatgactatgggcacactggg tatgggccttctggtggcagcagaaaaagcatcagtaattctcacctttcatggtcaaca gacagcactgcaaacaagcaactgtctagacattga

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