Homo sapiens (human): 6608
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Entry
6608 CDS
T01001
Symbol
SMO, CRJS, FZD11, Gx, PHLS, SMOH
Name
(RefSeq) smoothened, frizzled class receptor
KO
K06226
smoothened
Organism
hsa
Homo sapiens (human)
Pathway
hsa04340
Hedgehog signaling pathway
hsa04360
Axon guidance
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05217
Basal cell carcinoma
Network
nt06217
HH signaling (cancer)
nt06269
Basal cell carcinoma
nt06501
HH signaling
Element
N00010
Mutation-inactivated PTCH1 to Hedgehog signaling pathway
N00017
Mutation-activated SMO to Hedgehog signaling pathway
N00062
Hedgehog signaling pathway
Disease
H00039
Basal cell carcinoma
H01556
Meningioma
H01667
Medulloblastoma
Drug target
Glasdegib (
DG02912
):
D10636
D11107
<US>
Patidegib
Saridegib (
DG01274
):
D10324
D10325
Sonidegib (
DG01854
):
D10119
D10729
<US>
Taladegib:
D10671
Vismodegib:
D09992
<US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04340 Hedgehog signaling pathway
6608 (SMO)
09150 Organismal Systems
09158 Development and regeneration
04360 Axon guidance
6608 (SMO)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
6608 (SMO)
05205 Proteoglycans in cancer
6608 (SMO)
09162 Cancer: specific types
05217 Basal cell carcinoma
6608 (SMO)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:
hsa04030
]
6608 (SMO)
G protein-coupled receptors [BR:
hsa04030
]
Frizzled / Smoothened family
6608 (SMO)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Frizzled
Fz
7tm_2
Dicty_CAR
Motif
Other DBs
NCBI-GeneID:
6608
NCBI-ProteinID:
NP_005622
OMIM:
601500
HGNC:
11119
Ensembl:
ENSG00000128602
Pharos:
Q99835
(Tclin)
UniProt:
Q99835
Structure
PDB
PDBj
LinkDB
All DBs
Position
7:129188633..129213545
Genome browser
AA seq
787 aa
AA seq
DB search
MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
MDADSDF
NT seq
2364 nt
NT seq
+upstream
nt +downstream
nt
atggccgctgcccgcccagcgcgggggccggagctcccgctcctggggctgctgctgctg
ctgctgctgggggacccgggccggggggcggcctcgagcgggaacgcgaccgggcctggg
cctcggagcgcgggcgggagcgcgaggaggagcgcggcggtgactggccctccgccgccg
ctgagccactgcggccgggctgccccctgcgagccgctgcgctacaacgtgtgcctgggc
tcggtgctgccctacggggccacctccacactgctggccggagactcggactcccaggag
gaagcgcacggcaagctcgtgctctggtcgggcctccggaatgccccccgctgctgggca
gtgatccagcccctgctgtgtgccgtatacatgcccaagtgtgagaatgaccgggtggag
ctgcccagccgtaccctctgccaggccacccgaggcccctgtgccatcgtggagagggag
cggggctggcctgacttcctgcgctgcactcctgaccgcttccctgaaggctgcacgaat
gaggtgcagaacatcaagttcaacagttcaggccagtgcgaagtgcccttggttcggaca
gacaaccccaagagctggtacgaggacgtggagggctgcggcatccagtgccagaacccg
ctcttcacagaggctgagcaccaggacatgcacagctacatcgcggccttcggggccgtc
acgggcctctgcacgctcttcaccctggccacattcgtggctgactggcggaactcgaat
cgctaccctgctgttattctcttctacgtcaatgcgtgcttctttgtgggcagcattggc
tggctggcccagttcatggatggtgcccgccgagagatcgtctgccgtgcagatggcacc
atgaggcttggggagcccacctccaatgagactctgtcctgcgtcatcatctttgtcatc
gtgtactacgccctgatggctggtgtggtttggtttgtggtcctcacctatgcctggcac
acttccttcaaagccctgggcaccacctaccagcctctctcgggcaagacctcctacttc
cacctgctcacctggtcactcccctttgtcctcactgtggcaatccttgctgtggcgcag
gtggatggggactctgtgagtgggatttgttttgtgggctacaagaactaccgataccgt
gcgggcttcgtgctggccccaatcggcctggtgctcatcgtgggaggctacttcctcatc
cgaggagtcatgactctgttctccatcaagagcaaccaccccgggctgctgagtgagaag
gctgccagcaagatcaacgagaccatgctgcgcctgggcatttttggcttcctggccttt
ggctttgtgctcattaccttcagctgccacttctacgacttcttcaaccaggctgagtgg
gagcgcagcttccgggactatgtgctatgtcaggccaatgtgaccatcgggctgcccacc
aagcagcccatccctgactgtgagatcaagaatcgcccgagccttctggtggagaagatc
aacctgtttgccatgtttggaactggcatcgccatgagcacctgggtctggaccaaggcc
acgctgctcatctggaggcgtacctggtgcaggttgactgggcagagtgacgatgagcca
aagcggatcaagaagagcaagatgattgccaaggccttctctaagcggcacgagctcctg
cagaacccaggccaggagctgtccttcagcatgcacactgtgtcccacgacgggcccgtg
gcgggcttggcctttgacctcaatgagccctcagctgatgtctcctctgcctgggcccag
catgtcaccaagatggtggctcggagaggagccatactgccccaggatatttctgtcacc
cctgtggcaactccagtgcccccagaggaacaagccaacctgtggctggttgaggcagag
atctccccagagctgcagaagcgcctgggccggaagaagaagaggaggaagaggaagaag
gaggtgtgcccgctggcgccgccccctgagcttcacccccctgcccctgcccccagtacc
attcctcgactgcctcagctgccccggcagaaatgcctggtggctgcaggtgcctgggga
gctggggactcttgccgacagggagcgtggaccctggtctccaacccattctgcccagag
cccagtccccctcaggatccatttctgcccagtgcaccggcccccgtggcatgggctcat
ggccgccgacagggcctggggcctattcactcccgcaccaacctgatggacacagaactc
atggatgcagactcggacttctga
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