KEGG   Homo sapiens (human): 7170
Entry
7170              CDS       T01001                                 
Symbol
TPM3, CAPM1, CFTD, CMYO4A, CMYO4B, CMYP4A, CMYP4B, HEL-189, HEL-S-82p, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TM5, TPM3nu, TPMsk3, TRK, hscp30
Name
(RefSeq) tropomyosin alpha-3 chain isoform Tpm3.12st
  KO
K09290  tropomyosin 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04814  Motor proteins
hsa04820  Cytoskeleton in muscle cells
hsa05200  Pathways in cancer
hsa05216  Thyroid cancer
hsa05410  Hypertrophic cardiomyopathy
hsa05414  Dilated cardiomyopathy
Network
nt06539  Cytoskeleton in muscle cells
  Element
N01818  Actin thin filament, muscle contraction
N01819  Actin thin filament, length regulation
Disease
H00032  Thyroid cancer
H00698  Nemaline myopathy
H00701  Congenital fiber type disproportion
H00702  Cap myopathy
H01810  Congenital myopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    7170 (TPM3)
   04820 Cytoskeleton in muscle cells
    7170 (TPM3)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    7170 (TPM3)
   04261 Adrenergic signaling in cardiomyocytes
    7170 (TPM3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    7170 (TPM3)
  09162 Cancer: specific types
   05216 Thyroid cancer
    7170 (TPM3)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    7170 (TPM3)
   05414 Dilated cardiomyopathy
    7170 (TPM3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    7170 (TPM3)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Tropomyosins
     7170 (TPM3)
SSDB
Motif
Pfam: Tropomyosin CLZ HmpF CCDC39 CCDC170_1st CEP135_TSGA10_CC Pex17 Rod_CreS Sec2p PUMA_CC SCD2_helical_N TMF_DNA_bd FKBP15 DUF745 DUF3450 ATG16 CLIP1 CC_Bre1 XhlA Lebercilin CENP-F_leu_zip Nuf2_DHR10-like HAUS1 DUF1664 SlyX LEKR1 Laminin_I
Other DBs
NCBI-GeneID: 7170
NCBI-ProteinID: NP_689476
OMIM: 191030
HGNC: 12012
Ensembl: ENSP00000498577.1
UniProt: P06753
Structure
LinkDB
Position
1:complement(154155308..154192100)
AA seq 285 aa
MMEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDK
YSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKA
ADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERT
EERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRA
EFAERSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDMTSI
NT seq 858 nt   +upstreamnt  +downstreamnt
atgatggaggccatcaagaaaaagatgcagatgctgaagttagacaaggagaatgctctg
gatcgggcagagcaagctgaagctgagcagaagcaggcagaagaaagaagtaaacagctg
gaggatgagctggcagccatgcagaagaagctgaaagggacagaggatgagctggacaag
tattctgaagctttgaaggatgcccaggagaagctggaactggcagagaagaaggctgct
gatgctgaggctgaggtggcctccttgaaccgtaggatccagctggttgaagaagagctg
gaccgtgctcaggagcgcctggccactgccctgcaaaagctggaagaagctgaaaaagct
gctgatgagagtgagagaggtatgaaggttattgaaaaccgggccttaaaagatgaagaa
aagatggaactccaggaaatccaactcaaagaagctaagcacattgcagaagaggcagat
aggaagtatgaagaggtggctcgtaagttggtgatcattgaaggagacttggaacgcaca
gaggaacgagctgagctggcagagtctaagtgttctgagctggaggaggagctgaagaat
gtcaccaacaacctcaagtctcttgaggctcaggcggagaagtactctcaaaaagaagat
aaatatgaggaagaaatcaagattcttactgataaactcaaggaggcagagacccgtgct
gagtttgctgagagatcggtagccaagctggaaaagacaattgatgacctggaagatgag
ctctatgcccagaaactgaagtacaaggccattagcgaggagctggaccacgccctcaat
gacatgacctctatataa

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