KEGG   MODULE: hsa_M00861
Entry
hsa_M00861        Pathway   Module                                 
Name
beta-Oxidation, peroxisome, VLCFA
Definition
K00232 K12405 (K07513,K08764)
Diagram
hsa_M00861  beta-Oxidation, peroxisome, VLCFA
hsa_M00861

Class
Pathway modules; Lipid metabolism; Fatty acid metabolism
Pathway
hsa01040  Biosynthesis of unsaturated fatty acids
hsa01212  Fatty acid metabolism
hsa01100  Metabolic pathways
Organism
Homo sapiens (human) [GN:hsa]
Gene
30  ACAA1; 3-ketoacyl-CoA thiolase, peroxisomal isoform a [KO:K07513]
3295  HSD17B4; peroxisomal multifunctional enzyme type 2 isoform 2 [KO:K12405]
51  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform b [KO:K00232]
6342  SCP2; sterol carrier protein 2 isoform 1 precursor [KO:K08764]
8310  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform a [KO:K00232]
Reaction
R07934  
R07935  
R07936  
R07937  
R07950  
R07951  
R07952  
R07953  
Compound
C16168  (6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA
C16374  (2E,6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosaheptaenoyl-CoA
C16375  (3R,6Z,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosahexaenoyl-CoA
C16376  (6Z,9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosahexaenoyl-CoA
C16169  (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoyl-CoA
C16172  (6Z,9Z,12Z,15Z,18Z)-Tetracosapentaenoyl-CoA
C16387  (2E,6Z,9Z,12Z,15Z,18Z)-Tetracosahexaenoyl-CoA
C16388  (3R,6Z,9Z,12Z,15Z,18Z)-3-Hydroxytetracosapentaenoyl-CoA
C16389  (6Z,9Z,12Z,15Z,18Z)-3-Oxotetracosapentaenoyl-CoA
C16173  (4Z,7Z,10Z,13Z,16Z)-Docosapentaenoyl-CoA
RModule
RM018  Beta oxidation in acyl-CoA degradation
Reference
PMID:11734571
  Authors
Ferdinandusse S, Denis S, Mooijer PA, Zhang Z, Reddy JK, Spector AA, Wanders RJ
  Title
Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid.
  Journal
J Lipid Res 42:1987-95 (2001)
Reference
PMID:26611709
  Authors
Waterham HR, Ferdinandusse S, Wanders RJ
  Title
Human disorders of peroxisome metabolism and biogenesis.
  Journal
Biochim Biophys Acta 1863:922-33 (2016)
DOI:10.1016/j.bbamcr.2015.11.015
KO module
M00861
LinkDB

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