KEGG   VARIANT: 1950v1
Entry
1950v1                      Variant                                
Name
EGF overexpression
Type
Gain of function
Gene
EGF  epidermal growth factor [KO:K04357]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06260  Colorectal cancer
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00020  Colorectal cancer
Reference
PMID:7912978
  Authors
Hayashi Y, Widjono YW, Ohta K, Hanioka K, Obayashi C, Itoh K, Imai Y, Itoh H
  Title
Expression of EGF, EGF-receptor, p53, v-erb B and ras p21 in colorectal neoplasms by immunostaining paraffin-embedded tissues.
  Journal
Pathol Int 44:124-30 (1994)
DOI:10.1111/j.1440-1827.1994.tb01696.x
Reference
  Authors
Spano JP, Fagard R, Soria JC, Rixe O, Khayat D, Milano G
  Title
Epidermal growth factor receptor signaling in colorectal cancer: preclinical data and therapeutic perspectives.
  Journal
Ann Oncol 16:189-94 (2005)
DOI:10.1093/annonc/mdi057
LinkDB

KEGG   VARIANT: 7039v1
Entry
7039v1                      Variant                                
Name
TGFA overexpression
Type
Gain of function
Gene
TGFA  transforming growth factor alpha [KO:K08774]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06220  Calcium signaling (cancer)
nt06260  Colorectal cancer
nt06263  Hepatocellular carcinoma
nt06526  MAPK signaling
nt06528  Calcium signaling
nt06530  PI3K signaling
Disease
H00020  Colorectal cancer
H00048  Hepatocellular carcinoma
Reference
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
PMID:9815784
  Authors
Kiss A, Wang NJ, Xie JP, Thorgeirsson SS
  Title
Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth Factor/c-met,TGF-beta receptor type II, and p53 expression in human hepatocellular carcinomas.
  Journal
Clin Cancer Res 3:1059-66 (1997)
Reference
  Authors
Yarden Y, Sliwkowski MX.
  Title
Untangling the ErbB signalling network.
  Journal
Nat Rev Mol Cell Biol 2:127-37 (2001)
DOI:10.1038/35052073
LinkDB

KEGG   VARIANT: 2069v1
Entry
2069v1                      Variant                                
Name
EREG overexpression
Type
Gain of function
Gene
EREG  epiregulin [KO:K09784]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06260  Colorectal cancer
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00020  Colorectal cancer
Reference
  Authors
Di Fiore F, Sesboue R, Michel P, Sabourin JC, Frebourg T
  Title
Molecular determinants of anti-EGFR sensitivity and resistance in metastatic colorectal cancer.
  Journal
Br J Cancer 103:1765-72 (2010)
DOI:10.1038/sj.bjc.6606008
Reference
  Authors
Jing C, Jin YH, You Z, Qiong Q, Jun Z
  Title
Prognostic value of amphiregulin and epiregulin mRNA expression in metastatic colorectal cancer patients.
  Journal
Oncotarget 7:55890-55899 (2016)
DOI:10.18632/oncotarget.10151
Reference
  Authors
Li XD, Miao SY, Wang GL, Yang L, Shu YQ, Yin YM
  Title
Amphiregulin and epiregulin expression in colorectal carcinoma and the correlation with clinicopathological characteristics.
  Journal
Onkologie 33:353-8 (2010)
DOI:10.1159/000315380
LinkDB

KEGG   VARIANT: 374v1
Entry
374v1                      Variant                                 
Name
AREG overexpression
Type
Gain of function
Gene
AREG  amphiregulin [KO:K09782]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06260  Colorectal cancer
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00020  Colorectal cancer
Reference
  Authors
Di Fiore F, Sesboue R, Michel P, Sabourin JC, Frebourg T
  Title
Molecular determinants of anti-EGFR sensitivity and resistance in metastatic colorectal cancer.
  Journal
Br J Cancer 103:1765-72 (2010)
DOI:10.1038/sj.bjc.6606008
Reference
  Authors
Jing C, Jin YH, You Z, Qiong Q, Jun Z
  Title
Prognostic value of amphiregulin and epiregulin mRNA expression in metastatic colorectal cancer patients.
  Journal
Oncotarget 7:55890-55899 (2016)
DOI:10.18632/oncotarget.10151
Reference
  Authors
Li XD, Miao SY, Wang GL, Yang L, Shu YQ, Yin YM
  Title
Amphiregulin and epiregulin expression in colorectal carcinoma and the correlation with clinicopathological characteristics.
  Journal
Onkologie 33:353-8 (2010)
DOI:10.1159/000315380
LinkDB

KEGG   VARIANT: 3481v1
Entry
3481v1                      Variant                                
Name
IGF2 overexpression
Type
Gain of function
Gene
IGF2  insulin like growth factor 2 [KO:K13769]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00048  Hepatocellular carcinoma
Reference
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
Reference
  Authors
Alexia C, Fallot G, Lasfer M, Schweizer-Groyer G, Groyer A
  Title
An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis.
  Journal
Biochem Pharmacol 68:1003-15 (2004)
DOI:10.1016/j.bcp.2004.05.029
Reference
  Authors
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
  Title
Pathogenesis of hepatocellular carcinoma and molecular therapies.
  Journal
Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
LinkDB

KEGG   VARIANT: 3082v1
Entry
3082v1                      Variant                                
Name
HGF overexpression
Type
Gain of function
Gene
HGF  hepatocyte growth factor [KO:K05460]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06530  PI3K signaling
Disease
H00048  Hepatocellular carcinoma
Reference
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
  Authors
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
  Title
Pathogenesis of hepatocellular carcinoma and molecular therapies.
  Journal
Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
Reference
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
LinkDB

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