KEGG   PATHWAY: hvg04382
Entry
hvg04382                    Pathway                                
Name
Cornified envelope formation - Hordeum vulgare subsp. vulgare (domesticated barley)
Class
Organismal Systems; Development and regeneration
Pathway map
hvg04382  Cornified envelope formation
hvg04382

Organism
Hordeum vulgare subsp. vulgare (domesticated barley) [GN:hvg]
Gene
123395059  [KO:K11584]
123398603  [KO:K03456]
123399499  [KO:K04382] [EC:3.1.3.16]
123400211  [KO:K11584]
123401803  [KO:K04382] [EC:3.1.3.16]
123402277  [KO:K11583]
123403340  [KO:K04708] [EC:1.1.1.102]
123406345  [KO:K04354]
123407227  [KO:K11584]
123407426  [KO:K04354]
123411707  [KO:K17108] [EC:3.2.1.45]
123412106  [KO:K17108] [EC:3.2.1.45]
123412685  [KO:K04382] [EC:3.1.3.16]
123425344  [KO:K11583]
123426814  [KO:K11584]
123427048  [KO:K11584]
123430828  [KO:K17108] [EC:3.2.1.45]
123430999  [KO:K11583]
123435549  [KO:K17108] [EC:3.2.1.45]
123442995  [KO:K11584]
123443830  [KO:K04354]
123445320  [KO:K00654] [EC:2.3.1.50]
123447132  [KO:K11584]
123447845  [KO:K17108] [EC:3.2.1.45]
123449140  [KO:K00654] [EC:2.3.1.50]
123449540  [KO:K04382] [EC:3.1.3.16]
123449661  [KO:K11584]
123452851  [KO:K04382] [EC:3.1.3.16]
Compound
C00064  L-Glutamine
C00076  Calcium cation
C00135  L-Histidine
C00154  Palmitoyl-CoA
C00162  Fatty acid
C00187  Cholesterol
C00785  Urocanate
C00836  Sphinganine
C01879  5-Oxoproline
C02934  3-Dehydrosphinganine
C22352  Ultra-long-chain fatty acid
C22353  Ultra-long-chain omega-hydroxy fatty acid
C23027  Ultra-long-chain omega-hydroxy fatty acyl-CoA
C23028  Ultra-long-chain omega-hydroxyceramide
C23029  linoleate-esterified acylceramide
C23030  Acylglucosylceramide
Reference
  Authors
Candi E, Schmidt R, Melino G
  Title
The cornified envelope: a model of cell death in the skin.
  Journal
Nat Rev Mol Cell Biol 6:328-40 (2005)
DOI:10.1038/nrm1619
Reference
  Authors
Egawa G, Kabashima K
  Title
Barrier dysfunction in the skin allergy.
  Journal
Allergol Int 67:3-11 (2018)
DOI:10.1016/j.alit.2017.10.002
Reference
  Authors
Ishitsuka Y, Roop DR
  Title
Loricrin: Past, Present, and Future.
  Journal
Int J Mol Sci 21:ijms21072271 (2020)
DOI:10.3390/ijms21072271
Reference
  Authors
Gallegos-Alcala P, Jimenez M, Cervantes-Garcia D, Salinas E
  Title
The Keratinocyte as a Crucial Cell in the Predisposition, Onset, Progression, Therapy and Study of the Atopic Dermatitis.
  Journal
Int J Mol Sci 22:ijms221910661 (2021)
DOI:10.3390/ijms221910661
Reference
  Authors
Goleva E, Berdyshev E, Leung DY
  Title
Epithelial barrier repair and prevention of allergy.
  Journal
J Clin Invest 129:1463-1474 (2019)
DOI:10.1172/JCI124608
Reference
  Authors
Breiden B, Sandhoff K
  Title
The role of sphingolipid metabolism in cutaneous permeability barrier formation.
  Journal
Biochim Biophys Acta 1841:441-52 (2014)
DOI:10.1016/j.bbalip.2013.08.010
Reference
  Authors
Yamamoto H, Hattori M, Chamulitrat W, Ohno Y, Kihara A
  Title
Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid omega-O-acylceramide.
  Journal
Proc Natl Acad Sci U S A 117:2914-2922 (2020)
DOI:10.1073/pnas.1917525117
Reference
  Authors
Ge F, Sun K, Hu Z, Dong X
  Title
Role of Omega-Hydroxy Ceramides in Epidermis: Biosynthesis, Barrier Integrity and Analyzing Method.
  Journal
Int J Mol Sci 24:ijms24055035 (2023)
DOI:10.3390/ijms24055035
Related
pathway
hvg00600  Sphingolipid metabolism
KO pathway
ko04382   

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