KEGG   PATHWAY: ko04382
Entry
ko04382                     Pathway                                
Name
Cornified envelope formation
Class
Organismal Systems; Development and regeneration
Pathway map
ko04382  Cornified envelope formation
ko04382

Orthology
K00654  SPT; serine palmitoyltransferase [EC:2.3.1.50]
K00720  UGCG; ceramide glucosyltransferase [EC:2.4.1.80]
K01201  GBA, srfJ; glucosylceramidase [EC:3.2.1.45]
K01349  FURIN, PCSK3; furin [EC:3.4.21.75]
K01367  CAPN1; calpain-1 [EC:3.4.22.52]
K01372  BLMH, pepC; bleomycin hydrolase [EC:3.4.22.40]
K01481  E3.5.3.15; protein-arginine deiminase [EC:3.5.3.15]
K01745  hutH, HAL; histidine ammonia-lyase [EC:4.3.1.3]
K03456  PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K04354  PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K04401  CASP14; caspase 14 [EC:3.4.22.-]
K04708  KDSR; 3-dehydrosphinganine reductase [EC:1.1.1.102]
K05619  TGM1; transglutaminase 1 [EC:2.3.2.13]
K05620  TGM3; transglutaminase 3 [EC:2.3.2.13]
K05622  TGM5; transglutaminase 5 [EC:2.3.2.13]
K05646  ABCA12; ATP-binding cassette, subfamily A (ABC1), member 12
K05701  TJP1, ZO1; tight junction protein 1
K06087  CLDN; claudin
K06088  OCLN; occludin
K06237  COL4A; collagen type IV alpha
K06240  LAMA3_5; laminin, alpha 3/5
K06244  LAMB3; laminin, beta 3
K06246  LAMC2; laminin, gamma 2
K06485  ITGA6, CD49f; integrin alpha 6
K06525  ITGB4, CD104; integrin beta 4
K07596  DSG1; desmoglein 1
K07597  DSG2; desmoglein 2
K07598  DSG3; desmoglein 3
K07599  DSG4; desmoglein 4
K07600  DSC1; desmocollin 1
K07603  COL17A, BP180; collagen type XVII alpha
K07604  KRT1; type I keratin, acidic
K07605  KRT2; type II keratin, basic
K08021  ALOX12B; arachidonate 12-lipoxygenase (R-type) [EC:1.13.11.-]
K08664  PRSS8; prostasin [EC:3.4.21.-]
K08670  ST14, PRSS14; suppressor of tumorigenicity protein 14 [EC:3.4.21.109]
K08672  PCSK6; proprotein convertase subtilisin/kexin type 6 [EC:3.4.21.-]
K08726  EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase [EC:3.3.2.10 3.1.3.76]
K08745  SLC27A1_4, FATP1_4; solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-]
K10056  JUP, PG; junction plakoglobin
K10247  ELOVL1; elongation of very long chain fatty acids protein 1 [EC:2.3.1.199]
K10249  ELOVL4; elongation of very long chain fatty acids protein 4 [EC:2.3.1.199]
K10381  DSP; desmoplakin
K10382  DST; dystonin
K10383  EVPL; envoplakin
K10384  FLG; filaggrin
K10385  LOR; loricrin
K10386  PPL; periplakin
K10387  PKP1; plakophilin 1
K10388  PLEC; plectin
K11583  PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
K11584  PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K12642  PKP2; plakophilin 2
K13699  ABHD5, CGI-58; abhydrolase domain-containing protein 5 [EC:2.3.1.51]
K16628  COL7A; collagen type VII alpha
K16813  PNPLA1; omega-hydroxyceramide transacylase [EC:2.3.1.296]
K17108  GBA2; non-lysosomal glucosylceramidase [EC:3.2.1.45]
K17274  S100A10; protein S100-A10
K17731  CYP4F22; ultra-long-chain fatty acid omega-hydroxylase [EC:1.14.14.177]
K18626  TCHH; trichohyalin
K18684  ALOXE3; hydroperoxy icosatetraenoate dehydratase/isomerase [EC:4.2.1.152 5.4.4.7]
K21126  S100A7; protein S100-A7
K21127  S100A8; protein S100-A8
K21128  S100A9; protein S100-A9
K22368  EPHX3; epoxide hydrolase 3 [EC:3.3.2.10]
K23457  CDSN; corneodesmosin
K23757  HRNR, FLG3, S100A18; hornerin
K23758  S100A1; protein S100-A1
K23759  S100A2; protein S100-A2
K23760  S100A3, S100E; protein S100-A3
K23761  S100A4; protein S100-A4
K23762  S100A5, S100D; protein S100-A5
K23764  S100A6; protein S100-A6
K23765  S100A11_13, S100C; protein S100-A11/13
K23766  S100A12; protein S100-A12
K23767  S100A14; protein S100-A14
K23768  S100A16, S100F; protein S100-A16
K23769  TCHHL1, S100A17; trichohyalin-like protein 1
K24425  SDR9C7; short-chain dehydrogenase/reductase family 9C member 7
K24552  ASPRV1; retroviral-like aspartic protease 1
K24622  CERS3, LASS3; very-long-chain ceramide synthase / ultra-long-chain ceramide synthase
K28330  IVL; involucrin
K28331  SPRR; small proline-rich protein
K28332  LCE; late cornified envelope protein
K28333  TMEM79; transmembrane protein 79
K28344  KAZN; kazrin
K28841  PKP3; plakophilin 3
Compound
C00064  L-Glutamine
C00076  Calcium cation
C00135  L-Histidine
C00154  Palmitoyl-CoA
C00162  Fatty acid
C00187  Cholesterol
C00785  Urocanate
C00836  Sphinganine
C01879  5-Oxoproline
C02934  3-Dehydrosphinganine
C22352  Ultra-long-chain fatty acid
C22353  Ultra-long-chain omega-hydroxy fatty acid
C23027  Ultra-long-chain omega-hydroxy fatty acyl-CoA
C23028  Ultra-long-chain omega-hydroxyceramide
C23029  linoleate-esterified acylceramide
C23030  Acylglucosylceramide
Reference
PMID:15803139
  Authors
Candi E, Schmidt R, Melino G
  Title
The cornified envelope: a model of cell death in the skin.
  Journal
Nat Rev Mol Cell Biol 6:328-40 (2005)
DOI:10.1038/nrm1619
Reference
PMID:29153780
  Authors
Egawa G, Kabashima K
  Title
Barrier dysfunction in the skin allergy.
  Journal
Allergol Int 67:3-11 (2018)
DOI:10.1016/j.alit.2017.10.002
Reference
PMID:32218335
  Authors
Ishitsuka Y, Roop DR
  Title
Loricrin: Past, Present, and Future.
  Journal
Int J Mol Sci 21:ijms21072271 (2020)
DOI:10.3390/ijms21072271
Reference
PMID:34639001
  Authors
Gallegos-Alcala P, Jimenez M, Cervantes-Garcia D, Salinas E
  Title
The Keratinocyte as a Crucial Cell in the Predisposition, Onset, Progression, Therapy and Study of the Atopic Dermatitis.
  Journal
Int J Mol Sci 22:ijms221910661 (2021)
DOI:10.3390/ijms221910661
Reference
PMID:30776025
  Authors
Goleva E, Berdyshev E, Leung DY
  Title
Epithelial barrier repair and prevention of allergy.
  Journal
J Clin Invest 129:1463-1474 (2019)
DOI:10.1172/JCI124608
Reference
PMID:23954553
  Authors
Breiden B, Sandhoff K
  Title
The role of sphingolipid metabolism in cutaneous permeability barrier formation.
  Journal
Biochim Biophys Acta 1841:441-52 (2014)
DOI:10.1016/j.bbalip.2013.08.010
Reference
PMID:31974308
  Authors
Yamamoto H, Hattori M, Chamulitrat W, Ohno Y, Kihara A
  Title
Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid omega-O-acylceramide.
  Journal
Proc Natl Acad Sci U S A 117:2914-2922 (2020)
DOI:10.1073/pnas.1917525117
Reference
PMID:36902463
  Authors
Ge F, Sun K, Hu Z, Dong X
  Title
Role of Omega-Hydroxy Ceramides in Epidermis: Biosynthesis, Barrier Integrity and Analyzing Method.
  Journal
Int J Mol Sci 24:ijms24055035 (2023)
DOI:10.3390/ijms24055035
Related
pathway
ko00600  Sphingolipid metabolism

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