KEGG   PATHWAY: ko00331
Entry
ko00331                     Pathway                                
Name
Clavulanic acid biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
ko00331  Clavulanic acid biosynthesis
ko00331

Module
M00674  Clavaminate biosynthesis, arginine + glyceraldehyde-3P => clavaminate [PATH:ko00331]
Orthology
K12673  N2-(2-carboxyethyl)arginine synthase [EC:2.5.1.66]
K12674  (carboxyethyl)arginine beta-lactam-synthase [EC:6.3.3.4]
K12675  clavaminate synthase [EC:1.14.11.21]
K12676  proclavaminate amidinohydrolase [EC:3.5.3.22]
K12677  clavulanate-9-aldehyde reducatase
Compound
C00062  L-Arginine
C00118  D-Glyceraldehyde 3-phosphate
C06655  L-N2-(2-Carboxyethyl)arginine
C06656  Deoxyguanidinoproclavaminic acid
C06657  Guanidinoproclavaminic acid
C06658  Proclavaminic acid
C06659  Dihydroclavaminic acid
C06660  Clavaminic acid
C06661  Clavulanate-9-aldehyde
C06662  Clavulanic acid
Reference
PMID:9614345
  Authors
McGowan SJ, Bycroft BW, Salmond GP.
  Title
Bacterial production of carbapenems and clavams: evolution of beta-lactam antibiotic pathways.
  Journal
Trends Microbiol 6:203-8 (1998)
DOI:10.1016/S0966-842X(98)01251-7
Reference
  Authors
Caines ME, Elkins JM, Hewitson KS, Schofield CJ.
  Title
Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway.
  Journal
J Biol Chem 279:5685-92 (2004)
DOI:10.1074/jbc.M310803200
Related
pathway
ko00220  Arginine biosynthesis
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