KEGG   PATHWAY: ko00220
Entry
ko00220                     Pathway                                
Name
Arginine biosynthesis
Class
Metabolism; Amino acid metabolism
Pathway map
ko00220  Arginine biosynthesis
ko00220

Module
M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:ko00220]
M00029  Urea cycle [PATH:ko00220]
M00763  Ornithine biosynthesis, mediated by LysW, glutamate => ornithine [PATH:ko00220]
M00844  Arginine biosynthesis, ornithine => arginine [PATH:ko00220]
M00845  Arginine biosynthesis, glutamate => acetylcitrulline => arginine [PATH:ko00220]
M00978  Ornithine-ammonia cycle [PATH:ko00220]
Other DBs
GO: 0006526
Orthology
K00145  argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]
K00260  gudB, rocG; glutamate dehydrogenase [EC:1.4.1.2]
K00261  GLUD1_2, gdhA; glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3]
K00262  E1.4.1.4, gdhA; glutamate dehydrogenase (NADP+) [EC:1.4.1.4]
K00491  nos; nitric-oxide synthase, bacterial [EC:1.14.14.47]
K00611  OTC, argF, argI; ornithine carbamoyltransferase [EC:2.1.3.3]
K00618  ARG2; amino-acid N-acetyltransferase [EC:2.3.1.1]
K00619  argA; amino-acid N-acetyltransferase [EC:2.3.1.1]
K00620  argJ; glutamate N-acetyltransferase / amino-acid N-acetyltransferase [EC:2.3.1.35 2.3.1.1]
K00811  ASP5; aspartate aminotransferase, chloroplastic [EC:2.6.1.1]
K00812  aspB; aspartate aminotransferase [EC:2.6.1.1]
K00813  aspC; aspartate aminotransferase [EC:2.6.1.1]
K00814  GPT, ALT; alanine transaminase [EC:2.6.1.2]
K00818  E2.6.1.11, argD; acetylornithine aminotransferase [EC:2.6.1.11]
K00821  argD; acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17]
K00926  arcC; carbamate kinase [EC:2.7.2.2]
K00930  argB; acetylglutamate kinase [EC:2.7.2.8]
K01425  glsA, GLS; glutaminase [EC:3.5.1.2]
K01427  URE; urease [EC:3.5.1.5]
K01428  ureC; urease subunit alpha [EC:3.5.1.5]
K01429  ureB; urease subunit beta [EC:3.5.1.5]
K01430  ureA; urease subunit gamma [EC:3.5.1.5]
K01438  argE; acetylornithine deacetylase [EC:3.5.1.16]
K01457  atzF; allophanate hydrolase [EC:3.5.1.54]
K01476  rocF, arg; arginase [EC:3.5.3.1]
K01478  arcA; arginine deiminase [EC:3.5.3.6]
K01755  argH, ASL; argininosuccinate lyase [EC:4.3.2.1]
K01915  glnA, GLUL; glutamine synthetase [EC:6.3.1.2]
K01940  argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]
K01941  uca; urea carboxylase [EC:6.3.4.6]
K01948  CPS1; carbamoyl-phosphate synthase (ammonia) [EC:6.3.4.16]
K01954  K01954; carbamoyl-phosphate synthase [EC:6.3.5.5]
K01955  carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
K01956  carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
K05597  aspQ, ansB, ansA; glutamin-(asparagin-)ase [EC:3.5.1.38]
K05828  lysZ, argB; [amino group carrier protein]-L-2-aminoadipate/L-glutamate 6-kinase [EC:2.7.2.17 2.7.2.19]
K05829  lysY, argC; [amino group carrier protein]-6-phospho-L-2-aminoadipate/5-phospho-L-glutamate reductase [EC:1.2.1.103 1.2.1.106]
K05830  lysJ, argD; [amino-group carrier protein]-gamma-(L-lysyl/L-ornithyl)-L-glutamate aminotransferase [EC:2.6.1.118 2.6.1.124]
K05831  lysK, argE; [amino group carrier protein]-lysine/ornithine hydrolase [EC:3.5.1.130 3.5.1.132]
K09065  argF; N-acetylornithine carbamoyltransferase [EC:2.1.3.9]
K11067  NAGS; N-acetylglutamate synthase [EC:2.3.1.1]
K11358  yhdR; aspartate aminotransferase [EC:2.6.1.1]
K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
K11541  URA2; carbamoyl-phosphate synthase / aspartate carbamoyltransferase [EC:6.3.5.5 2.1.3.2]
K12659  ARG56; N-acetyl-gamma-glutamyl-phosphate reductase / acetylglutamate kinase [EC:1.2.1.38 2.7.2.8]
K13240  NOS1; nitric-oxide synthase, brain [EC:1.14.13.39]
K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
K13242  NOS3; nitric-oxide synthase, endothelial [EC:1.14.13.39]
K13427  NOA1; nitric-oxide synthase, plant [EC:1.14.13.39]
K14048  ureAB; urease subunit gamma/beta [EC:3.5.1.5]
K14260  alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
K14272  GGAT; glutamate--glyoxylate aminotransferase [EC:2.6.1.4 2.6.1.2 2.6.1.44]
K14454  GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
K14455  GOT2; aspartate aminotransferase, mitochondrial [EC:2.6.1.1]
K14541  DUR1; urea carboxylase / allophanate hydrolase [EC:6.3.4.6 3.5.1.54]
K14677  ACY1; aminoacylase [EC:3.5.1.14]
K14681  argHA; argininosuccinate lyase / amino-acid N-acetyltransferase [EC:4.3.2.1 2.3.1.1]
K14682  argAB; amino-acid N-acetyltransferase [EC:2.3.1.1]
K15371  GDH2; glutamate dehydrogenase [EC:1.4.1.2]
K19412  argX; glutamate---[amino group carrier protein] ligase [EC:6.3.2.60]
K22476  K22476; N-acetylglutamate synthase [EC:2.3.1.1]
K22477  argO; N-acetylglutamate synthase [EC:2.3.1.1]
K22478  K22478; bifunctional N-acetylglutamate synthase/kinase [EC:2.3.1.1 2.7.2.8]
K23265  purQ; phosphoribosylformylglycinamidine synthase subunit PurQ / glutaminase
K25032  K25032; alpha-aminoadipate-LysW ligase/glutamate-LysW ligase
K27542  argZ; arginine dihydrolase / ornithine cyclodeaminase
K27545  argZ; arginine dihydrolase
Compound
C00011  CO2
C00014  Ammonia
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00049  L-Aspartate
C00062  L-Arginine
C00064  L-Glutamine
C00077  L-Ornithine
C00086  Urea
C00122  Fumarate
C00169  Carbamoyl phosphate
C00288  HCO3-
C00327  L-Citrulline
C00437  N-Acetylornithine
C00624  N-Acetyl-L-glutamate
C01010  Urea-1-carboxylate
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C03406  N-(L-Arginino)succinate
C04133  N-Acetyl-L-glutamate 5-phosphate
C15532  N-Acetyl-L-citrulline
C20948  LysW-L-glutamate
C20949  LysW-L-glutamyl 5-phosphate
C20950  LysW-L-glutamate 5-semialdehyde
C20951  LysW-L-ornithine
Related
pathway
ko00020  Citrate cycle (TCA cycle)
ko00240  Pyrimidine metabolism
ko00250  Alanine, aspartate and glutamate metabolism
ko00330  Arginine and proline metabolism
ko00470  D-Amino acid metabolism
ko00910  Nitrogen metabolism

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