PATHWAY: ko03013 Help
Entry Name Nucleocytoplasmic transport
Description The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class Genetic Information Processing; TranslationBRITE hierarchy
Pathway map ko03013 Nucleocytoplasmic transport
Other DBs Orthology K03231 EEF1A; elongation factor 1-alpha
K03345 SENP2, AXAM2; sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68 ]
K07562 NMD3; 60S ribosomal export protein NMD3
K07936 RAN; GTP-binding nuclear protein Ran
K09291 TPR, MLP1, MLP2; nucleoprotein TPR
K10577 UBE2I, UBC9; ubiquitin-conjugating enzyme E2 I
K12160 SUMO, SMT3; small ubiquitin-related modifier
K12172 RANBP2, NUP358; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]
K12812 DDX39B, UAP56, SUB2; ATP-dependent RNA helicase UAP56/SUB2 [EC:5.6.2.7 ]
K12875 ACIN1, ACINUS; apoptotic chromatin condensation inducer in the nucleus
K12876 RBM8A, Y14; RNA-binding protein 8A
K12877 MAGOH; protein mago nashi
K12878 THOC1; THO complex subunit 1
K12879 THOC2; THO complex subunit 2
K12880 THOC3; THO complex subunit 3
K12881 THOC4, ALY; THO complex subunit 4
K12882 NCBP1, CBP80; nuclear cap-binding protein subunit 1
K12883 NCBP2, CBP20; nuclear cap-binding protein subunit 2
K13151 SNUPN, RNUT1; snurportin-1
K13171 SRRM1, SRM160; serine/arginine repetitive matrix protein 1
K13174 THOC5; THO complex subunit 5
K13175 THOC6; THO complex subunit 6
K13176 THOC7; THO complex subunit 7
K14004 SEC13; protein transport protein SEC13
K14284 NXF, TAP, MEX67; nuclear RNA export factor
K14285 NXT1_2, P15; NTF2-related export protein 1/2
K14291 PHAX; phosphorylated adapter RNA export protein
K14293 KPNB1, IPO1; importin subunit beta-1
K14294 WIBG, PYM; partner of Y14 and mago
K14295 NUP50, NPAP60; nuclear pore complex protein Nup50
K14296 NUP153; nuclear pore complex protein Nup153
K14297 NUP98, ADAR2, NUP116; nuclear pore complex protein Nup98-Nup96
K14298 RAE1, GLE2; mRNA export factor
K14300 NUP133; nuclear pore complex protein Nup133
K14301 NUP107, NUP84; nuclear pore complex protein Nup107
K14302 NUP37; nuclear pore complex protein Nup37
K14303 NUP160, NUP120; nuclear pore complex protein Nup160
K14304 NUP85; nuclear pore complex protein Nup85
K14305 NUP43; nuclear pore complex protein Nup43
K14306 NUP62, NSP1; nuclear pore complex protein Nup62
K14307 NUPL1, NUP49; nucleoporin p58/p45
K14308 NUP54, NUP57; nuclear pore complex protein Nup54
K14309 NUP93, NIC96; nuclear pore complex protein Nup93
K14310 NUP205, NUP192; nuclear pore complex protein Nup205
K14311 NUP188; nuclear pore complex protein Nup188
K14312 NUP155, NUP170, NUP157; nuclear pore complex protein Nup155
K14313 NUP35, NUP53; nuclear pore complex protein Nup53
K14314 NUP210, GP210; nuclear pore complex protein Nup210
K14315 NDC1, TMEM48; nucleoporin NDC1
K14316 POM121, NUP121; nuclear pore complex protein Nup121
K14317 NUP214, CAN; nuclear pore complex protein Nup214
K14318 NUP88; nuclear pore complex protein Nup88
K14319 RANGAP1; Ran GTPase-activating protein 1
K14321 NUPL2, NUP42, CG1; nucleoporin-like protein 2
K14323 CASC3, MLN51; protein CASC3
K14324 SAP18; histone deacetylase complex subunit SAP18
K14325 RNPS1; RNA-binding protein with serine-rich domain 1
K14327 UPF2, RENT2; regulator of nonsense transcripts 2
K14328 UPF3, RENT3; regulator of nonsense transcripts 3
K14543 MTR2; mRNA transport regulator MTR2
K15042 KPNA5_6; importin subunit alpha-6/7
K15043 KPNA2_7; importin subunit alpha-1/8
K15436 TRPO3, MTR10; transportin-3
K18423 CSE1, CAS, XPO2; exportin-2 (importin alpha re-exporter)
K18655 DDX19, DBP5; ATP-dependent RNA helicase DDX19/DBP5 [EC:5.6.2.7 ]
K18717 ASM4, NUP59; nucleoporin ASM4
K18718 NUP60; nucleoporin NUP60
K18720 NUP145; nucleoporin NUP145
K18724 POM34; nucleoporin POM34
K18725 POM152; nucleoporin POM152
K18727 TNPO2, IPO3, KPNB2B; transportin-2
K18752 TNPO1, IPO2, KPNB2; transportin-1
K18755 IPO8, RANBP8; importin-8
K20221 IPO4, RANBP4; importin-4
K20222 IPO5, KPNB3, RANBP5; importin-5
K20223 IPO7, RANBP7; importin-7
K20224 IPO9, RANBP9; importin-9
K20724 TMEM33; transmembrane protein 33
K23583 KPNA3_4; importin subunit alpha-4/3
K23940 KPNA1; importin subunit alpha-5
K24115 RANBP17; Ran-binding protein 17
K25129 AHCTF1, ELYS; protein ELYS
K25201 IPO11, RANBP11; importin-11
K25202 IPO13, RANBP13; importin-13
K25204 XPO6, RANBP20; exportin-6
Reference Authors Tran EJ, Wente SR
Title Dynamic nuclear pore complexes: life on the edge.
Journal Reference Authors Rodriguez MS, Dargemont C, Stutz F
Title Nuclear export of RNA.
Journal Reference Authors Palancade B, Doye V
Title Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
Journal Reference Authors Reed R, Cheng H
Title TREX, SR proteins and export of mRNA.
Journal Reference Authors Tange TO, Shibuya T, Jurica MS, Moore MJ
Title Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
Journal Reference Authors Beck M, Schirmacher P, Singer S
Title Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
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