KEGG   PATHWAY: ko04113
ko04113                     Pathway                                
Meiosis - yeast
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, then segregates from, its homologous pair, while the sister chromatids segregate from each other at meoisis II. In yeast, the switch to enter growth phase or meiosis phase is controlled by nutritional signals. At the onset of meiosis, nutritional signaling pathways converge on transcriptional regulation of Ime1. Ime1 is a transcriptional activator to promote expression of early meiosis-specific genes required for pre-meiotic DNA replication and meiotic recombination. Two of the early meiosis-specific genes, a transcriptional activator, Ndt80, and a CDK2 homolog, Ime2, are required for the transcription of middle meiosis-specific genes, which includes B-type cyclin genes and genes involved in spore wall formation. Polo-like kinase Cdc5, whose expression is activated by Ndt80, is required for the critical step in meiotic progression. Cdc5 regulates sister-kinetochore co-orientation by promoting the localization of Mam1 and Lrs4, components of the co-orientation complex, to kinetochores. Cdc5 also phosphorylates the meiotic cohesin subunit Rec8, which is essential for its cleavage and removal by separase. Moreover, Cdc5 promotes the release of protein phosphatase Cdc14 from the nuclezus, which is required for anaphase I spindle disassembly and exit from meiosis I. The centromeric protein Sgo1 is a key regulator of meiotic chromosome segregation. Sgo1 with PP2A may protect pericentromeric but not arm cohesion of sister chromatids during meiosis I. Sgo1 then disappears at meiosis II to allow sister chromatids to separate.
Cellular Processes; Cell growth and death
Pathway map
ko04113  Meiosis - yeast

Other DBs
GO: 0051321
K07203  serine/threonine-protein kinase mTOR [EC:]
K06646  G1/S-specific cyclin CLN3
K04563  cyclin-dependent kinase [EC:]
K06649  regulatory protein SWI4
K06648  regulatory protein SWI6
K06650  G1/S-specific cyclin CLN2
K09358  mating-type protein A1
K09359  mating-type protein A2
K09235  zinc finger protein RME1
K08139  MFS transporter, SP family, sugar:H+ symporter
K12761  carbon catabolite-derepressing protein kinase [EC:]
K12762  G protein-coupled receptor GPR1
K04630  guanine nucleotide-binding protein G(i) subunit alpha
K07827  GTPase KRas
K01768  adenylate cyclase [EC:]
K04345  protein kinase A [EC:]
K09468  zinc finger protein MSN2/4
K12763  enhanced filamentous growth protein 1
K12764  meiosis-inducing protein 1
K12765  meiosis induction protein kinase IME2/SME1 [EC:]
K03085  substrate and inhibitor of the cyclin-dependent protein kinase CDC28
K06651  S-phase entry cyclin 5/6
K02213  cell division control protein 6
K12414  DNA replication licensing factor, required for pre-replication complex assembly
K02603  origin recognition complex subunit 1
K02604  origin recognition complex subunit 2
K02605  origin recognition complex subunit 3
K02606  origin recognition complex subunit 4
K02607  origin recognition complex subunit 5
K02608  origin recognition complex subunit 6
K02540  DNA replication licensing factor MCM2 [EC:]
K02541  DNA replication licensing factor MCM3 [EC:]
K02212  DNA replication licensing factor MCM4 [EC:]
K02209  DNA replication licensing factor MCM5 [EC:]
K02542  DNA replication licensing factor MCM6 [EC:]
K02210  DNA replication licensing factor MCM7 [EC:]
K06628  cell division control protein 45
K02214  cell division control protein 7 [EC:]
K02309  regulatory subunit for Cdc7p protein kinase
K12766  serine/threonine-protein kinase MDS1/RIM11 [EC:]
K12767  serine/threonine-protein kinase RIM15 [EC:]
K09243  transcriptional regulatory protein UME6
K10878  meiotic recombination protein SPO11
K10872  meiotic recombination protein DMC1
K12768  synaptonemal complex protein ZIP1
K12769  meiosis-specific transcription factor NDT80
K12770  GLC7-interacting protein 1
K12771  sporulation-specific protein 1 [EC:]
K12772  sporulation-specific protein 4
K12773  sporulation-regulated protein 3
K02220  G2/mitotic-specific cyclin 1
K06659  G2/mitotic-specific cyclin 3/4
K06660  cell cycle serine/threonine-protein kinase CDC5/MSD2 [EC:]
K12576  sporulation-specific protein 12
K12575  kinetochore protein SLK19
K06639  cell division cycle 14 [EC:]
K12774  monopolin complex subunit MAM1
K12775  monopolin complex subunit LRS4
K06269  serine/threonine-protein phosphatase PP1 catalytic subunit [EC:]
K12776  meiosis-specific serine/threonine-protein kinase MEK1 [EC:]
K12777  protein RED1
K12778  meiosis-specific protein
K12779  suppressor of MAR1-1 protein
K03114  mitosis inhibitor protein kinase SWE1 [EC:]
K02544  G2-specific checkpoint protein
K06663  DNA damage checkpoint protein
K02830  cell cycle checkpoint protein [EC:]
K06662  cell cycle checkpoint protein
K02543  cell cycle checkpoint protein MEC1
K06661  DNA repair protein RAD9
K02831  ser/thr/tyr protein kinase RAD53 [EC:2.7.11.-]
K02216  serine/threonine-protein kinase CHEK1 [EC:]
K02627  cell cycle regulator
K02365  separase [EC:]
K06636  structural maintenance of chromosome 1
K06669  structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6)
K12780  meiotic recombination protein REC8, fungi type
K06671  cohesin complex subunit SA-1/2
K02537  mitotic spindle assembly checkpoint protein MAD2
K06679  mitotic spindle assembly checkpoint protein MAD1
K03348  anaphase-promoting complex subunit 1
K03349  anaphase-promoting complex subunit 2
K03350  anaphase-promoting complex subunit 3
K03351  anaphase-promoting complex subunit 4
K03352  anaphase-promoting complex subunit 5
K03353  anaphase-promoting complex subunit 6
K03354  anaphase-promoting complex subunit 7
K03355  anaphase-promoting complex subunit 8
K03356  anaphase-promoting complex subunit 9
K03357  anaphase-promoting complex subunit 10
K03358  anaphase-promoting complex subunit 11
K03359  anaphase-promoting complex subunit 12
K12416  anaphase-promoting complex subunit SWM1
K03363  cell division cycle 20, cofactor of APC complex
K02178  checkpoint serine/threonine-protein kinase [EC:]
K11582  shugoshin
K11584  serine/threonine-protein phosphatase 2A regulatory subunit B'
K04382  serine/threonine-protein phosphatase 2A catalytic subunit [EC:]
K03456  serine/threonine-protein phosphatase 2A regulatory subunit A
K12781  anaphase-promoting complex subunit MND2
K12782  meiosis-specific APC/C activator protein AMA1
K12783  sporulation-specific protein 1
K06683  cell division control protein CDC15 [EC:]
C00031  D-Glucose
C00288  HCO3-
C00575  3',5'-Cyclic AMP
Honigberg SM, Purnapatre K
Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast.
J Cell Sci 116:2137-47 (2003)
Kassir Y, Adir N, Boger-Nadjar E, Raviv NG, Rubin-Bejerano I, Sagee S, Shenhar G
Transcriptional regulation of meiosis in budding yeast.
Int Rev Cytol 224:111-71 (2003)
Honigberg SM
Ime2p and Cdc28p: co-pilots driving meiotic development.
J Cell Biochem 92:1025-33 (2004)
Hochwagen A, Amon A
Checking your breaks: surveillance mechanisms of meiotic recombination.
Curr Biol 16:R217-28 (2006)
Hollingsworth NM
Deconstructing meiosis one kinase at a time: polo pushes past pachytene.
Genes Dev 22:2596-600 (2008)
Sourirajan A, Lichten M
Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis.
Genes Dev 22:2627-32 (2008)
Roeder GS, Bailis JM
The pachytene checkpoint.
Trends Genet 16:395-403 (2000)
Barr FA, Sillje HH, Nigg EA
Polo-like kinases and the orchestration of cell division.
Nat Rev Mol Cell Biol 5:429-40 (2004)
Lee BH, Amon A
Polo kinase--meiotic cell cycle coordinator.
Cell Cycle 2:400-2 (2003)
Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Toth A, Nasmyth K
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.
Dev Cell 4:727-39 (2003)
Oelschlaegel T, Schwickart M, Matos J, Bogdanova A, Camasses A, Havlis J, Shevchenko A, Zachariae W
The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.
Cell 120:773-88 (2005)
Dai W, Wang X
The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A.
Cell Div 1:9 (2006)
Clift D, Bizzari F, Marston AL
Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.
Genes Dev 23:766-80 (2009)
Pesin JA, Orr-Weaver TL
Regulation of APC/C activators in mitosis and meiosis.
Annu Rev Cell Dev Biol 24:475-99 (2008)
Diamond AE, Park JS, Inoue I, Tachikawa H, Neiman AM
The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae.
Mol Biol Cell 20:134-45 (2009)
ko04111  Cell cycle - yeast
ko04120  Ubiquitin mediated proteolysis

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