Entry Name Meiosis - yeast
Description During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, then segregates from, its homologous pair, while the sister chromatids segregate from each other at meoisis II. In yeast, the switch to enter growth phase or meiosis phase is controlled by nutritional signals. At the onset of meiosis, nutritional signaling pathways converge on transcriptional regulation of Ime1. Ime1 is a transcriptional activator to promote expression of early meiosis-specific genes required for pre-meiotic DNA replication and meiotic recombination. Two of the early meiosis-specific genes, a transcriptional activator, Ndt80, and a CDK2 homolog, Ime2, are required for the transcription of middle meiosis-specific genes, which includes B-type cyclin genes and genes involved in spore wall formation. Polo-like kinase Cdc5, whose expression is activated by Ndt80, is required for the critical step in meiotic progression. Cdc5 regulates sister-kinetochore co-orientation by promoting the localization of Mam1 and Lrs4, components of the co-orientation complex, to kinetochores. Cdc5 also phosphorylates the meiotic cohesin subunit Rec8, which is essential for its cleavage and removal by separase. Moreover, Cdc5 promotes the release of protein phosphatase Cdc14 from the nuclezus, which is required for anaphase I spindle disassembly and exit from meiosis I. The centromeric protein Sgo1 is a key regulator of meiotic chromosome segregation. Sgo1 with PP2A may protect pericentromeric but not arm cohesion of sister chromatids during meiosis I. Sgo1 then disappears at meiosis II to allow sister chromatids to separate.
Class Cellular Processes; Cell growth and deathBRITE hierarchy
Pathway map Other DBs Orthology K02209 MCM5, CDC46; DNA replication licensing factor MCM5 [EC:5.6.2.3 ]
K02210 MCM7, CDC47; DNA replication licensing factor MCM7 [EC:5.6.2.3 ]
K02212 MCM4, CDC54; DNA replication licensing factor MCM4 [EC:5.6.2.3 ]
K02213 CDC6; cell division control protein 6
K02220 CLB1; G2/mitotic-specific cyclin 1
K02309 DBF4; regulatory subunit for Cdc7p protein kinase
K02537 MAD2; mitotic spindle assembly checkpoint protein MAD2
K02543 MEC1; cell cycle checkpoint protein MEC1
K02544 MEC3; G2-specific checkpoint protein
K02603 ORC1; origin recognition complex subunit 1
K02604 ORC2; origin recognition complex subunit 2
K02605 ORC3; origin recognition complex subunit 3
K02606 ORC4; origin recognition complex subunit 4
K02607 ORC5; origin recognition complex subunit 5
K02608 ORC6; origin recognition complex subunit 6
K02627 PDS1; cell cycle regulator
K02831 RAD53; ser/thr/tyr protein kinase RAD53 [EC:2.7.11.-]
K03085 SIC1; substrate and inhibitor of the cyclin-dependent protein kinase CDC28
K03348 APC1, ANAPC1; anaphase-promoting complex subunit 1
K03349 APC2, ANAPC2; anaphase-promoting complex subunit 2
K03350 APC3, CDC27; anaphase-promoting complex subunit 3
K03351 APC4, ANAPC4; anaphase-promoting complex subunit 4
K03352 APC5, ANAPC5; anaphase-promoting complex subunit 5
K03353 APC6, CDC16; anaphase-promoting complex subunit 6
K03354 APC7, ANAPC7; anaphase-promoting complex subunit 7
K03355 APC8, CDC23; anaphase-promoting complex subunit 8
K03356 APC9; anaphase-promoting complex subunit 9
K03357 APC10, ANAPC10, DOC1; anaphase-promoting complex subunit 10
K03358 APC11, ANAPC11; anaphase-promoting complex subunit 11
K03359 APC12, CDC26; anaphase-promoting complex subunit 12
K03363 CDC20; cell division cycle 20, cofactor of APC complex
K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16 ]
K04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha
K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16 ]
K06628 CDC45; cell division control protein 45
K06636 SMC1; structural maintenance of chromosome 1
K06646 CLN3; G1/S-specific cyclin CLN3
K06648 SWI6; regulatory protein SWI6
K06649 SWI4; regulatory protein SWI4
K06650 CLN2; G1/S-specific cyclin CLN2
K06651 CLB5_6; S-phase entry cyclin 5/6
K06659 CLB3_4; G2/mitotic-specific cyclin 3/4
K06660 CDC5; cell cycle serine/threonine-protein kinase CDC5/MSD2 [EC:2.7.11.21 ]
K06661 RAD9; DNA repair protein RAD9
K06662 HRAD17, RAD24; cell cycle checkpoint protein
K06663 DDC1; DNA damage checkpoint protein
K06669 SMC3, CSPG6; structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6)
K06671 STAG1_2, SCC3, IRR1; cohesin complex subunit SA-1/2
K06679 MAD1; mitotic spindle assembly checkpoint protein MAD1
K07203 MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1 ]
K07827 KRAS, KRAS2; GTPase KRas
K08139 HXT; MFS transporter, SP family, sugar:H+ symporter
K09235 RME1; zinc finger protein RME1
K09243 UME6; transcriptional regulatory protein UME6
K09358 MATA1; mating-type protein A1
K09359 MATA2; mating-type protein A2
K09468 MSN2_4; zinc finger protein MSN2/4
K10872 DMC1; meiotic recombination protein DMC1
K10878 SPO11; meiotic recombination protein SPO11
K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
K12414 TAH11; DNA replication licensing factor, required for pre-replication complex assembly
K12416 SWM1, APC13; anaphase-promoting complex subunit SWM1
K12575 SLK19; kinetochore protein SLK19
K12576 SPO12; sporulation-specific protein 12
K12761 SNF1; carbon catabolite-derepressing protein kinase [EC:2.7.11.1 ]
K12762 GPR1; G protein-coupled receptor GPR1
K12763 EFG1, SOK2; enhanced filamentous growth protein 1
K12764 IME1; meiosis-inducing protein 1
K12766 MDS1, RIM11; serine/threonine-protein kinase MDS1/RIM11 [EC:2.7.11.1 ]
K12768 ZIP1; synaptonemal complex protein ZIP1
K12769 NDT80; meiosis-specific transcription factor NDT80
K12770 GIP1; GLC7-interacting protein 1
K12772 SPS4; sporulation-specific protein 4
K12773 SPR3; sporulation-regulated protein 3
K12774 MAM1; monopolin complex subunit MAM1
K12775 LRS4; monopolin complex subunit LRS4
K12776 MEK1; meiosis-specific serine/threonine-protein kinase MEK1 [EC:2.7.11.1 ]
K12778 HORMAD, HOP1; meiosis-specific protein
K12779 SUM1; suppressor of MAR1-1 protein
K12780 REC8; meiotic recombination protein REC8, fungi type
K12781 MND2; anaphase-promoting complex subunit MND2
K12782 AMA1; meiosis-specific APC/C activator protein AMA1
K12783 SSP1; sporulation-specific protein 1
Compound Reference Authors Honigberg SM, Purnapatre K
Title Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast.
Journal Reference Authors Kassir Y, Adir N, Boger-Nadjar E, Raviv NG, Rubin-Bejerano I, Sagee S, Shenhar G
Title Transcriptional regulation of meiosis in budding yeast.
Journal Reference Authors Honigberg SM
Title Ime2p and Cdc28p: co-pilots driving meiotic development.
Journal Reference Authors Hochwagen A, Amon A
Title Checking your breaks: surveillance mechanisms of meiotic recombination.
Journal Reference Authors Hollingsworth NM
Title Deconstructing meiosis one kinase at a time: polo pushes past pachytene.
Journal Reference Authors Sourirajan A, Lichten M
Title Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis.
Journal Reference Authors Roeder GS, Bailis JM
Title The pachytene checkpoint.
Journal Reference Authors Barr FA, Sillje HH, Nigg EA
Title Polo-like kinases and the orchestration of cell division.
Journal Reference Authors Lee BH, Amon A
Title Polo kinase--meiotic cell cycle coordinator.
Journal Reference Authors Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Toth A, Nasmyth K
Title Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.
Journal Reference Authors Oelschlaegel T, Schwickart M, Matos J, Bogdanova A, Camasses A, Havlis J, Shevchenko A, Zachariae W
Title The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.
Journal Reference Authors Dai W, Wang X
Title The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A.
Journal Reference Authors Clift D, Bizzari F, Marston AL
Title Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.
Journal Reference Authors Pesin JA, Orr-Weaver TL
Title Regulation of APC/C activators in mitosis and meiosis.
Journal Reference Authors Diamond AE, Park JS, Inoue I, Tachikawa H, Neiman AM
Title The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae.
Journal Related ko04120 Ubiquitin mediated proteolysis
