KEGG   PATHWAY: mhas00061
Entry
mhas00061                   Pathway                                
Name
Fatty acid biosynthesis - Mycolicibacterium hassiacum
Class
Metabolism; Lipid metabolism
Pathway map
mhas00061  Fatty acid biosynthesis
mhas00061

Module
mhas_M00082  Fatty acid biosynthesis, initiation [PATH:mhas00061]
mhas_M00083  Fatty acid biosynthesis, elongation [PATH:mhas00061]
mhas_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:mhas00061]
Other DBs
GO: 0006633
Organism
Mycolicibacterium hassiacum [GN:mhas]
Gene
MHAS_00178  [KO:K00645] [EC:2.3.1.39]
MHAS_00267  fabH; 3-oxoacyl-[acyl-carrier-protein] synthase 3 [KO:K00648] [EC:2.3.1.180]
MHAS_00484  accA1_1; Acetyl-/propionyl-coenzyme A carboxylase alpha chain [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
MHAS_00559  [KO:K02160]
MHAS_00735  fadD_1; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
MHAS_00792  [KO:K02371] [EC:1.3.1.9]
MHAS_00805  fabG2_2; putative oxidoreductase [KO:K00059] [EC:1.1.1.100]
MHAS_00821  fabG_1; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
MHAS_01083  fabY; Beta-ketoacyl-[acyl-carrier-protein] synthase FabY [KO:K11533] [EC:2.3.1.-]
MHAS_01399  lcfB_5; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
MHAS_01447  accD6; putative propionyl-CoA carboxylase beta chain 6 [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
MHAS_01451  fabD; Malonyl CoA-acyl carrier protein transacylase [KO:K00645] [EC:2.3.1.39]
MHAS_01521  [KO:K01897] [EC:6.2.1.3]
MHAS_02393  [KO:K00059] [EC:1.1.1.100]
MHAS_02596  fabG_4; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
MHAS_02615  fabG_5; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
MHAS_02641  menE_1; 2-succinylbenzoate--CoA ligase [KO:K01897] [EC:6.2.1.3]
MHAS_02970  fabG_6; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
MHAS_02990  lcfB_12; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
MHAS_03076  fabG_8; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
MHAS_03092  lcfB_13; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
MHAS_03227  desA2; Putative acyl-[acyl-carrier-protein] desaturase DesA2 [KO:K03922] [EC:1.14.19.2 1.14.19.-]
MHAS_03582  desA1; Putative acyl-[acyl-carrier-protein] desaturase DesA1 [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
MHAS_03967  fabG_13; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
MHAS_04051  fabG_16; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
MHAS_04271  lcfB_17; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
MHAS_04576  fabG_17; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
MHAS_04979  [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
mhas00020  Citrate cycle (TCA cycle)
mhas00071  Fatty acid degradation
mhas00074  Mycolic acid biosynthesis
mhas00410  beta-Alanine metabolism
mhas00561  Glycerolipid metabolism
mhas00564  Glycerophospholipid metabolism
mhas00620  Pyruvate metabolism
mhas00785  Lipoic acid metabolism
KO pathway
ko00061   

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