KEGG   PATHWAY: mshg00290
Entry
mshg00290                   Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Mycobacterium shigaense
Class
Metabolism; Amino acid metabolism
Pathway map
mshg00290  Valine, leucine and isoleucine biosynthesis
mshg00290

Module
mshg_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:mshg00290]
mshg_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:mshg00290]
mshg_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:mshg00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Mycobacterium shigaense [GN:mshg]
Gene
MSG_00236  ilvB; acetolactate synthase I/II/III large subunit [KO:K01652] [EC:2.2.1.6]
MSG_00378  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
MSG_00428  [KO:K01652] [EC:2.2.1.6]
MSG_00541  [KO:K14260] [EC:2.6.1.66 2.6.1.2]
MSG_01571  ilvB1; acetolactate synthase large subunit IlvB1 [KO:K01652] [EC:2.2.1.6]
MSG_01572  ilvH; putative acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
MSG_01573  ilvC; ketol-acid reductoisomerase (NADP(+)) [KO:K00053] [EC:1.1.1.86]
MSG_01577  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
MSG_01585  leuC_1; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
MSG_01586  leuD_1; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
MSG_02049  leuD_2; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
MSG_02050  leuC1; 3-isopropylmalate dehydratase large subunit 1 [KO:K01703] [EC:4.2.1.33 4.2.1.35]
MSG_02229  ilvA; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
MSG_02406  leuD_3; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
MSG_02407  leuC_2; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
MSG_03103  ilvE; branched-chain-amino-acid aminotransferase [KO:K00826] [EC:2.6.1.42]
MSG_03432  leuC_3; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
MSG_03433  leuD_4; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
MSG_04494  ilvX; hypothetical protein [KO:K01652] [EC:2.2.1.6]
MSG_04718  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
mshg00260  Glycine, serine and threonine metabolism
mshg00280  Valine, leucine and isoleucine degradation
mshg00620  Pyruvate metabolism
KO pathway
ko00290   

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