KEGG   PATHWAY: ncx00061
Entry
ncx00061                    Pathway                                
Name
Fatty acid biosynthesis - Nonomuraea coxensis
Class
Metabolism; Lipid metabolism
Pathway map
ncx00061  Fatty acid biosynthesis
ncx00061

Module
ncx_M00082  Fatty acid biosynthesis, initiation [PATH:ncx00061]
ncx_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:ncx00061]
Other DBs
GO: 0006633
Organism
Nonomuraea coxensis [GN:ncx]
Gene
Nocox_03145  fabG1; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
Nocox_04735  fabG4; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
Nocox_04950  [KO:K00645] [EC:2.3.1.39]
Nocox_05380  cfiB1; 2-oxoglutarate carboxylase small subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
Nocox_06490  [KO:K01897] [EC:6.2.1.3]
Nocox_06565  lcfB1; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Nocox_09645  fabG9; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
Nocox_09820  fabG10; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
Nocox_12420  fabF1; 3-oxoacyl-[acyl-carrier-protein] synthase 2 [KO:K09458] [EC:2.3.1.179]
Nocox_12740  accC1; Biotin carboxylase [KO:K01961] [EC:6.4.1.2 6.3.4.14]
Nocox_12745  accB1; Biotin carboxyl carrier protein of acetyl-CoA carboxylase [KO:K02160]
Nocox_12770  fabG12; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
Nocox_12815  fabG13; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
Nocox_13490  fabG15; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
Nocox_14775  [KO:K01897] [EC:6.2.1.3]
Nocox_17310  [KO:K01897] [EC:6.2.1.3]
Nocox_17430  desA1; Putative acyl-[acyl-carrier-protein] desaturase desA1 [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
Nocox_17970  fabG17; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
Nocox_19740  baiB; Bile acid-coenzyme A ligase [KO:K01897] [EC:6.2.1.3]
Nocox_19770  cfiB2; 2-oxoglutarate carboxylase small subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
Nocox_20910  fabG20; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
Nocox_20920  fabG21; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
Nocox_20945  lcfB8; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Nocox_23790  lcfB10; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Nocox_25525  pksC; Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase PksC [KO:K00645] [EC:2.3.1.39]
Nocox_25545  fabF2; 3-oxoacyl-[acyl-carrier-protein] synthase 2 [KO:K09458] [EC:2.3.1.179]
Nocox_25555  fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [KO:K02372] [EC:4.2.1.59]
Nocox_25565  fabG23; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
Nocox_25660  accD3; putative propionyl-CoA carboxylase beta chain 6 [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
Nocox_26325  fabG24; 3-oxoacyl-[acyl-carrier-protein] reductase FabG1 [KO:K00059] [EC:1.1.1.100]
Nocox_27725  fabG25; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
Nocox_30550  [KO:K01897] [EC:6.2.1.3]
Nocox_31020  fabD; Malonyl CoA-acyl carrier protein transacylase [KO:K00645] [EC:2.3.1.39]
Nocox_31025  fabH4; 3-oxoacyl-[acyl-carrier-protein] synthase 3 [KO:K00648] [EC:2.3.1.180]
Nocox_31035  fabF3; 3-oxoacyl-[acyl-carrier-protein] synthase 2 [KO:K09458] [EC:2.3.1.179]
Nocox_31040  accD6; putative propionyl-CoA carboxylase beta chain 6 [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
Nocox_31465  lcfB12; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Nocox_31515  ped; (S)-1-Phenylethanol dehydrogenase [KO:K00059] [EC:1.1.1.100]
Nocox_32115  bdcA1; Cyclic-di-GMP-binding biofilm dispersal mediator protein [KO:K00059] [EC:1.1.1.100]
Nocox_32160  bdcA2; Cyclic-di-GMP-binding biofilm dispersal mediator protein [KO:K00059] [EC:1.1.1.100]
Nocox_33525  accC2; Biotin carboxylase [KO:K01961] [EC:6.4.1.2 6.3.4.14]
Nocox_33530  accB2; Biotin carboxyl carrier protein of acetyl-CoA carboxylase [KO:K02160]
Nocox_36025  [KO:K02160]
Nocox_36030  accA5; Acetyl-/propionyl-coenzyme A carboxylase alpha chain [KO:K01961] [EC:6.4.1.2 6.3.4.14]
Nocox_37275  [KO:K09458] [EC:2.3.1.179]
Nocox_38110  [KO:K01897] [EC:6.2.1.3]
Nocox_38225  fabG27; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
Nocox_39025  fadD; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Nocox_40350  lcfB14; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
PMID:12061798
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
PMID:12518017
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
PMID:11337402
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
PMID:17573542
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
PMID:30201289
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
PMID:25203508
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
PMID:19686777
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
PMID:27553474
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
ncx00020  Citrate cycle (TCA cycle)
ncx00071  Fatty acid degradation
ncx00074  Mycolic acid biosynthesis
ncx00410  beta-Alanine metabolism
ncx00561  Glycerolipid metabolism
ncx00564  Glycerophospholipid metabolism
ncx00620  Pyruvate metabolism
ncx00785  Lipoic acid metabolism
KO pathway
ko00061   

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