NETWORK: N00433
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Entry
N00433 Network
Name
CXCR4-GNB/G-RAC signaling pathway
Definition
CXCL12 -> CXCR4 -> GNB/G -> RAC -> PAK1 -> LIMK1 -> CFL
Expanded
6387 -> 7852 -> (2782,
2783,
2784,
59345,
10681,
54331,
2785,
2786,
2787,
2788,
94235,
2790,
2791,
55970,
51764,
2792,
2793) -> (5879,
5880,
5881) -> 5058 -> 3984 -> (1072,
1073)
Class
nt06161
Human immunodeficiency virus 1 (HIV-1)
Type
Reference
Pathway
hsa04062
Chemokine signaling pathway
Gene
6387
CXCL12; C-X-C motif chemokine ligand 12
7852
CXCR4; C-X-C motif chemokine receptor 4
2782
GNB1; G protein subunit beta 1
2783
GNB2; G protein subunit beta 2
2784
GNB3; G protein subunit beta 3
59345
GNB4; G protein subunit beta 4
10681
GNB5; G protein subunit beta 5
54331
GNG2; G protein subunit gamma 2
2785
GNG3; G protein subunit gamma 3
2786
GNG4; G protein subunit gamma 4
2787
GNG5; G protein subunit gamma 5
2788
GNG7; G protein subunit gamma 7
94235
GNG8; G protein subunit gamma 8
2790
GNG10; G protein subunit gamma 10
2791
GNG11; G protein subunit gamma 11
55970
GNG12; G protein subunit gamma 12
51764
GNG13; G protein subunit gamma 13
2792
GNGT1; G protein subunit gamma transducin 1
2793
GNGT2; G protein subunit gamma transducin 2
5879
RAC1; Rac family small GTPase 1
5880
RAC2; Rac family small GTPase 2
5881
RAC3; Rac family small GTPase 3
5058
PAK1; p21 (RAC1) activated kinase 1
3984
LIMK1; LIM domain kinase 1
1072
CFL1; cofilin 1
1073
CFL2; cofilin 2
Reference
PMID:
20041213
Authors
Wu Y, Yoder A
Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
Journal
PLoS Pathog 5:e1000520 (2009)
DOI:
10.1371/journal.ppat.1000520
Reference
PMID:
11784854
Authors
Nishita M, Aizawa H, Mizuno K
Title
Stromal cell-derived factor 1alpha activates LIM kinase 1 and induces cofilin phosphorylation for T-cell chemotaxis.
Journal
Mol Cell Biol 22:774-83 (2002)
DOI:
10.1128/MCB.22.3.774-783.2002
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