KEGG T01001: 6387

Homo sapiens (human): 6387

Entry

6387              CDS       T01001

Symbol

CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B

Name

(RefSeq) C-X-C motif chemokine ligand 12

K10031

C-X-C motif chemokine 12

Organism

hsa Homo sapiens (human)

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04061

Viral protein interaction with cytokine and cytokine receptor

hsa04062

Chemokine signaling pathway

hsa04064

NF-kappa B signaling pathway

hsa04360

Axon guidance

hsa04670

Leukocyte transendothelial migration

hsa04672

Intestinal immune network for IgA production

hsa04810

Regulation of actin cytoskeleton

hsa05163

Human cytomegalovirus infection

hsa05200

Pathways in cancer

hsa05323

Rheumatoid arthritis

Network

nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06227  Nuclear receptor signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06533  Chemokine signaling

Element

N00401

CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway

N00405

CXCR4-GNA12/13-Rho signaling pathway

N00413

CXCR4-GNB/G-PLCB-PKC signaling pathway

N00430

CXCR4-GNAI-PI3K-BAD signaling pathway

N00433

CXCR4-GNB/G-RAC signaling pathway

N00546

CXCL12-CXCR4-PKC-ERK signaling pathaway

N01362

Nuclear-initiated progesterone signaling pathway

N01765

CXCR4-GNAQ-PLCB/G signaling pathway

N01767

CXCR4-GNAI-Src signaling pathway

N01768

CXCR4-GNA12/13 signaling pathway

N01771

CXCR4-GNB/G signaling pathway

Disease

H01563

HIV infection

Drug target

Olaptesed pegol:

D12655

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    6387 (CXCL12)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    6387 (CXCL12)
   04061 Viral protein interaction with cytokine and cytokine receptor
    6387 (CXCL12)
09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    6387 (CXCL12)
09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    6387 (CXCL12)
   04672 Intestinal immune network for IgA production
    6387 (CXCL12)
   04062 Chemokine signaling pathway
    6387 (CXCL12)
  09158 Development and regeneration
   04360 Axon guidance
    6387 (CXCL12)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6387 (CXCL12)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    6387 (CXCL12)
  09163 Immune disease
   05323 Rheumatoid arthritis
    6387 (CXCL12)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    6387 (CXCL12)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    6387 (CXCL12)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Chemokines
   6387 (CXCL12)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
  Chemokines
   6387 (CXCL12)

SSDB

Motif

Pfam:

IL8

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

10:complement(44370165..44385097)

AA seq 93 aa
MNAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIV
ARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM

NT seq 282 nt +upstreamnt +downstreamnt
atgaacgccaaggtcgtggtcgtgctggtcctcgtgctgaccgcgctctgcctcagcgac
gggaagcccgtcagcctgagctacagatgcccatgccgattcttcgaaagccatgttgcc
agagccaacgtcaagcatctcaaaattctcaacactccaaactgtgcccttcagattgta
gcccggctgaagaacaacaacagacaagtgtgcattgacccgaagctaaagtggattcag
gagtacctggagaaagctttaaacaagaggttcaagatgtga

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