KEGG   PATHWAY: nth00260
Entry
nth00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Natranaerobius thermophilus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
nth00260  Glycine, serine and threonine metabolism
nth00260

Module
nth_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:nth00260]
nth_M00621  Glycine cleavage system [PATH:nth00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Natranaerobius thermophilus [GN:nth]
Gene
Nther_1458  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Nther_0670  aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Nther_1273  aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Nther_0669  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Nther_0910  homoserine kinase [KO:K00872] [EC:2.7.1.39]
Nther_0909  L-threonine synthase [KO:K01733] [EC:4.2.3.1]
Nther_2066  Pyridoxal-5'-phosphate-dependent protein beta subunit [KO:K01733] [EC:4.2.3.1]
Nther_0544  L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
Nther_2858  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Nther_0871  glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
Nther_2016  phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
Nther_0292  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
Nther_0293  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
Nther_2749  glycine dehydrogenase (decarboxylating) alpha subunit [KO:K00282] [EC:1.4.4.2]
Nther_2748  glycine dehydrogenase (decarboxylating) beta subunit [KO:K00283] [EC:1.4.4.2]
Nther_2751  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
Nther_2180  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Nther_2747  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Nther_0582  pyridine nucleotide-disulphide oxidoreductase dimerisation region [KO:K00382] [EC:1.8.1.4]
Nther_2750  glycine cleavage system H protein [KO:K02437]
Nther_0160  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
Nther_2054  iron-containing alcohol dehydrogenase [KO:K11440] [EC:1.1.1.1]
Nther_0677  Methyltransferase type 11 [KO:K18896] [EC:2.1.1.156]
Nther_0676  Methyltransferase type 11 [KO:K18897] [EC:2.1.1.157]
Nther_2853  L-serine dehydratase, iron-sulfur-dependent, beta subunit [KO:K01752] [EC:4.3.1.17]
Nther_2854  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
Nther_2160  hypothetical protein [KO:K01752] [EC:4.3.1.17]
Nther_0720  tryptophan synthase, beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
nth00010  Glycolysis / Gluconeogenesis
nth00020  Citrate cycle (TCA cycle)
nth00230  Purine metabolism
nth00250  Alanine, aspartate and glutamate metabolism
nth00270  Cysteine and methionine metabolism
nth00290  Valine, leucine and isoleucine biosynthesis
nth00300  Lysine biosynthesis
nth00330  Arginine and proline metabolism
nth00460  Cyanoamino acid metabolism
nth00470  D-Amino acid metabolism
nth00564  Glycerophospholipid metabolism
nth00620  Pyruvate metabolism
nth00630  Glyoxylate and dicarboxylate metabolism
nth00640  Propanoate metabolism
nth00680  Methane metabolism
nth00860  Porphyrin metabolism
nth00920  Sulfur metabolism
KO pathway
ko00260   
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