KEGG   PATHWAY: oas04721
Entry
oas04721                    Pathway                                
Name
Synaptic vesicle cycle - Ovis aries (sheep)
Description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class
Organismal Systems; Nervous system
Pathway map
oas04721  Synaptic vesicle cycle
oas04721

Other DBs
GO: 0016079 0048488
Organism
Ovis aries (sheep) [GN:oas]
Gene
101102025  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
101102111  CPLX4; complexin-4 [KO:K15295]
101102659  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
101102712  SYT1; synaptotagmin-1 isoform X1 [KO:K15290]
101103306  STXBP1; syntaxin-binding protein 1 isoform X1 [KO:K15292]
101103310  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
101103451  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
101104057  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 isoform X1 [KO:K02154]
101104796  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
101104980  SLC17A8; vesicular glutamate transporter 3 [KO:K12302]
101105268  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
101105536  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
101106572  CLTA; clathrin light chain A isoform X1 [KO:K04644]
101107114  CLTC; clathrin heavy chain 1 isoform X2 [KO:K04646]
101107117  DNM3; dynamin-3 isoform X3 [KO:K01528] [EC:3.6.5.5]
101107683  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
101107797  RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X43 [KO:K15291]
101107906  [KO:K11826]
101108392  CPLX2; complexin-2 [KO:K15294]
101108422  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
101108426  CPLX3; complexin-3 [KO:K15295]
101108509  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X2 [KO:K02146]
101108589  SNAP25; synaptosomal-associated protein 25 isoform X1 [KO:K18211]
101108595  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
101108737  DNM1; dynamin-1 isoform X5 [KO:K01528] [EC:3.6.5.5]
101109534  RAB3A; ras-related protein Rab-3A [KO:K07882]
101110043  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
101111194  CPLX1; complexin-1 [KO:K15294]
101111653  SLC17A7; vesicular glutamate transporter 1 [KO:K12302]
101111908  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
101112431  SLC17A6; vesicular glutamate transporter 2 [KO:K12302]
101112696  STX1A; syntaxin-1A isoform X1 [KO:K04560]
101112724  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
101113184  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
101113435  STX3; syntaxin-3 isoform X2 [KO:K08486]
101113504  ATP6V1H; V-type proton ATPase subunit H isoform X2 [KO:K02144]
101113588  UNC13A; protein unc-13 homolog A isoform X2 [KO:K15293]
101114221  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X2 [KO:K03661]
101114770  SLC6A12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045]
101115027  DNM2; dynamin-2 isoform X5 [KO:K23484]
101115974  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
101116078  SLC6A2; sodium-dependent noradrenaline transporter [KO:K05035]
101116777  [KO:K02149]
101117328  CLTB; clathrin light chain B isoform X2 [KO:K04645]
101117677  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
101117731  UNC13B; protein unc-13 homolog B isoform X1 [KO:K15293]
101118063  SLC1A7; excitatory amino acid transporter 5 [KO:K05618]
101118731  STX2; syntaxin-2 isoform X7 [KO:K08486]
101119072  NAPA; alpha-soluble NSF attachment protein [KO:K15296]
101119630  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X2 [KO:K05046]
101120344  NSF; vesicle-fusing ATPase isoform X6 [KO:K06027] [EC:3.6.4.6]
101120368  SLC6A5; sodium- and chloride-dependent glycine transporter 2 [KO:K05038]
101120920  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
101121091  SLC1A6; excitatory amino acid transporter 4 isoform X1 [KO:K05617]
101121176  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
101121462  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
101121491  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
101121550  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
101121898  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
101122020  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
101122320  AP2M1; AP-2 complex subunit mu isoform X2 [KO:K11826]
101122445  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
101122451  VAMP2; vesicle-associated membrane protein 2 [KO:K13504]
101122460  AP2S1; AP-2 complex subunit sigma [KO:K11827]
101122774  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101123296  SLC6A7; sodium-dependent proline transporter isoform X2 [KO:K05040]
101123332  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
101123470  UNC13C; protein unc-13 homolog C [KO:K15293]
101123476  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X3 [KO:K02154]
101123606  [KO:K02149]
105605099  SLC18A3; vesicular acetylcholine transporter [KO:K14636]
105606027  SLC6A9; sodium- and chloride-dependent glycine transporter 1 isoform X2 [KO:K05038]
114117536  [KO:K11826]
114117541  [KO:K11826]
443003  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
443246  SLC1A3; excitatory amino acid transporter 1 isoform X1 [KO:K05614]
443247  SLC1A2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
443479  STX1B; syntaxin-1B [KO:K08486]
443491  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
443514  SLC1A1; excitatory amino acid transporter 3 [KO:K05612]
494438  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
494439  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
Compound
C00002  ATP
C00025  L-Glutamate
C00037  Glycine
C00076  Calcium cation
C00080  H+
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00780  Serotonin
C01996  Acetylcholine
C03758  Dopamine
C16041  Leu-enkephalin
Reference
PMID:12827282
  Authors
Li L, Chin LS
  Title
The molecular machinery of synaptic vesicle exocytosis.
  Journal
Cell Mol Life Sci 60:942-60 (2003)
DOI:10.1007/s00018-003-2240-7
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
PMID:18275379
  Authors
Chapman ER
  Title
How does synaptotagmin trigger neurotransmitter release?
  Journal
Annu Rev Biochem 77:615-41 (2008)
DOI:10.1146/annurev.biochem.77.062005.101135
Reference
PMID:10212473
  Authors
Benfenati F, Onofri F, Giovedi S
  Title
Protein-protein interactions and protein modules in the control of neurotransmitter release.
  Journal
Philos Trans R Soc Lond B Biol Sci 354:243-57 (1999)
DOI:10.1098/rstb.1999.0376
Reference
PMID:20634814
  Authors
de Saint Basile G, Menasche G, Fischer A
  Title
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
  Journal
Nat Rev Immunol 10:568-79 (2010)
DOI:10.1038/nri2803
Reference
PMID:17767192
  Authors
Carr CM, Munson M
  Title
Tag team action at the synapse.
  Journal
EMBO Rep 8:834-8 (2007)
DOI:10.1038/sj.embor.7401051
Reference
PMID:15217342
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle.
  Journal
Annu Rev Neurosci 27:509-47 (2004)
DOI:10.1146/annurev.neuro.26.041002.131412
Reference
PMID:12563290
  Authors
Gundelfinger ED, Kessels MM, Qualmann B
  Title
Temporal and spatial coordination of exocytosis and endocytosis.
  Journal
Nat Rev Mol Cell Biol 4:127-39 (2003)
DOI:10.1038/nrm1016
Reference
PMID:16990140
  Authors
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
  Title
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
  Journal
Cell 126:1175-87 (2006)
DOI:10.1016/j.cell.2006.08.030
Reference
PMID:12094216
  Authors
Chapman ER
  Title
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
  Journal
Nat Rev Mol Cell Biol 3:498-508 (2002)
DOI:10.1038/nrm855
Reference
PMID:7791897
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle: a cascade of protein-protein interactions.
  Journal
Nature 375:645-53 (1995)
DOI:10.1038/375645a0
Reference
PMID:12154365
  Authors
Rizo J, Sudhof TC
  Title
Snares and Munc18 in synaptic vesicle fusion.
  Journal
Nat Rev Neurosci 3:641-53 (2002)
DOI:10.1038/nrn898
Reference
PMID:18726177
  Authors
Malsam J, Kreye S, Sollner TH
  Title
Membrane fusion: SNAREs and regulation.
  Journal
Cell Mol Life Sci 65:2814-32 (2008)
DOI:10.1007/s00018-008-8352-3
Related
pathway
oas04144  Endocytosis
oas04724  Glutamatergic synapse
oas04725  Cholinergic synapse
oas04726  Serotonergic synapse
oas04727  GABAergic synapse
oas04728  Dopaminergic synapse
KO pathway
ko04721   

DBGET integrated database retrieval system