KEGG   PATHWAY: omc00533
Entry
omc00533                    Pathway                                
Name
Glycosaminoglycan biosynthesis - keratan sulfate - Onychostoma macrolepis
Description
Keratan sulfate (KS) is a glycosaminoglycan with the basic disaccharide unit of N-acetyllactosamine, Gal(b1-4)GlcNAc(b1-3), with sulfate esters at C-6 of GlcNAc and Gal residues. There are two types of KS distinguished by the protein linkage: type I for N-linked via the N-glycan core structure and type II for O-linked via the O-glycan core 2 structure.
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
omc00533  Glycosaminoglycan biosynthesis - keratan sulfate
omc00533

Other DBs
GO: 0018146
Organism
Onychostoma macrolepis [GN:omc]
Gene
131523000  fut8a; alpha-(1,6)-fucosyltransferase [KO:K00717] [EC:2.4.1.68]
131526835  fut8b; alpha-(1,6)-fucosyltransferase isoform X1 [KO:K00717] [EC:2.4.1.68]
131548760  b4galt1; beta-1,4-galactosyltransferase 1 isoform X1 [KO:K07966] [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
131553294  b4galt1l; beta-1,4-galactosyltransferase 1 [KO:K07966] [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
131521286  b4galt2; beta-1,4-galactosyltransferase 2 [KO:K07967] [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
131532058  b4galt3; beta-1,4-galactosyltransferase 3 [KO:K07968] [EC:2.4.1.90 2.4.1.38 2.4.1.-]
131521700  si:dkey-199f5.8; beta-1,4-galactosyltransferase 3 [KO:K07968] [EC:2.4.1.90 2.4.1.38 2.4.1.-]
131522866  b3gnt2b; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 [KO:K00741] [EC:2.4.1.149]
131548999  b3gnt2a; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2a [KO:K00741] [EC:2.4.1.149]
131553115  si:dkey-160o24.3; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 isoform X1 [KO:K00741] [EC:2.4.1.149]
131529103  si:dkey-175m17.6; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 [KO:K00741] [EC:2.4.1.149]
131534006  chst6; carbohydrate sulfotransferase 6 [KO:K09671] [EC:2.8.2.-]
131540386  b4galt4; beta-1,4-galactosyltransferase 4 [KO:K07969] [EC:2.4.1.90 2.4.1.275 2.4.1.-]
131545442  b3gnt7l; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7, like [KO:K09664] [EC:2.4.1.-]
131530586  b3gnt7; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 [KO:K09664] [EC:2.4.1.-]
131523914  si:ch73-62b13.1; carbohydrate sulfotransferase 1-like [KO:K01022] [EC:2.8.2.21]
131533924  chst1; carbohydrate sulfotransferase 1 [KO:K01022] [EC:2.8.2.21]
131534562  carbohydrate sulfotransferase 1 [KO:K01022] [EC:2.8.2.21]
131542160  st3gal3a; LOW QUALITY PROTEIN: ST3 beta-galactoside alpha-2,3-sialyltransferase 3a [KO:K00781] [EC:2.4.3.6]
131552715  st3gal3b; ST3 beta-galactoside alpha-2,3-sialyltransferase 3b isoform X1 [KO:K00781] [EC:2.4.3.6]
131533445  chst2b; LOW QUALITY PROTEIN: carbohydrate sulfotransferase 2 [KO:K04745] [EC:2.8.2.-]
131527228  chst2a; carbohydrate sulfotransferase 2a [KO:K04745] [EC:2.8.2.-]
131526454  CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1-like isoform X1 [KO:K00780] [EC:2.4.3.2 2.4.3.4]
131524134  st3gal2; CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2 [KO:K03368] [EC:2.4.3.2 2.4.3.4]
Reference
PMID:11030741
  Authors
Funderburgh JL.
  Title
Keratan sulfate: structure, biosynthesis, and function.
  Journal
Glycobiology 10:951-958 (2000)
DOI:10.1093/glycob/10.10.951
Reference
PMID:14706853
  Authors
Seko A, Yamashita K.
  Title
beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans.
  Journal
FEBS Lett 556:216-20 (2004)
DOI:10.1016/S0014-5793(03)01440-6
Reference
PMID:12511560
  Authors
Seko A, Dohmae N, Takio K, Yamashita K.
  Title
Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.
  Journal
J Biol Chem 278:9150-8 (2003)
DOI:10.1074/jbc.M211480200
Related
pathway
omc00510  N-Glycan biosynthesis
omc00512  Mucin type O-glycan biosynthesis
KO pathway
ko00533   
LinkDB

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