KEGG   PATHWAY: pale03013
Entry
pale03013                   Pathway                                
Name
Nucleocytoplasmic transport - Pteropus alecto (black flying fox)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pale03013  Nucleocytoplasmic transport
pale03013

Other DBs
GO: 0050658
Organism
Pteropus alecto (black flying fox) [GN:pale]
Gene
102894790  AAAS; aladin isoform X1 [KO:K14320]
102896943  NUPL2; nucleoporin-like protein 2 [KO:K14321]
102899018  GLE1; nucleoporin GLE1 [KO:K18723]
102895835  DDX19A; ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
102896096  ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
102881845  RAE1; mRNA export factor [KO:K14298]
102892943  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
102896624  NUP214; nuclear pore complex protein Nup214 isoform X2 [KO:K14317]
102887786  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
102896535  LOW QUALITY PROTEIN: E3 SUMO-protein ligase RanBP2 [KO:K12172] [EC:2.3.2.-]
102892938  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
102889818  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
102879873  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
102880854  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
102881065  SUMO1; small ubiquitin-related modifier 1 isoform X1 [KO:K12160]
102896346  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
102880414  NUP85; nuclear pore complex protein Nup85 isoform X2 [KO:K14304]
102889166  SEC13; protein SEC13 homolog [KO:K14004]
102894609  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
102885861  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
102879485  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
102897041  NUP43; nucleoporin Nup43 isoform X1 [KO:K14305]
102891538  NUP37; nucleoporin Nup37 [KO:K14302]
102881553  AHCTF1; protein ELYS isoform X1 [KO:K25129]
102897282  NUP62CL; nucleoporin-62 C-terminal-like protein isoform X1 [KO:K14306]
102897147  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
102894500  NUP58; nucleoporin p58/p45 isoform X2 [KO:K14307]
102879893  NUP54; nucleoporin p54 isoform X2 [KO:K14308]
102884314  NUP205; LOW QUALITY PROTEIN: nuclear pore complex protein Nup205 [KO:K14310]
102891394  NUP188; nucleoporin NUP188 homolog [KO:K14311]
102882665  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
102886982  NUP93; nuclear pore complex protein Nup93 [KO:K14309]
102878935  NUP35; nucleoporin NUP35 isoform X1 [KO:K14313]
102887521  NDC1; nucleoporin NDC1 isoform X2 [KO:K14315]
102887767  NUP210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
102878776  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
102889445  POM121L2; POM121-like protein 2 [KO:K14316]
102893923  nuclear envelope pore membrane protein POM 121C [KO:K14316]
102882720  nuclear envelope pore membrane protein POM 121C-like [KO:K14316]
112477213  nuclear envelope pore membrane protein POM 121 [KO:K14316]
102883598  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
102887317  TPR; LOW QUALITY PROTEIN: nucleoprotein TPR [KO:K09291]
102879853  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
102889895  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
102881618  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
102887970  KPNA1; importin subunit alpha-5 [KO:K23940]
102894994  KPNA2; importin subunit alpha-1 [KO:K15043]
102898052  KPNA7; importin subunit alpha-8 [KO:K15043]
102886311  KPNA4; importin subunit alpha-3 isoform X2 [KO:K23583]
102890874  KPNA3; importin subunit alpha-4 [KO:K23583]
102882784  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
102893622  KPNA6; importin subunit alpha-7 isoform X3 [KO:K15042]
102894799  KPNB1; importin subunit beta-1 [KO:K14293]
102885999  TNPO1; transportin-1 isoform X1 [KO:K18752]
102878425  TNPO2; transportin-2 isoform X1 [KO:K18727]
102893153  TNPO3; transportin-3 isoform X1 [KO:K15436]
102894748  IPO4; importin-4 [KO:K20221]
102895076  IPO5; importin-5 [KO:K20222]
102885552  IPO7; importin-7 isoform X1 [KO:K20223]
102880417  IPO8; importin-8 isoform X1 [KO:K18755]
102894351  IPO9; importin-9 [KO:K20224]
102880986  IPO11; importin-11 isoform X2 [KO:K25201]
102883559  IPO13; importin-13 isoform X1 [KO:K25202]
102886112  SNUPN; snurportin-1 [KO:K13151]
102881186  XPO1; exportin-1 isoform X1 [KO:K14290]
102893363  CSE1L; exportin-2 [KO:K18423]
102878608  XPOT; exportin-T [KO:K14288]
102886618  XPO4; LOW QUALITY PROTEIN: exportin-4 [KO:K25203]
102892161  XPO5; exportin-5 isoform X1 [KO:K14289]
102883991  XPO6; LOW QUALITY PROTEIN: exportin-6 [KO:K25204]
102893616  XPO7; exportin-7 [KO:K18460]
102893875  RANBP17; ran-binding protein 17 isoform X2 [KO:K24115]
102893000  RAN; GTP-binding nuclear protein Ran [KO:K07936]
102882869  EEF1A1; LOW QUALITY PROTEIN: elongation factor 1-alpha 1 [KO:K03231]
102895186  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
102897478  elongation factor 1-alpha 1 [KO:K03231]
102893501  PHAX; phosphorylated adapter RNA export protein isoform X1 [KO:K14291]
102884320  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
102887305  NCBP2; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2 [KO:K12883]
102896797  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
102884986  NMD3; 60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
102896820  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
102880566  protein mago nashi homolog 2 isoform X1 [KO:K12877]
102886768  MAGOH; protein mago nashi homolog [KO:K12877]
102882114  CASC3; protein CASC3 [KO:K14323]
102885580  EIF4A3; eukaryotic initiation factor 4A-III isoform X1 [KO:K13025] [EC:5.6.2.7]
102883827  LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
102886868  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
102877902  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
102886168  PNN; pinin [KO:K13114]
102888897  ALYREF; THO complex subunit 4 [KO:K12881]
102884453  UPF1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
102894458  UPF2; regulator of nonsense transcripts 2 isoform X2 [KO:K14327]
102879573  UPF3A; regulator of nonsense transcripts 3A isoform X9 [KO:K14328]
102892473  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
102888158  nuclear RNA export factor 2 [KO:K14284]
102898356  NXF3; nuclear RNA export factor 3 [KO:K14284]
102887246  NXF1; nuclear RNA export factor 1 [KO:K14284]
102882095  nuclear RNA export factor 2 [KO:K14284]
102897103  NXT1; NTF2-related export protein 1 [KO:K14285]
102879117  NTF2-related export protein 2 [KO:K14285]
102888540  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
102885635  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
102892994  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
102880532  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
102884929  THOC2; THO complex subunit 2 isoform X7 [KO:K12879]
102886125  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
102893165  THOC6; THO complex subunit 6 homolog [KO:K13175]
102881824  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pale03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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