KEGG   PATHWAY: aaqu00290
Entry
aaqu00290                   Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Alcaligenes aquatilis
Class
Metabolism; Amino acid metabolism
Pathway map
aaqu00290  Valine, leucine and isoleucine biosynthesis
aaqu00290

Module
aaqu_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:aaqu00290]
aaqu_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:aaqu00290]
aaqu_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:aaqu00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Alcaligenes aquatilis [GN:aaqu]
Gene
D3M96_17390  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
D3M96_19765  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
D3M96_19705  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
D3M96_11625  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
D3M96_11620  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
D3M96_11615  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
D3M96_13195  thiamine pyrophosphate-binding protein [KO:K01652] [EC:2.2.1.6]
D3M96_00510  ilvB; biosynthetic-type acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
D3M96_14130  ilvB; biosynthetic-type acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
D3M96_14125  acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
D3M96_00070  ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
D3M96_14120  ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
D3M96_01955  dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
D3M96_18560  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
D3M96_01455  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
D3M96_12920  pyridoxal phosphate-dependent aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
D3M96_00640  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
D3M96_09435  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
aaqu00260  Glycine, serine and threonine metabolism
aaqu00280  Valine, leucine and isoleucine degradation
aaqu00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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