KEGG PATHWAY: afun04145

KEGG

PATHWAY: afun04145

Entry

afun04145                   Pathway

Name

Phagosome - Anopheles funestus (African malaria mosquito)

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

Phagosome

Other DBs

GO:

Organism

Anopheles funestus (African malaria mosquito) [GN:afun]

Gene

syntaxin-7 [KO:K08488]

actin-3-like [KO:K05692]

actin-5C [KO:K05692]

syntaxin-18 [KO:K08492]

vesicle-trafficking protein SEC22b isoform X1 [KO:K08517]

ras-related protein Rab-5B [KO:K07889]

phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]

hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]

V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]

V-type proton ATPase subunit B [KO:K02147]

V-type proton ATPase subunit C [KO:K02148]

V-type proton ATPase subunit D 1 [KO:K02149]

V-type proton ATPase subunit E [KO:K02150]

V-type proton ATPase subunit F [KO:K02151]

V-type proton ATPase subunit G-like [KO:K02152]

V-type proton ATPase subunit G-like [KO:K02152]

V-type proton ATPase subunit e 2-like [KO:K02153]

V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]

V-type proton ATPase 116 kDa subunit a 1-like [KO:K02154]

V-type proton ATPase 116 kDa subunit a 1-like [KO:K02154]

V-type proton ATPase subunit d [KO:K02146]

V-type proton ATPase subunit d-like [KO:K02146]

V-type proton ATPase subunit H isoform X1 [KO:K02144]

V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]

V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]

V-type proton ATPase subunit S1 [KO:K03662]

ras-related protein Rab-7a [KO:K07897]

dynein heavy chain, cytoplasmic isoform X1 [KO:K10413]

cytoplasmic dynein 2 heavy chain 1 [KO:K10414]

cytoplasmic dynein 1 intermediate chain isoform X1 [KO:K10415]

cytoplasmic dynein 1 light intermediate chain 1-like [KO:K10416]

cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]

tubulin alpha-1 chain-like [KO:K07374]

tubulin alpha-1 chain-like [KO:K07374]

tubulin alpha-1 chain [KO:K07374]

tubulin alpha-4 chain-like [KO:K07374]

tubulin alpha chain-like [KO:K07374]

tubulin alpha-8 chain-like [KO:K07374]

tubulin beta-3 chain isoform X1 [KO:K07375]

tubulin beta chain-like isoform X1 [KO:K07375]

tubulin beta chain-like [KO:K07375]

tubulin beta chain-like [KO:K07375]

tubulin beta-1 chain [KO:K07375]

lysosome-associated membrane glycoprotein 1-like [KO:K06528]

putative 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]

nitric oxide synthase isoform X1 [KO:K13240] [EC:1.14.13.39]

cathepsin L-like [KO:K01365] [EC:3.4.22.15]

protein transport protein Sec61 subunit alpha [KO:K10956]

protein transport protein Sec61 subunit beta [KO:K09481]

protein transport protein Sec61 subunit gamma [KO:K07342]

calreticulin [KO:K08057]

calnexin-like isoform X1 [KO:K08054]

integrin beta-PS isoform X1 [KO:K05719]

cartilage oligomeric matrix protein isoform X1 [KO:K04659]

ras-related protein Rac1 [KO:K04392]

ras-like GTP-binding protein RhoL [KO:K04392]

ras-related C3 botulinum toxin substrate 1 [KO:K04392]

ras-like GTP-binding protein RhoL [KO:K04392]

Compound

1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002

Reference

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R

Reference

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036

Reference

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005

Reference

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511

Reference

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217

Reference

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x

Related
pathway

Lysosome

Endocytosis

KO pathway

LinkDB

DBGET integrated database retrieval system