KEGG   ORTHOLOGY: K00921
Entry
K00921                      KO                                     

Symbol
PIKFYVE, FAB1
Name
1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
Pathway
map00562  Inositol phosphate metabolism
map01100  Metabolic pathways
map04070  Phosphatidylinositol signaling system
map04145  Phagosome
map04810  Regulation of actin cytoskeleton
Disease
H00957  Fleck corneal dystrophy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K00921  PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K00921  PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K00921  PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K00921  PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K00921  PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.150  1-phosphatidylinositol-3-phosphate 5-kinase
     K00921  PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase
Membrane trafficking [BR:ko04131]
 Endocytosis
  Macropinocytosis
   Kinases
    K00921  PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase
 Endosome - Golgi transport
  Others
   Others
    K00921  PIKFYVE, FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase
Other DBs
RN: R05802 R10951
GO: 0000285
Genes
HSA: 200576(PIKFYVE)
PTR: 459908(PIKFYVE)
PPS: 100981447(PIKFYVE)
GGO: 101152226(PIKFYVE)
PON: 100435223(PIKFYVE)
NLE: 100592353(PIKFYVE)
MCC: 710115(PIKFYVE)
MCF: 102116640(PIKFYVE)
CSAB: 103217737(PIKFYVE)
CATY: 105580121(PIKFYVE)
PANU: 101019788(PIKFYVE)
RBB: 108540354(PIKFYVE)
TFN: 117094591(PIKFYVE)
PTEH: 111547878(PIKFYVE)
CJC: 100415724(PIKFYVE)
SBQ: 101028683(PIKFYVE)
MMUR: 105864310(PIKFYVE)
MMU: 18711(Pikfyve)
MCAL: 110293039(Pikfyve)
MPAH: 110321148(Pikfyve)
RNO: 316457(Pikfyve)
MCOC: 116088520(Pikfyve)
MUN: 110563117(Pikfyve)
CGE: 100758487(Pikfyve)
PLEU: 114705066(Pikfyve)
NGI: 103744454(Pikfyve)
HGL: 101705294(Pikfyve)
CPOC: 100721082
CCAN: 109675421
OCU: 100357384(PIKFYVE)
OPI: 101530658(PIKFYVE)
TUP: 102469769(PIKFYVE)
CFA: 478890(PIKFYVE)
VVP: 112922603(PIKFYVE)
VLG: 121480596(PIKFYVE)
AML: 100480413(PIKFYVE)
UMR: 103659810(PIKFYVE)
UAH: 113250516(PIKFYVE)
ORO: 101377889(PIKFYVE)
ELK: 111145703
MPUF: 101683115(PIKFYVE)
EJU: 114215966(PIKFYVE)
MLX: 118012093(PIKFYVE)
FCA: 101094121(PIKFYVE)
PYU: 121030992(PIKFYVE)
PBG: 122481711(PIKFYVE)
PTG: 102966673(PIKFYVE)
PPAD: 109265143(PIKFYVE)
AJU: 106967092(PIKFYVE)
HHV: 120237361(PIKFYVE)
BTA: 790873(PIKFYVE)
BOM: 102287865(PIKFYVE)
BIU: 109570267(PIKFYVE)
BBUB: 102413075(PIKFYVE)
CHX: 102190275(PIKFYVE)
OAS: 101120727(PIKFYVE)
ODA: 120854549(PIKFYVE)
CCAD: 122426184(PIKFYVE)
SSC: 100521692(PIKFYVE)
CFR: 102506136(PIKFYVE)
CBAI: 105072953(PIKFYVE)
CDK: 105093550(PIKFYVE)
BACU: 103019601(PIKFYVE)
LVE: 103085543(PIKFYVE)
OOR: 101283366(PIKFYVE)
DLE: 111171780(PIKFYVE)
PCAD: 102977013(PIKFYVE)
PSIU: 116756549(PIKFYVE)
ECB: 100066445(PIKFYVE)
EPZ: 103540345(PIKFYVE)
EAI: 106828171(PIKFYVE)
MYB: 102241986(PIKFYVE)
MYD: 102758354(PIKFYVE)
MMYO: 118661148(PIKFYVE)
MLF: 102433515(PIKFYVE)
MNA: 107524720(PIKFYVE)
PKL: 118709988(PIKFYVE)
HAI: 109388303(PIKFYVE)
DRO: 112307670(PIKFYVE)
SHON: 118975709(PIKFYVE)
AJM: 119064378(PIKFYVE)
PDIC: 114494563(PIKFYVE)
MMF: 118624950(PIKFYVE)
RFQ: 117025879(PIKFYVE)
PALE: 102891645(PIKFYVE)
PGIG: 120587593(PIKFYVE)
RAY: 107505156(PIKFYVE)
MJV: 108398904(PIKFYVE)
TOD: 119256156(PIKFYVE)
LAV: 100672120(PIKFYVE)
TMU: 101359894
MDO: 100013564(PIKFYVE)
GAS: 123241918(PIKFYVE)
SHR: 100933218(PIKFYVE)
PCW: 110223272(PIKFYVE)
OAA: 100076756(PIKFYVE)
GGA: 424114(PIKFYVE)
PCOC: 116234034(PIKFYVE)
MGP: 100544400(PIKFYVE)
CJO: 107316589(PIKFYVE)
NMEL: 110399620(PIKFYVE)
APLA: 101800759(PIKFYVE)
ACYG: 106030055(PIKFYVE)
TGU: 100229363(PIKFYVE)
LSR: 110471078(PIKFYVE)
SCAN: 103814472(PIKFYVE)
PMOA: 120497393(PIKFYVE)
OTC: 121335411(PIKFYVE)
PRUF: 121356490(PIKFYVE)
GFR: 102039163(PIKFYVE)
FAB: 101821332(PIKFYVE)
PHI: 102112726(PIKFYVE)
PMAJ: 107207464(PIKFYVE)
CCAE: 111932425(PIKFYVE)
CCW: 104693820(PIKFYVE)
ETL: 114055769(PIKFYVE)
FPG: 101923292(PIKFYVE)
FCH: 102057143(PIKFYVE)
CLV: 102089113(PIKFYVE)
EGZ: 104125088(PIKFYVE)
NNI: 104010224(PIKFYVE)
ACUN: 113482503(PIKFYVE)
PADL: 103923799(PIKFYVE)
AAM: 106492453(PIKFYVE)
AROW: 112977045(PIKFYVE)
NPD: 112954389(PIKFYVE)
DNE: 112992816(PIKFYVE)
ASN: 102388365(PIKFYVE)
AMJ: 102568408(PIKFYVE)
CPOO: 109322909(PIKFYVE)
GGN: 109301997(PIKFYVE)
PSS: 102459996(PIKFYVE)
CMY: 102942791(PIKFYVE)
CPIC: 101941143(PIKFYVE)
TST: 117885001(PIKFYVE)
CABI: 116816078(PIKFYVE)
MRV: 120374290(PIKFYVE)
ACS: 100566486(pikfyve)
PVT: 110072395(PIKFYVE)
SUND: 121930840(PIKFYVE)
PBI: 103055422(PIKFYVE)
PMUR: 107286153(PIKFYVE)
PGUT: 117674059(PIKFYVE)
VKO: 123024269(PIKFYVE)
PMUA: 114581976(PIKFYVE)
ZVI: 118096450(PIKFYVE)
GJA: 107105889(PIKFYVE)
XLA: 108701477
XTR: 550069(pikfyve)
DRE: 337690(pikfyve)
SANH: 107681306 107690613(pikfyve)
IPU: 108266285(pikfyve)
PHYP: 113547525(pikfyve)
AMEX: 103023917(pikfyve)
EEE: 113572052(pikfyve)
TRU: 101078741(pikfyve)
LCO: 104932524(pikfyve)
CGOB: 115026392(pikfyve)
ELY: 117251327(pikfyve)
PLEP: 121948657(pikfyve)
SLUC: 116049425(pikfyve)
ECRA: 117953080(pikfyve)
PFLV: 114563984(pikfyve)
GAT: 120833674(pikfyve)
PPUG: 119228408(pikfyve)
MSAM: 119904556(pikfyve)
CUD: 121522514(pikfyve)
MZE: 101469447(pikfyve)
ONL: 100695781(pikfyve)
OAU: 116326814(pikfyve)
OLA: 101160530(pikfyve)
OML: 112137974(pikfyve)
XMA: 102220346(pikfyve)
XCO: 114148411(pikfyve)
XHE: 116722825(pikfyve)
PRET: 103482175(pikfyve)
GAF: 122839465(pikfyve)
CVG: 107097750(pikfyve)
CTUL: 119794060(pikfyve)
NFU: 107389520(pikfyve)
KMR: 108238853(pikfyve)
CSEM: 103391640(pikfyve)
POV: 109640967(pikfyve)
SSEN: 122760035(pikfyve)
HHIP: 117754820(pikfyve)
LCF: 108902449(pikfyve)
SDU: 111218477(pikfyve)
SLAL: 111654079(pikfyve)
XGL: 120801284(pikfyve)
HCQ: 109520001(pikfyve)
BPEC: 110170588(pikfyve)
MALB: 109971642(pikfyve)
SASA: 100380630(fyv1) 106586374
ELS: 105016282(pikfyve)
SFM: 108926494(pikfyve)
PKI: 111840818(pikfyve)
AANG: 118223839(pikfyve)
LOC: 102698842(pikfyve)
LCM: 102366969(PIKFYVE)
CMK: 103182931(pikfyve)
RTP: 109921822(pikfyve)
BFO: 118405695
BBEL: 109465397
CIN: 108949957
SCLV: 120347947
SPU: 579692
APLC: 110983433
SKO: 102809692
DME: Dmel_CG6355(fab1)
DER: 6546666
DSE: 6609692
DSI: Dsimw501_GD25438(Dsim_GD25438)
DAN: 6496064
DSR: 110177929
DPE: 6593045
DWI: 6652322
DGR: 6560132
DAZ: 108617168
DNV: 108654847
DHE: 111605347
DVI: 6624808
CCAT: 101457520
BOD: 106627435
MDE: 101888475
SCAC: 106089801
LCQ: 111677341
ACOZ: 120948113
AARA: 120893254
AAG: 5574640
AME: 410183
ACER: 107999026
BIM: 100741836
BBIF: 117211411
BVK: 117237150
BVAN: 117159664
BTER: 100643432
BPYO: 122571932
CCAL: 108623430
OBB: 114874533
MGEN: 117222746
NMEA: 116426308
CGIG: 122402039
SOC: 105201430
MPHA: 105838418
AEC: 105152151
ACEP: 105621988
PBAR: 105429104
VEM: 105559606
HST: 105192060
DQU: 106751898
CFO: 105249010
FEX: 115240672
LHU: 105679812
PGC: 109856183
OBO: 105277992
PCF: 106790192
PFUC: 122513732
VPS: 122633846
NVI: 100122133
CSOL: 105361499
TPRE: 106652806
MDL: 103578776
CGLO: 123263148
FAS: 105271085
DAM: 107043134
AGIF: 122853077
CCIN: 107264109
TCA: 658852
DPA: 109539339
ATD: 109594250
AGB: 108905231
LDC: 111504546
NVL: 108562777
APLN: 108734220
OTU: 111426822
BMOR: 101744814
BMAN: 114242196
MSEX: 115453914
BANY: 112053434
PMAC: 106716087
PXU: 106121362
PRAP: 110992518
ZCE: 119828187
HAW: 110375498
TNL: 113498026
API: 100161846
DNX: 107161632
AGS: 114125761
RMD: 113549146
BTAB: 109035024
CLEC: 106663040
HHAL: 106682726
NLU: 111044261
FOC: 113213591
ZNE: 110829128
CSEC: 111870168
FCD: 110843460
DMK: 116916316
PVM: 113818996
PJA: 122251879
HAME: 121859837
EAF: 111711402
DSV: 119431140
RSAN: 119376083
RMP: 119176516
VDE: 111245825
VJA: 111267290
DPTE: 113791765
CSCU: 111623368
PTEP: 107450590
SDM: 118199230
TSP: Tsp_05920
PCAN: 112560700
GAE: 121387428
CRG: 105338263
MYI: 110449617
PMAX: 117316957
OBI: 106882632
OSN: 115214903
EGL: EGR_07055
NVE: 5517971
EPA: 110243649
ATEN: 116304779
ADF: 107341828
AMIL: 114975307
PDAM: 113681826
SPIS: 111333363
DGT: 114517862
AQU: 100642005
ATH: AT1G34260(FAB1D) AT1G71010(FAB1C) AT3G14270(FAB1B) AT4G33240(FAB1A)
LJA: Lj3g3v2575590.1(Lj3g3v2575590.1) Lj4g3v2215310.1(Lj4g3v2215310.1)
DOSA: Os04t0691900-01(Os04g0691900) Os08t0104700-01(Os08g0104700) Os08t0428900-01(Os08g0428900) Os09t0278300-00(Os09g0278300) Os09t0402300-01(Os09g0402300) Os12t0236700-01(Os12g0236700)
SCE: YFR019W(FAB1)
KMX: KLMA_20473(FAB1)
NCS: NCAS_0D00550(NCAS0D00550)
NDI: NDAI_0H03600(NDAI0H03600)
TPF: TPHA_0A02260(TPHA0A02260)
TBL: TBLA_0A10150(TBLA0A10150)
TDL: TDEL_0D02300(TDEL0D02300)
KAF: KAFR_0C04440(KAFR0C04440)
PIC: PICST_59054(FAB1)
CAL: CAALFM_C201990CA(FAB1)
CDU: CD36_16790(FAB1)
SLB: AWJ20_3164(FAB1)
NCR: NCU02083
NTE: NEUTE1DRAFT89270(NEUTE1DRAFT_89270)
SMP: SMAC_04978(putative fab1)
MGR: MGG_14757
SSCK: SPSK_04789
MAW: MAC_05526
MAJ: MAA_05182
CMT: CCM_07600
BFU: BCIN_06g02360(Bcfab1)
MBE: MBM_09238
ANG: ANI_1_1124064(An07g08980)
CIM: CIMG_13275(CIMG08037)
ABE: ARB_06188
TVE: TRV_01658
PTE: PTT_11698
SPO: SPBC3E7.01(fab1)
TASA: A1Q1_02047
ABP: AGABI1DRAFT124322(AGABI1DRAFT_124322) AGABI1DRAFT80588(AGABI1DRAFT_80588)
ABV: AGABI2DRAFT113973(AGABI2DRAFT_113973) AGABI2DRAFT122330(AGABI2DRAFT_122330)
MGL: MGL_0467
MRT: MRET_2268
DDI: DDB_G0279149(pip5k3)
DFA: DFA_10824(pip5k3)
TAN: TA13405
BBO: BBOV_III010910(17.m10687)
 » show all
Reference
  Authors
Shisheva A
  Title
PIKfyve: Partners, significance, debates and paradoxes.
  Journal
Cell Biol Int 32:591-604 (2008)
DOI:10.1016/j.cellbi.2008.01.006
Reference
  Authors
Sbrissa D, Ikonomov OC, Deeb R, Shisheva A
  Title
Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells.
  Journal
J Biol Chem 277:47276-84 (2002)
DOI:10.1074/jbc.M207576200
  Sequence
[hsa:200576]
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