KEGG   PATHWAY: agra00061
Entry
agra00061                   Pathway                                
Name
Fatty acid biosynthesis - Actinomadura graeca
Class
Metabolism; Lipid metabolism
Pathway map
agra00061  Fatty acid biosynthesis
agra00061

Module
agra_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:agra00061]
Other DBs
GO: 0006633
Organism
Actinomadura graeca [GN:agra]
Gene
AGRA3207_001925  acetyl-CoA carboxylase biotin carboxyl carrier protein [KO:K02160]
AGRA3207_002375  acetyl-CoA carboxylase biotin carboxyl carrier protein subunit [KO:K02160]
AGRA3207_001924  ATP-grasp domain-containing protein [KO:K01961] [EC:6.4.1.2 6.3.4.14]
AGRA3207_002374  acetyl-CoA carboxylase biotin carboxylase subunit [KO:K01961] [EC:6.4.1.2 6.3.4.14]
AGRA3207_006017  biotin carboxylase [KO:K01961] [EC:6.4.1.2 6.3.4.14]
AGRA3207_003048  ATP-grasp domain-containing protein [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
AGRA3207_004554  biotin/lipoyl-binding protein [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
AGRA3207_000380  acyltransferase domain-containing protein [KO:K00645] [EC:2.3.1.39]
AGRA3207_001556  ACP S-malonyltransferase [KO:K00645] [EC:2.3.1.39]
AGRA3207_001557  ketoacyl-ACP synthase III [KO:K00648] [EC:2.3.1.180]
AGRA3207_005116  3-oxoacyl-ACP synthase III family protein [KO:K00648] [EC:2.3.1.180]
AGRA3207_001559  beta-ketoacyl-[acyl-carrier-protein] synthase family protein [KO:K09458] [EC:2.3.1.179]
AGRA3207_002236  hypothetical protein [KO:K09458] [EC:2.3.1.179]
AGRA3207_002238  hypothetical protein [KO:K09458] [EC:2.3.1.179]
AGRA3207_003370  beta-ketoacyl-[acyl-carrier-protein] synthase family protein [KO:K09458] [EC:2.3.1.179]
AGRA3207_002237  beta-ketoacyl-[acyl-carrier-protein] synthase family protein [KO:K09458] [EC:2.3.1.179]
AGRA3207_000537  beta-ketoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
AGRA3207_000854  SDR family NAD(P)-dependent oxidoreductase [KO:K00059] [EC:1.1.1.100]
AGRA3207_002233  fabG; 3-oxoacyl-ACP reductase FabG [KO:K00059] [EC:1.1.1.100]
AGRA3207_002384  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
AGRA3207_005104  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
AGRA3207_002365  nitronate monooxygenase [KO:K02371] [EC:1.3.1.9]
AGRA3207_002235  SDR family oxidoreductase [KO:K10780] [EC:1.3.1.104]
AGRA3207_004990  acyl-ACP desaturase [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
AGRA3207_006178  acyl-ACP desaturase [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
AGRA3207_001385  AMP-binding protein [KO:K01897] [EC:6.2.1.3]
AGRA3207_001646  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
AGRA3207_002841  acyl-CoA synthetase [KO:K01897] [EC:6.2.1.3]
AGRA3207_006757  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
agra00020  Citrate cycle (TCA cycle)
agra00071  Fatty acid degradation
agra00410  beta-Alanine metabolism
agra00561  Glycerolipid metabolism
agra00564  Glycerophospholipid metabolism
agra00620  Pyruvate metabolism
agra00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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