KEGG   PATHWAY: amer03013
Entry
amer03013                   Pathway                                
Name
Nucleocytoplasmic transport - Anopheles merus
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
amer03013  Nucleocytoplasmic transport
amer03013

Other DBs
GO: 0050658
Organism
Anopheles merus [GN:amer]
Gene
121600045  aladin-like [KO:K14320]
121597985  nucleoporin AMO1-like [KO:K14321]
121599263  nucleoporin Gle1 [KO:K18723]
121588675  DEAD-box helicase Dbp80 [KO:K18655] [EC:5.6.2.7]
121600446  protein Rae1 [KO:K14298]
121588897  nuclear pore complex protein Nup98-Nup96 [KO:K14297]
121598017  nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
121587816  nuclear pore complex protein Nup88 [KO:K14318]
121589373  E3 SUMO-protein ligase RanBP2 [KO:K12172] [EC:2.3.2.-]
121597730  ran GTPase-activating protein [KO:K14319]
121588458  SUMO-conjugating enzyme UBC9-like [KO:K10577]
121599730  SUMO-conjugating enzyme UBC9-B [KO:K10577]
121600273  SUMO-conjugating enzyme UBC9-A-like [KO:K10577]
121589356  small ubiquitin-related modifier 3-like [KO:K12160]
121593243  small ubiquitin-related modifier 2-like [KO:K12160]
121603588  nuclear pore complex protein Nup160 homolog isoform X1 [KO:K14303]
121598586  nuclear pore complex protein Nup75 [KO:K14304]
121589861  protein SEC13 homolog [KO:K14004]
121589499  nuclear pore complex protein Nup107 [KO:K14301]
121588932  nuclear pore complex protein Nup133 [KO:K14300]
121601397  nucleoporin seh1 [KO:K14299]
121592249  nucleoporin seh1-like [KO:K14299]
121591629  nucleoporin Nup43 [KO:K14305]
121598653  nucleoporin Nup37 [KO:K14302]
121603597  uncharacterized protein LOC121603597 [KO:K25129]
121599420  nuclear pore glycoprotein p62 [KO:K14306]
121597156  nuclear pore complex protein Nup58 [KO:K14307]
121591879  probable nucleoporin Nup54 [KO:K14308]
121596379  nuclear pore complex protein Nup205 [KO:K14310]
121594667  nucleoporin Nup188-like [KO:K14311]
121601598  LOW QUALITY PROTEIN: nucleoporin Nup188-like [KO:K14311]
121593317  nucleoporin Nup188-like isoform X1 [KO:K14311]
121597840  nuclear pore complex protein Nup154 isoform X1 [KO:K14312]
121588605  nuclear pore complex protein Nup93-1 [KO:K14309]
121597554  nucleoporin Nup35 [KO:K14313]
121603429  nucleoporin Ndc1 [KO:K14315]
121594781  nuclear pore membrane glycoprotein 210 [KO:K14314]
121596768  Krueppel homolog 2 [KO:K20724]
121601994  nucleoprotein TPR [KO:K09291]
121590280  nuclear pore complex protein Nup153 [KO:K14296]
121597276  importin subunit alpha [KO:K15043]
121603736  importin subunit alpha-3 [KO:K23583]
121593189  importin subunit alpha-7 [KO:K15042]
121596440  importin subunit beta isoform X1 [KO:K14293]
121594668  transportin-1 [KO:K18752]
121588362  transportin-3 isoform X1 [KO:K15436]
121594629  importin-4-like [KO:K20221]
121590989  importin-5 [KO:K20222]
121591603  importin-7 [KO:K20223]
121599429  importin-9 [KO:K20224]
121591012  importin-11 [KO:K25201]
121597807  importin-13 isoform X1 [KO:K25202]
121593454  snurportin-1 [KO:K13151]
121592640  uncharacterized protein LOC121592640 [KO:K13151]
121596638  exportin-1 [KO:K14290]
121598646  exportin-2 [KO:K18423]
121598863  exportin-4-like [KO:K25203]
121598651  exportin-5 [KO:K14289]
121589389  uncharacterized protein LOC121589389 [KO:K25204]
121587680  ran-binding protein 16 [KO:K18460]
121591409  GTP-binding nuclear protein Ran [KO:K07936]
121593126  elongation factor 1-alpha [KO:K03231]
121596703  phosphorylated adapter RNA export protein isoform X1 [KO:K14291]
121588492  nuclear cap-binding protein subunit 1 [KO:K12882]
121589155  nuclear cap-binding protein subunit 2 [KO:K12883]
121601857  nuclear cap-binding protein subunit 2 [KO:K12883]
121592651  60S ribosomal export protein NMD3 [KO:K07562]
121592798  RNA-binding protein 8A [KO:K12876]
121600012  protein mago nashi [KO:K12877]
121599275  ataxin-2 homolog [KO:K14323]
121602693  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
121598030  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
121587748  histone deacetylase complex subunit SAP18 [KO:K14324]
121597812  RNA-binding protein with serine-rich domain 1-B [KO:K14325]
121589400  pinin [KO:K13114]
121591969  THO complex subunit 4 [KO:K12881]
121589263  regulator of nonsense transcripts 1 homolog [KO:K14326] [EC:5.6.2.5 5.6.2.3]
121593346  regulator of nonsense transcripts 2 [KO:K14327]
121588551  nuclear RNA export factor 1 [KO:K14284]
121597362  NTF2-related export protein [KO:K14285]
121596065  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
121592161  serine/arginine repetitive matrix protein 1 [KO:K13171]
121593093  partner of Y14 and mago [KO:K14294]
121590418  THO complex subunit 1 [KO:K12878]
121595865  THO complex subunit 2 isoform X1 [KO:K12879]
121593692  THO complex subunit 5 homolog [KO:K13174]
121594806  THO complex subunit 6 [KO:K13175]
121603665  THO complex subunit 7 homolog [KO:K13176]
121587872  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
amer03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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