KEGG   PATHWAY: asa02010
Entry
asa02010                    Pathway                                
Name
ABC transporters - Aeromonas salmonicida subsp. salmonicida A449
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
asa02010  ABC transporters
asa02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Aeromonas salmonicida subsp. salmonicida A449 [GN:asa]
Gene
ASA_0593  cysP; ABC-type sulfate transport system, periplasmic component [KO:K23163]
ASA_0595  cysU; ABC-type sulfate transporter, permease component [KO:K02046]
ASA_0596  cysW; ABC-type sulfate transporter, permease component [KO:K02047]
ASA_0597  cysA; ABC-type sulfate transporter, ATPase component [KO:K02045] [EC:7.3.2.3]
ASA_3086  modA; ABC-type molybdate transporter, periplasmic-binding protein [KO:K05772]
ASA_3087  modB; ABC-type molybdate transporter, permease protein [KO:K05773]
ASA_3088  modC; ABC-type molybdate transporter, ATP-binding protein [KO:K06857] [EC:7.3.2.6]
ASA_2762  modA; ABC-type molybdate transporter, periplasmic binding protein [KO:K02020]
ASA_2761  modB; ABC-type molybdate transporter, permease component [KO:K02018]
ASA_2760  modC; ABC-type molybdate transporter, ATP-binding protein [KO:K02017] [EC:7.3.2.5]
ASA_0650  fbpA; ABC-type iron(III) transporter, periplasmic component [KO:K02012]
ASA_0651  fbpB; ABC-type iron(III) transporter, permease protein [KO:K02011]
ASA_0652  fbpC; ABC-type iron(III) transporter, ATP-binding protein [KO:K02010] [EC:7.2.2.7]
ASA_3415  thiB; ABC-type thiamine transporter, periplasmic binding protein [KO:K02064]
ASA_3416  thiP; ABC-type thiamine transporter, permease protein [KO:K02063]
ASA_3417  thiQ; ABC-type thiamine transporter, ATP binding protein [KO:K02062] [EC:7.6.2.15]
ASA_0174  potF1; ABC-type putrescine transporter, periplasmic binding protein [KO:K11073]
ASA_0175  potF2; ABC-type putrescine transporter, periplasmic binding protein [KO:K11073]
ASA_0178  potI; ABC-type putrescine transporter, permease protein [KO:K11074]
ASA_0177  potH; ABC-type putrescine transporter, permease protein [KO:K11075]
ASA_0176  potG; ABC-type putrescine transporter, ATP-binding protein [KO:K11076] [EC:7.6.2.16]
ASA_0935  proX; glycine betaine/L-proline transport system, periplasmic binding protein [KO:K02002]
ASA_0934  proW; glycine betaine/L-proline transport system permease protein [KO:K02001]
ASA_0933  proV; glycine betaine/L-proline transport system, ATPase component [KO:K02000] [EC:7.6.2.9]
ASA_2691  malE; ABC-type maltose transporter, periplasmic binding protein [KO:K10108]
ASA_2690  malF; ABC-type maltose transporter, permease protein [KO:K10109]
ASA_2689  malG; ABC-type maltose transporter, permease component [KO:K10110]
ASA_2688  malK; ABC-type maltose transporter, ATP-binding protein [KO:K10111] [EC:7.5.2.-]
ASA_2382  malE; ABC-type maltose/maltodextrin transporter, periplasmic binding protein [KO:K15770]
ASA_2381  malF; ABC-type maltose/maltodextrin transporter, permease protein [KO:K15771]
ASA_2380  malG; ABC-type maltose/maltodextrin transporter, permease protein [KO:K15772]
ASA_0306  toluene tolerance protein Ttg2D [KO:K07323]
ASA_0307  toluene tolerance protein TTG2C [KO:K02067]
ASA_0308  ABC-type transporter, permease subunit [KO:K02066]
ASA_0305  conserved hypothetical protein [KO:K07122]
ASA_0309  ABC-type transporter, ATP-binding protein [KO:K02065]
ASA_4177  ABC-type sugar transporter, permease component [KO:K23535]
ASA_4178  ABC-type sugar transporter, permease component [KO:K23536]
ASA_4176  ABC-type sugar transporter, ATP binding protein [KO:K23537]
ASA_4254  ABC-type sugar transporter, periplasmic component [KO:K17315]
ASA_1968  rbsB; ABC-type ribose transporter, periplasmic binding protein [KO:K10439]
ASA_1969  rbsC; ABC-type ribose transporter, permease protein [KO:K10440]
ASA_1971  rbsD; ABC-type ribose transporter protein [KO:K06726] [EC:5.4.99.62]
ASA_2396  araF; ABC-type arabinose transporter, periplasmic binding protein [KO:K10537]
ASA_2394  araH; ABC-type arabinose transporter, permease protein [KO:K10538]
ASA_2395  araG; ABC-type arabinose transporter, ATP-binding protein [KO:K10539] [EC:7.5.2.12]
ASA_2140  ABC-type sugar transporter, periplasmic binding protein [KO:K23508]
ASA_2137  ABC-type sugar transporter, permease protein [KO:K23509]
ASA_2138  ABC-type sugar transporter, permease protein [KO:K23509]
ASA_2139  ABC-type sugar transporter, ATP-binding protein [KO:K10820] [EC:7.5.2.9]
ASA_0214  mglB; ABC-type galactose transporter, periplasmic binding protein [KO:K10540]
ASA_0216  mglC; ABC-type galactoside transporter, permease subunit MglC [KO:K10541]
ASA_0215  mglA; ABC-type galactoside transporter, ATP-binding protein [KO:K10542] [EC:7.5.2.11]
ASA_1242  phosphate-binding protein [KO:K02040]
ASA_1519  pstC; ABC-type phosphate transporter, permease component [KO:K02037]
ASA_1520  pstA; ABC-type phosphate transporter, permease component [KO:K02038]
ASA_1521  pstB; ABC-type phosphate transporter, ATP-binding protein [KO:K02036] [EC:7.3.2.1]
ASA_0112  phnD; ABC-type phosphate/phosphonate transporter, periplasmic binding protein [KO:K02044]
ASA_0110  phnE; ABC-type phosphate/phosphonate transporter, permease component [KO:K02042]
ASA_0111  phnC; ABC-type phosphate/phosphonate transporter, ATP-binding protein [KO:K02041] [EC:7.3.2.2]
ASA_0656  artI; ABC-type arginine transporter, periplasmic binding protein [KO:K09997]
ASA_0658  artM; ABC-type arginine transporter, permease protein [KO:K09998]
ASA_0657  artQ; ABC-type arginine transporter, permease protein [KO:K09999]
ASA_0655  artP; ABC-type arginine transporter, ATP-binding protein [KO:K10000] [EC:7.4.2.1]
ASA_4388  ABC-type polar amino acid transporter, periplasmic binding protein [KO:K16961]
ASA_4387  ABC-type polar amino acid transporter, permease protein [KO:K16962]
ASA_4386  ABC-type polar amino acid transporter, ATP binding protein [KO:K16963]
ASA_2676  hisJ; ABC-type histidine/lysine/arginine/ornithine transporter, periplasmic binding protein [KO:K10022]
ASA_2403  ABC-type amino acid transporter, periplasmic binding protein [KO:K10022]
ASA_2674  hisM; ABC-type histidine/lysine/arginine/ornithine transporter, permease protein [KO:K10023]
ASA_2675  hisQ; ABC-type histidine/lysine/arginine/ornithine transporter, permease component [KO:K10024]
ASA_2677  hisP; ABC-type histidine/lysine/arginine/ornithine transporter, ATP-binding protein [KO:K10025] [EC:7.4.2.1]
ASA_4279  livK; ABC-type branched-chain amino acid transporter, periplasmic binding protein [KO:K01999]
ASA_4280  livH; ABC-type branched-chain amino acid transporter, permease protein [KO:K01997]
ASA_4281  livM; ABC-type branched-chain amino acid transporter, permease protein [KO:K01998]
ASA_4282  livG; ABC-type branched-chain amino acid transporter, ATP-binding protein [KO:K01995]
ASA_4283  livF; ABC-type branched-chain amino acid transporter, ATP-binding protein [KO:K01996]
ASA_3380  metQ; ABC-type methionine transporter, periplasmic binding protein [KO:K02073]
ASA_2536  nlpA; NlpA lipoprotein [KO:K02073]
ASA_3379  metI; ABC-type methionine transporter, permease protein [KO:K02072]
ASA_3378  metN; ABC-type methionine transporter, ATP-binding subunit [KO:K02071]
ASA_1698  oppA; ABC-type oligopeptide transporter, periplasmic binding protein [KO:K15580]
ASA_3625  mppA; periplasmic murein peptide-binding protein [KO:K15580]
ASA_1879  oppA; ABC-type oligopeptide transporter, periplasmic binding protein [KO:K15580]
ASA_1482  ABC-type oligopeptide transporter, periplasmic binding protein [KO:K15580]
ASA_1699  oppB; ABC-type oligopeptide transporter, permease protein [KO:K15581]
ASA_1700  oppC; ABC-type oligopeptide transporter, permease protein [KO:K15582]
ASA_1701  oppD; ABC-type oligopeptide transporter, ATP-binding protein [KO:K15583]
ASA_1702  oppF; ABC-type oligopeptide transporter, ATP-binding protein [KO:K10823]
ASA_2427  sapA; ABC-type peptide transporter, periplasmic binding protein [KO:K19226]
ASA_2428  sapB; ABC-type peptide transporter, permease protein [KO:K19227]
ASA_2429  sapC; ABC-type peptide transporter, permease protein [KO:K19228]
ASA_2430  sapD; ABC-type peptide transporter, ATP-binding protein [KO:K19229]
ASA_2431  sapF; ABC-type peptide transporter, ATP-binding protein [KO:K19230]
ASA_0883  appA; ABC-type oligopeptide transport system, periplasmic binding protein [KO:K13893]
ASA_0882  appC; ABC-type oligopeptide transport system, permease protein [KO:K13895]
ASA_1845  iron complex transport system, periplasmic binding protein [KO:K25286]
ASA_1849  ABC-type Fe3+-siderophore transporter, permease component [KO:K23186]
ASA_1848  ABC-type Fe3+-siderophore transporter, permease component [KO:K23187]
ASA_1847  ABC-type Fe3+-siderophore transporter, ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
ASA_4366  fhuD; ABC-type hydroxamate-type ferric siderophore transporter, periplasmic binding protein [KO:K23227]
ASA_4367  fhuE; ABC-type hydroxamate-type ferric siderophore transporter, permease protein [KO:K23228]
ASA_4365  fhuC; ABC-type hydroxamate-type ferric siderophore transporter, ATP binding protein [KO:K10829] [EC:7.2.2.16]
ASA_2655  btuF; cobalamin binding protein BtuF [KO:K06858]
ASA_1637  btuC; vitamin B12 import system permease protein BtuC [KO:K06073]
ASA_1638  btuD; vitamin B12 import ATP-binding protein BtuD [KO:K06074] [EC:7.6.2.8]
ASA_0558  znuA; ABC-type high affinity zinc transporter, periplasmic binding protein [KO:K09815]
ASA_0556  znuB; ABC-type high affinity zinc transporter, permease component [KO:K09816]
ASA_0557  znuC; ABC-type high-affinity zinc transporter, ATP-binding protein [KO:K09817] [EC:7.2.2.20]
ASA_1426  ABC-2 type transporter, permease protein [KO:K09690]
ASA_1439  abcA; ABC-type transporter protein AbcA [KO:K09691] [EC:7.5.2.14]
ASA_1883  lolE; lipoprotein releasing system transmembrane protein LolE [KO:K09808]
ASA_1885  lolE; Lipoprotein releasing system transmembrane protein LolE [KO:K09808]
ASA_1884  lolD; Lipoprotein releasing system ATP-binding protein LolD [KO:K09810] [EC:7.6.2.-]
ASA_1368  ccmD; heme exporter protein D [KO:K02196]
ASA_1367  ccmC; heme chaperone heme-lyase [KO:K02195]
ASA_1366  ccmB; heme exporter protein B [KO:K02194]
ASA_1365  ccmA; ATP binding protein of heme exporter A [KO:K02193] [EC:7.6.2.5]
ASA_3824  predicted permease [KO:K07091]
ASA_3825  predicted permease [KO:K11720]
ASA_0314  ABC-type transporter, ATP binding protein [KO:K06861] [EC:7.5.2.5]
ASA_3959  ftsX; cell division membrane protein FtsX [KO:K09811]
ASA_3960  ftsE; cell division ATP-binding protein FtsE [KO:K09812]
ASA_4374  ABC transporter, permease/ATP-binding protein [KO:K14698] [EC:7.-.-.-]
ASA_4373  ABC transporter, permease/ATP-binding protein [KO:K14699] [EC:7.-.-.-]
ASA_1551  msbA; lipid A export ATP-binding/permease [KO:K11085] [EC:7.5.2.6]
ASA_2284  mdlB; ABC-type multidrug transporter, ATP-binding protein [KO:K18890]
ASA_1669  toxin secretion ATP-binding protein [KO:K12541]
ASA_3051  cydC; ABC-type transporter, ATP-binding protein [KO:K16012]
ASA_3050  cydD; ABC-type transporter, ATP-binding protein [KO:K16013]
ASA_3590  macB; ABC-type macrolide transporter, fused permease and ATP-binding domains [KO:K05685] [EC:7.6.2.-]
ASA_3004  ABC-type transporter, ATP-binding protein [KO:K05685] [EC:7.6.2.-]
ASA_4364  fhuB; ABC-type hydroxamate-type ferric siderophore transporter, ATP-binding protein [KO:K06159]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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