KEGG   PATHWAY: ase00525
Entry
ase00525                    Pathway                                
Name
Acarbose and validamycin biosynthesis - Actinoplanes sp. SE50/110
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
ase00525  Acarbose and validamycin biosynthesis
ase00525

Module
ase_M00814  Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose [PATH:ase00525]
Organism
Actinoplanes sp. SE50/110 [GN:ase]
Gene
ACPL_6250  3-dehydroquinate synthase [KO:K19969] [EC:4.2.3.152]
ACPL_3680  acbC; 2-epi-5-epi-valiolone synthase [KO:K19969] [EC:4.2.3.152]
ACPL_3676  acbM; 2-epi-5-epi-valiolone 7-kinase [KO:K19979] [EC:2.7.1.188]
ACPL_6249  glucose kinase [KO:K19979] [EC:2.7.1.188]
ACPL_3679  acbO; 2-epi-5-epi-valiolone-7-phosphate 2-epimerase [KO:K19974] [EC:5.1.3.35]
ACPL_3677  acbL; cyclitol dehydrogenase [KO:K20424] [EC:1.1.1.-]
ACPL_6251  L-threonine 3-dehydrogenase [KO:K20424] [EC:1.1.1.-]
ACPL_3678  acbN; cyclitol oxidoreductase [KO:K20425]
ACPL_3668  acbU; 1-epi-valienol-7-phosphate 1-kinase [KO:K20426] [EC:2.7.-.-]
ACPL_3670  acbR; 1-epi-valienol-1,7-bisphosphate-1-adenylyltransferase [KO:K20427] [EC:2.7.7.91]
ACPL_3682  acbA; glucose-1-phosphate thymidylyltransferase [KO:K00973] [EC:2.7.7.24]
ACPL_3097  glucose-1-phosphate thymidylyltransferase [KO:K00973] [EC:2.7.7.24]
ACPL_3681  acbB; dTDP-glucose 4,6-dehydratase [KO:K01710] [EC:4.2.1.46]
ACPL_3096  rmlB; dTDP-glucose 4,6-dehydratase [KO:K01710] [EC:4.2.1.46]
ACPL_3667  acbV; dTDP-4-keto-6-deoxy-glucose 4-aminotransferase [KO:K20428] [EC:2.6.1.33]
ACPL_3669  acbS; glycosyltransferase [KO:K20430] [EC:2.4.-.-]
ACPL_3675  acbK; acarbose 7-kinase [KO:K19978] [EC:2.7.1.187]
ACPL_1792  PfkB domain protein [KO:K19978] [EC:2.7.1.187]
Compound
C00103  D-Glucose 1-phosphate
C00842  dTDP-glucose
C04268  dTDP-4-amino-4,6-dideoxy-D-glucose
C06802  Acarbose
C11907  dTDP-4-oxo-6-deoxy-D-glucose
C12112  Validamycin A
C17691  2-epi-5-epi-Valiolone
C17692  2-epi-5-epi-Valiolone 7-phosphate
C17693  5-epi-Valiolone 7-phosphate
C17694  5-epi-Valiolone
C17695  2-Keto-5-epi-valiolone
C17696  Valienone
C17697  Valienone 7-phosphate
C17698  Salbostatin
C17699  Cetoniacytone A
C17700  Validoxylamine A
C20956  alpha-D-Sedoheptulopyranose 7-phosphate
C21156  Acarbose 7IV-phosphate
C21204  5-epi-Valiolol 7-phosphate
C21205  1-epi-Valienol 7-phosphate
C21206  1,7-Diphospho-1-epi-valienol
C21207  NDP-1-epi-valienol 7-phosphate
C21208  dTDP-acarviose-7-phosphate
C21209  1-epi-Valienol 1-phosphate
C21210  NDP-1-epi-valienol
C21211  Salbostatin 6'-phosphate
C21216  Validamine 7-phosphate
C21218  Validone 7-phosphate
C21219  Validoxylamine A 7'-phosphate
C21247  2-Amino-5-epi-valiolone
C21248  2-Aminovalienone
C21249  Cetoniacytone B
C21293  Validamycin B
C21367  Valienol 1-phosphate
C21368  GDP-valienol
C21415  Valienol 7-phosphate
Reference
PMID:17390001
  Authors
Flatt PM, Mahmud T
  Title
Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds.
  Journal
Nat Prod Rep 24:358-92 (2007)
DOI:10.1039/b603816f
Reference
PMID:17661520
  Authors
Mahmud T, Flatt PM, Wu X
  Title
Biosynthesis of unusual aminocyclitol-containing natural products.
  Journal
J Nat Prod 70:1384-91 (2007)
DOI:10.1021/np070210q
Reference
PMID:22944206
  Authors
Wendler S, Hurtgen D, Kalinowski J, Klein A, Niehaus K, Schulte F, Schwientek P, Wehlmann H, Wehmeier UF, Puhler A
  Title
The cytosolic and extracellular proteomes of Actinoplanes sp. SE50/110 led to the identification of gene products involved in acarbose metabolism.
  Journal
J Biotechnol 167:178-89 (2013)
DOI:10.1016/j.jbiotec.2012.08.011
Reference
PMID:22443545
  Authors
Schwientek P, Szczepanowski R, Ruckert C, Kalinowski J, Klein A, Selber K, Wehmeier UF, Stoye J, Puhler A
  Title
The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110.
  Journal
BMC Genomics 13:112 (2012)
DOI:10.1186/1471-2164-13-112
Reference
PMID:17003911
  Authors
Deng Z, Bai L
  Title
Antibiotic biosynthetic pathways and pathway engineering--a growing research field in China.
  Journal
Nat Prod Rep 23:811-27 (2006)
DOI:10.1039/b611140h
Reference
PMID:21766819
  Authors
Asamizu S, Yang J, Almabruk KH, Mahmud T
  Title
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
  Journal
J Am Chem Soc 133:12124-35 (2011)
DOI:10.1021/ja203574u
Reference
PMID:18648803
  Authors
Choi WS, Wu X, Choeng YH, Mahmud T, Jeong BC, Lee SH, Chang YK, Kim CJ, Hong SK
  Title
Genetic organization of the putative salbostatin biosynthetic gene cluster including the 2-epi-5-epi-valiolone synthase gene in Streptomyces albus ATCC 21838.
  Journal
Appl Microbiol Biotechnol 80:637-45 (2008)
DOI:10.1007/s00253-008-1591-2
Reference
PMID:19101977
  Authors
Wu X, Flatt PM, Xu H, Mahmud T
  Title
Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.
  Journal
Chembiochem 10:304-14 (2009)
DOI:10.1002/cbic.200800527
Related
pathway
ase00030  Pentose phosphate pathway
ase00520  Amino sugar and nucleotide sugar metabolism
KO pathway
ko00525   
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