Entry Name Acarbose and validamycin biosynthesis
Class Metabolism; Biosynthesis of other secondary metabolitesBRITE hierarchy
Pathway map ko00525 Acarbose and validamycin biosynthesis
Module M00814 Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose [PATH:ko00525 ]
M00815 Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A [PATH:ko00525 ]
Orthology K00973 rfbA, rmlA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24 ]
K19969 acbC, salQ, valA, cetA; 2-epi-5-epi-valiolone synthase [EC:4.2.3.152 ]
K19974 acbO; 2-epi-5-epi-valiolone 7-phosphate 2-epimerase [EC:5.1.3.35 ]
K20424 acbL; 2-epi-valiolone-7-phosphate 1-reductase [EC:1.1.1.-]
K20425 acbN; cyclitol oxidoreductase
K20426 acbU; 1-epi-valienol-7-phosphate kinase [EC:2.7.-.-]
K20427 acbR, vldB; valienol-1-phosphate guanylyltransferase [EC:2.7.7.91 ]
K20428 acbV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33 ]
K20430 acbS; glycosyltransferase AcbS [EC:2.4.-.-]
K20432 valK; 5-epi-valiolone dehydratase [EC:4.2.1.-]
K20434 valN; cyclitol reductase
K20435 valM; validone 7-phosphate aminotransferase [EC:2.6.1.-]
K20436 valL, salC; validamine 7-phosphate valienyltransferase [EC:2.5.1.135 ]
K20439 salP; putative phosphohexomutase / phosphatase
K20440 salE; salbostatin 6'-phosphate phosphatase [EC:3.1.3.-]
K20441 cetL; 5-epi-valiolone oxidase [EC:1.1.3.-]
K20442 cetM; 2-keto-5-epi-valolone aminotransferase [EC:2.6.1.-]
K20443 cetD; cetoniacytone B acyltransferase [EC:2.3.1.-]
K23144 K23144 ; UDP-N-acetylglucosamine diphosphorylase / glucose-1-phosphate thymidylyltransferase / UDP-N-acetylgalactosamine diphosphorylase / glucosamine-1-phosphate N-acetyltransferase / galactosamine-1-phosphate N-acetyltransferase
Compound C04268 dTDP-4-amino-4,6-dideoxy-D-glucose
C11907 dTDP-4-oxo-6-deoxy-D-glucose
C17692 2-epi-5-epi-Valiolone 7-phosphate
C17693 5-epi-Valiolone 7-phosphate
C20956 alpha-D-Sedoheptulopyranose 7-phosphate
C21204 5-epi-Valiolol 7-phosphate
C21205 1-epi-Valienol 7-phosphate
C21206 1,7-Diphospho-1-epi-valienol
C21207 NDP-1-epi-valienol 7-phosphate
C21208 dTDP-acarviose-7-phosphate
C21209 1-epi-Valienol 1-phosphate
C21211 Salbostatin 6'-phosphate
C21219 Validoxylamine A 7'-phosphate
C21247 2-Amino-5-epi-valiolone
Reference Authors Flatt PM, Mahmud T
Title Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds.
Journal Reference Authors Mahmud T, Flatt PM, Wu X
Title Biosynthesis of unusual aminocyclitol-containing natural products.
Journal Reference Authors Wendler S, Hurtgen D, Kalinowski J, Klein A, Niehaus K, Schulte F, Schwientek P, Wehlmann H, Wehmeier UF, Puhler A
Title The cytosolic and extracellular proteomes of Actinoplanes sp. SE50/110 led to the identification of gene products involved in acarbose metabolism.
Journal Reference Authors Schwientek P, Szczepanowski R, Ruckert C, Kalinowski J, Klein A, Selber K, Wehmeier UF, Stoye J, Puhler A
Title The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110.
Journal Reference Authors Deng Z, Bai L
Title Antibiotic biosynthetic pathways and pathway engineering--a growing research field in China.
Journal Reference Authors Asamizu S, Yang J, Almabruk KH, Mahmud T
Title Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
Journal Reference Authors Choi WS, Wu X, Choeng YH, Mahmud T, Jeong BC, Lee SH, Chang YK, Kim CJ, Hong SK
Title Genetic organization of the putative salbostatin biosynthetic gene cluster including the 2-epi-5-epi-valiolone synthase gene in Streptomyces albus ATCC 21838.
Journal Reference Authors Wu X, Flatt PM, Xu H, Mahmud T
Title Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.
Journal Related ko00520 Amino sugar and nucleotide sugar metabolism
