Entry Name Endocytosis - Aegilops tauschii (wheat D)
Description Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class Cellular Processes; Transport and catabolismBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Aegilops tauschii (wheat D) [GN:
ats ]
Gene 109768713 uncharacterized calcium-binding protein C800.10c-like [KO:K12472 ]
109740232 protein EARLY-RESPONSIVE TO DEHYDRATION 7, chloroplastic-like [KO:K19366 ]
109774214 senescence/dehydration-associated protein At3g51250-like [KO:K19366 ]
109758701 senescence/dehydration-associated protein At3g51250-like [KO:K19366 ]
109784172 actin-related protein 2/3 complex subunit 3-like isoform X1 [KO:K05756 ]
109745079 probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283 ]
109782177 stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283 ]
109763441 vacuolar protein sorting-associated protein 35B isoform X1 [KO:K18468 ]
109751946 vacuolar protein sorting-associated protein 28 homolog 1-like [KO:K12184 ]
109746958 vacuolar protein-sorting-associated protein 37 homolog 1-like isoform X1 [KO:K12185 ]
109766209 vacuolar protein sorting-associated protein 22 homolog 1 [KO:K12188 ]
109774292 vacuolar protein sorting-associated protein 20 homolog 2-like [KO:K12195 ]
109748226 vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194 ]
109741576 vacuolar protein sorting-associated protein 32 homolog 2 [KO:K12194 ]
109776005 vacuolar protein sorting-associated protein 24 homolog 1-like [KO:K12193 ]
109782397 vacuolar protein sorting-associated protein 24 homolog 1-like [KO:K12193 ]
109781977 vacuolar protein sorting-associated protein 2 homolog 2-like [KO:K12191 ]
109741163 vacuolar protein sorting-associated protein 2 homolog 1 [KO:K12191 ]
109733358 vacuolar protein sorting-associated protein 2 homolog 3 [KO:K12192 ]
109767191 protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1-like [KO:K12196 ]
109732665 protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5 [KO:K12199 ]
109771950 vacuolar protein sorting-associated protein 45 homolog [KO:K12479 ]
109735984 probable ADP-ribosylation factor GTPase-activating protein AGD5 [KO:K12486 ]
109735185 ADP-ribosylation factor GTPase-activating protein AGD12-like [KO:K12486 ]
109735641 ADP-ribosylation factor GTPase-activating protein AGD12-like [KO:K12486 ]
109765823 probable ADP-ribosylation factor GTPase-activating protein AGD11 [KO:K12486 ]
109733381 probable ADP-ribosylation factor GTPase-activating protein AGD11 [KO:K12486 ]
109751792 ADP-ribosylation factor GTPase-activating protein AGD3-like [KO:K12489 ]
109766119 ADP-ribosylation factor GTPase-activating protein AGD2-like [KO:K12489 ]
109774299 ADP-ribosylation factor GTPase-activating protein AGD3-like [KO:K12489 ]
109745301 probable ADP-ribosylation factor GTPase-activating protein AGD6 [KO:K12492 ]
109754879 probable ADP-ribosylation factor GTPase-activating protein AGD9 [KO:K12493 ]
109750794 probable ADP-ribosylation factor GTPase-activating protein AGD8 [KO:K12493 ]
109754842 brefeldin A-inhibited guanine nucleotide-exchange protein 1-like [KO:K18442 ]
109746460 brefeldin A-inhibited guanine nucleotide-exchange protein 2-like [KO:K18442 ]
109736722 brefeldin A-inhibited guanine nucleotide-exchange protein 1-like [KO:K18442 ]
Compound C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11556 1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference Authors Acconcia F, Sigismund S, Polo S
Title Ubiquitin in trafficking: the network at work.
Journal Reference Authors Donaldson JG, Porat-Shliom N, Cohen LA
Title Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
Journal Reference Authors Sorkin A
Title Cargo recognition during clathrin-mediated endocytosis: a team effort.
Journal Reference Authors Raiborg C, Stenmark H
Title The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
Journal Reference Authors Scita G, Di Fiore PP
Title The endocytic matrix.
Journal Reference Authors Le Roy C, Wrana JL
Title Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
Journal Reference Authors Jovic M, Sharma M, Rahajeng J, Caplan S
Title The early endosome: a busy sorting station for proteins at the crossroads.
Journal Reference Authors Pietiainen VM, Marjomaki V, Heino J, Hyypia T
Title Viral entry, lipid rafts and caveosomes.
Journal Reference Authors Grant BD, Donaldson JG
Title Pathways and mechanisms of endocytic recycling.
Journal Reference Authors Cullen PJ, Korswagen HC
Title Sorting nexins provide diversity for retromer-dependent trafficking events.
Journal Related ats04070 Phosphatidylinositol signaling system
ats04130 SNARE interactions in vesicular transport
KO pathway LinkDB All DBs
