KEGG ORTHOLOGY: K12192

ORTHOLOGY: K12192

Entry

K12192                      KO

Symbol

CHMP2B

Name

charged multivesicular body protein 2B

Pathway

map04144

Endocytosis

map04217

Necroptosis

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H02342

Frontotemporal dementia and amyotrophic lateral sclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K12192  CHMP2B; charged multivesicular body protein 2B
  09143 Cell growth and death
   04217 Necroptosis
    K12192  CHMP2B; charged multivesicular body protein 2B
09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K12192  CHMP2B; charged multivesicular body protein 2B
   05022 Pathways of neurodegeneration - multiple diseases
    K12192  CHMP2B; charged multivesicular body protein 2B
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K12192  CHMP2B; charged multivesicular body protein 2B
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K12192  CHMP2B; charged multivesicular body protein 2B
Membrane trafficking [BR:ko04131]
Endosome - Lysosome transport
  Endosomal sorting complexes required for transport (ESCRT)
   ESCRT-III complex
    K12192  CHMP2B; charged multivesicular body protein 2B
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K12192  CHMP2B; charged multivesicular body protein 2B

Genes

HSA:	25978(CHMP2B)

PTR:	735485(CHMP2B)

PPS:	100972013(CHMP2B)

GGO:	101138549(CHMP2B)

PON:	100172566(CHMP2B)

PPYG:

129033826(CHMP2B)

NLE:	100592357(CHMP2B)

HMH:	116467055(CHMP2B)

SSYN:

129471287(CHMP2B)

MCC:	719340(CHMP2B)

MCF:	102117106(CHMP2B)

MTHB:

126949340

MNI:	105485504(CHMP2B)

CSAB:

103228544(CHMP2B)

CATY:

105583589(CHMP2B)

PANU:

100999632(CHMP2B)

TGE:	112618935(CHMP2B)

MLEU:

105537161(CHMP2B)

RRO:	104677664(CHMP2B)

RBB:	108512778(CHMP2B)

TFN:	117083654(CHMP2B)

PTEH:

111545138(CHMP2B)

CANG:

105501590(CHMP2B)

CJC:	100408012(CHMP2B)

SBQ:	101050656(CHMP2B)

CIMI:

108315084(CHMP2B)

ANAN:

105718831(CHMP2B)

CSYR:

103256549(CHMP2B)

MMUR:

105859315(CHMP2B)

LCAT:

123630631(CHMP2B)

PCOQ:

105810348(CHMP2B)

OGA:	100960120(CHMP2B)

MMU:	68942(Chmp2b)

MCAL:

110311481(Chmp2b)

MPAH:

110329591(Chmp2b)

RNO:	363720(Chmp2b)

MCOC:

116086049(Chmp2b)

ANU:	117718147(Chmp2b)

ASYL:

127666106(Chmp2b)

MUN:	110541151(Chmp2b)

CGE:	100773840(Chmp2b)

MAUA:

101844089(Chmp2b)

PROB:

127227427(Chmp2b)

PLEU:

114709042(Chmp2b)

PMAV:

102921043(Chmp2b)

MORG:

121465414(Chmp2b)

MFOT:

126505611

AAMP:

119824939(Chmp2b)

NGI:	103733425(Chmp2b)

HGL:	101717020(Chmp2b)

CPOC:

100734811(Chmp2b)

CCAN:

109692171(Chmp2b)

DORD:

105991526(Chmp2b)

DSP:	122105641(Chmp2b)

DMER:

138832435(Chmp2b)

PLOP:

125351585(Chmp2b)

NCAR:

124992306

MMMA:

107136394(Chmp2b)

ITI:	101971350(Chmp2b)

OCU:

100338505

OPI:	101529730(CHMP2B)

OCZ:	121156749(CHMP2B)

TUP:	102477762(CHMP2B)

GVR:	103590181(CHMP2B)

CFA:	487675(CHMP2B)

CLUD:

112661666(CHMP2B)

VVP:	112910195(CHMP2B)

VLG:	121479309(CHMP2B)

NPO:	129502478(CHMP2B)

AML:	100471117(CHMP2B)

UMR:	103675518(CHMP2B)

UAH:	113248787(CHMP2B)

UAR:	123784142(CHMP2B)

ELK:

111148914

LLV:

125095756

MPUF:

101671627(CHMP2B)

MNP:	132009809 132012298(CHMP2B)

MLK:	131825238(CHMP2B)

NVS:	122908402(CHMP2B)

ORO:	101379097(CHMP2B)

EJU:	114219107(CHMP2B)

ZCA:	113918190(CHMP2B)

MLX:	118017342(CHMP2B)

NSU:	110579743(CHMP2B)

LWW:	102743436(CHMP2B)

FCA:	101099491(CHMP2B)

PYU:	121036103(CHMP2B)

PCOO:

112849489(CHMP2B)

PBG:	122491318(CHMP2B)

PVIV:

125175626(CHMP2B)

LRUF:

124526644

LGF:	123610738(CHMP2B)

AJU:

106969434

PTG:	102963840(CHMP2B)

PPAD:

109255352(CHMP2B)

PUC:

125920835

PLEZ:

122229905(CHMP2B)

HHV:	120225449(CHMP2B)

BTA:	615954(CHMP2B)

BOM:	102278613(CHMP2B)

BIU:	109562036(CHMP2B)

BBUB:

102392044(CHMP2B)

BBIS:

104999298(CHMP2B)

CHX:	102187985(CHMP2B)

OAS:	101121224(CHMP2B)

BTAX:

128053922(CHMP2B)

CSUM:

138080075(CHMP2B)

ODA:	120853205(CHMP2B)

CCAD:

122428836(CHMP2B)

MREE:

136152418(CHMP2B)

OVR:	110137076(CHMP2B)

MBEZ:

129555796(CHMP2B)

SSC:	100516044(CHMP2B)

CFR:	102510627(CHMP2B)

CBAI:

105077952(CHMP2B)

CDK:	105087769(CHMP2B)

VPC:	102540679(CHMP2B)

BACU:

103014014(CHMP2B)

BMUS:

118894875(CHMP2B)

LVE:	103078435(CHMP2B)

OOR:	101272760(CHMP2B) 101281122

LALB:

132520657(CHMP2B)

GMF:	115855594(CHMP2B)

DDP:	132424626(CHMP2B)

DLE:	111178019(CHMP2B)

PCAD:

102992919(CHMP2B)

PSIU:

116753561(CHMP2B)

PPHC:

136122465(CHMP2B)

NASI:

112396894(CHMP2B)

ECB:	100070130(CHMP2B)

EPZ:	103540881(CHMP2B)

EAI:	106823264(CHMP2B)

MYB:	102243679(CHMP2B)

MYD:	102770007(CHMP2B)

MMYO:

118675378(CHMP2B)

MLF:	102421376(CHMP2B)

MDT:	132230500(CHMP2B)

MYUM:

139003772(CHMP2B)

PKL:	118722874(CHMP2B)

EFUS:

103296693(CHMP2B)

MNA:	107524608(CHMP2B)

DRO:	112302604(CHMP2B)

SHON:

118995865(CHMP2B)

AJM:	119038286(CHMP2B)

PDIC:

114490888(CHMP2B)

PHAS:

123827007(CHMP2B)

MMF:	118617688(CHMP2B)

PPAM:

129076256 129079947(CHMP2B)

HAI:	109374898(CHMP2B)

RFQ:	117013806(CHMP2B)

PALE:

102880830(CHMP2B)

PGIG:

120615093(CHMP2B)

PVP:	105289649(CHMP2B)

RAY:	107511461(CHMP2B)

MJV:	108402887(CHMP2B)

TOD:	119257607(CHMP2B)

SARA:

101545311(CHMP2B)

SFUM:

130043147(CHMP2B)

SETR:

126025717(CHMP2B)

LAV:	100662105(CHMP2B)

TMU:

101351988

ETF:	101659619(CHMP2B)

DNM:	101440465(CHMP2B)

MDO:	100030296(CHMP2B)

GAS:	123242522(CHMP2B)

SHR:	100928373(CHMP2B)

AFZ:

127553565

PCW:	110197103(CHMP2B)

TVP:	118844720 118848820(CHMP2B)

PBRV:

138165589(CHMP2B)

MLAO:

141491384(CHMP2B)

OAA:	100084750(CHMP2B)

TACU:

119945220(CHMP2B)

GGA:	418461(CHMP2B)

PCOC:

116242012(CHMP2B)

MGP:	100541435(CHMP2B)

CJO:	107322199(CHMP2B)

TPAI:

128091067(CHMP2B)

LMUT:

125700436(CHMP2B)

NMEL:

110401563(CHMP2B)

APLA:

101801259(CHMP2B)

ACYG:

106037202(CHMP2B)

CATA:

118245023(CHMP2B)

AFUL:

116498259(CHMP2B)

TGU:	100224229(CHMP2B)

LSR:	110476403(CHMP2B)

SCAN:

103818350(CHMP2B)

PMOA:

120504071(CHMP2B)

OTC:	121344748(CHMP2B)

PRUF:

121360445(CHMP2B)

ATRC:

139593082(CHMP2B)

GFR:	102041966(CHMP2B)

FAB:	101813595(CHMP2B)

OMA:	130254472(CHMP2B)

PHI:	102103006(CHMP2B)

PMAJ:

107212387(CHMP2B)

CCAE:

111943555(CHMP2B)

CCW:	104689409(CHMP2B)

CBRC:

103613733(CHMP2B)

ACOE:

138115211(CHMP2B)

ETL:	114066336(CHMP2B)

ZAB:	102072486(CHMP2B)

ZLE:	135454703(CHMP2B)

ACHL:

103803650(CHMP2B)

SVG:	106862204(CHMP2B)

MMEA:

130588914(CHMP2B)

HRT:	120749457(CHMP2B)

SATI:

136375393(CHMP2B)

CCIC:

134058203(CHMP2B)

FPG:	101919883(CHMP2B)

FCH:	102048105(CHMP2B)

CCRI:

104162798(CHMP2B)

NNT:	104412016(CHMP2B)

SHAB:

115601574(CHMP2B)

ACUN:

113479092(CHMP2B)

TALA:

104360562(CHMP2B)

ACHC:

115343875(CHMP2B)

HALD:

104316661(CHMP2B)

HLE:	104831577(CHMP2B)

AGEN:

126049032

HHAR:

128145059(CHMP2B)

GCL:

127016498

CSTI:

104557009(CHMP2B) 104559940

LDI:	104353834(CHMP2B)

MNB:	103773571(CHMP2B)

DPUB:

104298037(CHMP2B)

PPUS:

135180085(CHMP2B)

AVIT:

104267262(CHMP2B) 104275191

BRHI:

104497274(CHMP2B)

EGZ:	104123014(CHMP2B)

NNI:	104015010(CHMP2B)

PCRI:

104025522(CHMP2B)

PCAO:

104049541(CHMP2B)

PADL:

103916891(CHMP2B)

AFOR:

103895009(CHMP2B)

FGA:	104079155(CHMP2B)

CBOR:

142091261(CHMP2B)

GSTE:

104264666(CHMP2B)

CBOY:

140662436(CHMP2B)

MAME:

142416581(CHMP2B)

CLV:	102093151(CHMP2B)

CNIC:

135994233(CHMP2B)

MUI:	104543640(CHMP2B)

PGUU:

104467298(CHMP2B)

PLET:

104615134(CHMP2B)

EHS:	104504853(CHMP2B)

CMAC:

104484567(CHMP2B)

CUCA:

104056028(CHMP2B)

TEO:	104384303(CHMP2B)

BREG:

104642847(CHMP2B)

OHA:	104337360(CHMP2B)

ACAR:

104526379(CHMP2B)

CVF:	104290925(CHMP2B)

RTD:	128902173(CHMP2B)

CRID:

134521420(CHMP2B)

LMIC:

141747963(CHMP2B)

AAM:	106490746(CHMP2B)

AROW:

112974455(CHMP2B)

NPD:	112948305(CHMP2B)

TGT:	104565196(CHMP2B)

DNE:	112979295(CHMP2B)

SCAM:

104143958(CHMP2B)

ASN:	102369027(CHMP2B)

AMJ:	102561838(CHMP2B)

CPOO:

109305685(CHMP2B)

GGN:	109303492(CHMP2B)

PSS:	102444489(CHMP2B)

CIZ:	142014744(CHMP2B)

CMY:	102933951(CHMP2B)

CCAY:

125644688(CHMP2B)

DCC:	119849763(CHMP2B)

CPIC:

101947152(CHMP2B)

TST:	117888633(CHMP2B)

CABI:

116820723(CHMP2B)

MRV:	120395572(CHMP2B)

ACS:	100552916(chmp2b)

ASAO:

132771944(CHMP2B)

PVT:	110088615(CHMP2B)

SUND:

121926950(CHMP2B)

PBI:	103061699(CHMP2B)

PMUR:

107289027(CHMP2B)

CTIG:

120303888(CHMP2B)

TSR:	106537707(CHMP2B)

PGUT:

117666742(CHMP2B)

PCAE:

139316136(CHMP2B)

APRI:

131199697(CHMP2B)

PTEX:

113436326(CHMP2B)

NSS:	113409833(CHMP2B)

VKO:	123029507(CHMP2B)

PMUA:

114595974(CHMP2B)

PRAF:

128412906(CHMP2B)

ZVI:	118085331(CHMP2B)

HCG:	128351278(CHMP2B)

GJA:	107107395(CHMP2B)

STOW:

125431732(CHMP2B)

EMC:	129326652(CHMP2B)

XLA:	380442(chmp2b.S) 447576(chmp2b.L)

XTR:	407966(chmp2b)

NPR:	108792426(CHMP2B)

RTEM:

120927829(CHMP2B)

ACAT:

141129175(CHMP2B)

PADS:

140344632(CHMP2B)

BBUF:

120994580(CHMP2B)

BGAR:

122930859(CHMP2B) 122930861

DTC:	141097345(CHMP2B)

PWL:	138249911(CHMP2B)

MUO:	115470744(CHMP2B)

GSH:	117360049(CHMP2B)

DRE:	405840(chmp2bb) 569532(chmp2ba)

SRX:	107713700 107714304 107748903 107757639

SANH:

107654764 107661322 107688654 107691601

SGH:	107551976 107552237 107561317 107598748

CCAR:

109074944 109092339(chmp2ba) 109094333 122133988(chmp2bb)

CAUA:

113044284 113109011 113110725

CGIB:

127948732 127949348 127965040 128015959

PTET:

122342111(chmp2bb) 122351268(chmp2ba)

LROH:

127170858(chmp2bb) 127171361(chmp2ba)

GRF:	141336198 141336280(chmp2bb) 141340985(chmp2ba)

OMC:	131547067(chmp2ba) 131548584(chmp2bb)

PPRM:

120461423(chmp2bb) 120487283(chmp2ba)

RKG:	130075884(chmp2ba) 130087890(chmp2bb)

MAMB:

125269929(chmp2ba) 125272254(chmp2bb)

CIDE:

127512409 127518926

CERY:

137032845(chmp2bb) 137035812(chmp2ba)

MASI:

127444322 127444853 127447067 127448568

TROS:

130552394(chmp2bb) 130555348(chmp2ba)

TDW:	130407129(chmp2bb) 130427068(chmp2ba)

MANU:

129444489(chmp2bb) 129452041(chmp2ba)

PDAB:

135736119(chmp2bb) 135782620(chmp2ba)

IPU:	100528413(chmp2bb) 108266086(chmp2ba)

IFU:	128602257(chmp2bb) 128608828(chmp2ba)

PHYP:

113537748(chmp2b) 113547704

SMEO:

124378568(chmp2bb) 124382951(chmp2ba)

TFD:	113654004(chmp2bb) 113654184(chmp2ba)

TVC:	132839614(chmp2bb) 132850664(chmp2ba)

CGAR:

128506150(chmp2bb) 128524359(chmp2ba)

NGRA:

132866299(chmp2bb) 132891285(chmp2ba)

TRN:	134324598(chmp2ba) 134328676(chmp2bb)

AMEX:

103024321(chmp2bb) 103032982(chmp2ba)

CMAO:

118803050(chmp2bb) 118804883(chmp2ba)

EEE:	113576632 113577085

CHAR:

105893391(chmp2ba) 105905451(chmp2bb)

SPIL:

134070815(chmp2bb) 134078615(chmp2ba)

ASAD:

121698106(chmp2ba) 121698194(chmp2bb)

TRU:	101069954(chmp2b)

TFS:	130528694(chmp2ba)

TNG:	GSTEN00030441G001

LCO:	104923836(chmp2b)

TBEN:

117485704(chmp2ba)

CGOB:

115026722(chmp2b)

PGEO:

117466644(chmp2ba)

GACU:

117560102(chmp2ba)

EMAC:

134867260(chmp2ba)

ELY:	117251697(chmp2ba)

EFO:	125899468(chmp2ba)

PLEP:

121949395(chmp2ba)

SLUC:

116037741(chmp2ba)

ECRA:

117952825(chmp2ba)

ESP:	116698043(chmp2b)

PFLV:

114563884(chmp2b)

GAT:	120833972(chmp2ba)

PPUG:

119228624(chmp2ba)

AFB:	129104575(chmp2ba)

CLUM:

117750358(chmp2ba)

PSWI:

130208713(chmp2ba)

CANA:

137783019(chmp2ba)

CVE:	137892393(chmp2ba)

MSAM:

119903943(chmp2ba)

SCHU:

122885482(chmp2ba)

CUD:	121523095(chmp2ba)

SPUL:

138592890(chmp2ba)

LMIX:

132987249(chmp2ba)

HTC:

141808892

ALAT:

119026198(chmp2ba)

ASTR:

137604976(chmp2ba)

MZE:	101486518(chmp2b)

ONL:	100697869(chmp2b)

OAU:	116311984(chmp2ba)

OLA:	101166263(chmp2b)

OML:	112155352(chmp2ba)

CSAI:

133446053(chmp2ba)

XMA:	102238076(chmp2b)

XCO:	114148140(chmp2b)

XHE:	116723054(chmp2b)

PRET:

103461393(chmp2b)

PFOR:

103141466(chmp2b)

PLAI:

106952607(chmp2b)

PMEI:

106932593(chmp2b)

GAF:	122839341(chmp2ba)

PPRL:

129361291(chmp2ba)

CVG:	107090449(chmp2b)

CTUL:

119777504(chmp2ba)

GMU:	124871412(chmp2ba)

NFU:	107389400(chmp2b)

KMR:	108240428(chmp2ba)

ALIM:

106519728(chmp2b)

NWH:	119419069(chmp2ba)

AOCE:

111583064(chmp2ba)

EJA:	138201231(chmp2ba)

BFRE:

138620881(chmp2ba)

MCEP:

125017562(chmp2ba)

CSEM:

103392255(chmp2b)

POV:	109631474(chmp2b)

SSEN:

122765232(chmp2ba)

SSOE:

131455293(chmp2ba)

HHIP:

117754927(chmp2ba)

HSP:	118120205(chmp2ba)

PPLT:

128456005(chmp2ba)

SMAU:

118282627(chmp2ba)

LCF:	108900547(chmp2ba)

SDU:	111218376(chmp2b)

SLAL:

111662727(chmp2b)

XGL:	120802030(chmp2ba)

HCQ:	109531300(chmp2b)

SSCV:

125973609(chmp2ba)

SBIA:

133512587(chmp2ba)

PEE:	133410891(chmp2ba)

PTAO:

133486764(chmp2ba)

BPEC:

110156082(chmp2b)

ENY:	140359877(chmp2ba)

MALB:

109968275(chmp2b)

BSPL:

114847356(chmp2ba)

SJO:	128368442(chmp2ba)

SSCO:

133993076(chmp2ba)

TTY:	137192517(chmp2ba)

GMH:	115533241(chmp2b)

SASA:

106575904 106582169 106582223 106586513

STRU:

115155718 115161049 115184087 115184093

OTW:	112225508 112239858 112242331 121843641

OMY:	110501715 110520362(chmp2ba) 110527176 118936675

OGO:	124018721 124021069 124042956 124046393(chmp2ba)

ONE:	115111744 115129136

OKI:	109877794 109887345 109902933 116373002

OKE:	118371339 118377265 118382530

OMM:	135519220(chmp2ba) 135543103 135543109 135543110 135547506

OCLA:

139380195 139393716 139394106 139402217

SALP:

111959900 111978032

SNH:	120057940(chmp2ba) 120064264

SFON:

129816504 129820933(chmp2ba) 129842141

CCLU:

121536935(chmp2ba) 121562537(chmp2bb) 121571730

ELS:	105016369 105020089

OEP:	134007561(chmp2bb) 134017434(chmp2ba)

SFM:	108920441 108927663(chmp2b)

PKI:	111836215(chmp2b) 111852761

AANG:

118214589(chmp2ba) 118224107

AROT:

135240725(chmp2ba) 135250501

CCOG:

133116773(chmp2ba) 133124085

LOC:	102687452(chmp2b)

PSPA:

121320536 121327980

ARUT:

117405319 117406571

PSEX:

120523576(chmp2ba)

LCM:	102360574(CHMP2B)

CMK:

103180092

RTP:	109915038(chmp2ba)

CPLA:

122555315

CPUN:

140486394

HOC:

132820833

SCAU:

119968844(chmp2ba)

STOZ:

140427798(chmp2ba)

LERI:

129702931

HAKA:

140727589

PMRN:

116938436(CHMP2B)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

LVG:	121413847 121414020

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG4618(CHMP2B)

DER:

6544045

DSE:

6610856

DSI:	Dsimw501_GD13878(Dsim_GD13878)

DYA:	Dyak_GE21483

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI13330

DAZ:

108613239

DNV:

108651202

DHE:

111601659

DVI:	6622245(CHMP2B)

CCAT:

101456630

BOD:

106614100

BDR:

105232905

RZE:	108360075 108374849

AOQ:

129240634

ALUD:

128859694

TDA:	119668606 119669357

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135953837(CHMP2B)

GFS:

ECOE:

HIS:

CNS:

BCOO:

LLL:

PPAP:

TCA:

TMOL:

138139214(CHMP2B)

DPA:

109537810

ESIM:

136417785(CHMP2B)

EFOR:

136338753(CHMP2B)

SOY:

115887764

RFG:	143198417(CHMP2B)

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_201664

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137933602(CHMP2B)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141427130 141436796 141436890

CCRN:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111055413 120351777 120351778

LDA:	142321747(CHMP2B)

HVI:

124359335

MQU:

128983515

PHU:	Phum_PHUM569980

FOC:

TPAL:

ZNE:

CSEC:

PAME:

SGRE:

BROR:

IEL:

HAMR:

139700962(CHMP2B)

FCD:

110859775

DPX:	DAPPUDRAFT_303881

DMK:

116925479

DPZ:	124313360 124344043

PVM:	113801237(CHMP2B)

PJA:

122263912

PCHN:

125039946

HAME:

121862109

PCLA:

123775007(CHMP2B)

CQD:	128694302(CHMP2B)

PTRU:

123514739

ESN:

126995554

MRJ:	136840687(CHMP2B)

PORN:

139760371(CHMP2B)

HAZT:

108676396

OOT:

143036418

LSM:	121132355(CHMP2B)

TCF:

PPOI:

ISC:

DSV:

DALB:

135920222(CHMP2B)

RSAN:

RMP:

VDE:

VJA:

GOE:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136968661(CHMP2B)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_C01A2.4(C01A2.4)

CBR:

CBG_20395

CRQ:	GCK72_001718

NAI:	NECAME_00796

TSP:

Tsp_10475

HRO:	HELRODRAFT_167737

LGI:	LOTGIDRAFT_203267

PVUL:

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:	111099617 111099900

OED:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_070030

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_25101

AQU:	100636792 100640259

ATH:	AT1G03950(VPS2.3)

ALY:

9328251

CRB:

17898445

CSAT:

104738905 104754517 104761483

EUS:	EUTSA_v10008774mg

BRP:

103844298

BNA:	106370950 106397023

BOE:

106293004

RSZ:	108820778 108821178 130506471 130511553

THJ:

104801143

CPAP:

110807686

CIT:

102631163

CIC:	CICLE_v10022189mg

PVY:

116143124

MINC:

123216219

TCC:

18613108

GRA:	105767891 105798195

GHI:	107952890 107955524 107958637

GAB:	108470318 108470922

HSYR:

120186293 120189158

DZI:	111305311 111314328

EGR:

104428068

RARG:

115730547

GMX:	100306343 100499888

GSJ:	114398245 114406939

PVU:

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:	25484236 25499281

TPRA:

123888106 123913314

CAM:	101493614 101493818

PSAT:

127091597 127126026

VVO:	131610104 131638926 131640259

LJA:

130730518

ADU:	107473803 107491739

AIP:	107625016 107646198 110271613

AHF:	112695186 112727087 112740563 112758740

LANG:

109335107 109348451

PCIN:

129311543

QSA:	O6P43_006879 O6P43_010485

FVE:

101293447

AANS:

126782559

RCN:	112169122 112171345

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103435723 103445600

MSYL:

126585404 126622147

PXB:	103928768 103958858

PCOX:

ZJU:

MNT:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:	110650312 110663345 110663349

MESC:

110627435 110629055

POP:	7471955 7476932

PEU:	105110628 105113146 105128743

PALZ:

118052820 118062149

PNZ:	133692095 133693541

JRE:

CILL:

CAVE:

AGLU:

QSU:

QLO:

CSAA:

TWL:	119990788 120010322

VVI:

VRI:

SLY:

SPEN:

SOT:	102582862 102586046 102591990

SSTN:

125846731 125872869 125873989

SDUL:

CANN:

LBB:

NTA:

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:	111402455 111405793

EGT:	105950254 105956527

SSPL:

121752637 121794407 121798637

SMIL:

SHIS:

APAN:

HPUM:

PHUA:

PEBU:

PTAB:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

114287969 114303666 114319454

RVL:

131313082

AEW:	130753714 130767100 130770767

DLT:

127787712

BVG:

104899194

SOE:

110794417

CQI:	110689753 110727973

ATRI:

130813961

SLAF:

141591830 141591987 141603785

MOF:

131155053

NNU:	104600906 104602851

MING:

122069336 122090694

TSS:	122641661 122665856

PSOM:

OSA:

DOSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119268902 119321290

TAES:

123045480 123121297 123181063

TUA:

HVG:

LPER:

LRD:

SBI:

ZMA:

MFLO:

136484659 136536249 136538317 136538963

SITA:

SVS:

PVIR:

PHAI:

PAUA:

TANG:

PDA:	103703926 103717601

EGU:	105033610 105054476 140850988

MUS:

135612128

ZOF:	122042532 122047049

AOF:

MSIN:

ACAK:

NCOL:

ATR:

CJF:

SMO:	SELMODRAFT_130018 SELMODRAFT_228468 SELMODRAFT_266789 SELMODRAFT_441725

PPP:	112275455 112279590 112290251

CRE:	CHLRE_17g735400v5

VCN:	VOLCADRAFT_108220

MNG:

MNEG_6039

CVR:	CHLNCDRAFT_138002

APRO:

F751_2224

MBR:	MONBRDRAFT_22088

SRE:	PTSG_02740

NGR:	NAEGRDRAFT_53322

EHX:	EMIHUDRAFT_438481(VPS2B) EMIHUDRAFT_459029

GTT:	GUITHDRAFT_160836(VPS2A)

BFD:	NCTC4823_02733(mcpA_3)

» show all

Reference

PMID:22521643

Authors

Han JH, Ryu HH, Jun MH, Jang DJ, Lee JA

Title

The functional analysis of the CHMP2B missense mutation associated with neurodegenerative diseases in the endo-lysosomal pathway.

Journal

Biochem Biophys Res Commun 421:544-9 (2012)
DOI:10.1016/j.bbrc.2012.04.041

Sequence

[hsa:25978]

Reference

PMID:16041373

Authors

Skibinski G, Parkinson NJ, Brown JM, Chakrabarti L, Lloyd SL, Hummerich H, Nielsen JE, Hodges JR, Spillantini MG, Thusgaard T, Brandner S, Brun A, Rossor MN, Gade A, Johannsen P, Sorensen SA, Gydesen S, Fisher EM, Collinge J

Title

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia.

Journal

Nat Genet 37:806-8 (2005)
DOI:10.1038/ng1609

Sequence

[hsa:25978]

LinkDB

DBGET integrated database retrieval system