KEGG   PATHWAY: bbel00591
Entry
bbel00591                   Pathway                                
Name
Linoleic acid metabolism - Branchiostoma belcheri (Belcher's lancelet)
Class
Metabolism; Lipid metabolism
Pathway map
bbel00591  Linoleic acid metabolism
bbel00591

Other DBs
GO: 0043651
Organism
Branchiostoma belcheri (Belcher's lancelet) [GN:bbel]
Gene
109468636  basic phospholipase A2 KBf-VA-like [KO:K01047] [EC:3.1.1.4]
109468640  phospholipase A2 A2-actitoxin-Cgg2a-like [KO:K01047] [EC:3.1.1.4]
109470570  uncharacterized protein LOC109470570 [KO:K01047] [EC:3.1.1.4]
109478353  group XIIA secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
109462830  basic phospholipase A2 Vb-2-like [KO:K01047] [EC:3.1.1.4]
109487311  acidic phospholipase A2 PLA-1-like [KO:K01047] [EC:3.1.1.4]
109464209  phospholipase A2 A2-actitoxin-Ucs2a-like [KO:K01047] [EC:3.1.1.4]
109474620  acidic phospholipase A2 2-like [KO:K01047] [EC:3.1.1.4]
109474623  basic phospholipase A2 PA-11-like [KO:K01047] [EC:3.1.1.4]
109483840  basic phospholipase A2 acanthin-2-like [KO:K01047] [EC:3.1.1.4]
109462020  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
109483454  85/88 kDa calcium-independent phospholipase A2-like isoform X1 [KO:K16343] [EC:3.1.1.4]
109483502  retinoic acid receptor responder protein 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
109483565  HRAS-like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
109475746  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
109484161  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
109470437  cytochrome P450 2C30-like [KO:K07413] [EC:1.14.14.1]
109461524  vitamin D(3) 25-hydroxylase-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109461651  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109461725  cytochrome P450 2U1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109461727  cytochrome P450 2U1-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109485002  cytochrome P450 2D6-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109477936  cytochrome P450 2D4-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109462264  cytochrome P450 2D6-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109471284  cytochrome P450 2C31-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109472128  LOW QUALITY PROTEIN: cytochrome P450 2D6-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109472267  cytochrome P450 2D6-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109472270  LOW QUALITY PROTEIN: cytochrome P450 2U1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109480295  cytochrome P450 2U1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109465453  cytochrome P450 2D4-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109465656  cytochrome P450 2U1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109482013  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109482167  cytochrome P450 2J1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109466367  cytochrome P450 2D6-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109475266  cytochrome P450 2U1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109467919  cytochrome P450 2U1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109483920  cytochrome P450 2U1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109483935  cytochrome P450 2U1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109483947  cytochrome P450 2U1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109483948  cytochrome P450 2U1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109468932  cytochrome P450 3A41-like [KO:K07424] [EC:1.14.14.1]
109477106  cytochrome P450 3A8-like [KO:K07424] [EC:1.14.14.1]
109469473  cytochrome P450 3A8-like [KO:K07424] [EC:1.14.14.1]
109485683  cytochrome P450 3A29-like [KO:K07424] [EC:1.14.14.1]
109485810  cytochrome P450 3A24-like [KO:K07424] [EC:1.14.14.1]
109485811  cytochrome P450 3A24-like [KO:K07424] [EC:1.14.14.1]
109485812  cytochrome P450 3A8-like [KO:K07424] [EC:1.14.14.1]
109485813  cytochrome P450 3A24-like [KO:K07424] [EC:1.14.14.1]
109470714  cytochrome P450 3A8-like [KO:K07424] [EC:1.14.14.1]
109478808  cytochrome P450 3A8-like isoform X1 [KO:K07424] [EC:1.14.14.1]
109486688  cytochrome P450 3A8-like [KO:K07424] [EC:1.14.14.1]
109471346  cytochrome P450 3A13-like [KO:K07424] [EC:1.14.14.1]
109471464  cytochrome P450 3A9-like isoform X1 [KO:K07424] [EC:1.14.14.1]
109463787  cytochrome P450 3A21-like [KO:K07424] [EC:1.14.14.1]
109464201  cytochrome P450 3A24-like [KO:K07424] [EC:1.14.14.1]
109467470  cytochrome P450 3A29-like [KO:K07424] [EC:1.14.14.1]
109475399  cytochrome P450 3A19-like [KO:K07424] [EC:1.14.14.1]
109476094  cytochrome P450 3A8-like [KO:K07424] [EC:1.14.14.1]
109484389  cytochrome P450 3A8-like [KO:K07424] [EC:1.14.14.1]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C01595  Linoleate
C03242  Dihomo-gamma-linolenate
C04056  Rumenic acid
C04717  (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid
C06426  (6Z,9Z,12Z)-Octadecatrienoic acid
C07289  Crepenynate
C07338  (9Z,12Z)-(11S)-11-Hydroperoxyoctadeca-9,12-dienoic acid
C07354  (7S,8S)-DiHODE
C14762  13(S)-HODE
C14765  13-OxoODE
C14766  9-OxoODE
C14767  9(S)-HODE
C14825  9(10)-EpOME
C14826  12(13)-EpOME
C14827  9(S)-HPODE
C14828  9,10-DHOME
C14829  12,13-DHOME
C14831  8(R)-HPODE
C14832  12,13-Epoxy-9-hydroxy-10-octadecenoate
C14833  9,12,13-TriHOME
C14834  9,10-Epoxy-13-hydroxy-11-octadecenoate
C14835  9,10,13-TriHOME
C14836  9,10-12,13-Diepoxyoctadecanoate
C14837  9,10-Dihydroxy-12,13-epoxyoctadecanoate
C19937  (8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoate
C20186  5S,8R-DiHODE
C22918  (9Z,11E)-12-[(1E)-Hex-1-en-1-yloxy]dodeca-9,11-dienoic acid
Reference
  Authors
Nowak G, Grant DF, Moran JH.
  Title
Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia.
  Journal
Toxicol Lett 147:161-75 (2004)
DOI:10.1016/j.toxlet.2003.11.002
Reference
  Authors
Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM.
  Title
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
  Journal
Proc Natl Acad Sci U S A 100:9968-73 (2003)
DOI:10.1073/pnas.1631086100
Reference
  Authors
Spiteller G.
  Title
Do changes in the cell membrane structure induce the generation of lipid peroxidation products which serve as first signalling molecules in cell to cell communication?
  Journal
Prostaglandins Leukot Essent Fatty Acids 67:151-62 (2002)
DOI:10.1054/plef.2002.0413
Reference
  Authors
Jude AR, Little JM, Bull AW, Podgorski I, Radominska-Pandya A.
  Title
13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases.
  Journal
Drug Metab Dispos 29:652-5 (2001)
Reference
PMID:9694817
  Authors
Su C, Sahlin M, Oliw EH.
  Title
A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities.
  Journal
J Biol Chem 273:20744-51 (1998)
DOI:10.1074/jbc.273.33.20744
Reference
PMID:1634517
  Authors
Brodowsky ID, Hamberg M, Oliw EH.
  Title
A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid.
  Journal
J Biol Chem 267:14738-45 (1992)
Reference
  Authors
Hamberg M, Hamberg G.
  Title
Peroxygenase-Catalyzed Fatty Acid Epoxidation in Cereal Seeds (Sequential Oxidation of Linoleic Acid into 9(S),12(S),13(S)-Trihydroxy-10(E)-Octadecenoic Acid).
  Journal
Plant Physiol 110:807-815 (1996)
DOI:10.1104/pp.110.3.807
Reference
PMID:8765137
  Authors
Moghaddam M, Motoba K, Borhan B, Pinot F, Hammock BD.
  Title
Novel metabolic pathways for linoleic and arachidonic acid metabolism.
  Journal
Biochim Biophys Acta 1290:327-39 (1996)
DOI:10.1016/0304-4165(96)00037-2
Related
pathway
bbel00590  Arachidonic acid metabolism
KO pathway
ko00591   
LinkDB

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