KEGG   PATHWAY: bgu02020
Entry
bgu02020                    Pathway                                
Name
Two-component system - Burkholderia glumae LMG 2196 = ATCC 33617
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
bgu02020  Two-component system
bgu02020

Other DBs
GO: 0000160
Organism
Burkholderia glumae LMG 2196 = ATCC 33617 [GN:bgu]
Gene
KS03_2087  phoR; phosphate regulon sensor kinase PhoR [KO:K07636] [EC:2.7.13.3]
KS03_2086  phoB; phosphate regulon transcriptional regulatory protein PhoB [KO:K07657]
KS03_2081  pstS; phosphate ABC transporter, phosphate-binding protein PstS [KO:K02040]
KS03_2294  HAMP domain protein [KO:K07638] [EC:2.7.13.3]
KS03_224  HAMP domain protein [KO:K07638] [EC:2.7.13.3]
KS03_4226  HAMP domain protein [KO:K07638] [EC:2.7.13.3]
KS03_2295  hypothetical protein [KO:K07659]
KS03_225  hypothetical protein [KO:K07659]
KS03_4225  hypothetical protein [KO:K07659]
KS03_1893  peptidase Do family protein [KO:K04771] [EC:3.4.21.107]
KS03_417  peptidase Do family protein [KO:K04771] [EC:3.4.21.107]
KS03_5384  trypsin family protein [KO:K04771] [EC:3.4.21.107]
KS03_1955  efflux transporter, RND family, MFP subunit [KO:K07799]
KS03_1954  acrB/AcrD/AcrF family protein [KO:K07788]
KS03_1953  acrB/AcrD/AcrF family protein [KO:K07789]
KS03_5165  acrB/AcrD/AcrF family protein [KO:K07789]
KS03_1093  flagellar transcriptional activator family protein [KO:K02403]
KS03_1094  flhC; flagellar transcriptional regulator FlhC [KO:K02402]
KS03_1086  hypothetical protein [KO:K02406]
KS03_4635  hypothetical protein [KO:K02406]
KS03_3942  hypothetical protein [KO:K02406]
KS03_5025  hypothetical protein [KO:K02406]
KS03_3961  hypothetical protein [KO:K02406]
KS03_1113  RNA polymerase sigma factor, FliA/WhiG family protein [KO:K02405]
KS03_1095  motA; flagellar motor stator protein MotA [KO:K02556]
KS03_2302  motA; flagellar motor stator protein MotA [KO:K02556]
KS03_4388  motA/TolQ/ExbB proton channel family protein [KO:K02556]
KS03_69  universal stress family protein [KO:K07646] [EC:2.7.13.3]
KS03_68  response regulator [KO:K07667]
KS03_72  kdpA; K+-transporting ATPase, A subunit [KO:K01546]
KS03_71  kdpB; K+-transporting ATPase, B subunit [KO:K01547] [EC:7.2.2.6]
KS03_70  kdpC; K+-transporting ATPase, C subunit [KO:K01548]
KS03_2191  nitrate reductase delta subunit [KO:K03533]
KS03_3466  nitrate reductase delta subunit [KO:K03533]
KS03_3063  his Kinase A domain protein [KO:K07649] [EC:2.7.13.3]
KS03_466  his Kinase A domain protein [KO:K07649] [EC:2.7.13.3]
KS03_3064  hypothetical protein [KO:K07774]
KS03_467  hypothetical protein [KO:K07774]
KS03_619  cytochrome oxidase assembly family protein [KO:K02259] [EC:1.17.99.9]
KS03_916  dnaA; chromosomal replication initiator protein DnaA [KO:K02313]
KS03_2541  hypothetical protein [KO:K14205] [EC:2.3.2.3]
KS03_5096  hpcH/HpaI aldolase/citrate lyase family protein [KO:K01644] [EC:4.1.3.34]
KS03_3654  bacterial regulatory s, luxR family protein [KO:K07684]
KS03_4191  nitrate reductase, alpha subunit [KO:K00370] [EC:1.7.5.1 1.7.99.-]
KS03_4190  narH; nitrate reductase, beta subunit [KO:K00371] [EC:1.7.5.1 1.7.99.-]
KS03_4188  narI; respiratory nitrate reductase, gamma subunit [KO:K00374] [EC:1.7.5.1 1.7.99.-]
KS03_4189  narJ; nitrate reductase molybdenum cofactor assembly chaperone [KO:K00373]
KS03_3480  response regulator [KO:K07677] [EC:2.7.13.3]
KS03_3129  his Kinase A domain protein [KO:K07677] [EC:2.7.13.3]
KS03_3128  bacterial regulatory s, luxR family protein [KO:K07687]
KS03_3470  bacterial regulatory s, luxR family protein [KO:K07687]
KS03_804  bacterial regulatory s, luxR family protein [KO:K07689]
KS03_3976  bacterial regulatory s, luxR family protein [KO:K07689]
KS03_3504  hypothetical protein [KO:K07347]
KS03_3126  hypothetical protein [KO:K07347]
KS03_2975  flp/Fap pilin component family protein [KO:K02651]
KS03_2840  flp/Fap pilin component family protein [KO:K02651]
KS03_2837  cpaB; Flp pilus assembly protein CpaB [KO:K02279]
KS03_2836  bacterial type II and III secretion system family protein [KO:K02280]
KS03_2835  response regulator [KO:K02282]
KS03_2834  type II/IV secretion system family protein [KO:K02283] [EC:7.4.2.8]
KS03_2833  type II secretion system (T2SS), F family protein [KO:K12510]
KS03_2832  type II secretion system (T2SS), F family protein [KO:K12511]
KS03_2831  TPR repeat family protein [KO:K27079]
KS03_2829  tad-like Flp pilus-assembly family protein [KO:K27080]
KS03_2233  glnD; protein-P-II uridylyltransferase [KO:K00990] [EC:2.7.7.59]
KS03_233  glnB; nitrogen regulatory protein P-II [KO:K04751]
KS03_3268  sensory box protein [KO:K07708] [EC:2.7.13.3]
KS03_3267  ntrC; nitrogen regulation protein NR [KO:K07712]
KS03_3269  glnA; glutamine synthetase, type I [KO:K01915] [EC:6.3.1.2]
KS03_3281  glutamine synthetase, catalytic domain protein [KO:K01915] [EC:6.3.1.2]
KS03_866  HAMP domain protein [KO:K13598] [EC:2.7.13.3]
KS03_865  bacterial regulatory, Fis family protein [KO:K13599]
KS03_594  atoE; short-chain fatty acids transporter [KO:K02106]
KS03_698  acetyl-CoA C-acyltransferase family protein [KO:K00626] [EC:2.3.1.9]
KS03_2489  acetyl-CoA C-acyltransferase family protein [KO:K00626] [EC:2.3.1.9]
KS03_2339  acetyl-CoA C-acyltransferase family protein [KO:K00626] [EC:2.3.1.9]
KS03_2440  acetyl-CoA C-acyltransferase family protein [KO:K00626] [EC:2.3.1.9]
KS03_652  his Kinase A domain protein [KO:K10125] [EC:2.7.13.3]
KS03_651  AAA domain family protein [KO:K10126]
KS03_1468  dicarboxylate symporter family protein [KO:K11103]
KS03_653  dicarboxylate symporter family protein [KO:K11103]
KS03_2111  rpoN; RNA polymerase sigma-54 factor [KO:K03092]
KS03_577  rpoN; RNA polymerase sigma-54 factor [KO:K03092]
KS03_445  hypothetical protein [KO:K02650]
KS03_2115  cheR methyltransferase, SAM binding domain protein [KO:K00575] [EC:2.1.1.80]
KS03_1101  cheR methyltransferase, SAM binding domain protein [KO:K00575] [EC:2.1.1.80]
KS03_3936  cheR methyltransferase, SAM binding domain protein [KO:K00575] [EC:2.1.1.80]
KS03_3088  hypothetical protein [KO:K03406]
KS03_3298  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_4737  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_4741  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_4745  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_3020  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_3527  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_3810  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_4803  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_4980  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_5019  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_3932  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_3941  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_4957  hypothetical protein [KO:K03406]
KS03_3437  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_5465  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_5467  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_5487  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_5921  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_5923  hypothetical protein [KO:K03406]
KS03_5641  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_5643  hypothetical protein [KO:K03406]
KS03_4681  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_4386  hypothetical protein [KO:K03406]
KS03_3863  hypothetical protein [KO:K03406]
KS03_3975  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K03406]
KS03_3856  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K05874]
KS03_5387  hypothetical protein [KO:K05874]
KS03_4202  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K05874]
KS03_4117  hypothetical protein [KO:K05874]
KS03_4518  methyl-accepting chemotaxis (MCP) signaling domain protein [KO:K05874]
KS03_1100  hypothetical protein [KO:K05874]
KS03_5584  sensory box protein [KO:K03776]
KS03_5930  sensory box protein [KO:K03776]
KS03_3082  cheW-like domain protein [KO:K03408]
KS03_1099  cheW-like domain protein [KO:K03408]
KS03_3933  cheW-like domain protein [KO:K03408]
KS03_3838  cheW-like domain protein [KO:K03408]
KS03_1098  cheW-like domain protein [KO:K03407] [EC:2.7.13.3]
KS03_3938  cheW-like domain protein [KO:K03407] [EC:2.7.13.3]
KS03_341  hpt domain protein [KO:K03407] [EC:2.7.13.3]
KS03_1104  response regulator [KO:K03413]
KS03_1097  response regulator [KO:K03413]
KS03_337  response regulator [KO:K03413]
KS03_3937  response regulator [KO:K03413]
KS03_3940  response regulator [KO:K03413]
KS03_1103  cheB methylesterase family protein [KO:K03412] [EC:3.1.1.61 3.5.1.44]
KS03_2114  cheB methylesterase family protein [KO:K03412] [EC:3.1.1.61 3.5.1.44]
KS03_3934  cheB methylesterase family protein [KO:K03412] [EC:3.1.1.61 3.5.1.44]
KS03_3808  response regulator [KO:K03415]
KS03_4236  methyltransferase domain protein [KO:K13486]
KS03_4234  hypothetical protein [KO:K13487]
KS03_4235  cheW-like domain protein [KO:K13488]
KS03_4237  cheW-like domain protein [KO:K13489]
KS03_4238  cheW-like domain protein [KO:K13490]
KS03_4239  cheB methylesterase family protein [KO:K13491] [EC:3.1.1.61]
KS03_1151  response regulator [KO:K11444] [EC:2.7.7.65]
KS03_4068  GAF domain protein [KO:K11354] [EC:2.7.13.3]
KS03_1492  ABC transporter family protein [KO:K10004] [EC:7.4.2.1]
KS03_1491  amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K10002]
KS03_1490  amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K10003]
KS03_1489  bacterial extracellular solute-binding s, 3 family protein [KO:K10001]
KS03_357  crp-like helix-turn-helix domain protein [KO:K10914]
KS03_4118  glsA; glutaminase A [KO:K01425] [EC:3.5.1.2]
KS03_840  his Kinase A domain protein [KO:K15011] [EC:2.7.13.3]
KS03_839  bacterial regulatory, Fis family protein [KO:K15012]
KS03_1291  petA; ubiquinol-cytochrome c reductase, iron-sulfur subunit [KO:K00411] [EC:7.1.1.8]
KS03_1292  hypothetical protein [KO:K00412]
KS03_1293  cytochrome C1 family protein [KO:K00413]
KS03_1132  cytochrome c family protein [KO:K08738]
KS03_278  cytochrome c family protein [KO:K08738]
KS03_3883  putative cytochrome c, class I [KO:K08738]
KS03_604  bacterial Cytochrome Ubiquinol Oxidase family protein [KO:K00425] [EC:7.1.1.7]
KS03_3778  bacterial Cytochrome Ubiquinol Oxidase family protein [KO:K00425] [EC:7.1.1.7]
KS03_4658  bacterial Cytochrome Ubiquinol Oxidase family protein [KO:K00425] [EC:7.1.1.7]
KS03_605  cydB; cytochrome d ubiquinol oxidase, subunit II [KO:K00426] [EC:7.1.1.7]
KS03_3777  cydB; cytochrome d ubiquinol oxidase, subunit II [KO:K00426] [EC:7.1.1.7]
KS03_4659  cydB; cytochrome d ubiquinol oxidase, subunit II [KO:K00426] [EC:7.1.1.7]
KS03_606  cyd operon protein YbgT [KO:K00424] [EC:7.1.1.7]
KS03_1581  polysaccharide biosynthesis/export family protein [KO:K01991]
KS03_4290  polysaccharide biosynthesis/export family protein [KO:K01991]
KS03_4289  low molecular weight phosphotyrosine phosphatase family protein [KO:K25307] [EC:3.1.3.48]
KS03_3240  low molecular weight phosphotyrosine phosphatase family protein [KO:K25307] [EC:3.1.3.48]
KS03_4291  capsular exopolysaccharide family domain protein [KO:K16692] [EC:2.7.10.3]
KS03_4036  pectinesterase family protein [KO:K01051] [EC:3.1.1.11]
KS03_4490  autoinducer synthetase family protein [KO:K13061] [EC:2.3.1.184]
KS03_3158  bacterial regulatory s, luxR family protein [KO:K19666]
KS03_4864  RNA polymerase sigma factor, sigma-70 family protein [KO:K23514]
KS03_4699  RNA polymerase sigma factor, sigma-70 family protein [KO:K23514]
KS03_4863  fecR family protein [KO:K07165]
KS03_4700  fecR family protein [KO:K07165]
KS03_3869  amino acid permease family protein [KO:K20974] [EC:2.7.13.3]
KS03_780  flgM; flagellar biosynthesis anti-sigma factor FlgM [KO:K02398]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
PMID:15522865
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
PMID:16030210
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
PMID:15813739
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
PMID:11973328
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
PMID:16077119
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
PMID:12107133
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
PMID:15322361
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
PMID:11004187
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
PMID:11929534
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
PMID:14604015
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
DOI:10.1016/S0079-6603(03)75008-9
Reference
PMID:10648521
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
DOI:10.1128/JB.182.4.961-966.2000
Reference
PMID:15326287
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
DOI:10.1073/pnas.0403064101
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
DOI:10.1128/JB.171.8.4436-4441.1989
Reference
PMID:11555295
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
DOI:10.1046/j.1365-2958.2001.02576.x
Reference
PMID:10972837
  Authors
Zhang X, Hulett FM.
  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
DOI:10.1046/j.1365-2958.2000.02076.x
Reference
PMID:15937169
  Authors
Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
  Title
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
  Journal
J Bacteriol 187:4064-76 (2005)
DOI:10.1128/JB.187.12.4064-4076.2005
Reference
PMID:15601704
  Authors
He H, Zahrt TC.
  Title
Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
  Journal
J Bacteriol 187:202-12 (2005)
DOI:10.1128/JB.187.1.202-212.2005
Reference
PMID:17448786
  Authors
Hutchings MI
  Title
Unusual two-component signal transduction pathways in the actinobacteria.
  Journal
Adv Appl Microbiol 61:1-26 (2007)
DOI:10.1016/S0065-2164(06)61001-0
Reference
PMID:19308662
  Authors
Kramer R
  Title
Osmosensing and osmosignaling in Corynebacterium glutamicum.
  Journal
Amino Acids 37:487-97 (2009)
DOI:10.1007/s00726-009-0271-6
Reference
PMID:7751278
  Authors
Eraso JM, Kaplan S.
  Title
Oxygen-insensitive synthesis of the photosynthetic membranes of Rhodobacter sphaeroides: a mutant histidine kinase.
  Journal
J Bacteriol 177:2695-706 (1995)
DOI:10.1128/JB.177.10.2695-2706.1995
Reference
PMID:10089160
  Authors
Haydel SE, Dunlap NE, Benjamin WH Jr.
  Title
In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
  Journal
Microb Pathog 26:195-206 (1999)
DOI:10.1006/mpat.1998.0265
Reference
PMID:11673427
  Authors
Quisel JD, Burkholder WF, Grossman AD.
  Title
In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
  Journal
J Bacteriol 183:6573-8 (2001)
DOI:10.1128/JB.183.22.6573-6578.2001
Reference
PMID:11889485
  Authors
Kaspar S, Bott M.
  Title
The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor.
  Journal
Arch Microbiol 177:313-21 (2002)
DOI:10.1007/s00203-001-0393-z
Reference
PMID:12167640
  Authors
Janausch IG, Garcia-Moreno I, Unden G.
  Title
Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro.
  Journal
J Biol Chem 277:39809-14 (2002)
DOI:10.1074/jbc.M204482200
Reference
PMID:8550490
  Authors
Brunskill EW, Bayles KW.
  Title
Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus.
  Journal
J Bacteriol 178:611-8 (1996)
DOI:10.1128/JB.178.3.611-618.1996
Reference
PMID:10940023
  Authors
Fujimoto DF, Brunskill EW, Bayles KW.
  Title
Analysis of genetic elements controlling Staphylococcus aureus lrgAB expression: potential role of DNA topology in SarA regulation.
  Journal
J Bacteriol 182:4822-8 (2000)
DOI:10.1128/JB.182.17.4822-4828.2000
Reference
PMID:11807079
  Authors
Dufour P, Jarraud S, Vandenesch F, Greenland T, Novick RP, Bes M, Etienne J, Lina G.
  Title
High genetic variability of the agr locus in Staphylococcus species.
  Journal
J Bacteriol 184:1180-6 (2002)
DOI:10.1128/JB.184.4.1180-1186.2002
Reference
PMID:8501030
  Authors
Rabin RS, Stewart V.
  Title
Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12.
  Journal
J Bacteriol 175:3259-68 (1993)
DOI:10.1128/JB.175.11.3259-3268.1993
Reference
PMID:9220011
  Authors
Chiang RC, Cavicchioli R, Gunsalus RP.
  Title
'Locked-on' and 'locked-off' signal transduction mutations in the periplasmic domain of the Escherichia coli NarQ and NarX sensors affect nitrate- and nitrite-dependent regulation by NarL and NarP.
  Journal
Mol Microbiol 24:1049-60 (1997)
DOI:10.1046/j.1365-2958.1997.4131779.x
Reference
PMID:12107138
  Authors
Verhamme DT, Postma PW, Crielaard W, Hellingwerf KJ.
  Title
Cooperativity in signal transfer through the Uhp system of Escherichia coli.
  Journal
J Bacteriol 184:4205-10 (2002)
DOI:10.1128/JB.184.15.4205-4210.2002
Reference
PMID:13129944
  Authors
Hagiwara D, Sugiura M, Oshima T, Mori H, Aiba H, Yamashino T, Mizuno T.
  Title
Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli.
  Journal
J Bacteriol 185:5735-46 (2003)
DOI:10.1128/JB.185.19.5735-5746.2003
Reference
PMID:12951338
  Authors
Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A.
  Title
Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli.
  Journal
J Antimicrob Chemother 52:576-82 (2003)
DOI:10.1093/jac/dkg406
Reference
PMID:12193630
  Authors
Suzuki K, Wang X, Weilbacher T, Pernestig AK, Melefors O, Georgellis D, Babitzke P, Romeo T.
  Title
Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli.
  Journal
J Bacteriol 184:5130-40 (2002)
DOI:10.1128/JB.184.18.5130-5140.2002
Reference
PMID:10923791
  Authors
Kato A, Ohnishi H, Yamamoto K, Furuta E, Tanabe H, Utsumi R.
  Title
Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12.
  Journal
Biosci Biotechnol Biochem 64:1203-9 (2000)
DOI:10.1271/bbb.64.1203
Reference
PMID:14679219
  Authors
Ansaldi M, Dubnau D.
  Title
Diversifying selection at the Bacillus quorum-sensing locus and determinants of modification specificity during synthesis of the ComX pheromone.
  Journal
J Bacteriol 186:15-21 (2004)
DOI:10.1128/JB.186.1.15-21.2004
Reference
PMID:16035234
  Authors
Gabdrakhmanova L, Vishniakov I, Sharipova M, Balaban N, Kostrov S, Leshchinskaya I.
  Title
Salt stress induction of glutamyl endopeptidase biosynthesis in Bacillus intermedius.
  Journal
Microbiol Res 160:233-42 (2005)
DOI:10.1016/j.micres.2004.05.005
Reference
PMID:11285232
  Authors
Aguilar PS, Hernandez-Arriaga AM, Cybulski LE, Erazo AC, de Mendoza D.
  Title
Molecular basis of thermosensing: a two-component signal transduction thermometer in Bacillus subtilis.
  Journal
EMBO J 20:1681-91 (2001)
DOI:10.1093/emboj/20.7.1681
Reference
PMID:12864861
  Authors
Kuroda M, Kuroda H, Oshima T, Takeuchi F, Mori H, Hiramatsu K.
  Title
Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus.
  Journal
Mol Microbiol 49:807-21 (2003)
DOI:10.1046/j.1365-2958.2003.03599.x
Reference
PMID:15073296
  Authors
Saini DK, Malhotra V, Dey D, Pant N, Das TK, Tyagi JS.
  Title
DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.
  Journal
Microbiology 150:865-75 (2004)
DOI:10.1099/mic.0.26218-0
Reference
PMID:12426351
  Authors
Fedtke I, Kamps A, Krismer B, Gotz F.
  Title
The nitrate reductase and nitrite reductase operons and the narT gene of Staphylococcus carnosus are positively controlled by the novel two-component system NreBC.
  Journal
J Bacteriol 184:6624-34 (2002)
DOI:10.1128/JB.184.23.6624-6634.2002
Reference
PMID:8416895
  Authors
Shiau SP, Chen P, Reitzer LJ.
  Title
Effects of insertions and deletions in glnG (ntrC) of Escherichia coli on nitrogen regulator I-dependent DNA binding and transcriptional activation.
  Journal
J Bacteriol 175:190-9 (1993)
DOI:10.1128/JB.175.1.190-199.1993
Reference
PMID:11243806
  Authors
Leonhartsberger S, Huber A, Lottspeich F, Bock A.
  Title
The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system.
  Journal
J Mol Biol 307:93-105 (2001)
DOI:10.1006/jmbi.2000.4451
Reference
PMID:15200682
  Authors
Lioliou EE, Kyriakidis DA.
  Title
The role of bacterial antizyme: From an inhibitory protein to AtoC transcriptional regulator.
  Journal
Microb Cell Fact 3:8 (2004)
DOI:10.1186/1475-2859-3-8
Reference
PMID:15773991
  Authors
Yamamoto K, Ishihama A
  Title
Transcriptional response of Escherichia coli to external copper.
  Journal
Mol Microbiol 56:215-27 (2005)
DOI:10.1111/j.1365-2958.2005.04532.x
Reference
PMID:10585546
  Authors
Ashby MK, Mullineaux CW
  Title
Cyanobacterial ycf27 gene products regulate energy transfer from phycobilisomes to photosystems I and II.
  Journal
FEMS Microbiol Lett 181:253-60 (1999)
DOI:10.1111/j.1574-6968.1999.tb08852.x
Reference
PMID:11849552
  Authors
Lopez-Maury L, Garcia-Dominguez M, Florencio FJ, Reyes JC
  Title
A two-component signal transduction system involved in nickel sensing in the cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Mol Microbiol 43:247-56 (2002)
DOI:10.1046/j.1365-2958.2002.02741.x
Reference
PMID:17526710
  Authors
Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR Jr
  Title
The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.
  Journal
J Bacteriol 189:5495-503 (2007)
DOI:10.1128/JB.00190-07
Reference
PMID:15175302
  Authors
Hsiao HY, He Q, Van Waasbergen LG, Grossman AR
  Title
Control of photosynthetic and high-light-responsive genes by the histidine kinase DspA: negative and positive regulation and interactions between signal transduction pathways.
  Journal
J Bacteriol 186:3882-8 (2004)
DOI:10.1128/JB.186.12.3882-3888.2004
Reference
PMID:12626498
  Authors
Mutsuda M, Michel KP, Zhang X, Montgomery BL, Golden SS
  Title
Biochemical properties of CikA, an unusual phytochrome-like histidine protein kinase that resets the circadian clock in Synechococcus elongatus PCC 7942.
  Journal
J Biol Chem 278:19102-10 (2003)
DOI:10.1074/jbc.M213255200
Reference
PMID:9278513
  Authors
Yeh KC, Wu SH, Murphy JT, Lagarias JC
  Title
A cyanobacterial phytochrome two-component light sensory system.
  Journal
Science 277:1505-8 (1997)
DOI:10.1126/science.277.5331.1505
Reference
PMID:7635815
  Authors
Niu S, Jiang SQ, Hong J
  Title
Salmonella typhimurium pgtB mutants conferring constitutive expression of phosphoglycerate transporter pgtP independent of pgtC.
  Journal
J Bacteriol 177:4297-302 (1995)
DOI:10.1128/JB.177.15.4297-4302.1995
Reference
PMID:16882723
  Authors
Takai N, Nakajima M, Oyama T, Kito R, Sugita C, Sugita M, Kondo T, Iwasaki H
  Title
A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria.
  Journal
Proc Natl Acad Sci U S A 103:12109-14 (2006)
DOI:10.1073/pnas.0602955103
Reference
PMID:11803016
  Authors
Janausch IG, Zientz E, Tran QH, Kroger A, Unden G
  Title
C4-dicarboxylate carriers and sensors in bacteria.
  Journal
Biochim Biophys Acta 1553:39-56 (2002)
DOI:10.1016/S0005-2728(01)00233-X
Reference
PMID:18725229
  Authors
Zhou YF, Nan B, Nan J, Ma Q, Panjikar S, Liang YH, Wang Y, Su XD
  Title
C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.
  Journal
J Mol Biol 383:49-61 (2008)
DOI:10.1016/j.jmb.2008.08.010
Reference
PMID:14523104
  Authors
Novick RP, Jiang D
  Title
The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing.
  Journal
Microbiology 149:2709-17 (2003)
DOI:10.1099/mic.0.26575-0
Reference
PMID:17981963
  Authors
Leech AJ, Sprinkle A, Wood L, Wozniak DJ, Ohman DE
  Title
The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter.
  Journal
J Bacteriol 190:581-9 (2008)
DOI:10.1128/JB.01307-07
Reference
PMID:18455986
  Authors
Paul R, Jaeger T, Abel S, Wiederkehr I, Folcher M, Biondi EG, Laub MT, Jenal U
  Title
Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.
  Journal
Cell 133:452-61 (2008)
DOI:10.1016/j.cell.2008.02.045
Reference
PMID:15101991
  Authors
Whitchurch CB, Leech AJ, Young MD, Kennedy D, Sargent JL, Bertrand JJ, Semmler AB, Mellick AS, Martin PR, Alm RA, Hobbs M, Beatson SA, Huang B, Nguyen L, Commolli JC, Engel JN, Darzins A, Mattick JS.
  Title
Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa.
  Journal
Mol Microbiol 52:873-93 (2004)
DOI:10.1111/j.1365-2958.2004.04026.x
Reference
PMID:15170479
  Authors
Yoshihara S, Ikeuchi M.
  Title
Phototactic motility in the unicellular cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Photochem Photobiol Sci 3:512-8 (2004)
DOI:10.1039/b402320j
Reference
PMID:12039966
  Authors
Ogawa T, Bao DH, Katoh H, Shibata M, Pakrasi HB, Bhattacharyya-Pakrasi M
  Title
A two-component signal transduction pathway regulates manganese homeostasis in Synechocystis 6803, a photosynthetic organism.
  Journal
J Biol Chem 277:28981-6 (2002)
DOI:10.1074/jbc.M204175200
Reference
PMID:12417709
  Authors
Yamaguchi K, Suzuki I, Yamamoto H, Lyukevich A, Bodrova I, Los DA, Piven I, Zinchenko V, Kanehisa M, Murata N
  Title
A two-component Mn2+-sensing system negatively regulates expression of the mntCAB operon in Synechocystis.
  Journal
Plant Cell 14:2901-13 (2002)
DOI:10.1105/tpc.006262
Reference
PMID:15273097
  Authors
Mascher T, Zimmer SL, Smith TA, Helmann JD
  Title
Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis.
  Journal
Antimicrob Agents Chemother 48:2888-96 (2004)
DOI:10.1128/AAC.48.8.2888-2896.2004
Reference
PMID:15856219
  Authors
Hyyrylainen HL, Sarvas M, Kontinen VP
  Title
Transcriptome analysis of the secretion stress response of Bacillus subtilis.
  Journal
Appl Microbiol Biotechnol 67:389-96 (2005)
DOI:10.1007/s00253-005-1898-1
Reference
PMID:15941986
  Authors
Serizawa M, Sekiguchi J
  Title
The Bacillus subtilis YdfHI two-component system regulates the transcription of ydfJ, a member of the RND superfamily.
  Journal
Microbiology 151:1769-78 (2005)
DOI:10.1099/mic.0.27619-0
Reference
PMID:12890034
  Authors
Ohki R, Giyanto, Tateno K, Masuyama W, Moriya S, Kobayashi K, Ogasawara N
  Title
The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.
  Journal
Mol Microbiol 49:1135-44 (2003)
DOI:10.1046/j.1365-2958.2003.03653.x
Reference
PMID:17322186
  Authors
Ogura M, Tsukahara K, Hayashi K, Tanaka T
  Title
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
  Journal
Microbiology 153:667-75 (2007)
DOI:10.1099/mic.0.2006/003673-0
Reference
PMID:10972810
  Authors
Yamamoto H, Murata M, Sekiguchi J
  Title
The CitST two-component system regulates the expression of the Mg-citrate transporter in Bacillus subtilis.
  Journal
Mol Microbiol 37:898-912 (2000)
DOI:10.1046/j.1365-2958.2000.02055.x
Reference
PMID:15995196
  Authors
Satomura T, Shimura D, Asai K, Sadaie Y, Hirooka K, Fujita Y
  Title
Enhancement of glutamine utilization in Bacillus subtilis through the GlnK-GlnL two-component regulatory system.
  Journal
J Bacteriol 187:4813-21 (2005)
DOI:10.1128/JB.187.14.4813-4821.2005
Reference
PMID:12949160
  Authors
Doan T, Servant P, Tojo S, Yamaguchi H, Lerondel G, Yoshida K, Fujita Y, Aymerich S
  Title
The Bacillus subtilis ywkA gene encodes a malic enzyme and its transcription is activated by the YufL/YufM two-component system in response to malate.
  Journal
Microbiology 149:2331-43 (2003)
DOI:10.1099/mic.0.26256-0
Reference
PMID:12949159
  Authors
Tanaka K, Kobayashi K, Ogasawara N
  Title
The Bacillus subtilis YufLM two-component system regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium.
  Journal
Microbiology 149:2317-29 (2003)
DOI:10.1099/mic.0.26257-0
Reference
PMID:10708364
  Authors
Asai K, Baik SH, Kasahara Y, Moriya S, Ogasawara N
  Title
Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis.
  Journal
Microbiology 146 ( Pt 2):263-71 (2000)
DOI:10.1099/00221287-146-2-263
Reference
PMID:8455557
  Authors
Hamblin MJ, Shaw JG, Kelly DJ
  Title
Sequence analysis and interposon mutagenesis of a sensor-kinase (DctS) and response-regulator (DctR) controlling synthesis of the high-affinity C4-dicarboxylate transport system in Rhodobacter capsulatus.
  Journal
Mol Gen Genet 237:215-24 (1993)
DOI:10.1007/BF00282803
Reference
PMID:9287004
  Authors
Forward JA, Behrendt MC, Wyborn NR, Cross R, Kelly DJ
  Title
TRAP transporters: a new family of periplasmic solute transport systems encoded by the dctPQM genes of Rhodobacter capsulatus and by homologs in diverse gram-negative bacteria.
  Journal
J Bacteriol 179:5482-93 (1997)
DOI:10.1128/JB.179.17.5482-5493.1997
Reference
PMID:16820295
  Authors
Martin B, Quentin Y, Fichant G, Claverys JP
  Title
Independent evolution of competence regulatory cascades in streptococci?
  Journal
Trends Microbiol 14:339-45 (2006)
DOI:10.1016/j.tim.2006.06.007
Reference
PMID:10231485
  Authors
Hensel M, Hinsley AP, Nikolaus T, Sawers G, Berks BC
  Title
The genetic basis of tetrathionate respiration in Salmonella typhimurium.
  Journal
Mol Microbiol 32:275-87 (1999)
DOI:10.1046/j.1365-2958.1999.01345.x
Reference
PMID:18028314
  Authors
Guvener ZT, Harwood CS
  Title
Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces.
  Journal
Mol Microbiol 66:1459-73 (2007)
DOI:10.1111/j.1365-2958.2007.06008.x
Reference
PMID:17339222
  Authors
Bantinaki E, Kassen R, Knight CG, Robinson Z, Spiers AJ, Rainey PB
  Title
Adaptive divergence in experimental populations of Pseudomonas fluorescens. III. Mutational origins of wrinkly spreader diversity.
  Journal
Genetics 176:441-53 (2007)
DOI:10.1534/genetics.106.069906
Reference
PMID:11069677
  Authors
Jiang M, Shao W, Perego M, Hoch JA
  Title
Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis.
  Journal
Mol Microbiol 38:535-42 (2000)
DOI:10.1046/j.1365-2958.2000.02148.x
Reference
PMID:19781638
  Authors
Jenal U
  Title
The role of proteolysis in the Caulobacter crescentus cell cycle and development.
  Journal
Res Microbiol 160:687-95 (2009)
DOI:10.1016/j.resmic.2009.09.006
Reference
PMID:19246239
  Authors
Jenal U, Galperin MY
  Title
Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.
  Journal
Curr Opin Microbiol 12:152-60 (2009)
DOI:10.1016/j.mib.2009.01.010
Reference
PMID:16640581
  Authors
Drepper T, Wiethaus J, Giaourakis D, Gross S, Schubert B, Vogt M, Wiencek Y, McEwan AG, Masepohl B
  Title
Cross-talk towards the response regulator NtrC controlling nitrogen metabolism in Rhodobacter capsulatus.
  Journal
FEMS Microbiol Lett 258:250-6 (2006)
DOI:10.1111/j.1574-6968.2006.00228.x
Reference
PMID:1661370
  Authors
Pawlowski K, Klosse U, de Bruijn FJ
  Title
Characterization of a novel Azorhizobium caulinodans ORS571 two-component regulatory system, NtrY/NtrX, involved in nitrogen fixation and metabolism.
  Journal
Mol Gen Genet 231:124-38 (1991)
DOI:10.1007/BF00293830
Reference
PMID:18422428
  Authors
Chatterjee S, Almeida RP, Lindow S
  Title
Living in two worlds: the plant and insect lifestyles of Xylella fastidiosa.
  Journal
Annu Rev Phytopathol 46:243-71 (2008)
DOI:10.1146/annurev.phyto.45.062806.094342
Reference
PMID:18506032
  Authors
Dow M
  Title
Diversification of the function of cell-to-cell signaling in regulation of virulence within plant pathogenic xanthomonads.
  Journal
Sci Signal 1:pe23 (2008)
DOI:10.1126/stke.121pe23
Reference
PMID:17902112
  Authors
Colnaghi Simionato AV, da Silva DS, Lambais MR, Carrilho E
  Title
Characterization of a putative Xylella fastidiosa diffusible signal factor by HRGC-EI-MS.
  Journal
J Mass Spectrom 42:1375-81 (2007)
DOI:10.1002/jms.1325
Reference
PMID:19203648
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
DOI:10.1016/S0065-2164(08)00803-4
Reference
PMID:8760916
  Authors
Eder S, Shi L, Jensen K, Yamane K, Hulett FM
  Title
A Bacillus subtilis secreted phosphodiesterase/alkaline phosphatase is the product of a Pho regulon gene, phoD.
  Journal
Microbiology 142 ( Pt 8):2041-7 (1996)
DOI:10.1099/13500872-142-8-2041
Related
pathway
bgu00190  Oxidative phosphorylation
bgu00550  Peptidoglycan biosynthesis
bgu00910  Nitrogen metabolism
bgu02030  Bacterial chemotaxis
bgu02040  Flagellar assembly
bgu03070  Bacterial secretion system
KO pathway
ko02020   
LinkDB

DBGET integrated database retrieval system