KEGG   PATHWAY: biu04961
Entry
biu04961                    Pathway                                
Name
Endocrine and other factor-regulated calcium reabsorption - Bos indicus (zebu cattle)
Description
Calcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis is finely maintained through the coordination of intestinal absorption, renal reabsorption, and bone resorption. In kidney, the late part of the distal convoluted tubule (DCT) and the connecting tubule (CNT) are the site of active Ca2+ transport and precisely regulate Ca2+ reabsorption. Following Ca2+ entry through TRPV5, Ca2+ bound to calbindin-D28K diffuses to the basolateral side, where it is extruded into the blood compartment through NCX1 and to a lesser extent PMCA1b. In the urinary compartment, both klotho and tissue kallikrein (TK) increase the apical abundance of TRPV5. In the blood compartment, PTH, 1,25(OH)2D3 and estrogen increase the transcription and protein expression of the luminal Ca2+ channels, calbindins, and the extrusion systems.
Class
Organismal Systems; Excretory system
Pathway map
biu04961  Endocrine and other factor-regulated calcium reabsorption
biu04961

Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109569363  PTH; parathyroid hormone isoform X1 [KO:K05261]
109576420  PTH1R; LOW QUALITY PROTEIN: parathyroid hormone/parathyroid hormone-related peptide receptor [KO:K04585]
109567291  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
109567292  neuroendocrine secretory protein 55 [KO:K04632]
109559159  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
109578364  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
109556827  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
109561498  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
109559171  VDR; vitamin D3 receptor [KO:K08539]
109558142  TRPV5; transient receptor potential cation channel subfamily V member 5 [KO:K04974]
109566788  KL; klotho [KO:K14756] [EC:3.2.1.31]
109566503  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
109570608  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
109561599  DNM2; dynamin-2 [KO:K23484] [EC:3.6.5.5]
109560938  dynamin-2-like [KO:K23484] [EC:3.6.5.5]
109571782  AP2A1; LOW QUALITY PROTEIN: AP-2 complex subunit alpha-1 [KO:K11824]
109573850  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
109557437  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
109572907  AP2S1; AP-2 complex subunit sigma [KO:K11827]
109563034  CLTA; clathrin light chain A isoform X1 [KO:K04644]
109561880  CLTB; clathrin light chain B [KO:K04645]
109573167  CLTC; clathrin heavy chain 1 [KO:K04646]
109564694  RAB11A; ras-related protein Rab-11A [KO:K07904]
109568290  CALB1; calbindin [KO:K14757]
109578704  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
109578722  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
109555876  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
109571737  ATP1A3; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
109555144  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
109574423  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
109570324  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
109559642  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
109569778  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
109572570  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
109565298  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
109566012  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
109555546  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
109558967  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
109570406  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
109576121  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
109571921  KLK1; kallikrein-1 [KO:K01325] [EC:3.4.21.35]
109575666  BDKRB2; B2 bradykinin receptor [KO:K03916]
109562978  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
109554384  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
109567852  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
109567854  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
109564927  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
109573366  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
109578560  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109572998  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C00951  Estradiol-17beta
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01673  Calcitriol
Reference
PMID:18989697
  Authors
Boros S, Bindels RJ, Hoenderop JG
  Title
Active Ca(2+) reabsorption in the connecting tubule.
  Journal
Pflugers Arch 458:99-109 (2009)
DOI:10.1007/s00424-008-0602-6
Reference
PMID:16518325
  Authors
Lambers TT, Bindels RJ, Hoenderop JG
  Title
Coordinated control of renal Ca2+ handling.
  Journal
Kidney Int 69:650-4 (2006)
DOI:10.1038/sj.ki.5000169
Reference
PMID:18596722
  Authors
de Groot T, Bindels RJ, Hoenderop JG
  Title
TRPV5: an ingeniously controlled calcium channel.
  Journal
Kidney Int 74:1241-6 (2008)
DOI:10.1038/ki.2008.320
Reference
PMID:20969972
  Authors
Markadieu N, Bindels RJ, Hoenderop JG
  Title
The renal connecting tubule: Resolved and unresolved issues in Ca(2+) transport.
  Journal
Int J Biochem Cell Biol 43:1-4 (2011)
DOI:10.1016/j.biocel.2010.10.006
Reference
PMID:15618484
  Authors
Hoenderop JG, Nilius B, Bindels RJ
  Title
Calcium absorption across epithelia.
  Journal
Physiol Rev 85:373-422 (2005)
DOI:10.1152/physrev.00003.2004
Reference
PMID:15747113
  Authors
van Abel M, Hoenderop JG, Bindels RJ
  Title
The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 371:295-306 (2005)
DOI:10.1007/s00210-005-1021-2
Reference
PMID:16044309
  Authors
Nijenhuis T, Hoenderop JG, Bindels RJ
  Title
TRPV5 and TRPV6 in Ca(2+) (re)absorption: regulating Ca(2+) entry at the gate.
  Journal
Pflugers Arch 451:181-92 (2005)
DOI:10.1007/s00424-005-1430-6
Reference
PMID:12684797
  Authors
Hoenderop JG, Nilius B, Bindels RJ
  Title
Epithelial calcium channels: from identification to function and regulation.
  Journal
Pflugers Arch 446:304-8 (2003)
DOI:10.1007/s00424-003-1045-8
Reference
PMID:17006539
  Authors
Gkika D, Topala CN, Chang Q, Picard N, Thebault S, Houillier P, Hoenderop JG, Bindels RJ
  Title
Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5.
  Journal
EMBO J 25:4707-16 (2006)
DOI:10.1038/sj.emboj.7601357
Reference
PMID:17233615
  Authors
Schoeber JP, Hoenderop JG, Bindels RJ
  Title
Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.
  Journal
Biochem Soc Trans 35:115-9 (2007)
DOI:10.1042/BST0350115
Reference
PMID:18293139
  Authors
Renkema KY, Alexander RT, Bindels RJ, Hoenderop JG
  Title
Calcium and phosphate homeostasis: concerted interplay of new regulators.
  Journal
Ann Med 40:82-91 (2008)
DOI:10.1080/07853890701689645
Reference
PMID:19423690
  Authors
de Groot T, Lee K, Langeslag M, Xi Q, Jalink K, Bindels RJ, Hoenderop JG
  Title
Parathyroid hormone activates TRPV5 via PKA-dependent phosphorylation.
  Journal
J Am Soc Nephrol 20:1693-704 (2009)
DOI:10.1681/ASN.2008080873
Related
pathway
biu04144  Endocytosis
biu04530  Tight junction
KO pathway
ko04961   
LinkDB

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