KEGG PATHWAY: cam04145

KEGG

PATHWAY: cam04145

Entry

cam04145                    Pathway

Name

Phagosome - Cicer arietinum (chickpea)

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

Phagosome

Other DBs

GO:

Organism

Cicer arietinum (chickpea) [GN:cam]

Gene

syntaxin-81 [KO:K08492]

25.3 kDa vesicle transport protein [KO:K08517]

25.3 kDa vesicle transport protein [KO:K08517]

25.3 kDa vesicle transport protein-like [KO:K08517]

ras-related protein RHN1-like [KO:K07889]

ras-related protein RHN1 [KO:K07889]

ras-related protein RHN1-like [KO:K07889]

phosphatidylinositol 3-kinase, root isoform [KO:K00914] [EC:2.7.1.137]

V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]

V-type proton ATPase subunit B 2 [KO:K02147]

V-type proton ATPase subunit B 2-like [KO:K02147]

V-type proton ATPase subunit C [KO:K02148]

V-type proton ATPase subunit D [KO:K02149]

V-type proton ATPase subunit E-like [KO:K02150]

V-type proton ATPase subunit E2 [KO:K02150]

V-type proton ATPase subunit E-like [KO:K02150]

V-type proton ATPase subunit F [KO:K02151]

V-type proton ATPase subunit G 1-like [KO:K02152]

V-type proton ATPase subunit G1-like [KO:K02152]

V-type proton ATPase subunit G1-like [KO:K02152]

V-type proton ATPase subunit e1 [KO:K02153]

V-type proton ATPase subunit a1 [KO:K02154]

V-type proton ATPase subunit a2-like [KO:K02154]

V-type proton ATPase subunit a1-like [KO:K02154]

V-type proton ATPase subunit a2 [KO:K02154]

V-type proton ATPase subunit d2 [KO:K02146]

V-type proton ATPase subunit H [KO:K02144]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]

V-type proton ATPase subunit c4-like [KO:K02155]

V-type proton ATPase subunit c''2 [KO:K03661]

ras-related protein Rab7-like [KO:K07897]

ras-related protein Rab7 [KO:K07897]

ras-related protein Rab7-like [KO:K07897]

ras-related protein Rab7 [KO:K07897]

ras-related protein Rab7-like [KO:K07897]

ras-related protein Rab7-like [KO:K07897]

ras-related protein Rab7-like [KO:K07897]

tubulin alpha-3 chain-like [KO:K07374]

tubulin alpha chain [KO:K07374]

tubulin alpha chain [KO:K07374]

tubulin alpha-3 chain [KO:K07374]

tubulin alpha-3 chain-like [KO:K07374]

TUBB; tubulin, beta class I [KO:K07375]

tubulin beta chain [KO:K07375]

tubulin beta-1 chain [KO:K07375]

tubulin beta-3 chain [KO:K07375]

tubulin beta-1 chain-like [KO:K07375]

tubulin beta-1 chain [KO:K07375]

tubulin beta-2 chain [KO:K07375]

tubulin beta-1 chain [KO:K07375]

putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D [KO:K00921] [EC:2.7.1.150]

putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C [KO:K00921] [EC:2.7.1.150]

1-phosphatidylinositol-3-phosphate 5-kinase FAB1A [KO:K00921] [EC:2.7.1.150]

1-phosphatidylinositol-3-phosphate 5-kinase FAB1B [KO:K00921] [EC:2.7.1.150]

cathepsin L1-like [KO:K01365] [EC:3.4.22.15]

protein transport protein Sec61 subunit alpha-like [KO:K10956]

protein transport protein Sec61 subunit alpha-like [KO:K10956]

protein transport protein Sec61 subunit alpha-like [KO:K10956]

preprotein translocase subunit SECY, chloroplastic [KO:K10956]

protein transport protein Sec61 subunit beta-like [KO:K09481]

protein transport protein Sec61 subunit beta-like [KO:K09481]

protein transport protein Sec61 subunit beta-like [KO:K09481]

protein transport protein Sec61 subunit beta-like [KO:K09481]

protein transport protein Sec61 subunit beta-like [KO:K09481]

protein transport protein Sec61 subunit gamma [KO:K07342]

calreticulin-3-like [KO:K08057]

calreticulin [KO:K08057]

calreticulin-3 [KO:K08057]

calnexin homolog [KO:K08054]

calnexin homolog [KO:K08054]

rac-like GTP-binding protein RAC2 [KO:K04392]

rac-like GTP-binding protein RAC2 [KO:K04392]

rac-like GTP-binding protein ARAC8 [KO:K04392]

rac-like GTP-binding protein ARAC7 [KO:K04392]

rac-like GTP-binding protein RHO1 [KO:K04392]

rac-like GTP-binding protein RAC13 [KO:K04392]

rac-like GTP-binding protein RAC1-like [KO:K04392]

rac-like GTP-binding protein RHO1 [KO:K04392]

Compound

1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002

Reference

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R

Reference

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036

Reference

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005

Reference

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511

Reference

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217

Reference

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x

Related
pathway

Endocytosis

KO pathway

LinkDB

DBGET integrated database retrieval system