Entry
Name
ABC transporters - Citrobacter arsenatis
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Citrobacter arsenatis [GN:
cars ]
Gene
E1B03_04880 thiP; thiamine/thiamine pyrophosphate ABC transporter permease ThiP [KO:K02063 ]
E1B03_10840 potD; spermidine/putrescine ABC transporter substrate-binding protein PotD [KO:K11069 ]
E1B03_09505 potF; spermidine/putrescine ABC transporter substrate-binding protein PotF [KO:K11073 ]
E1B03_20540 proX; proline/glycine betaine ABC transporter substrate-binding protein ProX [KO:K02002 ]
E1B03_02640 malE; maltose/maltodextrin ABC transporter substrate-binding protein MalE [KO:K10108 ]
E1B03_02645 malK; maltose/maltodextrin ABC transporter ATP-binding protein MalK [KO:K10111 ] [EC:7.5.2.-]
E1B03_23150 ugpC; sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC [KO:K10112 ] [EC:7.5.2.-]
E1B03_23480 mlaD; outer membrane lipid asymmetry maintenance protein MlaD [KO:K02067 ]
E1B03_23485 mlaE; lipid asymmetry maintenance ABC transporter permease subunit MlaE [KO:K02066 ]
E1B03_03710 ytfQ; galactofuranose ABC transporter substrate-binding protein YtfQ [KO:K23508 ]
E1B03_17700 mglB; galactose/glucose ABC transporter substrate-binding protein MglB [KO:K10540 ]
E1B03_17690 mglC; galactose/methyl galactoside ABC transporter permease MglC [KO:K10541 ]
E1B03_24725 ugpB; sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB [KO:K05813 ]
E1B03_01040 pstS; phosphate ABC transporter substrate-binding protein PstS [KO:K02040 ]
E1B03_18485 argT; lysine/arginine/ornithine ABC transporter substrate-binding protein ArgT [KO:K10013 ]
E1B03_18480 hisJ; histidine ABC transporter substrate-binding protein HisJ [KO:K10014 ]
E1B03_09260 glnH; glutamine ABC transporter substrate-binding protein GlnH [KO:K10036 ]
E1B03_08405 gltI; glutamate/aspartate ABC transporter substrate-binding protein GltI [KO:K10001 ]
E1B03_24755 livk; high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK [KO:K01999 ]
E1B03_24765 branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999 ]
E1B03_24750 livH; high-affinity branched-chain amino acid ABC transporter permease LivH [KO:K01997 ]
E1B03_24745 high-affinity branched-chain amino acid ABC transporter permease LivM [KO:K01998 ]
E1B03_24740 livG; high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG [KO:K01995 ]
E1B03_24735 livF; high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF [KO:K01996 ]
E1B03_05490 metQ; methionine ABC transporter membrane-anchored lipoprotein MetQ [KO:K02073 ]
E1B03_07270 sfbB; virulence-associated ABC transporter ATP-binding protein SfbB [KO:K02071 ]
E1B03_14775 oppA; oligopeptide ABC transporter substrate-binding protein OppA [KO:K15580 ]
E1B03_14760 oppD; murein tripeptide/oligopeptide ABC transporter ATP binding protein OppD [KO:K15583 ]
E1B03_14755 oppF; murein tripeptide/oligopeptide ABC transporter ATP binding protein OppF [KO:K10823 ]
E1B03_09360 gsiB; glutathione ABC transporter substrate-binding protein GsiB [KO:K13889 ]
E1B03_08125 fepB; Fe2+-enterobactin ABC transporter substrate-binding protein [KO:K23185 ]
E1B03_05270 fhuD; Fe(3+)-hydroxamate ABC transporter substrate-binding protein FhuD [KO:K23227 ]
E1B03_05300 btuF; vitamin B12 ABC transporter substrate-binding protein BtuF [KO:K06858 ]
E1B03_20860 sitB; iron/manganese ABC transporter ATP-binding protein SitB [KO:K11607 ]
E1B03_16635 energy-coupling factor ABC transporter substrate-binding protein [KO:K02009 ]
E1B03_21915 energy-coupling factor transporter transmembrane protein EcfT [KO:K16785 ]
E1B03_21920 energy-coupling factor ABC transporter ATP-binding protein [KO:K16786 ] [EC:7.-.-.-]
E1B03_10815 lolC; lipoprotein-releasing ABC transporter permease subunit LolC [KO:K09808 ]
E1B03_10825 lolE; lipoprotein-releasing ABC transporter permease subunit LolE [KO:K09808 ]
E1B03_10820 lolD; lipoprotein-releasing ABC transporter ATP-binding protein LolD [KO:K09810 ] [EC:7.6.2.-]
E1B03_06985 SmdA family multidrug ABC transporter permease/ATP-binding protein [KO:K18889 ]
E1B03_06990 SmdB family multidrug efflux ABC transporter permease/ATP-binding protein [KO:K18890 ]
E1B03_09580 cydC; cysteine/glutathione ABC transporter ATP-binding protein/permease CydC [KO:K16012 ]
E1B03_09585 cydD; cysteine/glutathione ABC transporter permease/ATP-binding protein CydD [KO:K16013 ]
E1B03_17215 macB; macrolide ABC transporter ATP-binding protein/permease MacB [KO:K05685 ] [EC:7.6.2.-]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway
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