KEGG   PATHWAY: crw00061
Entry
crw00061                    Pathway                                
Name
Fatty acid biosynthesis - Clostridium felsineum DSM 7320
Class
Metabolism; Lipid metabolism
Pathway map
crw00061  Fatty acid biosynthesis
crw00061

Module
crw_M00082  Fatty acid biosynthesis, initiation [PATH:crw00061]
crw_M00083  Fatty acid biosynthesis, elongation [PATH:crw00061]
crw_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:crw00061]
Other DBs
GO: 0006633
Organism
Clostridium felsineum DSM 7320 [GN:crw]
Gene
CROST_029150  accA_1; Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha [KO:K01962] [EC:6.4.1.2 2.1.3.15]
CROST_044690  accA_2; Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha [KO:K01962] [EC:6.4.1.2 2.1.3.15]
CROST_029160  accB_1; Biotin carboxyl carrier protein of acetyl-CoA carboxylase [KO:K02160]
CROST_044730  accB_2; Biotin carboxyl carrier protein of acetyl-CoA carboxylase [KO:K02160]
CROST_029170  cfiB; 2-oxoglutarate carboxylase small subunit [KO:K01961] [EC:6.4.1.2 6.3.4.14]
CROST_044710  accC; Biotin carboxylase [KO:K01961] [EC:6.4.1.2 6.3.4.14]
CROST_029140  accD_1; Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta [KO:K01963] [EC:6.4.1.2 2.1.3.15]
CROST_044700  accD_2; Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta [KO:K01963] [EC:6.4.1.2 2.1.3.15]
CROST_012100  fabD_1; Malonyl CoA-acyl carrier protein transacylase [KO:K00645] [EC:2.3.1.39]
CROST_027960  fenF; Malonyl CoA-acyl carrier protein transacylase [KO:K00645] [EC:2.3.1.39]
CROST_029100  hypothetical protein [KO:K00645] [EC:2.3.1.39]
CROST_044760  fabD_2; Malonyl CoA-acyl carrier protein transacylase [KO:K00645] [EC:2.3.1.39]
CROST_013580  fabH_1; 3-oxoacyl-[acyl-carrier-protein] synthase 3 [KO:K00648] [EC:2.3.1.180]
CROST_029070  fabH_2; 3-oxoacyl-[acyl-carrier-protein] synthase 3 [KO:K00648] [EC:2.3.1.180]
CROST_038820  fabH_3; 3-oxoacyl-[acyl-carrier-protein] synthase 3 [KO:K00648] [EC:2.3.1.180]
CROST_042520  fabH_4; 3-oxoacyl-[acyl-carrier-protein] synthase 3 [KO:K00648] [EC:2.3.1.180]
CROST_044790  fabH_5; 3-oxoacyl-[acyl-carrier-protein] synthase 3 [KO:K00648] [EC:2.3.1.180]
CROST_012180  hypothetical protein [KO:K09458] [EC:2.3.1.179]
CROST_021620  fabF_1; 3-oxoacyl-[acyl-carrier-protein] synthase 2 [KO:K09458] [EC:2.3.1.179]
CROST_021630  fabF_2; 3-oxoacyl-[acyl-carrier-protein] synthase 2 [KO:K09458] [EC:2.3.1.179]
CROST_021640  fabF_3; 3-oxoacyl-[acyl-carrier-protein] synthase 2 [KO:K09458] [EC:2.3.1.179]
CROST_038840  fabF_4; 3-oxoacyl-[acyl-carrier-protein] synthase 2 [KO:K09458] [EC:2.3.1.179]
CROST_044740  fabF_5; 3-oxoacyl-[acyl-carrier-protein] synthase 2 [KO:K09458] [EC:2.3.1.179]
CROST_012110  fabG_1; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
CROST_021670  fabG_2; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
CROST_033800  fabG_3; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
CROST_038810  fabG_4; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
CROST_043720  fabG_5; 3-oxoacyl-[acyl-carrier-protein] reductase [KO:K00059] [EC:1.1.1.100]
CROST_044750  fabG_6; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
CROST_012130  fabZ_1; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [KO:K02372] [EC:4.2.1.59]
CROST_044720  fabZ_2; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [KO:K02372] [EC:4.2.1.59]
CROST_044770  NADH:quinone reductase [KO:K02371] [EC:1.3.1.9]
CROST_042410  menE_3; 2-succinylbenzoate--CoA ligase [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
crw00020  Citrate cycle (TCA cycle)
crw00071  Fatty acid degradation
crw00410  beta-Alanine metabolism
crw00561  Glycerolipid metabolism
crw00564  Glycerophospholipid metabolism
crw00620  Pyruvate metabolism
KO pathway
ko00061   
LinkDB

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