KEGG   PATHWAY: cti00290
Entry
cti00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Cupriavidus taiwanensis
Class
Metabolism; Amino acid metabolism
Pathway map
cti00290  Valine, leucine and isoleucine biosynthesis
cti00290

Module
cti_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:cti00290]
cti_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:cti00290]
cti_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:cti00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Cupriavidus taiwanensis [GN:cti]
Gene
RALTA_A0369  ilvA; threonine deaminase [KO:K01754] [EC:4.3.1.19]
RALTA_A0672  leuC2; 3-isopropylmalate isomerase subunit, dehydratase component [KO:K01703] [EC:4.2.1.33 4.2.1.35]
RALTA_B0053  leuC3; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
RALTA_A2120  leuC1; 3-isopropylmalate isomerase [KO:K01703] [EC:4.2.1.33 4.2.1.35]
RALTA_B0856  putative Hydro-Lyase; similar to 3-isopropylmalate dehydratase and Aconitase [KO:K01703] [EC:4.2.1.33 4.2.1.35]
RALTA_B0052  leuD3; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
RALTA_A0673  leuD2; 3-isopropylmalate isomerase, subunit with LeuC [KO:K01704] [EC:4.2.1.33 4.2.1.35]
RALTA_A2119  leuD1; 3-isopropylmalate isomerase, subunit with LeuC [KO:K01704] [EC:4.2.1.33 4.2.1.35]
RALTA_A2118  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
RALTA_A1770  ilvG1; ACETOLACTATE SYNTHASE ISOZYME II (LARGE SUBUNIT) PROTEIN [KO:K01652] [EC:2.2.1.6]
RALTA_A1019  ilvI1; acetolactate synthase III, valine-sensitive, large subunit [KO:K01652] [EC:2.2.1.6]
pRALTA_0396  ilvI2; Acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
RALTA_B0384  putative Thiamine pyrophosphate-requiring enzyme; Benzoylformate decarboxylase, Acetolactate synthase isozyme II large subunit [KO:K01652] [EC:2.2.1.6]
RALTA_A1425  ilvG2; ACETOLACTATE SYNTHASE ISOZYME II (LARGE SUBUNIT) PROTEIN [KO:K01652] [EC:2.2.1.6]
RALTA_B0571  putative Acetolactate synthase [KO:K01652] [EC:2.2.1.6]
RALTA_A1020  ilvH; acetolactate synthase III, valine-sensitive, small subunit [KO:K01653] [EC:2.2.1.6]
RALTA_A1021  ilvC; KETOL-ACID REDUCTOISOMERASE [KO:K00053] [EC:1.1.1.86]
RALTA_B0295  ilvD; dihydroxyacid dehydratase [KO:K01687] [EC:4.2.1.9]
RALTA_A2461  ilvD; dihydroxyacid dehydratase [KO:K01687] [EC:4.2.1.9]
RALTA_A1402  putative branched-chain-amino-acid aminotransferase [KO:K00826] [EC:2.6.1.42]
RALTA_A0516  ilvE; branched-chain amino-acid aminotransferase [KO:K00826] [EC:2.6.1.42]
RALTA_A1811  putative aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
RALTA_A1025  leuA1; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
RALTA_B0072  leuA2; 2-isopropylmalate synthase 2 (Alpha-isopropylmalate synthase 2) (Alpha-IPM synthetase 2) [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
cti00260  Glycine, serine and threonine metabolism
cti00280  Valine, leucine and isoleucine degradation
cti00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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