Entry
Name
ABC transporters - Escherichia coli 55989 (EAEC)
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Escherichia coli 55989 (EAEC) [GN:
eck ]
Gene
EC55989_2714 cysP; thiosulfate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K02048 ]
EC55989_4395 sbp; sulfate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K23163 ]
EC55989_2713 cysU; sulfate/thiosulfate transporter subunit; membrane component of ABC superfamily [KO:K02046 ]
EC55989_2712 cysW; sulfate/thiosulfate transporter subunit; membrane component of ABC superfamily [KO:K02047 ]
EC55989_2711 cysA; sulfate/thiosulfate transporter subunit; ATP-binding component of ABC superfamily [KO:K02045 ] [EC:7.3.2.3 ]
EC55989_0372 tauA; taurine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K15551 ]
EC55989_0374 tauC; taurine transporter subunit; membrane component of ABC superfamily [KO:K15552 ]
EC55989_0985 ssuA; alkanesulfonate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K15553 ]
EC55989_0983 ssuC; alkanesulfonate transporter subunit; membrane component of ABC superfamily [KO:K15554 ]
EC55989_0743 modA; molybdate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K02020 ]
EC55989_0744 modB; molybdate transporter subunit; membrane component of ABC superfamily [KO:K02018 ]
EC55989_0739 modF; fused molybdate transporter subunits of ABC superfamily: ATP-binding components [KO:K05776 ]
EC55989_0066 tbpA; thiamin transporter subunit; periplasmic-binding component of ABC superfamily [KO:K02064 ]
EC55989_0065 thiP; fused thiamin transporter subunits of ABC superfamily: membrane components [KO:K02063 ]
EC55989_1235 potD; polyamine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K11069 ]
EC55989_1236 potC; polyamine transporter subunit; membrane component of ABC superfamily [KO:K11070 ]
EC55989_1237 potB; polyamine transporter subunit; membrane component of ABC superfamily [KO:K11071 ]
EC55989_0899 potF; putrescine transporter subunit: periplasmic-binding component of ABC superfamily [KO:K11073 ]
EC55989_0902 potI; putrescine transporter subunit: membrane component of ABC superfamily [KO:K11074 ]
EC55989_0901 potH; putrescine transporter subunit: membrane component of ABC superfamily [KO:K11075 ]
EC55989_2947 proX; glycine betaine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K02002 ]
EC55989_2946 proW; glycine betaine transporter subunit; membrane component of ABC superfamily [KO:K02001 ]
EC55989_2381 yehZ; putative transporter subunit: periplasmic-binding component of ABC superfamily [KO:K05845 ]
EC55989_2378 yehW; putative transporter subunit: permease component of ABC superfamily transporter [KO:K05846 ]
EC55989_2380 yehY; putative transporter subunit: permease component of ABC superfamily [KO:K05846 ]
EC55989_2379 yehX; putative transporter subunit: ATP-binding component of ABC superfamily transporter [KO:K05847 ] [EC:7.6.2.9 ]
EC55989_4525 malE; maltose transporter subunit; periplasmic-binding component of ABC superfamily [KO:K10108 ]
EC55989_4524 malF; maltose transporter subunit; membrane component of ABC superfamily [KO:K10109 ]
EC55989_4523 malG; maltose transporter subunit; membrane component of ABC superfamily [KO:K10110 ]
EC55989_4526 malK; fused maltose transport subunit, ATP-binding component of ABC superfamily; regulatory protein [KO:K10111 ] [EC:7.5.2.-]
EC55989_1482 ycjV; putative sugar transporter subunit: ATP-binding component of ABC superfamily transporter [KO:K10112 ] [EC:7.5.2.-]
EC55989_2834 yphF; putative sugar transporter subunit: periplasmic-binding component of ABC superfamily [KO:K23545 ]
EC55989_2832 yphD; putative sugar transporter subunit: membrane component of ABC superfamily [KO:K23546 ]
EC55989_2833 yphE; fused putative sugar transporter subunits of ABC superfamily: ATP-binding components [KO:K23547 ]
EC55989_3610 yrbC; toluene transporter subunit: membrane component of ABC superfamily [KO:K07323 ]
EC55989_3611 yrbD; toluene transporter subunit: membrane component of ABC superfamily [KO:K02067 ]
EC55989_3612 yrbE; toluene transporter subunit: membrane component of ABC superfamily [KO:K02066 ]
EC55989_3613 yrbF; toluene transporter subunit: ATP-binding component of ABC superfamily [KO:K02065 ]
EC55989_4226 rbsB; D-ribose transporter subunit; periplasmic-binding compoent of ABC superfamily [KO:K10439 ]
EC55989_4225 rbsC; D-ribose transporter subunit; membrane component of ABC superfamily [KO:K10440 ]
EC55989_2077 araF; L-arabinose transporter subunit; periplasmic-binding component of ABC superfamily [KO:K10537 ]
EC55989_2075 araH; fused L-arabinose transporter subunits of ABC superfamily: membrane components [KO:K10538 ]
EC55989_4786 ytfQ; putative sugar transporter subunit: periplasmic-binding component of ABC superfamily [KO:K23508 ]
EC55989_4789 yjfF; putative sugar transporter subunit: membrane component of ABC superfamily [KO:K23509 ]
EC55989_4788 ytfT; putative sugar transporter subunit: membrane component of ABC superfamily [KO:K23509 ]
EC55989_2400 mglB; methyl-galactoside transporter subunit; periplasmic-binding component of ABC superfamily [KO:K10540 ]
EC55989_2398 mglC; methyl-galactoside transporter subunit; membrane component of ABC superfamily [KO:K10541 ]
EC55989_2399 mglA; fused methyl-galactoside transporter subunits of ABC superfamily: ATP-binding components [KO:K10542 ] [EC:7.5.2.11 ]
EC55989_4021 xylF; D-xylose transporter subunit; periplasmic-binding component of ABC superfamily [KO:K10543 ]
EC55989_4023 xylH; D-xylose transporter subunit; membrane component of ABC superfamily [KO:K10544 ]
EC55989_3861 ugpB; glycerol-3-phosphate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K05813 ]
EC55989_3860 ugpA; glycerol-3-phosphate transporter subunit; membrane component of ABC superfamily [KO:K05814 ]
EC55989_3859 ugpE; glycerol-3-phosphate transporter subunit; membrane component of ABC superfamily [KO:K05815 ]
EC55989_4199 pstS; phosphate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K02040 ]
EC55989_4198 pstC; phosphate transporter subunit; membrane component of ABC superfamily [KO:K02037 ]
EC55989_4197 pstA; phosphate transporter subunit; membrane component of ABC superfamily [KO:K02038 ]
EC55989_4595 phnD; phosphonate/organophosphate ester transporter subunit; periplasmic binding component of ABC superfamily [KO:K02044 ]
EC55989_4596 phnC; phosphonate/organophosphate ester transporter subunit; ATP-binding component of ABC superfamily [KO:K02041 ] [EC:7.3.2.2 ]
EC55989_2554 argT; lysine/arginine/ornithine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K10013 ]
EC55989_2551 hisM; histidine/lysine/arginine/ornithine transporter subunit; membrane component of ABC superfamily [KO:K10015 ]
EC55989_2552 hisQ; histidine/lysine/arginine/ornithine transporter subunit; membrane component of ABC superfamily [KO:K10016 ]
EC55989_2550 hisP; histidine/lysine/arginine/ornithine transporter subunit; ATP-binding component of ABC superfamily [KO:K10017 ] [EC:7.4.2.1 ]
EC55989_2553 hisJ; histidine/lysine/arginine/ornithine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K10014 ]
EC55989_0855 glnH; glutamine transporter subunit; periplasmic binding component of ABC superfamily [KO:K10036 ]
EC55989_0854 glnP; glutamine transporter subunit; membrane component of ABC superfamily [KO:K10037 ]
EC55989_0905 artJ; arginine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K09996 ]
EC55989_0908 artI; arginine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K09997 ]
EC55989_0906 artM; arginine transporter subunit; membrane component of ABC superfamily [KO:K09998 ]
EC55989_0907 artQ; arginine transporter subunit; membrane component of ABC superfamily [KO:K09999 ]
EC55989_0649 gltI; glutamate and aspartate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K10001 ]
EC55989_0647 gltK; glutamate and aspartate transporter subunit; membrane component of ABC superfamily [KO:K10002 ]
EC55989_0648 gltJ; glutamate and aspartate transporter subunit; membrane component of ABC superfamily [KO:K10003 ]
EC55989_0646 gltL; glutamate and aspartate transporter subunit; ATP-binding component of ABC superfamily [KO:K10004 ] [EC:7.4.2.1 ]
EC55989_3683 aapJ; amino-acid transporter subunit; periplasmic-binding component of ABC superfamily [KO:K09969 ]
EC55989_3684 aapQ; amino-acid transporter subunit; membrane component of ABC superfamily [KO:K09970 ]
EC55989_3685 aapM; amino-acid transporter subunit; membrane component of ABC superfamily [KO:K09971 ]
EC55989_2141 fliY; cystine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K02424 ]
EC55989_2139 yecS; putative transporter subunit: permease component of ABC superfamily transporter [KO:K10009 ]
EC55989_2138 yecC; putative transporter subunit: ATP-binding component of ABC superfamily transporter [KO:K10010 ] [EC:7.4.2.1 ]
EC55989_3866 livK; leucine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K01999 ]
EC55989_3868 livJ; leucine/isoleucine/valine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K01999 ]
EC55989_3865 livH; leucine/isoleucine/valine transporter subunit; membrane component of ABC superfamily [KO:K01997 ]
EC55989_3864 livM; leucine/isoleucine/valine transporter subunit; membrane component of ABC superfamily [KO:K01998 ]
EC55989_3863 livG; leucine/isoleucine/valine transporter subunit; ATP-binding component of ABC superfamily [KO:K01995 ]
EC55989_3862 livF; leucine/isoleucine/valine transporter subunit; ATP-binding component of ABC superfamily [KO:K01996 ]
EC55989_0195 metQ; DL-methionine transporter subunit; periplasmic-binding component of ABC superfamily [KO:K02073 ]
EC55989_0196 metI; DL-methionine transporter subunit; membrane component protein of ABC superfamily [KO:K02072 ]
EC55989_0197 metN; DL-methionine transporter subunit; ATP-binding component of ABC superfamily [KO:K02071 ]
EC55989_1494 mppA; murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit; periplasmic-binding component of ABC superfamily [KO:K15580 ]
EC55989_1340 oppA; oligopeptide transporter subunit; periplasmic-binding component of ABC superfamily [KO:K15580 ]
EC55989_1341 oppB; oligopeptide transporter subunit; membrane component of ABC superfamily [KO:K15581 ]
EC55989_1342 oppC; oligopeptide transporter subunit; membrane component of ABC superfamily [KO:K15582 ]
EC55989_1343 oppD; oligopeptide transporter subunit; ATP-binding component of ABC superfamily [KO:K15583 ]
EC55989_1344 oppF; oligopeptide transporter subunit; ATP-binding component of ABC superfamily [KO:K10823 ]
EC55989_3996 dppA; dipeptide transporter; periplasmic-binding component of ABC superfamily [KO:K12368 ]
EC55989_3994 dppB; dipeptide transporter; membrane component of ABC superfamily [KO:K12369 ]
EC55989_3993 dppC; dipeptide transporter; membrane component of ABC superfamily [KO:K12370 ]
EC55989_3992 dppD; dipeptide transporter; ATP-binding component of ABC superfamily [KO:K12371 ]
EC55989_3991 dppF; dipeptide transporter; ATP-binding component of ABC superfamily [KO:K12372 ]
EC55989_1456 sapA; antimicrobial peptide transporter subunit; periplasmic-binding component of ABC superfamily transporter [KO:K19226 ]
EC55989_1455 sapB; antimicrobial peptide transporter subunit; permease component of ABC superfamily transporter [KO:K19227 ]
EC55989_1454 sapC; antimicrobial peptide transporter subunit; permease component of ABC superfamily transporter [KO:K19228 ]
EC55989_1453 sapD; antimicrobial peptide transporter subunit; ATP-binding component of ABC superfamily transporter [KO:K19229 ]
EC55989_1452 sapF; antimicrobial peptide transporter subunit; ATP-binding component of ABC superfamily transporter [KO:K19230 ]
EC55989_3884 nikA; nickel transporter subunit; periplasmic-binding component of ABC superfamily [KO:K15584 ]
EC55989_3885 nikB; nickel transporter subunit; membrane component of ABC superfamily [KO:K15585 ]
EC55989_3886 nikC; nickel transporter subunit; membrane component of ABC superfamily [KO:K15586 ]
EC55989_0875 yliB; putative peptide transporter subunit: periplasmic-binding component of ABC superfamily [KO:K13889 ]
EC55989_0876 yliC; putative peptide transporter permease subunit: membrane component of ABC superfamily [KO:K13890 ]
EC55989_0877 yliD; putative peptide transporter permease subunit: membrane component of ABC superfamily [KO:K13891 ]
EC55989_0874 yliA; putative peptide transport fused subunits of ABC superfamily: ATP-binding components [KO:K13892 ]
EC55989_2431 yejA; putative oligopeptide transporter subunit; periplasmic-binding component of ABC superfamily transporter [KO:K13893 ]
EC55989_2432 yejB; putative oligopeptide transporter subunit; permease component of ABC superfamily [KO:K13894 ]
EC55989_2433 yejE; putative oligopeptide transporter subunit; permease component of ABC superfamily transporter [KO:K13895 ]
EC55989_2434 yejF; putative fused oligopeptide transporter subunits of ABC superfamily: ATP-binding components [KO:K13896 ]
EC55989_4963 fecB; iron-dicitrate transporter subunit; periplasmic-binding component of ABC superfamily; KpLE2 phage-like element [KO:K23181 ]
EC55989_4961 fecD; iron-dicitrate transporter subunit; membrane component of ABC superfamily; KpLE2 phage-like element [KO:K23182 ]
EC55989_4962 fecC; iron-dicitrate transporter subunit; membrane component of ABC superfamily; KpLE2 phage-like element [KO:K23183 ]
EC55989_4959 fecE; iron-dicitrate transporter subunit; ATP-binding component of ABC superfamily; KpLE2 phage-like element [KO:K23184 ] [EC:7.2.2.18 ]
EC55989_0584 fepB; iron-enterobactin transporter subunit; periplasmic-binding component of ABC superfamily [KO:K23185 ]
EC55989_0582 fepD; iron-enterobactin transporter subunit; membrane component of ABC superfamily [KO:K23186 ]
EC55989_0581 fepG; iron-enterobactin transporter subunit; membrane component of ABC superfamily [KO:K23187 ]
EC55989_0580 fepC; iron-enterobactin transporter subunit; ATP-binding component of ABC superfamily [KO:K23188 ] [EC:7.2.2.17 7.2.2.-]
EC55989_0146 fhuD; iron-hydroxamate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K23227 ]
EC55989_0147 fhuB; fused iron-hydroxamate transporter subunits of ABC superfamily: membrane components [KO:K23228 ]
EC55989_0153 btuF; vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily [KO:K06858 ]
EC55989_1879 btuC; vitamin B12 transporter subunit: membrane component of ABC superfamily [KO:K06073 ]
EC55989_2036 znuA; zinc transporter subunit: periplasmic-binding component of ABC superfamily [KO:K09815 ]
EC55989_2038 znuB; zinc transporter subunit: membrane component of ABC superfamily [KO:K09816 ]
EC55989_3219 putative ATP-binding protein of ABC transport system [KO:K16786 ] [EC:7.-.-.-]
EC55989_3220 putative ATP-binding protein of ABC transport system [KO:K16787 ] [EC:7.-.-.-]
EC55989_1649 lsrB; AI2 transporter; periplasmic-binding component of ABC superfamily [KO:K10555 ]
EC55989_1646 ego; fused AI2 transporter subunits of ABC superfamily: ATP-binding components [KO:K10558 ]
EC55989_1228 lolC; outer membrane-specific lipoprotein transporter subunit; membrane component of ABC superfamily [KO:K09808 ]
EC55989_1230 lolE; outer membrane-specific lipoprotein transporter subunit; membrane component of ABC superfamily [KO:K09808 ]
EC55989_1229 lolD; outer membrane-specific lipoprotein transporter subunit; ATP-binding component of ABC superfamily [KO:K09810 ] [EC:7.6.2.-]
EC55989_2452 ccmC; heme exporter subunit; membrane component of ABC superfamily [KO:K02195 ]
EC55989_2453 ccmB; heme exporter subunit; membrane component of ABC superfamily [KO:K02194 ]
EC55989_4819 yjgP; conserved hypothetical protein; putative inner membrane protein [KO:K07091 ]
EC55989_4820 yjgQ; conserved hypothetical protein; putative inner membrane protein [KO:K11720 ]
EC55989_3619 lptB; putative lipopolysaccharide transport protein B: ATP-binding component of ABC superfamily [KO:K06861 ] [EC:7.5.2.5 ]
EC55989_3871 ftsE; transporter subunit: ATP-binding component of ABC superfamily [KO:K09812 ]
EC55989_2205 irp; permease and ATP-binding protein of yersiniabactin-iron ABC transporter YbtP [KO:K14698 ] [EC:7.-.-.-]
EC55989_2204 irp; permease and ATP-binding protein of yersiniabactin-iron ABC transporter YbtQ [KO:K14699 ] [EC:7.-.-.-]
EC55989_0959 msbA; fused lipid transporter subunits of ABC superfamily: membrane component; ATP-binding component [KO:K11085 ] [EC:7.5.2.6 ]
EC55989_0462 mdlA; putative fused ATPase and permease component of metabolite transporter [KO:K18889 ]
EC55989_0463 mdlB; putative fused ATPase and permease component of metabolite ABC transporter [KO:K18890 ]
EC55989_0931 cydC; fused cysteine transporter subunits of ABC superfamily: membrane component; ATP-binding component [KO:K16012 ]
EC55989_0932 cydD; fused cysteine transporter subunits of ABC superfamily: membrane component; ATP-binding component [KO:K16013 ]
EC55989_0924 macB; fused macrolide transporter subunits of ABC superfamily: ATP-binding component; membrane component [KO:K05685 ] [EC:7.6.2.-]
EC55989_2466 yojI; fused multidrug transport subunits of ABC superfamily transporter: permease component/ATP-binding component [KO:K06159 ]
EC55989_1628 yddA; putative multidrug transporter fused subunits of ABC superfamily transporter: permease component; ATP-binding component [KO:K02471 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway
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